4uuj - Revision history

OCA at 10:36, 10 January 2024

OCA — Wed, 10 Jan 2024 10:36:35 GMT

←Older revision		Revision as of 10:36, 10 January 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4uuj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UUJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UUJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4uuj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UUJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UUJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=DGA:DIACYL+GLYCEROL'>DGA</scene>, <scene name='pdbligand=F09:NONAN-1-OL'>F09</scene>, <scene name='pdbligand=IND:INDOLE'>IND</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=XA7:TETRAHEXYL+AMMONNIUM'>XA7</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=DGA:DIACYL+GLYCEROL'>DGA</scene>, <scene name='pdbligand=F09:NONAN-1-OL'>F09</scene>, <scene name='pdbligand=IND:INDOLE'>IND</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=XA7:TETRAHEXYL+AMMONNIUM'>XA7</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uuj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uuj OCA], [https://pdbe.org/4uuj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uuj RCSB], [https://www.ebi.ac.uk/pdbsum/4uuj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uuj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uuj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uuj OCA], [https://pdbe.org/4uuj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uuj RCSB], [https://www.ebi.ac.uk/pdbsum/4uuj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uuj ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:39, 29 March 2023

OCA — Wed, 29 Mar 2023 07:39:04 GMT

←Older revision		Revision as of 07:39, 29 March 2023
Line 3:		Line 3:
	<StructureSection load='4uuj' size='340' side='right'caption='[[4uuj]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='4uuj' size='340' side='right'caption='[[4uuj]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4uuj]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"actinomyces_lividans"_krasil'nikov_et_al._1965 "actinomyces lividans" krasil'nikov et al. 1965~~] and [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UUJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4UUJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4uuj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UUJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UUJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=DGA:DIACYL+GLYCEROL'>DGA</scene>, <scene name='pdbligand=F09:NONAN-1-OL'>F09</scene>, <scene name='pdbligand=IND:INDOLE'>IND</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=XA7:TETRAHEXYL+AMMONNIUM'>XA7</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=DGA:DIACYL+GLYCEROL'>DGA</scene>, <scene name='pdbligand=F09:NONAN-1-OL'>F09</scene>, <scene name='pdbligand=IND:INDOLE'>IND</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=XA7:TETRAHEXYL+AMMONNIUM'>XA7</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4uuj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uuj OCA], [~~http~~://pdbe.org/4uuj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4uuj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4uuj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4uuj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uuj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uuj OCA], [https://pdbe.org/4uuj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uuj RCSB], [https://www.ebi.ac.uk/pdbsum/4uuj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uuj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI]] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref>	+	[https://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:
	==See Also==		==See Also==
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
-	*[[Potassium ~~Channel~~\|Potassium ~~Channel~~]]	+	*[[Potassium channel 3D structures\|Potassium channel 3D structures]]
		+	*[[3D structures of non-human antibody\|3D structures of non-human antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Actinomyces lividans krasil'nikov et al. 1965]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Burdette, D]]	+	[[Category: Streptomyces lividans]]
-	[[Category: Focia~~, P J~~]]	+	[[Category: Burdette D]]
-	[[Category: Gross, A]]	+	[[Category: Focia PJ]]
-	[[Category: Lenaeus~~, M J~~]]	+	[[Category: Gross A]]
-	[[Category: Wagner, T]]	+	[[Category: Lenaeus MJ]]
-	~~[[Category: Immune system-metal transport complex]]~~	+	[[Category: Wagner T]]
-	~~[[Category: Ion transport]]~~	+
-	~~[[Category: Ionic channel]]~~	+
-	~~[[Category: Potassium channel]]~~	+
-	~~[[Category: Protein-antibody fab complex]]~~	+
-	~~[[Category: Quaternary ammonium~~]]	+

OCA at 08:41, 21 May 2019

OCA — Tue, 21 May 2019 08:41:35 GMT

←Older revision		Revision as of 08:41, 21 May 2019
Line 1:		Line 1:

	==POTASSIUM CHANNEL KCSA-FAB WITH TETRAHEXYLAMMONIUM==		==POTASSIUM CHANNEL KCSA-FAB WITH TETRAHEXYLAMMONIUM==
-	<StructureSection load='4uuj' size='340' side='right' caption='[[4uuj]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='4uuj' size='340' side='right'caption='[[4uuj]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4uuj]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UUJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UUJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4uuj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_lividans"_krasil'nikov_et_al._1965 "actinomyces lividans" krasil'nikov et al. 1965] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UUJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UUJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=DGA:DIACYL+GLYCEROL'>DGA</scene>, <scene name='pdbligand=F09:NONAN-1-OL'>F09</scene>, <scene name='pdbligand=IND:INDOLE'>IND</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=XA7:TETRAHEXYL+AMMONNIUM'>XA7</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=DGA:DIACYL+GLYCEROL'>DGA</scene>, <scene name='pdbligand=F09:NONAN-1-OL'>F09</scene>, <scene name='pdbligand=IND:INDOLE'>IND</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=XA7:TETRAHEXYL+AMMONNIUM'>XA7</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uuj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uuj OCA], [http://pdbe.org/4uuj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uuj RCSB], [http://www.ebi.ac.uk/pdbsum/4uuj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uuj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uuj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uuj OCA], [http://pdbe.org/4uuj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uuj RCSB], [http://www.ebi.ac.uk/pdbsum/4uuj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uuj ProSAT]</span></td></tr>
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4uuj" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4uuj" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Potassium Channel\|Potassium Channel]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Actinomyces lividans krasil'nikov et al. 1965]]
		+	[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Burdette, D]]		[[Category: Burdette, D]]
	[[Category: Focia, P J]]		[[Category: Focia, P J]]

OCA at 19:48, 5 August 2016

OCA — Fri, 05 Aug 2016 19:48:13 GMT

←Older revision		Revision as of 19:48, 5 August 2016
Line 1:		Line 1:
		+
	==POTASSIUM CHANNEL KCSA-FAB WITH TETRAHEXYLAMMONIUM==		==POTASSIUM CHANNEL KCSA-FAB WITH TETRAHEXYLAMMONIUM==
	<StructureSection load='4uuj' size='340' side='right' caption='[[4uuj]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='4uuj' size='340' side='right' caption='[[4uuj]], [[Resolution\|resolution]] 2.40Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4uuj]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UUJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UUJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4uuj]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UUJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UUJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=DGA:DIACYL+GLYCEROL'>DGA</scene>, <scene name='pdbligand=F09:NONAN-1-OL'>F09</scene>, <scene name='pdbligand=IND:INDOLE'>IND</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=XA7:TETRAHEXYL+AMMONNIUM'>XA7</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=DGA:DIACYL+GLYCEROL'>DGA</scene>, <scene name='pdbligand=F09:NONAN-1-OL'>F09</scene>, <scene name='pdbligand=IND:INDOLE'>IND</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=XA7:TETRAHEXYL+AMMONNIUM'>XA7</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uuj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uuj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uuj RCSB], [http://www.ebi.ac.uk/pdbsum/4uuj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uuj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uuj OCA], [http://pdbe.org/4uuj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uuj RCSB], [http://www.ebi.ac.uk/pdbsum/4uuj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uuj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4uuj" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:20, 25 December 2014

OCA — Thu, 25 Dec 2014 05:20:46 GMT

←Older revision		Revision as of 05:20, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4uuj]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UUJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UUJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4uuj]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UUJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UUJ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=DGA:DIACYL+GLYCEROL'>DGA</scene>, <scene name='pdbligand=F09:NONAN-1-OL'>F09</scene>, <scene name='pdbligand=IND:INDOLE'>IND</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=XA7:TETRAHEXYL+AMMONNIUM'>XA7</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=DGA:DIACYL+GLYCEROL'>DGA</scene>, <scene name='pdbligand=F09:NONAN-1-OL'>F09</scene>, <scene name='pdbligand=IND:INDOLE'>IND</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=XA7:TETRAHEXYL+AMMONNIUM'>XA7</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uuj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uuj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uuj RCSB], [http://www.ebi.ac.uk/pdbsum/4uuj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uuj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uuj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uuj RCSB], [http://www.ebi.ac.uk/pdbsum/4uuj PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI]] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Burdette, D.]]	+	[[Category: Burdette, D]]
-	[[Category: Focia, P J.]]	+	[[Category: Focia, P J]]
-	[[Category: Gross, A.]]	+	[[Category: Gross, A]]
-	[[Category: Lenaeus, M J.]]	+	[[Category: Lenaeus, M J]]
-	[[Category: Wagner, T.]]	+	[[Category: Wagner, T]]
	[[Category: Immune system-metal transport complex]]		[[Category: Immune system-metal transport complex]]
	[[Category: Ion transport]]		[[Category: Ion transport]]

