4uqk - Revision history

OCA at 07:32, 29 March 2023

OCA — Wed, 29 Mar 2023 07:32:45 GMT

←Older revision		Revision as of 07:32, 29 March 2023
Line 3:		Line 3:
	<SX load='4uqk' size='340' side='right' viewer='molstar' caption='[[4uqk]], [[Resolution\|resolution]] 16.40Å' scene=''>		<SX load='4uqk' size='340' side='right' viewer='molstar' caption='[[4uqk]], [[Resolution\|resolution]] 16.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4uqk]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UQK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=4UQK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4uqk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UQK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QUS:(S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC+ACID'>QUS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QUS:(S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC+ACID'>QUS</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uq6\|4uq6]], [[4uqj\|4uqj]], [[4uqq\|4uqq]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uqk OCA], [https://pdbe.org/4uqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uqk RCSB], [https://www.ebi.ac.uk/pdbsum/4uqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uqk ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=4uqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uqk OCA], [~~http~~://pdbe.org/4uqk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4uqk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4uqk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4uqk ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>	+	[https://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 25:
	__TOC__		__TOC__
	</SX>		</SX>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bartesaghi, A]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Chittori, S]]	+	[[Category: Bartesaghi A]]
-	[[Category: Kumar, J]]	+	[[Category: Chittori S]]
-	[[Category: Mayer~~, M L~~]]	+	[[Category: Kumar J]]
-	[[Category: Meyerson~~, J R~~]]	+	[[Category: Mayer ML]]
-	[[Category: Pierson, J]]	+	[[Category: Meyerson JR]]
-	[[Category: Rao, P]]	+	[[Category: Pierson J]]
-	[[Category: Subramaniam, S]]	+	[[Category: Rao P]]
-	~~[[Category: Glua2em restored active state]]~~	+	[[Category: Subramaniam S]]
-	~~[[Category: Transport protein~~]]	+

OCA at 19:13, 10 April 2020

OCA — Fri, 10 Apr 2020 19:13:38 GMT

←Older revision		Revision as of 19:13, 10 April 2020
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	<SX load='4uqk' size='340' side='right' viewer='molstar' caption='[[4uqk]], [[Resolution\|resolution]] 16.40Å' scene=''>		<SX load='4uqk' size='340' side='right' viewer='molstar' caption='[[4uqk]], [[Resolution\|resolution]] 16.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4uqk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UQK OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4UQK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4uqk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UQK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=4UQK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QUS:(S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC+ACID'>QUS</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QUS:(S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC+ACID'>QUS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uq6\|4uq6]], [[4uqj\|4uqj]], [[4uqq\|4uqq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uq6\|4uq6]], [[4uqj\|4uqj]], [[4uqq\|4uqq]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4uqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uqk OCA], [http://pdbe.org/4uqk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uqk RCSB], [http://www.ebi.ac.uk/pdbsum/4uqk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uqk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=4uqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uqk OCA], [http://pdbe.org/4uqk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uqk RCSB], [http://www.ebi.ac.uk/pdbsum/4uqk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uqk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 17:58, 6 March 2020

OCA — Fri, 06 Mar 2020 17:58:29 GMT

←Older revision		Revision as of 17:58, 6 March 2020
Line 1:		Line 1:

	==Electron density map of GluA2em in complex with quisqualate and LY451646==		==Electron density map of GluA2em in complex with quisqualate and LY451646==
-	<~~StructureSection~~ load='4uqk' size='340' side='right'caption='[[4uqk]], [[Resolution\|resolution]] 16.40Å' scene=''>	+	<SX load='4uqk' size='340' side='right' viewer='molstar' caption='[[4uqk]], [[Resolution\|resolution]] 16.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4uqk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UQK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UQK FirstGlance]. <br>		<table><tr><td colspan='2'>[[4uqk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UQK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UQK FirstGlance]. <br>
Line 25:		Line 25:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 11:15, 26 February 2020

OCA — Wed, 26 Feb 2020 11:15:25 GMT

←Older revision		Revision as of 11:15, 26 February 2020
Line 1:		Line 1:

