4ucy - Revision history

OCA at 08:17, 22 March 2023

OCA — Wed, 22 Mar 2023 08:17:27 GMT

←Older revision		Revision as of 08:17, 22 March 2023
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	<StructureSection load='4ucy' size='340' side='right'caption='[[4ucy]], [[Resolution\|resolution]] 2.83Å' scene=''>		<StructureSection load='4ucy' size='340' side='right'caption='[[4ucy]], [[Resolution\|resolution]] 2.83Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ucy]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Hmpv Hmpv~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UCY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4UCY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ucy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_metapneumovirus Human metapneumovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UCY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UCY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uci\|4uci]], [[4ucj\|4ucj]], [[4uck\|4uck]], [[4ucl\|4ucl]], [[4ucz\|4ucz]], [[4ud0\|4ud0]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ucy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ucy OCA], [https://pdbe.org/4ucy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ucy RCSB], [https://www.ebi.ac.uk/pdbsum/4ucy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ucy ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ucy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ucy OCA], [~~http~~://pdbe.org/4ucy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ucy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ucy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ucy ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q91L20_9MONO Q91L20_9MONO]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 20:

	==See Also==		==See Also==
-	*[[RNA polymerase\|RNA polymerase]]	+	*[[RNA polymerase 3D structures\|RNA polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Hmpv~~]]	+	[[Category: Human metapneumovirus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Canard, B]]	+	[[Category: Canard B]]
-	[[Category: Collet, A]]	+	[[Category: Collet A]]
-	[[Category: Debart, F]]	+	[[Category: Debart F]]
-	[[Category: Decroly, E]]	+	[[Category: Decroly E]]
-	[[Category: Grimes~~, J M~~]]	+	[[Category: Grimes JM]]
-	[[Category: Paesen~~, G C~~]]	+	[[Category: Paesen GC]]
-	[[Category: Sallamand, C]]	+	[[Category: Sallamand C]]
-	[[Category: Vasseur~~, J J]]~~	+	[[Category: Vasseur JJ]]
-	~~[[Category: Capping]]~~	+
-	~~[[Category: L protein]]~~	+
-	~~[[Category: Rossmann]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Triphosphatase~~]]	+

OCA at 07:29, 24 April 2019

OCA — Wed, 24 Apr 2019 07:29:26 GMT

←Older revision		Revision as of 07:29, 24 April 2019
Line 1:		Line 1:
		+
	==X-ray structure and activities of an essential Mononegavirales L- protein domain==		==X-ray structure and activities of an essential Mononegavirales L- protein domain==
-	<StructureSection load='4ucy' size='340' side='right' caption='[[4ucy]], [[Resolution\|resolution]] 2.83Å' scene=''>	+	<StructureSection load='4ucy' size='340' side='right'caption='[[4ucy]], [[Resolution\|resolution]] 2.83Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ucy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UCY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UCY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ucy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hmpv Hmpv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UCY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UCY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uci\|4uci]], [[4ucj\|4ucj]], [[4uck\|4uck]], [[4ucl\|4ucl]], [[4ucz\|4ucz]], [[4ud0\|4ud0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uci\|4uci]], [[4ucj\|4ucj]], [[4uck\|4uck]], [[4ucl\|4ucl]], [[4ucz\|4ucz]], [[4ud0\|4ud0]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ucy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ucy OCA], [http://pdbe.org/4ucy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ucy RCSB], [http://www.ebi.ac.uk/pdbsum/4ucy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ucy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ucy OCA], [http://pdbe.org/4ucy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ucy RCSB], [http://www.ebi.ac.uk/pdbsum/4ucy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ucy ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 4ucy" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4ucy" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[RNA polymerase\|RNA polymerase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Hmpv]]
		+	[[Category: Large Structures]]
	[[Category: Canard, B]]		[[Category: Canard, B]]
	[[Category: Collet, A]]		[[Category: Collet, A]]

OCA at 18:55, 1 December 2015

OCA — Tue, 01 Dec 2015 18:55:48 GMT

←Older revision		Revision as of 18:55, 1 December 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==X-ray structure and activities of an essential Mononegavirales L- protein domain==
		+	<StructureSection load='4ucy' size='340' side='right' caption='[[4ucy]], [[Resolution\|resolution]] 2.83Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4ucy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UCY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UCY FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uci\|4uci]], [[4ucj\|4ucj]], [[4uck\|4uck]], [[4ucl\|4ucl]], [[4ucz\|4ucz]], [[4ud0\|4ud0]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ucy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ucy OCA], [http://pdbe.org/4ucy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ucy RCSB], [http://www.ebi.ac.uk/pdbsum/4ucy PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The L protein of mononegaviruses harbours all catalytic activities for genome replication and transcription. It contains six conserved domains (CR-I to -VI; Fig. 1a). CR-III has been linked to polymerase and polyadenylation activity, CR-V to mRNA capping and CR-VI to cap methylation. However, how these activities are choreographed is poorly understood. Here we present the 2.2-A X-ray structure and activities of CR-VI+, a portion of human Metapneumovirus L consisting of CR-VI and the poorly conserved region at its C terminus, the +domain. The CR-VI domain has a methyltransferase fold, which besides the typical S-adenosylmethionine-binding site ((SAM)P) also contains a novel pocket ((NS)P) that can accommodate a nucleoside. CR-VI lacks an obvious cap-binding site, and the (SAM)P-adjoining site holding the nucleotides undergoing methylation ((SUB)P) is unusually narrow because of the overhanging +domain. CR-VI+ sequentially methylates caps at their 2'O and N7 positions, and also displays nucleotide triphosphatase activity.