OCA at 08:42, 27 August 2014

OCA — Wed, 27 Aug 2014 08:42:57 GMT

←Older revision		Revision as of 08:42, 27 August 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==POTASSIUM CHANNEL KCSA-FAB WITH TETRAHEXYLAMMONIUM==
		+	<StructureSection load='4uuj' size='340' side='right' caption='[[4uuj]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4uuj]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UUJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UUJ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=DGA:DIACYL+GLYCEROL'>DGA</scene>, <scene name='pdbligand=F09:NONAN-1-OL'>F09</scene>, <scene name='pdbligand=IND:INDOLE'>IND</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=XA7:TETRAHEXYL+AMMONNIUM'>XA7</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uuj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uuj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uuj RCSB], [http://www.ebi.ac.uk/pdbsum/4uuj PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Potassium channels allow for the passive movement of potassium ions across the cell membrane and are instrumental in controlling the membrane potential in all cell types. Quaternary ammonium (QA) compounds block potassium channels and have long been used to study the functional and structural properties of these channels. Here we describe the interaction between three symmetrical hydrophobic QAs and the prokaryotic potassium channel KcsA. The structures demonstrate the presence of a hydrophobic pocket between the inner helices of KcsA and provide insight into the binding site and blocking mechanism of hydrophobic QAs. The structures also reveal a structurally hidden pathway between the central cavity and the outside membrane environment reminiscent of the lateral fenestration observed in sodium channels that can be accessed through small conformational changes in the pore wall. We propose that the hydrophobic binding pocket stabilizes the alkyl chains of long-chain QA molecules and may play a key role in hydrophobic drug binding in general.

-	~~The entry 4uuj is ON HOLD until Paper Publication~~	+	Structures of KcsA in Complex with Symmetrical Quaternary Ammonium Compounds Reveal a Hydrophobic Binding Site.,Lenaeus MJ, Burdette D, Wagner T, Focia PJ, Gross A Biochemistry. 2014 Aug 19;53(32):5365-73. doi: 10.1021/bi500525s. Epub 2014 Aug, 8. PMID:25093676<ref>PMID:25093676</ref>

-	~~Authors: Lenaeus~~, M.J., Burdette, D.~~, Wagner, T.,~~ Focia, P.J., Gross, A.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~POTASSIUM CHANNEL KCSA~~-~~FAB COMPLEX WITH TETRAHEXYLAMMONIUM~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Burdette, D.]]
		+	[[Category: Focia, P J.]]
		+	[[Category: Gross, A.]]
		+	[[Category: Lenaeus, M J.]]
		+	[[Category: Wagner, T.]]
		+	[[Category: Immune system-metal transport complex]]
		+	[[Category: Ion transport]]
		+	[[Category: Ionic channel]]
		+	[[Category: Potassium channel]]
		+	[[Category: Protein-antibody fab complex]]
		+	[[Category: Quaternary ammonium]]

OCA at 15:12, 20 August 2014

OCA — Wed, 20 Aug 2014 15:12:10 GMT

←Older revision		Revision as of 15:12, 20 August 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4uuj is ON HOLD	+	The entry 4uuj is ON HOLD until Paper Publication

	Authors: Lenaeus, M.J., Burdette, D., Wagner, T., Focia, P.J., Gross, A.		Authors: Lenaeus, M.J., Burdette, D., Wagner, T., Focia, P.J., Gross, A.

	Description: POTASSIUM CHANNEL KCSA-FAB COMPLEX WITH TETRAHEXYLAMMONIUM		Description: POTASSIUM CHANNEL KCSA-FAB COMPLEX WITH TETRAHEXYLAMMONIUM

OCA at 08:14, 13 August 2014

OCA — Wed, 13 Aug 2014 08:14:08 GMT

←Older revision		Revision as of 08:14, 13 August 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4uuj is ON HOLD ~~until sometime in the future~~	+	The entry 4uuj is ON HOLD

	Authors: Lenaeus, M.J., Burdette, D., Wagner, T., Focia, P.J., Gross, A.		Authors: Lenaeus, M.J., Burdette, D., Wagner, T., Focia, P.J., Gross, A.

	Description: POTASSIUM CHANNEL KCSA-FAB COMPLEX WITH TETRAHEXYLAMMONIUM		Description: POTASSIUM CHANNEL KCSA-FAB COMPLEX WITH TETRAHEXYLAMMONIUM

OCA: Protected "4uuj" [edit=sysop:move=sysop]

OCA — Thu, 07 Aug 2014 01:37:27 GMT

Protected "4uuj" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:37, 7 August 2014

OCA: New page: '''Unreleased structure''' The entry 4uuj is ON HOLD until sometime in the future Authors: Lenaeus, M.J., Burdette, D., Wagner, T., Focia, P.J., Gross, A. Description: POTASSIUM CHANNE...

OCA — Thu, 07 Aug 2014 01:37:26 GMT

New page: '''Unreleased structure''' The entry 4uuj is ON HOLD until sometime in the future Authors: Lenaeus, M.J., Burdette, D., Wagner, T., Focia, P.J., Gross, A. Description: POTASSIUM CHANNE...

New page

'''Unreleased structure'''

The entry 4uuj is ON HOLD until sometime in the future

Authors: Lenaeus, M.J., Burdette, D., Wagner, T., Focia, P.J., Gross, A.

Description: POTASSIUM CHANNEL KCSA-FAB COMPLEX WITH TETRAHEXYLAMMONIUM