4u59 - Revision history

OCA at 12:27, 20 December 2023

OCA — Wed, 20 Dec 2023 12:27:01 GMT

←Older revision		Revision as of 12:27, 20 December 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4u59]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U59 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U59 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4u59]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U59 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U59 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MEQ:N5-METHYLGLUTAMINE'>MEQ</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.09Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MEQ:N5-METHYLGLUTAMINE'>MEQ</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u59 OCA], [https://pdbe.org/4u59 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u59 RCSB], [https://www.ebi.ac.uk/pdbsum/4u59 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u59 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u59 OCA], [https://pdbe.org/4u59 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u59 RCSB], [https://www.ebi.ac.uk/pdbsum/4u59 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u59 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:03, 22 March 2023

OCA — Wed, 22 Mar 2023 08:03:05 GMT

←Older revision		Revision as of 08:03, 22 March 2023
Line 3:		Line 3:
	<StructureSection load='4u59' size='340' side='right'caption='[[4u59]], [[Resolution\|resolution]] 3.09Å' scene=''>		<StructureSection load='4u59' size='340' side='right'caption='[[4u59]], [[Resolution\|resolution]] 3.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4u59]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_typhimurium"_loeffler_1892 "bacillus typhimurium" loeffler 1892~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U59 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4U59 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4u59]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U59 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U59 FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=MEQ:N5-METHYLGLUTAMINE'>MEQ</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MEQ:N5-METHYLGLUTAMINE'>MEQ</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CY43_13515 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90371 "Bacillus typhimurium" Loeffler 1892])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u59 OCA], [https://pdbe.org/4u59 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u59 RCSB], [https://www.ebi.ac.uk/pdbsum/4u59 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u59 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4u59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u59 OCA], [~~http~~://pdbe.org/4u59 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4u59 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4u59 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4u59 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8ZN46_SALTY Q8ZN46_SALTY]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus typhimurium loeffler 1892]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Dessen, A~~]]	+	[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
-	[[Category: ~~Wong, S G~~]]	+	[[Category: Dessen A]]
-	[[Category: ~~Hydrolase inhibitor]]~~	+	[[Category: Wong SG]]
-	~~[[Category: Macroglobulin]]~~	+
-	~~[[Category: Methylamine]]~~	+
-	~~[[Category: Protease inhibitor]]~~	+
-	~~[[Category: Thioester~~]]	+

OCA at 14:45, 10 May 2019

OCA — Fri, 10 May 2019 14:45:28 GMT

←Older revision		Revision as of 14:45, 10 May 2019
Line 1:		Line 1:

	==Crystal structure of Salmonella alpha-2-macroglobulin reacted with methylamine==		==Crystal structure of Salmonella alpha-2-macroglobulin reacted with methylamine==
-	<StructureSection load='4u59' size='340' side='right' caption='[[4u59]], [[Resolution\|resolution]] 3.09Å' scene=''>	+	<StructureSection load='4u59' size='340' side='right'caption='[[4u59]], [[Resolution\|resolution]] 3.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4u59]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U59 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4u59]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_typhimurium"_loeffler_1892 "bacillus typhimurium" loeffler 1892]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U59 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MEQ:N5-METHYLGLUTAMINE'>MEQ</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MEQ:N5-METHYLGLUTAMINE'>MEQ</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CY43_13515 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90371 "Bacillus typhimurium" Loeffler 1892])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u59 OCA], [http://pdbe.org/4u59 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4u59 RCSB], [http://www.ebi.ac.uk/pdbsum/4u59 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4u59 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u59 OCA], [http://pdbe.org/4u59 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4u59 RCSB], [http://www.ebi.ac.uk/pdbsum/4u59 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4u59 ProSAT]</span></td></tr>
	</table>		</table>
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus typhimurium loeffler 1892]]
		+	[[Category: Large Structures]]
	[[Category: Dessen, A]]		[[Category: Dessen, A]]
	[[Category: Wong, S G]]		[[Category: Wong, S G]]

