4uam - Revision history

OCA at 07:27, 27 September 2023

OCA — Wed, 27 Sep 2023 07:27:14 GMT

←Older revision		Revision as of 07:27, 27 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4uam]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_NCGM2.S1 Pseudomonas aeruginosa NCGM2.S1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UAM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UAM FirstGlance]. <br>		<table><tr><td colspan='2'>[[4uam]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_NCGM2.S1 Pseudomonas aeruginosa NCGM2.S1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UAM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UAM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uam OCA], [https://pdbe.org/4uam PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uam RCSB], [https://www.ebi.ac.uk/pdbsum/4uam PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uam ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uam OCA], [https://pdbe.org/4uam PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uam RCSB], [https://www.ebi.ac.uk/pdbsum/4uam PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uam ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:12, 22 March 2023

OCA — Wed, 22 Mar 2023 08:12:03 GMT

←Older revision		Revision as of 08:12, 22 March 2023
Line 1:		Line 1:

	==1.8 Angstrom crystal structure of IMP-1 metallo-beta-lactamase with a mixed iron-zinc center in the active site==		==1.8 Angstrom crystal structure of IMP-1 metallo-beta-lactamase with a mixed iron-zinc center in the active site==
-	<StructureSection load='4uam' size='340' side='right' caption='[[4uam]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='4uam' size='340' side='right'caption='[[4uam]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4uam]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Pseudomonas_aeruginosa_ncgm2~~.s1 Pseudomonas aeruginosa ~~ncgm2~~.s1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UAM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4UAM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4uam]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_NCGM2.S1 Pseudomonas aeruginosa NCGM2.S1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UAM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UAM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uam OCA], [https://pdbe.org/4uam PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uam RCSB], [https://www.ebi.ac.uk/pdbsum/4uam PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uam ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bla IMP, NCGM2_1757 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1089456 Pseudomonas aeruginosa NCGM2.S1])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4uam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uam OCA], [~~http~~://pdbe.org/4uam PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4uam RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4uam PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4uam ProSAT]</span></td></tr>	+
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 4uam" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4uam" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-lactamase 3D structures\|Beta-lactamase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Pseudomonas aeruginosa ~~ncgm2 s1~~]]	+	[[Category: Large Structures]]
-	[[Category: Carr~~, P D~~]]	+	[[Category: Pseudomonas aeruginosa NCGM2 S1]]
-	[[Category: Carruthers~~, T J~~]]	+	[[Category: Carr PD]]
-	[[Category: Jackson~~, C J~~]]	+	[[Category: Carruthers TJ]]
-	[[Category: Otting, G]]	+	[[Category: Jackson CJ]]
-	~~[[Category: Antibiotic resistance]]~~	+	[[Category: Otting G]]
-	~~[[Category: Binuclear metal center]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 22:39, 15 November 2017

OCA — Wed, 15 Nov 2017 22:39:56 GMT

←Older revision		Revision as of 22:39, 15 November 2017
Line 3:		Line 3:
	<StructureSection load='4uam' size='340' side='right' caption='[[4uam]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4uam' size='340' side='right' caption='[[4uam]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4uam]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UAM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UAM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4uam]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_ncgm2.s1 Pseudomonas aeruginosa ncgm2.s1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UAM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UAM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bla IMP, NCGM2_1757 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1089456 Pseudomonas aeruginosa NCGM2.S1])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uam OCA], [http://pdbe.org/4uam PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uam RCSB], [http://www.ebi.ac.uk/pdbsum/4uam PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uam ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uam OCA], [http://pdbe.org/4uam PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uam RCSB], [http://www.ebi.ac.uk/pdbsum/4uam PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uam ProSAT]</span></td></tr>
	</table>		</table>
Line 17:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4uam" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4uam" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Beta-lactamase\|Beta-lactamase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Pseudomonas aeruginosa ncgm2 s1]]
	[[Category: Carr, P D]]		[[Category: Carr, P D]]
	[[Category: Carruthers, T J]]		[[Category: Carruthers, T J]]

OCA at 01:24, 19 January 2017

OCA — Thu, 19 Jan 2017 01:24:11 GMT

←Older revision		Revision as of 01:24, 19 January 2017
Line 1:		Line 1:
		+
	==1.8 Angstrom crystal structure of IMP-1 metallo-beta-lactamase with a mixed iron-zinc center in the active site==		==1.8 Angstrom crystal structure of IMP-1 metallo-beta-lactamase with a mixed iron-zinc center in the active site==
	<StructureSection load='4uam' size='340' side='right' caption='[[4uam]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4uam' size='340' side='right' caption='[[4uam]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uam OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uam RCSB], [http://www.ebi.ac.uk/pdbsum/4uam PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uam OCA], [http://pdbe.org/4uam PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uam RCSB], [http://www.ebi.ac.uk/pdbsum/4uam PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uam ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4uam" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 11:44, 18 March 2015