	==Electron density map of GluA2em in complex with quisqualate and LY451646==		==Electron density map of GluA2em in complex with quisqualate and LY451646==
-	<StructureSection load='4uqk' size='340' side='right' caption='[[4uqk]], [[Resolution\|resolution]] 16.40Å' scene=''>	+	<StructureSection load='4uqk' size='340' side='right'caption='[[4uqk]], [[Resolution\|resolution]] 16.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4uqk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UQK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UQK FirstGlance]. <br>		<table><tr><td colspan='2'>[[4uqk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UQK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UQK FirstGlance]. <br>
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4uqk" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4uqk" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Glutamate receptor 3D structures\|Glutamate receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Bartesaghi, A]]		[[Category: Bartesaghi, A]]
	[[Category: Chittori, S]]		[[Category: Chittori, S]]

OCA at 03:02, 16 November 2017

OCA — Thu, 16 Nov 2017 03:02:40 GMT

←Older revision		Revision as of 03:02, 16 November 2017
Line 3:		Line 3:
	<StructureSection load='4uqk' size='340' side='right' caption='[[4uqk]], [[Resolution\|resolution]] 16.40Å' scene=''>		<StructureSection load='4uqk' size='340' side='right' caption='[[4uqk]], [[Resolution\|resolution]] 16.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4uqk]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UQK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UQK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4uqk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UQK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UQK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QUS:(S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC+ACID'>QUS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QUS:(S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC+ACID'>QUS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uq6\|4uq6]], [[4uqj\|4uqj]], [[4uqq\|4uqq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uq6\|4uq6]], [[4uqj\|4uqj]], [[4uqq\|4uqq]]</td></tr>
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4uqk" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4uqk" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Ionotropic Glutamate Receptors\|Ionotropic Glutamate Receptors]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
	[[Category: Bartesaghi, A]]		[[Category: Bartesaghi, A]]
	[[Category: Chittori, S]]		[[Category: Chittori, S]]

OCA at 12:53, 5 August 2016

OCA — Fri, 05 Aug 2016 12:53:58 GMT

←Older revision		Revision as of 12:53, 5 August 2016
Line 1:		Line 1:
		+
	==Electron density map of GluA2em in complex with quisqualate and LY451646==		==Electron density map of GluA2em in complex with quisqualate and LY451646==
	<StructureSection load='4uqk' size='340' side='right' caption='[[4uqk]], [[Resolution\|resolution]] 16.40Å' scene=''>		<StructureSection load='4uqk' size='340' side='right' caption='[[4uqk]], [[Resolution\|resolution]] 16.40Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QUS:(S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC+ACID'>QUS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QUS:(S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC+ACID'>QUS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uq6\|4uq6]], [[4uqj\|4uqj]], [[4uqq\|4uqq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uq6\|4uq6]], [[4uqj\|4uqj]], [[4uqq\|4uqq]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uqk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uqk RCSB], [http://www.ebi.ac.uk/pdbsum/4uqk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uqk OCA], [http://pdbe.org/4uqk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uqk RCSB], [http://www.ebi.ac.uk/pdbsum/4uqk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uqk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4uqk" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ionotropic Glutamate Receptors\|Ionotropic Glutamate Receptors]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 02:37, 25 December 2014

OCA — Thu, 25 Dec 2014 02:37:43 GMT

←Older revision		Revision as of 02:37, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uqk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uqk RCSB], [http://www.ebi.ac.uk/pdbsum/4uqk PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uqk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uqk RCSB], [http://www.ebi.ac.uk/pdbsum/4uqk PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bartesaghi, A.]]	+	[[Category: Bartesaghi, A]]
-	[[Category: Chittori, S.]]	+	[[Category: Chittori, S]]
-	[[Category: Kumar, J.]]	+	[[Category: Kumar, J]]
-	[[Category: Mayer, M L.]]	+	[[Category: Mayer, M L]]
-	[[Category: Meyerson, J R.]]	+	[[Category: Meyerson, J R]]
-	[[Category: Pierson, J.]]	+	[[Category: Pierson, J]]
-	[[Category: Rao, P.]]	+	[[Category: Rao, P]]
-	[[Category: Subramaniam, S.]]	+	[[Category: Subramaniam, S]]
	[[Category: Glua2em restored active state]]		[[Category: Glua2em restored active state]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 08:52, 22 October 2014

