4u4j - Revision history

OCA at 12:26, 20 December 2023

OCA — Wed, 20 Dec 2023 12:26:40 GMT

←Older revision		Revision as of 12:26, 20 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4u4j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U4J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U4J FirstGlance]. <br>		<table><tr><td colspan='2'>[[4u4j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U4J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U4J FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u4j OCA], [https://pdbe.org/4u4j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u4j RCSB], [https://www.ebi.ac.uk/pdbsum/4u4j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u4j ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u4j OCA], [https://pdbe.org/4u4j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u4j RCSB], [https://www.ebi.ac.uk/pdbsum/4u4j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u4j ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 08:01, 22 March 2023

OCA — Wed, 22 Mar 2023 08:01:57 GMT

←Older revision		Revision as of 08:01, 22 March 2023
Line 3:		Line 3:
	<StructureSection load='4u4j' size='340' side='right'caption='[[4u4j]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='4u4j' size='340' side='right'caption='[[4u4j]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4u4j]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Salty Salty~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U4J OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4U4J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4u4j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U4J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U4J FirstGlance]. <br>
-	</td></tr>~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STM2532 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 SALTY])</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u4j OCA], [https://pdbe.org/4u4j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u4j RCSB], [https://www.ebi.ac.uk/pdbsum/4u4j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u4j ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4u4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u4j OCA], [~~http~~://pdbe.org/4u4j PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4u4j RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4u4j PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4u4j ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8ZN46_SALTY Q8ZN46_SALTY]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Salty~~]]	+	[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
-	[[Category: Dessen, A]]	+	[[Category: Dessen A]]
-	[[Category: Wong~~, S G]]~~	+	[[Category: Wong SG]]
-	~~[[Category: Hydrolase inhibitor]]~~	+
-	~~[[Category: Protease inhibitor]]~~	+
-	~~[[Category: Thioester~~]]	+

OCA at 14:51, 10 May 2019

OCA — Fri, 10 May 2019 14:51:21 GMT

←Older revision		Revision as of 14:51, 10 May 2019
Line 1:		Line 1:

	==Crystal structure of Salmonella alpha-2-macroglobulin mutant Y1175G==		==Crystal structure of Salmonella alpha-2-macroglobulin mutant Y1175G==
-	<StructureSection load='4u4j' size='340' side='right' caption='[[4u4j]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='4u4j' size='340' side='right'caption='[[4u4j]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4u4j]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U4J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U4J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4u4j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Salty Salty]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U4J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U4J FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u4j OCA], [http://pdbe.org/4u4j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4u4j RCSB], [http://www.ebi.ac.uk/pdbsum/4u4j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4u4j ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STM2532 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 SALTY])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u4j OCA], [http://pdbe.org/4u4j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4u4j RCSB], [http://www.ebi.ac.uk/pdbsum/4u4j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4u4j ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 19:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Salty]]
	[[Category: Dessen, A]]		[[Category: Dessen, A]]
	[[Category: Wong, S G]]		[[Category: Wong, S G]]

OCA at 01:13, 19 January 2017

OCA — Thu, 19 Jan 2017 01:13:44 GMT

←Older revision		Revision as of 01:13, 19 January 2017
Line 1:		Line 1:
		+
	==Crystal structure of Salmonella alpha-2-macroglobulin mutant Y1175G==		==Crystal structure of Salmonella alpha-2-macroglobulin mutant Y1175G==
	<StructureSection load='4u4j' size='340' side='right' caption='[[4u4j]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='4u4j' size='340' side='right' caption='[[4u4j]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4u4j]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U4J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U4J FirstGlance]. <br>		<table><tr><td colspan='2'>[[4u4j]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U4J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U4J FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u4j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u4j RCSB], [http://www.ebi.ac.uk/pdbsum/4u4j PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u4j OCA], [http://pdbe.org/4u4j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4u4j RCSB], [http://www.ebi.ac.uk/pdbsum/4u4j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4u4j ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 13:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4u4j" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:40, 20 January 2015

OCA — Tue, 20 Jan 2015 10:40:23 GMT

←Older revision		Revision as of 10:40, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4u4j]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U4J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U4J FirstGlance]. <br>		<table><tr><td colspan='2'>[[4u4j]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U4J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U4J FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u4j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u4j RCSB], [http://www.ebi.ac.uk/pdbsum/4u4j PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u4j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u4j RCSB], [http://www.ebi.ac.uk/pdbsum/4u4j PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Dessen, A.]]	+	[[Category: Dessen, A]]
-	[[Category: Wong, S G.]]	+	[[Category: Wong, S G]]
	[[Category: Hydrolase inhibitor]]		[[Category: Hydrolase inhibitor]]
	[[Category: Protease inhibitor]]		[[Category: Protease inhibitor]]
	[[Category: Thioester]]		[[Category: Thioester]]

OCA at 22:05, 1 October 2014

OCA — Wed, 01 Oct 2014 22:05:49 GMT

←Older revision		Revision as of 22:05, 1 October 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of Salmonella alpha-2-macroglobulin mutant Y1175G==
		+	<StructureSection load='4u4j' size='340' side='right' caption='[[4u4j]], [[Resolution\|resolution]] 2.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4u4j]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U4J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U4J FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u4j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u4j RCSB], [http://www.ebi.ac.uk/pdbsum/4u4j PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. Surprisingly, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. Bacterial A2Ms are located in the periplasm where they are believed to provide protection to the cell by trapping external proteases through a covalent interaction with an activated thioester. Here we report the crystal structures and characterization of Salmonella enterica ser. Typhimurium A2M in different states of thioester activation. The structures reveal thirteen domains whose arrangement displays high similarity to proteins involved in eukaryotic immune defence. A structural lock mechanism maintains the stability of the buried thioester, a requirement for its protease-trapping activity. These findings indicate that bacteria have developed a rudimentary innate immune system whose mechanism mimics that of eukaryotes.

-	~~The entry 4u4j is ON HOLD until Paper Publication~~	+	Structure of a bacterial alpha2-macroglobulin reveals mimicry of eukaryotic innate immunity.,Wong SG, Dessen A Nat Commun. 2014 Sep 15;5:4917. doi: 10.1038/ncomms5917. PMID:25221932<ref>PMID:25221932</ref>

-	~~Authors: Wong~~, S.G., Dessen, A.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~:	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Dessen, A.]]
		+	[[Category: Wong, S G.]]
		+	[[Category: Hydrolase inhibitor]]
		+	[[Category: Protease inhibitor]]
		+	[[Category: Thioester]]

OCA at 08:03, 13 August 2014

OCA — Wed, 13 Aug 2014 08:03:35 GMT

←Older revision		Revision as of 08:03, 13 August 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4u4j is ON HOLD	+	The entry 4u4j is ON HOLD until Paper Publication

	Authors: Wong, S.G., Dessen, A.		Authors: Wong, S.G., Dessen, A.

	Description:		Description:

OCA: Protected "4u4j" [edit=sysop:move=sysop]

OCA — Wed, 30 Jul 2014 07:16:18 GMT

Protected "4u4j" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:16, 30 July 2014

OCA: New page: '''Unreleased structure''' The entry 4u4j is ON HOLD Authors: Wong, S.G., Dessen, A. Description:

OCA — Wed, 30 Jul 2014 07:16:17 GMT

New page: '''Unreleased structure''' The entry 4u4j is ON HOLD Authors: Wong, S.G., Dessen, A. Description:

New page

'''Unreleased structure'''

The entry 4u4j is ON HOLD

Authors: Wong, S.G., Dessen, A.

Description: