4uud - Revision history

OCA at 11:23, 9 May 2024

OCA — Thu, 09 May 2024 11:23:36 GMT

←Older revision		Revision as of 11:23, 9 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4uud]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UUD FirstGlance]. <br>		<table><tr><td colspan='2'>[[4uud]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UUD FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uud OCA], [https://pdbe.org/4uud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uud RCSB], [https://www.ebi.ac.uk/pdbsum/4uud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uud ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 12.5Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uud OCA], [https://pdbe.org/4uud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uud RCSB], [https://www.ebi.ac.uk/pdbsum/4uud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uud ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 07:38, 29 March 2023

OCA — Wed, 29 Mar 2023 07:38:49 GMT

←Older revision		Revision as of 07:38, 29 March 2023
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	<SX load='4uud' size='340' side='right' viewer='molstar' caption='[[4uud]], [[Resolution\|resolution]] 12.50Å' scene=''>		<SX load='4uud' size='340' side='right' viewer='molstar' caption='[[4uud]], [[Resolution\|resolution]] 12.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4uud]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UUD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=4UUD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4uud]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UUD FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uuk\|4uuk]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uud OCA], [https://pdbe.org/4uud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uud RCSB], [https://www.ebi.ac.uk/pdbsum/4uud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uud ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dynamin_GTPase Dynamin GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.5 3.6.5.5] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=4uud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uud OCA], [~~http~~://pdbe.org/4uud PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4uud RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4uud PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4uud ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DYN1_HUMAN DYN1_HUMAN]] Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.	+	[https://www.uniprot.org/uniprot/DYN1_HUMAN DYN1_HUMAN] Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 4uud" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4uud" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Dynamin 3D structures\|Dynamin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</SX>		</SX>
-	[[Category: ~~Dynamin GTPase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chappie~~, J S~~]]	+	[[Category: Chappie JS]]
-	[[Category: Fang, S]]	+	[[Category: Fang S]]
-	[[Category: Heymann~~, J A~~]]	+	[[Category: Heymann JA]]
-	[[Category: Hinshaw~~, J E~~]]	+	[[Category: Hinshaw JE]]
-	[[Category: Ray, P]]	+	[[Category: Ray P]]
-	[[Category: Sundborger~~, A C]]~~	+	[[Category: Sundborger AC]]
-	~~[[Category: Dynamin]]~~	+
-	~~[[Category: Endocytosis]]~~	+
-	~~[[Category: Gtpase]]~~	+
-	~~[[Category: Hydrolysis]]~~	+
-	~~[[Category: Intracellular trafficking]]~~	+
-	~~[[Category: Membrane fission]]~~	+
-	~~[[Category: Structural protein]]~~	+
-	~~[[Category: Superconstriction~~]]	+

OCA at 19:14, 10 April 2020

OCA — Fri, 10 Apr 2020 19:14:40 GMT

←Older revision		Revision as of 19:14, 10 April 2020
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	<SX load='4uud' size='340' side='right' viewer='molstar' caption='[[4uud]], [[Resolution\|resolution]] 12.50Å' scene=''>		<SX load='4uud' size='340' side='right' viewer='molstar' caption='[[4uud]], [[Resolution\|resolution]] 12.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4uud]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UUD OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4UUD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4uud]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UUD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=4UUD FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uuk\|4uuk]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uuk\|4uuk]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dynamin_GTPase Dynamin GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.5 3.6.5.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dynamin_GTPase Dynamin GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.5 3.6.5.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4uud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uud OCA], [http://pdbe.org/4uud PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uud RCSB], [http://www.ebi.ac.uk/pdbsum/4uud PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uud ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=4uud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uud OCA], [http://pdbe.org/4uud PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uud RCSB], [http://www.ebi.ac.uk/pdbsum/4uud PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uud ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 17:58, 6 March 2020

OCA — Fri, 06 Mar 2020 17:58:52 GMT

←Older revision		Revision as of 17:58, 6 March 2020
Line 1:		Line 1:

	==Human dynamin 1 K44A superconstricted polymer stabilized with GTP==		==Human dynamin 1 K44A superconstricted polymer stabilized with GTP==
-	<~~StructureSection~~ load='4uud' size='340' side='right'caption='[[4uud]], [[Resolution\|resolution]] 12.50Å' scene=''>	+	<SX load='4uud' size='340' side='right' viewer='molstar' caption='[[4uud]], [[Resolution\|resolution]] 12.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4uud]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UUD FirstGlance]. <br>		<table><tr><td colspan='2'>[[4uud]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UUD FirstGlance]. <br>
Line 25:		Line 25:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Dynamin GTPase]]		[[Category: Dynamin GTPase]]
	[[Category: Human]]		[[Category: Human]]

OCA at 09:29, 21 May 2019

OCA — Tue, 21 May 2019 09:29:12 GMT

←Older revision		Revision as of 09:29, 21 May 2019
Line 1:		Line 1:

	==Human dynamin 1 K44A superconstricted polymer stabilized with GTP==		==Human dynamin 1 K44A superconstricted polymer stabilized with GTP==
-	<StructureSection load='4uud' size='340' side='right' caption='[[4uud]], [[Resolution\|resolution]] 12.50Å' scene=''>	+	<StructureSection load='4uud' size='340' side='right'caption='[[4uud]], [[Resolution\|resolution]] 12.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4uud]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UUD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4uud]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UUD FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uuk\|4uuk]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uuk\|4uuk]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dynamin_GTPase Dynamin GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.5 3.6.5.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dynamin_GTPase Dynamin GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.5 3.6.5.5] </span></td></tr>
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4uud" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4uud" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Dynamin 3D structures\|Dynamin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Dynamin GTPase]]		[[Category: Dynamin GTPase]]
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Chappie, J S]]		[[Category: Chappie, J S]]
	[[Category: Fang, S]]		[[Category: Fang, S]]

OCA at 03:49, 5 August 2016

OCA — Fri, 05 Aug 2016 03:49:58 GMT

←Older revision		Revision as of 03:49, 5 August 2016
Line 1:		Line 1:
		+
	==Human dynamin 1 K44A superconstricted polymer stabilized with GTP==		==Human dynamin 1 K44A superconstricted polymer stabilized with GTP==
	<StructureSection load='4uud' size='340' side='right' caption='[[4uud]], [[Resolution\|resolution]] 12.50Å' scene=''>		<StructureSection load='4uud' size='340' side='right' caption='[[4uud]], [[Resolution\|resolution]] 12.50Å' scene=''>
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	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uuk\|4uuk]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uuk\|4uuk]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dynamin_GTPase Dynamin GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.5 3.6.5.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dynamin_GTPase Dynamin GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.5 3.6.5.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uud OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uud RCSB], [http://www.ebi.ac.uk/pdbsum/4uud PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uud OCA], [http://pdbe.org/4uud PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uud RCSB], [http://www.ebi.ac.uk/pdbsum/4uud PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uud ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4uud" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:36, 25 December 2014

OCA — Thu, 25 Dec 2014 15:36:56 GMT

←Older revision		Revision as of 15:36, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4uud]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UUD FirstGlance]. <br>		<table><tr><td colspan='2'>[[4uud]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UUD FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uuk\|4uuk]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uuk\|4uuk]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dynamin_GTPase Dynamin GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.5 3.6.5.5] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dynamin_GTPase Dynamin GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.5 3.6.5.5] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uud OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uud RCSB], [http://www.ebi.ac.uk/pdbsum/4uud PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uud OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uud RCSB], [http://www.ebi.ac.uk/pdbsum/4uud PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DYN1_HUMAN DYN1_HUMAN]] Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Dynamin GTPase]]		[[Category: Dynamin GTPase]]
-	[[Category: Chappie, J S.]]	+	[[Category: Chappie, J S]]
-	[[Category: Fang, S.]]	+	[[Category: Fang, S]]
-	[[Category: Heymann, J A.]]	+	[[Category: Heymann, J A]]
-	[[Category: Hinshaw, J E.]]	+	[[Category: Hinshaw, J E]]
-	[[Category: Ray, P.]]	+	[[Category: Ray, P]]
-	[[Category: Sundborger, A C.]]	+	[[Category: Sundborger, A C]]
	[[Category: Dynamin]]		[[Category: Dynamin]]
	[[Category: Endocytosis]]		[[Category: Endocytosis]]

OCA at 08:45, 27 August 2014

OCA — Wed, 27 Aug 2014 08:45:45 GMT

←Older revision		Revision as of 08:45, 27 August 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Human dynamin 1 K44A superconstricted polymer stabilized with GTP==
		+	<StructureSection load='4uud' size='340' side='right' caption='[[4uud]], [[Resolution\|resolution]] 12.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4uud]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UUD FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uuk\|4uuk]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dynamin_GTPase Dynamin GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.5 3.6.5.5] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uud OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uud RCSB], [http://www.ebi.ac.uk/pdbsum/4uud PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Dynamin is a 100 kDa GTPase that organizes into helical assemblies at the base of nascent clathrin-coated vesicles. Formation of these oligomers stimulates the intrinsic GTPase activity of dynamin, which is necessary for efficient membrane fission during endocytosis. Recent evidence suggests that the transition state of dynamin's GTP hydrolysis reaction serves as a key determinant of productive fission. Here, we present the structure of a transition-state-defective dynamin mutant K44A trapped in a prefission state at 12.5 A resolution. This structure constricts to 3.7 nm, reaching the theoretical limit required for spontaneous membrane fission. Computational docking indicates that the ground-state conformation of the dynamin polymer is sufficient to achieve this superconstricted prefission state and reveals how a two-start helical symmetry promotes the most efficient packing of dynamin tetramers around the membrane neck. These data suggest a model for the assembly and regulation of the minimal dynamin fission machine.

-	~~The entry 4uud is ON HOLD~~	+	A dynamin mutant defines a superconstricted prefission state.,Sundborger AC, Fang S, Heymann JA, Ray P, Chappie JS, Hinshaw JE Cell Rep. 2014 Aug 7;8(3):734-42. doi: 10.1016/j.celrep.2014.06.054. Epub 2014, Jul 31. PMID:25088425<ref>PMID:25088425</ref>

-	~~Authors: Sundborger~~, A.C., Fang, S., Heymann, J.A., Ray, P., ~~Chappie, J.S., Hinshaw, J.E~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Human dynamin 1 K44A superconstricted polymer stabilized with GTP~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Dynamin GTPase]]
		+	[[Category: Chappie, J S.]]
		+	[[Category: Fang, S.]]
		+	[[Category: Heymann, J A.]]
		+	[[Category: Hinshaw, J E.]]
		+	[[Category: Ray, P.]]
		+	[[Category: Sundborger, A C.]]
		+	[[Category: Dynamin]]
		+	[[Category: Endocytosis]]
		+	[[Category: Gtpase]]
		+	[[Category: Hydrolysis]]
		+	[[Category: Intracellular trafficking]]
		+	[[Category: Membrane fission]]
		+	[[Category: Structural protein]]
		+	[[Category: Superconstriction]]

OCA at 08:14, 13 August 2014

OCA — Wed, 13 Aug 2014 08:14:01 GMT

←Older revision		Revision as of 08:14, 13 August 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4uud is ON HOLD ~~until sometime in the future~~	+	The entry 4uud is ON HOLD

	Authors: Sundborger, A.C., Fang, S., Heymann, J.A., Ray, P., Chappie, J.S., Hinshaw, J.E.		Authors: Sundborger, A.C., Fang, S., Heymann, J.A., Ray, P., Chappie, J.S., Hinshaw, J.E.

	Description: Human dynamin 1 K44A superconstricted polymer stabilized with GTP		Description: Human dynamin 1 K44A superconstricted polymer stabilized with GTP

OCA: Protected "4uud" [edit=sysop:move=sysop]

OCA — Thu, 07 Aug 2014 01:37:15 GMT

Protected "4uud" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:37, 7 August 2014