OCA — Wed, 22 Oct 2014 08:52:29 GMT

←Older revision		Revision as of 08:52, 22 October 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4uqk]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UQK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UQK FirstGlance]. <br>		<table><tr><td colspan='2'>[[4uqk]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UQK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UQK FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QUS:(S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC+ACID'>QUS</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QUS:(S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC+ACID'>QUS</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uq6\|4uq6]], [[4uqj\|4uqj]], [[4uqq\|4uqq]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uq6\|4uq6]], [[4uqj\|4uqj]], [[4uqq\|4uqq]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uqk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uqk RCSB], [http://www.ebi.ac.uk/pdbsum/4uqk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uqk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uqk RCSB], [http://www.ebi.ac.uk/pdbsum/4uqk PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 05:53, 27 August 2014

OCA — Wed, 27 Aug 2014 05:53:22 GMT

←Older revision		Revision as of 05:53, 27 August 2014
Line 7:		Line 7:
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uqk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uqk RCSB], [http://www.ebi.ac.uk/pdbsum/4uqk PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uqk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uqk RCSB], [http://www.ebi.ac.uk/pdbsum/4uqk PDBsum]</span></td></tr>
	<table>		<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ionotropic glutamate receptors are ligand-gated ion channels that mediate excitatory synaptic transmission in the vertebrate brain. To gain a better understanding of how structural changes gate ion flux across the membrane, we trapped rat AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) and kainate receptor subtypes in their major functional states and analysed the resulting structures using cryo-electron microscopy. We show that transition to the active state involves a 'corkscrew' motion of the receptor assembly, driven by closure of the ligand-binding domain. Desensitization is accompanied by disruption of the amino-terminal domain tetramer in AMPA, but not kainate, receptors with a two-fold to four-fold symmetry transition in the ligand-binding domains in both subtypes. The 7.6 A structure of a desensitized kainate receptor shows how these changes accommodate channel closing. These findings integrate previous physiological, biochemical and structural analyses of glutamate receptors and provide a molecular explanation for key steps in receptor gating.
		+
		+	Structural mechanism of glutamate receptor activation and desensitization.,Meyerson JR, Kumar J, Chittori S, Rao P, Pierson J, Bartesaghi A, Mayer ML, Subramaniam S Nature. 2014 Aug 3. doi: 10.1038/nature13603. PMID:25119039<ref>PMID:25119039</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 09:22, 13 August 2014

OCA — Wed, 13 Aug 2014 09:22:28 GMT

←Older revision		Revision as of 09:22, 13 August 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Electron density map of GluA2em in complex with quisqualate and LY451646==
-		+	<StructureSection load='4uqk' size='340' side='right' caption='[[4uqk]], [[Resolution\|resolution]] 16.40Å' scene=''>
-	~~The entry~~ 4uqk is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4uqk]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UQK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UQK FirstGlance]. <br>
-	~~Authors~~: ~~Meyerson, J~~.R., ~~Kumar~~, J., ~~Chittori~~, S., ~~Rao, P~~., ~~Pierson, J~~., Bartesaghi, A., Mayer, M.L., Subramaniam, S.	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QUS:(S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC+ACID'>QUS</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uq6\|4uq6]], [[4uqj\|4uqj]], [[4uqq\|4uqq]]</td></tr>
-	~~Description~~: ~~Electron density map of GluA2em in complex with quisqualate and LY451646~~	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uqk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uqk RCSB], [http://www.ebi.ac.uk/pdbsum/4uqk PDBsum]</span></td></tr>
		+	<table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bartesaghi, A.]]
		+	[[Category: Chittori, S.]]
		+	[[Category: Kumar, J.]]
		+	[[Category: Mayer, M L.]]
		+	[[Category: Meyerson, J R.]]
		+	[[Category: Pierson, J.]]
		+	[[Category: Rao, P.]]
		+	[[Category: Subramaniam, S.]]
		+	[[Category: Glua2em restored active state]]
		+	[[Category: Transport protein]]