4u7y - Revision history

OCA at 07:25, 27 September 2023

OCA — Wed, 27 Sep 2023 07:25:53 GMT

←Older revision		Revision as of 07:25, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4u7y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U7Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U7Y FirstGlance]. <br>		<table><tr><td colspan='2'>[[4u7y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U7Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U7Y FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u7y OCA], [https://pdbe.org/4u7y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u7y RCSB], [https://www.ebi.ac.uk/pdbsum/4u7y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u7y ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.502Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u7y OCA], [https://pdbe.org/4u7y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u7y RCSB], [https://www.ebi.ac.uk/pdbsum/4u7y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u7y ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 08:07, 22 March 2023

OCA — Wed, 22 Mar 2023 08:07:35 GMT

←Older revision		Revision as of 08:07, 22 March 2023
Line 3:		Line 3:
	<StructureSection load='4u7y' size='340' side='right'caption='[[4u7y]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4u7y' size='340' side='right'caption='[[4u7y]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4u7y]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U7Y OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4U7Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4u7y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U7Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U7Y FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4u7e\|4u7e]], [[4u7i\|4u7i]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u7y OCA], [https://pdbe.org/4u7y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u7y RCSB], [https://www.ebi.ac.uk/pdbsum/4u7y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u7y ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VPS4B, SKD1, VPS42, MIG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IST1, KIAA0174 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Vesicle-fusing_ATPase Vesicle-fusing ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.6 3.6.4.6] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4u7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u7y OCA], [~~http~~://pdbe.org/4u7y PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4u7y RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4u7y PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4u7y ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/VPS4B_HUMAN VPS4B_HUMAN]] Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses).<ref>PMID:11563910</ref> <ref>PMID:14505570</ref> <ref>PMID:18687924</ref> [[http://www.uniprot.org/uniprot/IST1_HUMAN IST1_HUMAN]] Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells.<ref>PMID:19129479</ref> <ref>PMID:19129480</ref>	+	[https://www.uniprot.org/uniprot/VPS4B_HUMAN VPS4B_HUMAN] Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses).<ref>PMID:11563910</ref> <ref>PMID:14505570</ref> <ref>PMID:18687924</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 19:

	==See Also==		==See Also==
-	*[[Vacuolar protein sorting-associated protein\|Vacuolar protein sorting-associated protein]]	+	*[[Vacuolar protein sorting-associated protein 3D structures\|Vacuolar protein sorting-associated protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Vesicle-fusing ATPase]]~~	+	[[Category: Guo EZ]]
-	[[Category: Guo~~, E Z~~]]	+	[[Category: Xu Z]]
-	[[Category: Xu, Z]]	+
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Mim1]]~~	+
-	~~[[Category: Protein transport~~]]	+

OCA at 10:23, 25 December 2019

OCA — Wed, 25 Dec 2019 10:23:02 GMT

←Older revision		Revision as of 10:23, 25 December 2019
Line 1:		Line 1:

	==Structure of the complex of VPS4B MIT and IST1 MIM==		==Structure of the complex of VPS4B MIT and IST1 MIM==
-	<StructureSection load='4u7y' size='340' side='right' caption='[[4u7y]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='4u7y' size='340' side='right'caption='[[4u7y]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4u7y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U7Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U7Y FirstGlance]. <br>		<table><tr><td colspan='2'>[[4u7y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U7Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U7Y FirstGlance]. <br>
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4u7y" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4u7y" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Vacuolar protein sorting-associated protein\|Vacuolar protein sorting-associated protein]]
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Vesicle-fusing ATPase]]		[[Category: Vesicle-fusing ATPase]]
	[[Category: Guo, E Z]]		[[Category: Guo, E Z]]