OCA at 01:11, 19 January 2017

OCA — Thu, 19 Jan 2017 01:11:11 GMT

←Older revision		Revision as of 01:11, 19 January 2017
Line 1:		Line 1:
		+
	==Crystal structure of Salmonella alpha-2-macroglobulin reacted with methylamine==		==Crystal structure of Salmonella alpha-2-macroglobulin reacted with methylamine==
	<StructureSection load='4u59' size='340' side='right' caption='[[4u59]], [[Resolution\|resolution]] 3.09Å' scene=''>		<StructureSection load='4u59' size='340' side='right' caption='[[4u59]], [[Resolution\|resolution]] 3.09Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4u59]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U59 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4u59]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U59 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MEQ:N5-METHYLGLUTAMINE'>MEQ</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MEQ:N5-METHYLGLUTAMINE'>MEQ</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u59 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u59 RCSB], [http://www.ebi.ac.uk/pdbsum/4u59 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u59 OCA], [http://pdbe.org/4u59 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4u59 RCSB], [http://www.ebi.ac.uk/pdbsum/4u59 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4u59 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4u59" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:21, 20 January 2015

OCA — Tue, 20 Jan 2015 08:21:48 GMT

←Older revision		Revision as of 08:21, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4u59]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U59 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4u59]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U59 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MEQ:N5-METHYLGLUTAMINE'>MEQ</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MEQ:N5-METHYLGLUTAMINE'>MEQ</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u59 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u59 RCSB], [http://www.ebi.ac.uk/pdbsum/4u59 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u59 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u59 RCSB], [http://www.ebi.ac.uk/pdbsum/4u59 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Dessen, A.]]	+	[[Category: Dessen, A]]
-	[[Category: Wong, S G.]]	+	[[Category: Wong, S G]]
	[[Category: Hydrolase inhibitor]]		[[Category: Hydrolase inhibitor]]
	[[Category: Macroglobulin]]		[[Category: Macroglobulin]]

OCA at 21:57, 1 October 2014

OCA — Wed, 01 Oct 2014 21:57:12 GMT

←Older revision		Revision as of 21:57, 1 October 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of Salmonella alpha-2-macroglobulin reacted with methylamine==
		+	<StructureSection load='4u59' size='340' side='right' caption='[[4u59]], [[Resolution\|resolution]] 3.09Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4u59]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U59 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MEQ:N5-METHYLGLUTAMINE'>MEQ</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u59 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u59 RCSB], [http://www.ebi.ac.uk/pdbsum/4u59 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. Surprisingly, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. Bacterial A2Ms are located in the periplasm where they are believed to provide protection to the cell by trapping external proteases through a covalent interaction with an activated thioester. Here we report the crystal structures and characterization of Salmonella enterica ser. Typhimurium A2M in different states of thioester activation. The structures reveal thirteen domains whose arrangement displays high similarity to proteins involved in eukaryotic immune defence. A structural lock mechanism maintains the stability of the buried thioester, a requirement for its protease-trapping activity. These findings indicate that bacteria have developed a rudimentary innate immune system whose mechanism mimics that of eukaryotes.

-	~~The entry 4u59 is ON HOLD until Paper Publication~~	+	Structure of a bacterial alpha2-macroglobulin reveals mimicry of eukaryotic innate immunity.,Wong SG, Dessen A Nat Commun. 2014 Sep 15;5:4917. doi: 10.1038/ncomms5917. PMID:25221932<ref>PMID:25221932</ref>

-	~~Authors: Wong~~, S.G., Dessen, A.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~:	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Dessen, A.]]
		+	[[Category: Wong, S G.]]
		+	[[Category: Hydrolase inhibitor]]
		+	[[Category: Macroglobulin]]
		+	[[Category: Methylamine]]
		+	[[Category: Protease inhibitor]]
		+	[[Category: Thioester]]

OCA at 01:30, 7 August 2014

OCA — Thu, 07 Aug 2014 01:30:35 GMT

←Older revision		Revision as of 01:30, 7 August 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4u59 is ON HOLD	+	The entry 4u59 is ON HOLD until Paper Publication

	Authors: Wong, S.G., Dessen, A.		Authors: Wong, S.G., Dessen, A.

	Description:		Description:

OCA: Protected "4u59" [edit=sysop:move=sysop]

OCA — Wed, 30 Jul 2014 07:17:32 GMT

Protected "4u59" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:17, 30 July 2014

OCA: New page: '''Unreleased structure''' The entry 4u59 is ON HOLD Authors: Wong, S.G., Dessen, A. Description:

OCA — Wed, 30 Jul 2014 07:17:31 GMT

New page: '''Unreleased structure''' The entry 4u59 is ON HOLD Authors: Wong, S.G., Dessen, A. Description:

New page

'''Unreleased structure'''

The entry 4u59 is ON HOLD

Authors: Wong, S.G., Dessen, A.

Description: