4uba - Revision history

OCA at 11:19, 9 May 2024

OCA — Thu, 09 May 2024 11:19:37 GMT

←Older revision		Revision as of 11:19, 9 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4uba]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UBA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UBA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4uba]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UBA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UBA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3G5:4-(6,8-DIBROMO-3-HYDROXY-4-OXO-4H-CHROMEN-2-YL)BENZOIC+ACID'>3G5</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.995Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3G5:4-(6,8-DIBROMO-3-HYDROXY-4-OXO-4H-CHROMEN-2-YL)BENZOIC+ACID'>3G5</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uba OCA], [https://pdbe.org/4uba PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uba RCSB], [https://www.ebi.ac.uk/pdbsum/4uba PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uba ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uba OCA], [https://pdbe.org/4uba PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uba RCSB], [https://www.ebi.ac.uk/pdbsum/4uba PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uba ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:13, 22 March 2023

OCA — Wed, 22 Mar 2023 08:13:08 GMT

←Older revision		Revision as of 08:13, 22 March 2023
Line 3:		Line 3:
	<StructureSection load='4uba' size='340' side='right'caption='[[4uba]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4uba' size='340' side='right'caption='[[4uba]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4uba]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UBA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4UBA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4uba]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UBA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UBA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3G5:4-(6,8-DIBROMO-3-HYDROXY-4-OXO-4H-CHROMEN-2-YL)BENZOIC+ACID'>3G5</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3G5:4-(6,8-DIBROMO-3-HYDROXY-4-OXO-4H-CHROMEN-2-YL)BENZOIC+ACID'>3G5</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ub7\|4ub7]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uba OCA], [https://pdbe.org/4uba PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uba RCSB], [https://www.ebi.ac.uk/pdbsum/4uba PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uba ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CSNK2A1, CK2A1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4uba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uba OCA], [~~http~~://pdbe.org/4uba PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4uba RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4uba PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4uba ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CSK21_HUMAN CSK21_HUMAN]] Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV.<ref>PMID:11239457</ref> <ref>PMID:11704824</ref> <ref>PMID:16193064</ref> <ref>PMID:19188443</ref>	+	[https://www.uniprot.org/uniprot/CSK21_HUMAN CSK21_HUMAN] Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV.<ref>PMID:11239457</ref> <ref>PMID:11704824</ref> <ref>PMID:16193064</ref> <ref>PMID:19188443</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Non-specific serine/threonine protein kinase]]~~	+	[[Category: Bischoff N]]
-	[[Category: Bischoff, N]]	+	[[Category: Golub A]]
-	[[Category: Golub, A]]	+	[[Category: Guerra B]]
-	[[Category: Guerra, B]]	+	[[Category: Issinger O-G]]
-	[[Category: Issinger, O G]]	+	[[Category: Niefind K]]
-	[[Category: Niefind, K]]	+
-	~~[[Category: 4'-carboxy-6]]~~	+
-	~~[[Category: 8-bromo-flavonol]]~~	+
-	~~[[Category: Atp-competitive inhibitor]]~~	+
-	~~[[Category: Halogen bond]]~~	+
-	~~[[Category: Protein kinase ck2]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 09:07, 21 May 2019

OCA — Tue, 21 May 2019 09:07:21 GMT

←Older revision		Revision as of 09:07, 21 May 2019
Line 1:		Line 1:

	==Low-salt structure of protein kinase CK2 catalytic subunit with 4'-carboxy-6,8-bromo-flavonol (FLC26)==		==Low-salt structure of protein kinase CK2 catalytic subunit with 4'-carboxy-6,8-bromo-flavonol (FLC26)==
-	<StructureSection load='4uba' size='340' side='right' caption='[[4uba]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='4uba' size='340' side='right'caption='[[4uba]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4uba]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UBA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UBA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4uba]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UBA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UBA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3G5:4-(6,8-DIBROMO-3-HYDROXY-4-OXO-4H-CHROMEN-2-YL)BENZOIC+ACID'>3G5</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3G5:4-(6,8-DIBROMO-3-HYDROXY-4-OXO-4H-CHROMEN-2-YL)BENZOIC+ACID'>3G5</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ub7\|4ub7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ub7\|4ub7]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CSNK2A1, CK2A1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uba OCA], [http://pdbe.org/4uba PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uba RCSB], [http://www.ebi.ac.uk/pdbsum/4uba PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uba ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uba OCA], [http://pdbe.org/4uba PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uba RCSB], [http://www.ebi.ac.uk/pdbsum/4uba PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uba ProSAT]</span></td></tr>
Line 22:		Line 23:

	==See Also==		==See Also==
-	*[[Casein kinase\|Casein kinase]]	+	*[[Casein kinase 3D structures\|Casein kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Bischoff, N]]		[[Category: Bischoff, N]]

OCA at 13:29, 4 May 2017

OCA — Thu, 04 May 2017 13:29:14 GMT

←Older revision		Revision as of 13:29, 4 May 2017
Line 1:		Line 1:
		+
	==Low-salt structure of protein kinase CK2 catalytic subunit with 4'-carboxy-6,8-bromo-flavonol (FLC26)==		==Low-salt structure of protein kinase CK2 catalytic subunit with 4'-carboxy-6,8-bromo-flavonol (FLC26)==
	<StructureSection load='4uba' size='340' side='right' caption='[[4uba]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4uba' size='340' side='right' caption='[[4uba]], [[Resolution\|resolution]] 3.00Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ub7\|4ub7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ub7\|4ub7]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uba OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uba RCSB], [http://www.ebi.ac.uk/pdbsum/4uba PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uba OCA], [http://pdbe.org/4uba PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uba RCSB], [http://www.ebi.ac.uk/pdbsum/4uba PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uba ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4uba" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Casein kinase\|Casein kinase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:08, 1 July 2015

OCA — Wed, 01 Jul 2015 12:08:00 GMT

←Older revision		Revision as of 12:08, 1 July 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Low-salt structure of protein kinase CK2 catalytic subunit with 4'-carboxy-6,8-bromo-flavonol (FLC26)==
		+	<StructureSection load='4uba' size='340' side='right' caption='[[4uba]], [[Resolution\|resolution]] 3.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4uba]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UBA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UBA FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3G5:4-(6,8-DIBROMO-3-HYDROXY-4-OXO-4H-CHROMEN-2-YL)BENZOIC+ACID'>3G5</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ub7\|4ub7]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uba OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uba RCSB], [http://www.ebi.ac.uk/pdbsum/4uba PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CSK21_HUMAN CSK21_HUMAN]] Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV.<ref>PMID:11239457</ref> <ref>PMID:11704824</ref> <ref>PMID:16193064</ref> <ref>PMID:19188443</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	CK2 is a Ser/Thr kinase recruited by tumor cells to avoid cell death. 4'-Carboxy-6,8-dibromo-flavonol (FLC26) is a nanomolar CK2 inhibitor reducing the physiological phosphorylation of CK2 biomarkers and inducing cell death. Its binding mode to the ATP site was predicted to depend primarily on noncovalent interactions not comprising halogen bonds. We confirm this by two independent cocrystal structures which additionally show that FLC26 is selective for an open, protein kinase-untypical conformation of the hinge/helix alphaD region. The structures suggest how the bromo substituents, found previously in lead optimization studies, contribute to the inhibitory efficacy. In this context, one of the complex structures, obtained by crystallization with the kosmotropic salt NaCl, revealed an unconventional pi-halogen bond between the 8-bromo substituent of FLC26 and an aromatic side chain which is absent under low-salt conditions. The kosmotropic salt sensitivity of pi-halogen bonds is a novel feature which requires attention in structural comparisons and halogen-bond-based explanations.

-	~~The entry 4uba is ON HOLD~~	+	A Note of Caution on the Role of Halogen Bonds for Protein Kinase/Inhibitor Recognition Suggested by High- And Low-Salt CK2alpha Complex Structures.,Guerra B, Bischoff N, Bdzhola VG, Yarmoluk SM, Issinger OG, Golub AG, Niefind K ACS Chem Biol. 2015 May 15. PMID:25961323<ref>PMID:25961323</ref>

-	~~Authors: Niefind~~, K.~~, Bischoff, N~~.~~, Guerra, B., Golub, A., Issinger, O.-G~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Low~~-~~salt structure of~~ protein kinase ~~CK2 catalytic subunit with 4'-carboxy-6,8-bromo-flavonol (FLC26)~~	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Non-specific serine/threonine protein kinase]]
		+	[[Category: Bischoff, N]]
	[[Category: Golub, A]]		[[Category: Golub, A]]
-	[[Category: Bischoff, N]]
	[[Category: Guerra, B]]		[[Category: Guerra, B]]
		+	[[Category: Issinger, O G]]
	[[Category: Niefind, K]]		[[Category: Niefind, K]]
-	[[Category: ~~Issinger, O.~~-G]]	+	[[Category: 4'-carboxy-6]]
		+	[[Category: 8-bromo-flavonol]]
		+	[[Category: Atp-competitive inhibitor]]
		+	[[Category: Halogen bond]]
		+	[[Category: Protein kinase ck2]]
		+	[[Category: Transferase]]

OCA at 18:19, 24 December 2014

OCA — Wed, 24 Dec 2014 18:19:10 GMT

←Older revision		Revision as of 18:19, 24 December 2014
Line 6:		Line 6:

	Description: Low-salt structure of protein kinase CK2 catalytic subunit with 4'-carboxy-6,8-bromo-flavonol (FLC26)		Description: Low-salt structure of protein kinase CK2 catalytic subunit with 4'-carboxy-6,8-bromo-flavonol (FLC26)
		+	[[Category: Unreleased Structures]]
		+	[[Category: Golub, A]]
		+	[[Category: Bischoff, N]]
		+	[[Category: Guerra, B]]
		+	[[Category: Niefind, K]]
		+	[[Category: Issinger, O.-G]]

OCA: Protected "4uba" [edit=sysop:move=sysop]

OCA — Wed, 20 Aug 2014 15:08:11 GMT

Protected "4uba" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:08, 20 August 2014

OCA: New page: '''Unreleased structure''' The entry 4uba is ON HOLD Authors: Niefind, K., Bischoff, N., Guerra, B., Golub, A., Issinger, O.-G. Description: Low-salt structure of protein kinase CK2 ca...

OCA — Wed, 20 Aug 2014 15:08:10 GMT

New page: '''Unreleased structure''' The entry 4uba is ON HOLD Authors: Niefind, K., Bischoff, N., Guerra, B., Golub, A., Issinger, O.-G. Description: Low-salt structure of protein kinase CK2 ca...

New page

'''Unreleased structure'''

The entry 4uba is ON HOLD

Authors: Niefind, K., Bischoff, N., Guerra, B., Golub, A., Issinger, O.-G.

Description: Low-salt structure of protein kinase CK2 catalytic subunit with 4'-carboxy-6,8-bromo-flavonol (FLC26)