4uhg - Revision history

OCA at 11:20, 9 May 2024

OCA — Thu, 09 May 2024 11:20:49 GMT

←Older revision		Revision as of 11:20, 9 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4uhg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UHG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UHG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4uhg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UHG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UHG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SZ5:2-(4-METHYLPHENYL)-3,4-DIHYDROQUINAZOLIN-4-ONE'>SZ5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SZ5:2-(4-METHYLPHENYL)-3,4-DIHYDROQUINAZOLIN-4-ONE'>SZ5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uhg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uhg OCA], [https://pdbe.org/4uhg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uhg RCSB], [https://www.ebi.ac.uk/pdbsum/4uhg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uhg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uhg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uhg OCA], [https://pdbe.org/4uhg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uhg RCSB], [https://www.ebi.ac.uk/pdbsum/4uhg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uhg ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:24, 22 March 2023

OCA — Wed, 22 Mar 2023 08:24:15 GMT

←Older revision		Revision as of 08:24, 22 March 2023
Line 3:		Line 3:
	<StructureSection load='4uhg' size='340' side='right'caption='[[4uhg]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4uhg' size='340' side='right'caption='[[4uhg]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4uhg]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UHG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4UHG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4uhg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UHG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UHG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SZ5:2-(4-METHYLPHENYL)-3,4-DIHYDROQUINAZOLIN-4-ONE'>SZ5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SZ5:2-(4-METHYLPHENYL)-3,4-DIHYDROQUINAZOLIN-4-ONE'>SZ5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ufu\|4ufu]], [[4ufy\|4ufy]], [[4ui3\|4ui3]], [[4ui4\|4ui4]], [[4ui5\|4ui5]], [[4ui6\|4ui6]], [[4ui7\|4ui7]], [[4ui8\|4ui8]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uhg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uhg OCA], [https://pdbe.org/4uhg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uhg RCSB], [https://www.ebi.ac.uk/pdbsum/4uhg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uhg ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4uhg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uhg OCA], [~~http~~://pdbe.org/4uhg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4uhg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4uhg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4uhg ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>	+	[https://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:

	==See Also==		==See Also==
-	*[[Poly (ADP-ribose) polymerase\|Poly (ADP-ribose) polymerase]]	+	*[[Poly(ADP-ribose) polymerase 3D structures\|Poly(ADP-ribose) polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Haikarainen, T]]	+	[[Category: Haikarainen T]]
-	[[Category: Lehtio, L]]	+	[[Category: Lehtio L]]
-	~~[[Category: Adp- ribosylation]]~~	+
-	~~[[Category: Diphtheria toxin like fold]]~~	+
-	~~[[Category: Protein-ligand complex]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 09:05, 21 May 2019

OCA — Tue, 21 May 2019 09:05:11 GMT

←Older revision		Revision as of 09:05, 21 May 2019
Line 1:		Line 1:

	==Crystal structure of human tankyrase 2 in complex with TA-21==		==Crystal structure of human tankyrase 2 in complex with TA-21==
-	<StructureSection load='4uhg' size='340' side='right' caption='[[4uhg]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='4uhg' size='340' side='right'caption='[[4uhg]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4uhg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UHG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UHG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4uhg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UHG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UHG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SZ5:2-(4-METHYLPHENYL)-3,4-DIHYDROQUINAZOLIN-4-ONE'>SZ5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SZ5:2-(4-METHYLPHENYL)-3,4-DIHYDROQUINAZOLIN-4-ONE'>SZ5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ufu\|4ufu]], [[4ufy\|4ufy]], [[4ui3\|4ui3]], [[4ui4\|4ui4]], [[4ui5\|4ui5]], [[4ui6\|4ui6]], [[4ui7\|4ui7]], [[4ui8\|4ui8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ufu\|4ufu]], [[4ufy\|4ufy]], [[4ui3\|4ui3]], [[4ui4\|4ui4]], [[4ui5\|4ui5]], [[4ui6\|4ui6]], [[4ui7\|4ui7]], [[4ui8\|4ui8]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uhg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uhg OCA], [http://pdbe.org/4uhg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uhg RCSB], [http://www.ebi.ac.uk/pdbsum/4uhg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uhg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uhg OCA], [http://pdbe.org/4uhg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uhg RCSB], [http://www.ebi.ac.uk/pdbsum/4uhg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uhg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4uhg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4uhg" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Poly (ADP-ribose) polymerase\|Poly (ADP-ribose) polymerase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Haikarainen, T]]		[[Category: Haikarainen, T]]
	[[Category: Lehtio, L]]		[[Category: Lehtio, L]]

OCA at 08:07, 1 June 2016

OCA — Wed, 01 Jun 2016 08:07:56 GMT

←Older revision		Revision as of 08:07, 1 June 2016
Line 11:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>		[[http://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Tankyrases (TNKSs), members of the PARP (Poly(ADP-ribose)polymerases) superfamily of enzymes, have gained interest as therapeutic drug targets, especially as they are involved in the regulation of Wnt signalling. A series of 2-arylquinazolin-4-ones with varying substituents at the 8-position was synthesised. An 8-methyl group (compared to 8-H, 8-OMe, 8-OH), together with a 4'-hydrophobic or electron-withdrawing group, provided the most potency and selectivity towards TNKSs. Co-crystal structures of selected compounds with TNKS-2 revealed that the protein around the 8-position is more hydrophobic in TNKS-2 compared to PARP-1/2, rationalising the selectivity. The NAD+-binding site contains a hydrophobic cavity which accommodates the 2-aryl group; in TNKS-2, this has a tunnel to the exterior but the cavity is closed in PARP-1. 8-Methyl-2-(4-trifluoromethylphenyl)quinazolin-4-one was identified as a potent and selective inhibitor of TNKSs and Wnt signalling. This compound and analogues could serve as molecular probes to study proliferative signalling and for development of inhibitors of TNKSs as drugs.
		+
		+	Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases.,Nathubhai A, Haikarainen T, Hayward PC, Munoz-Descalzo S, Thompson AS, Lloyd MD, Lehtio L, Threadgill MD Eur J Med Chem. 2016 Apr 20;118:316-327. doi: 10.1016/j.ejmech.2016.04.041. PMID:27163581<ref>PMID:27163581</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4uhg" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:16, 12 May 2016

OCA — Thu, 12 May 2016 11:16:29 GMT

←Older revision		Revision as of 11:16, 12 May 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 4uhg is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of human tankyrase 2 in complex with TA-21==
-		+	<StructureSection load='4uhg' size='340' side='right' caption='[[4uhg]], [[Resolution\|resolution]] 1.70Å' scene=''>
-	~~Authors~~: ~~Haikarainen~~, T., ~~Lehtio~~, L.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4uhg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UHG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UHG FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure~~ of ~~human tankyrase~~ 2 in complex ~~with TA~~-21	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SZ5:2-(4-METHYLPHENYL)-3,4-DIHYDROQUINAZOLIN-4-ONE'>SZ5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ufu\|4ufu]], [[4ufy\|4ufy]], [[4ui3\|4ui3]], [[4ui4\|4ui4]], [[4ui5\|4ui5]], [[4ui6\|4ui6]], [[4ui7\|4ui7]], [[4ui8\|4ui8]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uhg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uhg OCA], [http://pdbe.org/4uhg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uhg RCSB], [http://www.ebi.ac.uk/pdbsum/4uhg PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Haikarainen, T]]
	[[Category: Lehtio, L]]		[[Category: Lehtio, L]]
-	[[Category: ~~Haikarainen, T~~]]	+	[[Category: Adp- ribosylation]]
		+	[[Category: Diphtheria toxin like fold]]
		+	[[Category: Protein-ligand complex]]
		+	[[Category: Transferase]]
		+	[[Category: Transferase-transferase inhibitor complex]]

OCA at 07:44, 8 April 2015

OCA — Wed, 08 Apr 2015 07:44:37 GMT

←Older revision		Revision as of 07:44, 8 April 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4uhg is ON HOLD until ~~sometime in the future~~	+	The entry 4uhg is ON HOLD until Paper Publication

	Authors: Haikarainen, T., Lehtio, L.		Authors: Haikarainen, T., Lehtio, L.

OCA: Protected "4uhg" [edit=sysop:move=sysop]

OCA — Wed, 01 Apr 2015 09:43:57 GMT

Protected "4uhg" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:43, 1 April 2015

OCA: New page: '''Unreleased structure''' The entry 4uhg is ON HOLD until sometime in the future Authors: Haikarainen, T., Lehtio, L. Description: Crystal structure of human tankyrase 2 in complex wi...

OCA — Wed, 01 Apr 2015 09:43:56 GMT

New page: '''Unreleased structure''' The entry 4uhg is ON HOLD until sometime in the future Authors: Haikarainen, T., Lehtio, L. Description: Crystal structure of human tankyrase 2 in complex wi...

New page

'''Unreleased structure'''

The entry 4uhg is ON HOLD until sometime in the future

Authors: Haikarainen, T., Lehtio, L.

Description: Crystal structure of human tankyrase 2 in complex with TA-21
[[Category: Unreleased Structures]]
[[Category: Lehtio, L]]
[[Category: Haikarainen, T]]