4u48 - Revision history

OCA at 08:01, 22 March 2023

OCA — Wed, 22 Mar 2023 08:01:08 GMT

←Older revision		Revision as of 08:01, 22 March 2023
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	==Crystal structure of Salmonella alpha-2-macroglobulin==		==Crystal structure of Salmonella alpha-2-macroglobulin==
-	<StructureSection load='4u48' size='340' side='right' caption='[[4u48]], [[Resolution\|resolution]] 2.95Å' scene=''>	+	<StructureSection load='4u48' size='340' side='right'caption='[[4u48]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4u48]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Salty Salty~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U48 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4U48 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4u48]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U48 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U48 FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STM2532 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 SALTY])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u48 OCA], [https://pdbe.org/4u48 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u48 RCSB], [https://www.ebi.ac.uk/pdbsum/4u48 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u48 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4u48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u48 OCA], [~~http~~://pdbe.org/4u48 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4u48 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4u48 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4u48 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8ZN46_SALTY Q8ZN46_SALTY]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Salty~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Dessen, A~~]]	+	[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
-	[[Category: ~~Wong, S G~~]]	+	[[Category: Dessen A]]
-	[[Category: ~~Hydrolase inhibitor]]~~	+	[[Category: Wong SG]]
-	~~[[Category: Protease inhibitor]]~~	+
-	~~[[Category: Thioester]]~~	+
-	~~[[Category: Unknown function~~]]	+

OCA at 16:12, 16 November 2017

OCA — Thu, 16 Nov 2017 16:12:19 GMT

←Older revision		Revision as of 16:12, 16 November 2017
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		+
	==Crystal structure of Salmonella alpha-2-macroglobulin==		==Crystal structure of Salmonella alpha-2-macroglobulin==
	<StructureSection load='4u48' size='340' side='right' caption='[[4u48]], [[Resolution\|resolution]] 2.95Å' scene=''>		<StructureSection load='4u48' size='340' side='right' caption='[[4u48]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4u48]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U48 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U48 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4u48]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Salty Salty]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U48 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U48 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u48 OCA], [http://pdbe.org/4u48 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4u48 RCSB], [http://www.ebi.ac.uk/pdbsum/4u48 PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STM2532 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 SALTY])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u48 OCA], [http://pdbe.org/4u48 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4u48 RCSB], [http://www.ebi.ac.uk/pdbsum/4u48 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4u48 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Salty]]
	[[Category: Dessen, A]]		[[Category: Dessen, A]]
	[[Category: Wong, S G]]		[[Category: Wong, S G]]

OCA at 08:11, 30 September 2015

OCA — Wed, 30 Sep 2015 08:11:02 GMT

←Older revision		Revision as of 08:11, 30 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[4u48]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U48 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U48 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4u48]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U48 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U48 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u48 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u48 RCSB], [http://www.ebi.ac.uk/pdbsum/4u48 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u48 OCA], [http://pdbe.org/4u48 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4u48 RCSB], [http://www.ebi.ac.uk/pdbsum/4u48 PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4u48" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:57, 20 January 2015

OCA — Tue, 20 Jan 2015 10:57:01 GMT

←Older revision		Revision as of 10:57, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4u48]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U48 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U48 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4u48]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U48 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U48 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u48 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u48 RCSB], [http://www.ebi.ac.uk/pdbsum/4u48 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u48 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u48 RCSB], [http://www.ebi.ac.uk/pdbsum/4u48 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Dessen, A.]]	+	[[Category: Dessen, A]]
-	[[Category: Wong, S G.]]	+	[[Category: Wong, S G]]
	[[Category: Hydrolase inhibitor]]		[[Category: Hydrolase inhibitor]]
	[[Category: Protease inhibitor]]		[[Category: Protease inhibitor]]
	[[Category: Thioester]]		[[Category: Thioester]]
	[[Category: Unknown function]]		[[Category: Unknown function]]

OCA at 22:34, 1 October 2014

OCA — Wed, 01 Oct 2014 22:34:49 GMT

←Older revision		Revision as of 22:34, 1 October 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of Salmonella alpha-2-macroglobulin==
		+	<StructureSection load='4u48' size='340' side='right' caption='[[4u48]], [[Resolution\|resolution]] 2.95Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4u48]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U48 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U48 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u48 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u48 RCSB], [http://www.ebi.ac.uk/pdbsum/4u48 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. Surprisingly, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. Bacterial A2Ms are located in the periplasm where they are believed to provide protection to the cell by trapping external proteases through a covalent interaction with an activated thioester. Here we report the crystal structures and characterization of Salmonella enterica ser. Typhimurium A2M in different states of thioester activation. The structures reveal thirteen domains whose arrangement displays high similarity to proteins involved in eukaryotic immune defence. A structural lock mechanism maintains the stability of the buried thioester, a requirement for its protease-trapping activity. These findings indicate that bacteria have developed a rudimentary innate immune system whose mechanism mimics that of eukaryotes.

-	~~The entry 4u48 is ON HOLD until Paper Publication~~	+	Structure of a bacterial alpha2-macroglobulin reveals mimicry of eukaryotic innate immunity.,Wong SG, Dessen A Nat Commun. 2014 Sep 15;5:4917. doi: 10.1038/ncomms5917. PMID:25221932<ref>PMID:25221932</ref>

-	~~Authors: Wong~~, S.G., Dessen, A.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~:	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Dessen, A.]]
		+	[[Category: Wong, S G.]]
		+	[[Category: Hydrolase inhibitor]]
		+	[[Category: Protease inhibitor]]
		+	[[Category: Thioester]]
		+	[[Category: Unknown function]]

OCA at 08:03, 13 August 2014

OCA — Wed, 13 Aug 2014 08:03:14 GMT

←Older revision		Revision as of 08:03, 13 August 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4u48 is ON HOLD	+	The entry 4u48 is ON HOLD until Paper Publication

	Authors: Wong, S.G., Dessen, A.		Authors: Wong, S.G., Dessen, A.

	Description:		Description:

OCA: Protected "4u48" [edit=sysop:move=sysop]

OCA — Wed, 30 Jul 2014 07:16:01 GMT

Protected "4u48" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:16, 30 July 2014

OCA: New page: '''Unreleased structure''' The entry 4u48 is ON HOLD Authors: Wong, S.G., Dessen, A. Description:

OCA — Wed, 30 Jul 2014 07:16:01 GMT

New page: '''Unreleased structure''' The entry 4u48 is ON HOLD Authors: Wong, S.G., Dessen, A. Description:

New page

'''Unreleased structure'''

The entry 4u48 is ON HOLD

Authors: Wong, S.G., Dessen, A.

Description: