4uim - Revision history

OCA at 10:29, 10 January 2024

OCA — Wed, 10 Jan 2024 10:29:54 GMT

←Older revision		Revision as of 10:29, 10 January 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4uim]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UIM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UIM FirstGlance]. <br>		<table><tr><td colspan='2'>[[4uim]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UIM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UIM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uim OCA], [https://pdbe.org/4uim PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uim RCSB], [https://www.ebi.ac.uk/pdbsum/4uim PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uim ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uim OCA], [https://pdbe.org/4uim PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uim RCSB], [https://www.ebi.ac.uk/pdbsum/4uim PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uim ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:26, 22 March 2023

OCA — Wed, 22 Mar 2023 08:26:37 GMT

←Older revision		Revision as of 08:26, 22 March 2023
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	<StructureSection load='4uim' size='340' side='right'caption='[[4uim]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='4uim' size='340' side='right'caption='[[4uim]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4uim]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UIM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4UIM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4uim]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UIM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UIM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uik\|4uik]], [[4uil\|4uil]], [[4uin\|4uin]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uim OCA], [https://pdbe.org/4uim PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uim RCSB], [https://www.ebi.ac.uk/pdbsum/4uim PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uim ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4uim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uim OCA], [~~http~~://pdbe.org/4uim PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4uim RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4uim PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4uim ProSAT]</span></td></tr>	+
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Aster~~, R H~~]]	+	[[Category: Aster RH]]
-	[[Category: Bougie~~, D W~~]]	+	[[Category: Bougie DW]]
-	[[Category: Springer~~, T A~~]]	+	[[Category: Springer TA]]
-	[[Category: Zhu, J]]	+	[[Category: Zhu J]]
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Mouse mab]]~~	+
-	~~[[Category: Quinine-dependent~~]]	+

OCA at 11:11, 26 February 2020

OCA — Wed, 26 Feb 2020 11:11:21 GMT

←Older revision		Revision as of 11:11, 26 February 2020
Line 1:		Line 1:

	==crystal structure of quinine-dependent Fab 314.3==		==crystal structure of quinine-dependent Fab 314.3==
-	<StructureSection load='4uim' size='340' side='right' caption='[[4uim]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='4uim' size='340' side='right'caption='[[4uim]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4uim]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UIM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UIM FirstGlance]. <br>		<table><tr><td colspan='2'>[[4uim]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UIM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UIM FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Aster, R H]]		[[Category: Aster, R H]]

OCA at 14:25, 16 November 2017

OCA — Thu, 16 Nov 2017 14:25:08 GMT

←Older revision		Revision as of 14:25, 16 November 2017
Line 1:		Line 1:
		+
	==crystal structure of quinine-dependent Fab 314.3==		==crystal structure of quinine-dependent Fab 314.3==
	<StructureSection load='4uim' size='340' side='right' caption='[[4uim]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='4uim' size='340' side='right' caption='[[4uim]], [[Resolution\|resolution]] 2.70Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uik\|4uik]], [[4uil\|4uil]], [[4uin\|4uin]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uik\|4uik]], [[4uil\|4uil]], [[4uin\|4uin]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uim OCA], [http://pdbe.org/4uim PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uim RCSB], [http://www.ebi.ac.uk/pdbsum/4uim PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uim OCA], [http://pdbe.org/4uim PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uim RCSB], [http://www.ebi.ac.uk/pdbsum/4uim PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uim ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 21:38, 30 November 2015

OCA — Mon, 30 Nov 2015 21:38:30 GMT

←Older revision		Revision as of 21:38, 30 November 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uik\|4uik]], [[4uil\|4uil]], [[4uin\|4uin]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uik\|4uik]], [[4uil\|4uil]], [[4uin\|4uin]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uim OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uim RCSB], [http://www.ebi.ac.uk/pdbsum/4uim PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uim OCA], [http://pdbe.org/4uim PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uim RCSB], [http://www.ebi.ac.uk/pdbsum/4uim PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4uim" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:23, 2 September 2015

OCA — Wed, 02 Sep 2015 12:23:56 GMT

←Older revision		Revision as of 12:23, 2 September 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==crystal structure of quinine-dependent Fab 314.3==
		+	<StructureSection load='4uim' size='340' side='right' caption='[[4uim]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4uim]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UIM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UIM FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uik\|4uik]], [[4uil\|4uil]], [[4uin\|4uin]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uim OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uim RCSB], [http://www.ebi.ac.uk/pdbsum/4uim PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Drug-induced immune thrombocytopenia (DITP) is caused by antibodies that react with specific platelet membrane glycoproteins when the provoking drug is present. More than 100 drugs have been implicated as triggers for this condition, quinine being one of the most common. The cause of DITP in most cases appears to be a drug-induced antibody that binds to a platelet membrane glycoprotein only when drug is present. How soluble drug promotes binding of an otherwise non-reactive immunoglobulin to its target, leading to platelet destruction is uncertain, in part because of the difficulties of working with polyclonal human antibodies usually available only in small quantities. Recently, quinine-dependent murine monoclonal antibodies were developed that recognize a defined epitope on the beta-propeller domain of the platelet integrin alphaIIb-subunit (GPIIb) only when drug is present and closely mimic the behavior of antibodies found in human patients with quinine-induced thrombocytopenia in vitro and in vivo. Here, we demonstrate specific, high affinity binding of quinine to the complementarity-determining regions (CDR) of these antibodies and define in crystal structures the changes induced in the CDR by this interaction. Since in previous studies, no detectable binding of quinine to the target integrin could be demonstrated, the findings indicate that a hybrid paratope consisting of quinine and reconfigured antibody CDR plays a critical role in recognition of its target epitope by antibody and suggest that, in this type of drug-induced immunologic injury, the primary reaction involves binding of drug to antibody CDR, causing it to acquire specificity for a site on a platelet integrin.

-	~~The entry 4uim is ON HOLD until Paper Publication~~	+	Structural basis for quinine-dependent antibody binding to platelet integrin alphaIIbbeta3.,Zhu J, Zhu J, Bougie DW, Aster RH, Springer TA Blood. 2015 Aug 17. pii: blood-2015-04-639351. PMID:26282540<ref>PMID:26282540</ref>

-	~~Authors: Zhu~~, J.~~, Zhu, J~~.~~, Bougie, D.W., Aster, R.H., Springer, T.A~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~crystal structure of quinine-dependent Fab 314.3~~	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
-	[[Category: Bougie, D.W]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Mus musculus]]
		+	[[Category: Aster, R H]]
		+	[[Category: Bougie, D W]]
		+	[[Category: Springer, T A]]
	[[Category: Zhu, J]]		[[Category: Zhu, J]]
-	[[Category: ~~Springer, T.A~~]]	+	[[Category: Immune system]]
-	[[Category: ~~Aster, R.H~~]]	+	[[Category: Mouse mab]]
		+	[[Category: Quinine-dependent]]

OCA at 09:18, 22 April 2015

OCA — Wed, 22 Apr 2015 09:18:40 GMT

←Older revision		Revision as of 09:18, 22 April 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4uim is ON HOLD	+	The entry 4uim is ON HOLD until Paper Publication

	Authors: Zhu, J., Zhu, J., Bougie, D.W., Aster, R.H., Springer, T.A.		Authors: Zhu, J., Zhu, J., Bougie, D.W., Aster, R.H., Springer, T.A.

OCA at 09:12, 15 April 2015

OCA — Wed, 15 Apr 2015 09:12:43 GMT

←Older revision		Revision as of 09:12, 15 April 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4uim is ON HOLD ~~until sometime in the future~~	+	The entry 4uim is ON HOLD

	Authors: Zhu, J., Zhu, J., Bougie, D.W., Aster, R.H., Springer, T.A.		Authors: Zhu, J., Zhu, J., Bougie, D.W., Aster, R.H., Springer, T.A.

OCA: Protected "4uim" [edit=sysop:move=sysop]

OCA — Wed, 08 Apr 2015 07:47:59 GMT

Protected "4uim" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:47, 8 April 2015

OCA: New page: '''Unreleased structure''' The entry 4uim is ON HOLD until sometime in the future Authors: Zhu, J., Zhu, J., Bougie, D.W., Aster, R.H., Springer, T.A. Description: crystal structure of...

OCA — Wed, 08 Apr 2015 07:47:58 GMT

New page: '''Unreleased structure''' The entry 4uim is ON HOLD until sometime in the future Authors: Zhu, J., Zhu, J., Bougie, D.W., Aster, R.H., Springer, T.A. Description: crystal structure of...

New page

'''Unreleased structure'''

The entry 4uim is ON HOLD until sometime in the future

Authors: Zhu, J., Zhu, J., Bougie, D.W., Aster, R.H., Springer, T.A.

Description: crystal structure of quinine-dependent Fab 314.3
[[Category: Unreleased Structures]]
[[Category: Bougie, D.W]]
[[Category: Zhu, J]]
[[Category: Springer, T.A]]
[[Category: Aster, R.H]]