OCA at 12:07, 6 November 2017

OCA — Mon, 06 Nov 2017 12:07:11 GMT

←Older revision		Revision as of 12:07, 6 November 2017
Line 3:		Line 3:
	<StructureSection load='4u7y' size='340' side='right' caption='[[4u7y]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4u7y' size='340' side='right' caption='[[4u7y]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4u7y]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U7Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U7Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4u7y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U7Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U7Y FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4u7e\|4u7e]], [[4u7i\|4u7i]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4u7e\|4u7e]], [[4u7i\|4u7i]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VPS4B, SKD1, VPS42, MIG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IST1, KIAA0174 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Vesicle-fusing_ATPase Vesicle-fusing ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.6 3.6.4.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Vesicle-fusing_ATPase Vesicle-fusing ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.6 3.6.4.6] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u7y OCA], [http://pdbe.org/4u7y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4u7y RCSB], [http://www.ebi.ac.uk/pdbsum/4u7y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4u7y ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u7y OCA], [http://pdbe.org/4u7y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4u7y RCSB], [http://www.ebi.ac.uk/pdbsum/4u7y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4u7y ProSAT]</span></td></tr>
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Vesicle-fusing ATPase]]		[[Category: Vesicle-fusing ATPase]]
	[[Category: Guo, E Z]]		[[Category: Guo, E Z]]
Line 28:		Line 30:
	[[Category: Complex]]		[[Category: Complex]]
	[[Category: Mim1]]		[[Category: Mim1]]
		+	[[Category: Protein transport]]

OCA at 01:23, 19 January 2017

OCA — Thu, 19 Jan 2017 01:23:31 GMT

←Older revision		Revision as of 01:23, 19 January 2017
Line 1:		Line 1:
		+
	==Structure of the complex of VPS4B MIT and IST1 MIM==		==Structure of the complex of VPS4B MIT and IST1 MIM==
	<StructureSection load='4u7y' size='340' side='right' caption='[[4u7y]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4u7y' size='340' side='right' caption='[[4u7y]], [[Resolution\|resolution]] 2.50Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4u7e\|4u7e]], [[4u7i\|4u7i]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4u7e\|4u7e]], [[4u7i\|4u7i]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Vesicle-fusing_ATPase Vesicle-fusing ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.6 3.6.4.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Vesicle-fusing_ATPase Vesicle-fusing ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.6 3.6.4.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u7y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u7y RCSB], [http://www.ebi.ac.uk/pdbsum/4u7y PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u7y OCA], [http://pdbe.org/4u7y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4u7y RCSB], [http://www.ebi.ac.uk/pdbsum/4u7y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4u7y ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4u7y" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:33, 18 February 2015

OCA — Wed, 18 Feb 2015 07:33:34 GMT

←Older revision		Revision as of 07:33, 18 February 2015
Line 9:		Line 9:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/VPS4B_HUMAN VPS4B_HUMAN]] Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses).<ref>PMID:11563910</ref> <ref>PMID:14505570</ref> <ref>PMID:18687924</ref> [[http://www.uniprot.org/uniprot/IST1_HUMAN IST1_HUMAN]] Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells.<ref>PMID:19129479</ref> <ref>PMID:19129480</ref>		[[http://www.uniprot.org/uniprot/VPS4B_HUMAN VPS4B_HUMAN]] Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses).<ref>PMID:11563910</ref> <ref>PMID:14505570</ref> <ref>PMID:18687924</ref> [[http://www.uniprot.org/uniprot/IST1_HUMAN IST1_HUMAN]] Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells.<ref>PMID:19129479</ref> <ref>PMID:19129480</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The endosomal sorting complex required for transport (ESCRT) machinery is responsible for membrane remodeling in a number of biological processes including multi-vesicular body biogenesis, cytokinesis, and enveloped virus budding. In mammalian cells, efficient abscission during cytokinesis requires proper function of the ESCRT-III protein IST1, which binds to the Microtubule Interacting and Trafficking (MIT) domains of VPS4, LIP5, and Spartin via its C-terminal MIT-Interacting Motif (MIM). Here, we studied the molecular interactions between IST1 and the three MIT domain-containing proteins to understand the structural basis that governs pairwise MIT-MIM interaction. Crystal structures of the three molecular complexes revealed that IST1 binds to the MIT domains of VPS4, LIP5 and Spartin using two different mechanisms (MIM1 mode versus MIM3 mode). Structural comparison revealed that structural features in both MIT and MIM contribute to determine the specific binding mechanism. Within the IST1 MIM sequence, two phenylalanine residues were shown to be important in discriminating MIM1 versus MIM3 binding. These observations enabled us to deduce a preliminary binding code, which we applied to provide CHMP2A, a protein that normally only binds the MIT domain in the MIM1 mode, the additional ability to bind the MIT domain of Spartin in the MIM3 mode.
		+
		+	Distinct Mechanisms of Recognizing Endosomal Sorting Complex Required for Transport (ESCRT)-III Protein IST1 by Different Microtubule Interacting and Trafficking (MIT) Domains.,Guo EZ, Xu Z J Biol Chem. 2015 Feb 5. pii: jbc.M114.607903. PMID:25657007<ref>PMID:25657007</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:02, 12 February 2015