OCA — Wed, 18 Mar 2015 11:44:28 GMT

←Older revision		Revision as of 11:44, 18 March 2015
Line 15:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[Beta-lactamase\|Beta-lactamase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:48, 12 November 2014

OCA — Wed, 12 Nov 2014 07:48:17 GMT

←Older revision		Revision as of 07:48, 12 November 2014
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[4uam]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UAM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UAM FirstGlance]. <br>		<table><tr><td colspan='2'>[[4uam]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UAM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UAM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~CSW~~:~~CYSTEINE~~-~~S-DIOXIDE~~'>~~CSW~~</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uam OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uam RCSB], [http://www.ebi.ac.uk/pdbsum/4uam PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uam OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uam RCSB], [http://www.ebi.ac.uk/pdbsum/4uam PDBsum]</span></td></tr>
	</table>		</table>
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Carr, P D.]]	+	[[Category: Carr, P D]]
-	[[Category: Carruthers, T J.]]	+	[[Category: Carruthers, T J]]
-	[[Category: Jackson, C J.]]	+	[[Category: Jackson, C J]]
-	[[Category: Otting, G.]]	+	[[Category: Otting, G]]
	[[Category: Antibiotic resistance]]		[[Category: Antibiotic resistance]]
	[[Category: Binuclear metal center]]		[[Category: Binuclear metal center]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 07:06, 5 November 2014

OCA — Wed, 05 Nov 2014 07:06:41 GMT

←Older revision		Revision as of 07:06, 5 November 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==1.8 Angstrom crystal structure of IMP-1 metallo-beta-lactamase with a mixed iron-zinc center in the active site==
		+	<StructureSection load='4uam' size='340' side='right' caption='[[4uam]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4uam]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UAM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UAM FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSW:CYSTEINE-S-DIOXIDE'>CSW</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uam OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uam RCSB], [http://www.ebi.ac.uk/pdbsum/4uam PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Heterodinuclear metalloenzymes are an important class of metalloproteins, but determining the location of the different metal ions can be difficult. Herein we present a new NMR spectroscopy method that uses pseudocontact shifts (PCS) to achieve this without assumptions about the coordinating ligands. The approach is illustrated with the dinuclear [FeZn] complex of IMP-1, which is a prototypical metallo-beta-lactamase (MbetaL) that confers resistance to beta-lactam antibiotics. Results from single-crystal X-ray diffraction were compromised by degradation during crystallization. With [GaZn]-IMP-1 as diamagnetic reference, the PCSs unambiguously identified the iron binding site in fresh samples of [FeZn]-IMP-1, even though the two metal centers are less than 3.8 A apart and the iron is high-spin Fe3+ , which produces only small PCSs. [FeZn]-MbetaLs may be important drug targets, as [FeZn]-IMP-1 is enzymatically active and readily produced in the presence of small amounts of Fe3+ .

-	~~The entry 4uam is ON HOLD~~	+	Iron(III) Located in the Dinuclear Metallo-beta-Lactamase IMP-1 by Pseudocontact Shifts.,Carruthers TJ, Carr PD, Loh CT, Jackson CJ, Otting G Angew Chem Int Ed Engl. 2014 Oct 15. doi: 10.1002/anie.201408693. PMID:25320022<ref>PMID:25320022</ref>

-	~~Authors: Carruthers~~, T.J., Carr, P.D., Jackson, C.J., Otting, G.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~1.8 Angstrom crystal structure of IMP-1 metallo-beta-lactamase with a mixed iron-zinc~~ center ~~in the active site~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Carr, P D.]]
		+	[[Category: Carruthers, T J.]]
		+	[[Category: Jackson, C J.]]
		+	[[Category: Otting, G.]]
		+	[[Category: Antibiotic resistance]]
		+	[[Category: Binuclear metal center]]
		+	[[Category: Hydrolase]]

OCA: Protected "4uam" [edit=sysop:move=sysop]

OCA — Wed, 20 Aug 2014 15:06:42 GMT

Protected "4uam" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:06, 20 August 2014

OCA: New page: '''Unreleased structure''' The entry 4uam is ON HOLD Authors: Carruthers, T.J., Carr, P.D., Jackson, C.J., Otting, G. Description: 1.8 Angstrom crystal structure of IMP-1 metallo-beta-...

OCA — Wed, 20 Aug 2014 15:06:40 GMT

New page: '''Unreleased structure''' The entry 4uam is ON HOLD Authors: Carruthers, T.J., Carr, P.D., Jackson, C.J., Otting, G. Description: 1.8 Angstrom crystal structure of IMP-1 metallo-beta-...

New page

'''Unreleased structure'''

The entry 4uam is ON HOLD

Authors: Carruthers, T.J., Carr, P.D., Jackson, C.J., Otting, G.

Description: 1.8 Angstrom crystal structure of IMP-1 metallo-beta-lactamase with a mixed iron-zinc center in the active site