4uu7 - Revision history

OCA at 11:49, 1 February 2024

OCA — Thu, 01 Feb 2024 11:49:53 GMT

←Older revision		Revision as of 11:49, 1 February 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4uu7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UU7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UU7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4uu7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UU7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UU7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=JO3:(2R)-2-METHYLBUTANEDIOIC+ACID'>JO3</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SUH:(2S)-2-METHYLBUTANEDIOIC+ACID'>SUH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=JO3:(2R)-2-METHYLBUTANEDIOIC+ACID'>JO3</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SUH:(2S)-2-METHYLBUTANEDIOIC+ACID'>SUH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uu7 OCA], [https://pdbe.org/4uu7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uu7 RCSB], [https://www.ebi.ac.uk/pdbsum/4uu7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uu7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uu7 OCA], [https://pdbe.org/4uu7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uu7 RCSB], [https://www.ebi.ac.uk/pdbsum/4uu7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uu7 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:28, 3 November 2022

OCA — Thu, 03 Nov 2022 07:28:10 GMT

←Older revision		Revision as of 07:28, 3 November 2022
Line 3:		Line 3:
	<StructureSection load='4uu7' size='340' side='right'caption='[[4uu7]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4uu7' size='340' side='right'caption='[[4uu7]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4uu7]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Brachidanio_rerio Brachidanio~~ rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UU7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4UU7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4uu7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UU7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UU7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=JO3:(2R)-2-METHYLBUTANEDIOIC+ACID'>JO3</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SUH:(2S)-2-METHYLBUTANEDIOIC+ACID'>SUH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=JO3:(2R)-2-METHYLBUTANEDIOIC+ACID'>JO3</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SUH:(2S)-2-METHYLBUTANEDIOIC+ACID'>SUH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uu7 OCA], [https://pdbe.org/4uu7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uu7 RCSB], [https://www.ebi.ac.uk/pdbsum/4uu7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uu7 ProSAT]</span></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4utn\|4utn]], [[4utr\|4utr]], [[4utv\|4utv]], [[4utx\|4utx]], [[4utz\|4utz]], [[4uu8\|4uu8]], [[4uua\|4uua]], [[4uub\|4uub]]</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4uu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uu7 OCA], [~~http~~://pdbe.org/4uu7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4uu7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4uu7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4uu7 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SIR5_DANRE SIR5_DANRE]] NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo (By similarity).	+	[https://www.uniprot.org/uniprot/SIR5_DANRE SIR5_DANRE] NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:

	==See Also==		==See Also==
-	*[[Histone deacetylase\|Histone deacetylase]]	+	*[[Histone deacetylase 3D structures\|Histone deacetylase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Brachidanio~~ rerio]]	+	[[Category: Danio rerio]]
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gertz, M]]	+	[[Category: Gertz M]]
-	[[Category: Pannek, M]]	+	[[Category: Pannek M]]
-	[[Category: Steegborn, C]]	+	[[Category: Steegborn C]]
-	~~[[Category: Deacylase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Mitochondrial]]~~	+
-	~~[[Category: Regulatory enzyme]]~~	+
-	~~[[Category: Rossmann-fold]]~~	+
-	~~[[Category: Sirtuin 5]]~~	+
-	~~[[Category: Zinc-binding~~]]	+

OCA at 09:04, 21 May 2019

OCA — Tue, 21 May 2019 09:04:31 GMT

←Older revision		Revision as of 09:04, 21 May 2019
Line 1:		Line 1:

	==Crystal structure of zebrafish Sirtuin 5 in complex with 3-methyl- succinylated CPS1-peptide==		==Crystal structure of zebrafish Sirtuin 5 in complex with 3-methyl- succinylated CPS1-peptide==
-	<StructureSection load='4uu7' size='340' side='right' caption='[[4uu7]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='4uu7' size='340' side='right'caption='[[4uu7]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4uu7]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UU7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UU7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4uu7]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UU7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UU7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=JO3:(2R)-2-METHYLBUTANEDIOIC+ACID'>JO3</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SUH:(2S)-2-METHYLBUTANEDIOIC+ACID'>SUH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=JO3:(2R)-2-METHYLBUTANEDIOIC+ACID'>JO3</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SUH:(2S)-2-METHYLBUTANEDIOIC+ACID'>SUH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>
Line 27:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Brachidanio rerio]]
		+	[[Category: Large Structures]]
	[[Category: Gertz, M]]		[[Category: Gertz, M]]
	[[Category: Pannek, M]]		[[Category: Pannek, M]]

OCA at 13:39, 5 August 2016

OCA — Fri, 05 Aug 2016 13:39:40 GMT

←Older revision		Revision as of 13:39, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of zebrafish Sirtuin 5 in complex with 3-methyl- succinylated CPS1-peptide==		==Crystal structure of zebrafish Sirtuin 5 in complex with 3-methyl- succinylated CPS1-peptide==
	<StructureSection load='4uu7' size='340' side='right' caption='[[4uu7]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4uu7' size='340' side='right' caption='[[4uu7]], [[Resolution\|resolution]] 3.00Å' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4utn\|4utn]], [[4utr\|4utr]], [[4utv\|4utv]], [[4utx\|4utx]], [[4utz\|4utz]], [[4uu8\|4uu8]], [[4uua\|4uua]], [[4uub\|4uub]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4utn\|4utn]], [[4utr\|4utr]], [[4utv\|4utv]], [[4utx\|4utx]], [[4utz\|4utz]], [[4uu8\|4uu8]], [[4uua\|4uua]], [[4uub\|4uub]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uu7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uu7 RCSB], [http://www.ebi.ac.uk/pdbsum/4uu7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uu7 OCA], [http://pdbe.org/4uu7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uu7 RCSB], [http://www.ebi.ac.uk/pdbsum/4uu7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uu7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4uu7" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Histone deacetylase\|Histone deacetylase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 02:57, 25 December 2014

OCA — Thu, 25 Dec 2014 02:57:24 GMT

←Older revision		Revision as of 02:57, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uu7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uu7 RCSB], [http://www.ebi.ac.uk/pdbsum/4uu7 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uu7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uu7 RCSB], [http://www.ebi.ac.uk/pdbsum/4uu7 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SIR5_DANRE SIR5_DANRE]] NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Gertz, M.]]	+	[[Category: Gertz, M]]
-	[[Category: Pannek, M.]]	+	[[Category: Pannek, M]]
-	[[Category: Steegborn, C.]]	+	[[Category: Steegborn, C]]
	[[Category: Deacylase]]		[[Category: Deacylase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 05:29, 8 October 2014

OCA — Wed, 08 Oct 2014 05:29:17 GMT

←Older revision		Revision as of 05:29, 8 October 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4uu7]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UU7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UU7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4uu7]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UU7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UU7 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=JO3:(2R)-2-METHYLBUTANEDIOIC+ACID'>JO3</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SUH:(2S)-2-METHYLBUTANEDIOIC+ACID'>SUH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=JO3:(2R)-2-METHYLBUTANEDIOIC+ACID'>JO3</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SUH:(2S)-2-METHYLBUTANEDIOIC+ACID'>SUH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4utn\|4utn]], [[4utr\|4utr]], [[4utv\|4utv]], [[4utx\|4utx]], [[4utz\|4utz]], [[4uu8\|4uu8]], [[4uua\|4uua]], [[4uub\|4uub]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4utn\|4utn]], [[4utr\|4utr]], [[4utv\|4utv]], [[4utx\|4utx]], [[4utz\|4utz]], [[4uu8\|4uu8]], [[4uua\|4uua]], [[4uub\|4uub]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uu7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uu7 RCSB], [http://www.ebi.ac.uk/pdbsum/4uu7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uu7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uu7 RCSB], [http://www.ebi.ac.uk/pdbsum/4uu7 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 16:17, 20 August 2014

OCA — Wed, 20 Aug 2014 16:17:32 GMT

←Older revision		Revision as of 16:17, 20 August 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of zebrafish Sirtuin 5 in complex with 3-methyl- succinylated CPS1-peptide==
		+	<StructureSection load='4uu7' size='340' side='right' caption='[[4uu7]], [[Resolution\|resolution]] 3.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4uu7]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UU7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UU7 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=JO3:(2R)-2-METHYLBUTANEDIOIC+ACID'>JO3</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SUH:(2S)-2-METHYLBUTANEDIOIC+ACID'>SUH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4utn\|4utn]], [[4utr\|4utr]], [[4utv\|4utv]], [[4utx\|4utx]], [[4utz\|4utz]], [[4uu8\|4uu8]], [[4uua\|4uua]], [[4uub\|4uub]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uu7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uu7 RCSB], [http://www.ebi.ac.uk/pdbsum/4uu7 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Sirtuins are NAD+ -dependent deacetylases acting as sensors in metabolic pathways and stress response. In mammals there are seven isoforms. The mitochondrial sirtuin 5 is a weak deacetylase but a very efficient demalonylase and desuccinylase; however, its substrate acyl specificity has not been systematically analyzed. Herein, we investigated a carbamoyl phosphate synthetase 1 derived peptide substrate and modified the lysine side chain systematically to determine the acyl specificity of Sirt5. From that point we designed six potent peptide-based inhibitors that interact with the NAD+ binding pocket. To characterize the interaction details causing the different substrate and inhibition properties we report several X-ray crystal structures of Sirt5 complexed with these peptides. Our results reveal the Sirt5 acyl selectivity and its molecular basis and enable the design of inhibitors for Sirt5.

-	~~The entry 4uu7 is ON HOLD until Paper Publication~~	+	Chemical Probing of the Human Sirtuin 5 Active Site Reveals Its Substrate Acyl Specificity and Peptide-Based Inhibitors.,Roessler C, Nowak T, Pannek M, Gertz M, Nguyen GT, Scharfe M, Born I, Sippl W, Steegborn C, Schutkowski M Angew Chem Int Ed Engl. 2014 Aug 11. doi: 10.1002/anie.201402679. PMID:25111069<ref>PMID:25111069</ref>

-	~~Authors: Pannek~~, M., Gertz, M., Steegborn, C.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of zebrafish~~ Sirtuin 5 ~~in complex with 3-methyl-succinylated CPS1~~-~~peptide~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Gertz, M.]]
		+	[[Category: Pannek, M.]]
		+	[[Category: Steegborn, C.]]
		+	[[Category: Deacylase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Mitochondrial]]
		+	[[Category: Regulatory enzyme]]
		+	[[Category: Rossmann-fold]]
		+	[[Category: Sirtuin 5]]
		+	[[Category: Zinc-binding]]

OCA at 08:13, 13 August 2014

OCA — Wed, 13 Aug 2014 08:13:46 GMT

←Older revision		Revision as of 08:13, 13 August 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4uu7 is ON HOLD	+	The entry 4uu7 is ON HOLD until Paper Publication

	Authors: Pannek, M., Gertz, M., Steegborn, C.		Authors: Pannek, M., Gertz, M., Steegborn, C.

	Description: Crystal structure of zebrafish Sirtuin 5 in complex with 3-methyl-succinylated CPS1-peptide		Description: Crystal structure of zebrafish Sirtuin 5 in complex with 3-methyl-succinylated CPS1-peptide

OCA at 01:37, 7 August 2014

OCA — Thu, 07 Aug 2014 01:37:07 GMT

←Older revision		Revision as of 01:37, 7 August 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4uu7 is ON HOLD ~~until sometime in the future~~	+	The entry 4uu7 is ON HOLD

	Authors: Pannek, M., Gertz, M., Steegborn, C.		Authors: Pannek, M., Gertz, M., Steegborn, C.

	Description: Crystal structure of zebrafish Sirtuin 5 in complex with 3-methyl-succinylated CPS1-peptide		Description: Crystal structure of zebrafish Sirtuin 5 in complex with 3-methyl-succinylated CPS1-peptide

OCA: Protected "4uu7" [edit=sysop:move=sysop]

OCA — Wed, 30 Jul 2014 07:21:12 GMT

Protected "4uu7" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:21, 30 July 2014