OCA — Thu, 12 Feb 2015 12:02:06 GMT

←Older revision		Revision as of 12:02, 12 February 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Structure of the complex of VPS4B MIT and IST1 MIM==
-		+	<StructureSection load='4u7y' size='340' side='right' caption='[[4u7y]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~The entry~~ 4u7y is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4u7y]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U7Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U7Y FirstGlance]. <br>
-	~~Authors~~: ~~Guo~~, E.Z., Xu, Z.	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4u7e\|4u7e]], [[4u7i\|4u7i]]</td></tr>
-		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Vesicle-fusing_ATPase Vesicle-fusing ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.6 3.6.4.6] </span></td></tr>
-	~~Description~~: ~~Structure~~ of the ~~complex~~ of ~~VPS4B MIT~~ and ~~IST1 MIM~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u7y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u7y RCSB], [http://www.ebi.ac.uk/pdbsum/4u7y PDBsum]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
-	[[Category: Guo, E.Z]]	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/VPS4B_HUMAN VPS4B_HUMAN]] Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses).<ref>PMID:11563910</ref> <ref>PMID:14505570</ref> <ref>PMID:18687924</ref> [[http://www.uniprot.org/uniprot/IST1_HUMAN IST1_HUMAN]] Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells.<ref>PMID:19129479</ref> <ref>PMID:19129480</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Vesicle-fusing ATPase]]
		+	[[Category: Guo, E Z]]
	[[Category: Xu, Z]]		[[Category: Xu, Z]]
		+	[[Category: Complex]]
		+	[[Category: Mim1]]

OCA at 18:14, 24 December 2014

OCA — Wed, 24 Dec 2014 18:14:15 GMT

←Older revision		Revision as of 18:14, 24 December 2014
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	Description: Structure of the complex of VPS4B MIT and IST1 MIM		Description: Structure of the complex of VPS4B MIT and IST1 MIM
		+	[[Category: Unreleased Structures]]
		+	[[Category: Guo, E.Z]]
		+	[[Category: Xu, Z]]

OCA at 08:48, 24 September 2014

OCA — Wed, 24 Sep 2014 08:48:45 GMT

←Older revision		Revision as of 08:48, 24 September 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4u7y is ON HOLD	+	The entry 4u7y is ON HOLD until Paper Publication

	Authors: Guo, E.Z., Xu, Z.		Authors: Guo, E.Z., Xu, Z.

	Description: Structure of the complex of VPS4B MIT and IST1 MIM		Description: Structure of the complex of VPS4B MIT and IST1 MIM

OCA: Protected "4u7y" [edit=sysop:move=sysop]

OCA — Thu, 07 Aug 2014 01:34:30 GMT

Protected "4u7y" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:34, 7 August 2014