-	~~The entry 4ucy is ON HOLD until Paper Publication~~	+	X-ray structure and activities of an essential Mononegavirales L-protein domain.,Paesen GC, Collet A, Sallamand C, Debart F, Vasseur JJ, Canard B, Decroly E, Grimes JM Nat Commun. 2015 Nov 9;6:8749. doi: 10.1038/ncomms9749. PMID:26549102<ref>PMID:26549102</ref>

-	~~Authors: Paesen~~, G.C.~~, Collet, A., Sallamand, C., Debart, F., Vasseur, J.J., Canard, B., Decroly, E., Grimes, J.M~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: X~~-~~ray structure and activities of an essential Mononegavirales L~~-~~protein domain~~	+	<div class="pdbe-citations 4ucy" style="background-color:#fffaf0;"></div>
-	~~[[Category: Unreleased Structures]]~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Canard, B]]		[[Category: Canard, B]]
-	[[Category: Sallamand, C]]
	[[Category: Collet, A]]		[[Category: Collet, A]]
-	[[Category: ~~Paesen~~, ~~G.C]]~~	+	[[Category: Debart, F]]
-	~~[[Category: Grimes, J.M]]~~	+
-	~~[[Category: Vasseur, J.J~~]]	+
	[[Category: Decroly, E]]		[[Category: Decroly, E]]
-	[[Category: ~~Debart~~, F]]	+	[[Category: Grimes, J M]]
		+	[[Category: Paesen, G C]]
		+	[[Category: Sallamand, C]]
		+	[[Category: Vasseur, J J]]
		+	[[Category: Capping]]
		+	[[Category: L protein]]
		+	[[Category: Rossmann]]
		+	[[Category: Transferase]]
		+	[[Category: Triphosphatase]]

OCA at 00:28, 22 October 2015

OCA — Thu, 22 Oct 2015 00:28:08 GMT

←Older revision		Revision as of 00:28, 22 October 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4ucy is ON HOLD	+	The entry 4ucy is ON HOLD until Paper Publication

	Authors: Paesen, G.C., Collet, A., Sallamand, C., Debart, F., Vasseur, J.J., Canard, B., Decroly, E., Grimes, J.M.		Authors: Paesen, G.C., Collet, A., Sallamand, C., Debart, F., Vasseur, J.J., Canard, B., Decroly, E., Grimes, J.M.

OCA at 18:23, 24 December 2014

OCA — Wed, 24 Dec 2014 18:23:54 GMT

←Older revision		Revision as of 18:23, 24 December 2014
Line 6:		Line 6:

	Description: X-ray structure and activities of an essential Mononegavirales L-protein domain		Description: X-ray structure and activities of an essential Mononegavirales L-protein domain
		+	[[Category: Unreleased Structures]]
		+	[[Category: Canard, B]]
		+	[[Category: Sallamand, C]]
		+	[[Category: Collet, A]]
		+	[[Category: Paesen, G.C]]
		+	[[Category: Grimes, J.M]]
		+	[[Category: Vasseur, J.J]]
		+	[[Category: Decroly, E]]
		+	[[Category: Debart, F]]

OCA at 11:20, 17 December 2014

OCA — Wed, 17 Dec 2014 11:20:10 GMT

←Older revision		Revision as of 11:20, 17 December 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4ucy is ON HOLD ~~until sometime in the future~~	+	The entry 4ucy is ON HOLD

	Authors: Paesen, G.C., Collet, A., Sallamand, C., Debart, F., Vasseur, J.J., Canard, B., Decroly, E., Grimes, J.M.		Authors: Paesen, G.C., Collet, A., Sallamand, C., Debart, F., Vasseur, J.J., Canard, B., Decroly, E., Grimes, J.M.

	Description: X-ray structure and activities of an essential Mononegavirales L-protein domain		Description: X-ray structure and activities of an essential Mononegavirales L-protein domain

OCA: Protected "4ucy" [edit=sysop:move=sysop]

OCA — Wed, 10 Dec 2014 13:47:36 GMT

Protected "4ucy" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:47, 10 December 2014

OCA: New page: '''Unreleased structure''' The entry 4ucy is ON HOLD until sometime in the future Authors: Paesen, G.C., Collet, A., Sallamand, C., Debart, F., Vasseur, J.J., Canard, B., Decroly, E., G...

OCA — Wed, 10 Dec 2014 13:47:35 GMT

New page: '''Unreleased structure''' The entry 4ucy is ON HOLD until sometime in the future Authors: Paesen, G.C., Collet, A., Sallamand, C., Debart, F., Vasseur, J.J., Canard, B., Decroly, E., G...

New page

'''Unreleased structure'''

The entry 4ucy is ON HOLD until sometime in the future

Authors: Paesen, G.C., Collet, A., Sallamand, C., Debart, F., Vasseur, J.J., Canard, B., Decroly, E., Grimes, J.M.

Description: X-ray structure and activities of an essential Mononegavirales L-protein domain