4uw1 - Revision history

OCA at 10:37, 10 January 2024

OCA — Wed, 10 Jan 2024 10:37:22 GMT

←Older revision		Revision as of 10:37, 10 January 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4uw1]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UW1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UW1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4uw1]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UW1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UW1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=92R:3-{4-[(DIMETHYLAMINO)METHYL]PHENYL}-5-METHOXYISOQUINOLIN-1(2H)-ONE'>92R</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.37Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=92R:3-{4-[(DIMETHYLAMINO)METHYL]PHENYL}-5-METHOXYISOQUINOLIN-1(2H)-ONE'>92R</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uw1 OCA], [https://pdbe.org/4uw1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uw1 RCSB], [https://www.ebi.ac.uk/pdbsum/4uw1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uw1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uw1 OCA], [https://pdbe.org/4uw1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uw1 RCSB], [https://www.ebi.ac.uk/pdbsum/4uw1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uw1 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:44, 29 March 2023

OCA — Wed, 29 Mar 2023 07:44:11 GMT

←Older revision		Revision as of 07:44, 29 March 2023
Line 3:		Line 3:
	<StructureSection load='4uw1' size='340' side='right'caption='[[4uw1]], [[Resolution\|resolution]] 3.37Å' scene=''>		<StructureSection load='4uw1' size='340' side='right'caption='[[4uw1]], [[Resolution\|resolution]] 3.37Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4uw1]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UW1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4UW1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4uw1]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UW1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UW1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=92R:3-{4-[(DIMETHYLAMINO)METHYL]PHENYL}-5-METHOXYISOQUINOLIN-1(2H)-ONE'>92R</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=92R:3-{4-[(DIMETHYLAMINO)METHYL]PHENYL}-5-METHOXYISOQUINOLIN-1(2H)-ONE'>92R</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uuh\|4uuh]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uw1 OCA], [https://pdbe.org/4uw1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uw1 RCSB], [https://www.ebi.ac.uk/pdbsum/4uw1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uw1 ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4uw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uw1 OCA], [~~http~~://pdbe.org/4uw1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4uw1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4uw1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4uw1 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TNKS1_HUMAN TNKS1_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1.<ref>PMID:10988299</ref> <ref>PMID:11739745</ref> <ref>PMID:16076287</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref> <ref>PMID:22864114</ref>	+	[https://www.uniprot.org/uniprot/TNKS1_HUMAN TNKS1_HUMAN] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1.<ref>PMID:10988299</ref> <ref>PMID:11739745</ref> <ref>PMID:16076287</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref> <ref>PMID:22864114</ref>

	==See Also==		==See Also==
-	*[[Poly (ADP-ribose) polymerase\|Poly (ADP-ribose) polymerase]]	+	*[[Poly(ADP-ribose) polymerase 3D structures\|Poly(ADP-ribose) polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Oliver~~, A W~~]]	+	[[Category: Oliver AW]]
-	[[Category: Pearl~~, L H~~]]	+	[[Category: Pearl LH]]
-	[[Category: Rajasekaran~~, M B]]~~	+	[[Category: Rajasekaran MB]]
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Tnk]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Wnt signalling~~]]	+

OCA at 08:29, 23 May 2019

OCA — Thu, 23 May 2019 08:29:21 GMT

←Older revision		Revision as of 08:29, 23 May 2019
Line 1:		Line 1:
		+
	==X-ray crystal structure of human TNKS in complex with a small molecule inhibitor==		==X-ray crystal structure of human TNKS in complex with a small molecule inhibitor==
-	<StructureSection load='4uw1' size='340' side='right' caption='[[4uw1]], [[Resolution\|resolution]] 3.37Å' scene=''>	+	<StructureSection load='4uw1' size='340' side='right'caption='[[4uw1]], [[Resolution\|resolution]] 3.37Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4uw1]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UW1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UW1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4uw1]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UW1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UW1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=92R:3-{4-[(DIMETHYLAMINO)METHYL]PHENYL}-5-METHOXYISOQUINOLIN-1(2H)-ONE'>92R</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=92R:3-{4-[(DIMETHYLAMINO)METHYL]PHENYL}-5-METHOXYISOQUINOLIN-1(2H)-ONE'>92R</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uuh\|4uuh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uuh\|4uuh]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uw1 OCA], [http://pdbe.org/4uw1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uw1 RCSB], [http://www.ebi.ac.uk/pdbsum/4uw1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uw1 OCA], [http://pdbe.org/4uw1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uw1 RCSB], [http://www.ebi.ac.uk/pdbsum/4uw1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uw1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/TNKS1_HUMAN TNKS1_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1.<ref>PMID:10988299</ref> <ref>PMID:11739745</ref> <ref>PMID:16076287</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref> <ref>PMID:22864114</ref>		[[http://www.uniprot.org/uniprot/TNKS1_HUMAN TNKS1_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1.<ref>PMID:10988299</ref> <ref>PMID:11739745</ref> <ref>PMID:16076287</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref> <ref>PMID:22864114</ref>
		+
		+	==See Also==
		+	*[[Poly (ADP-ribose) polymerase\|Poly (ADP-ribose) polymerase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Oliver, A W]]		[[Category: Oliver, A W]]
	[[Category: Pearl, L H]]		[[Category: Pearl, L H]]

OCA at 12:26, 13 January 2016

OCA — Wed, 13 Jan 2016 12:26:00 GMT

←Older revision		Revision as of 12:26, 13 January 2016
Line 6:		Line 6:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uuh\|4uuh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uuh\|4uuh]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uw1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uw1 RCSB], [http://www.ebi.ac.uk/pdbsum/4uw1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uw1 OCA], [http://pdbe.org/4uw1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uw1 RCSB], [http://www.ebi.ac.uk/pdbsum/4uw1 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 14:52, 8 July 2015

OCA — Wed, 08 Jul 2015 14:52:14 GMT

←Older revision		Revision as of 14:52, 8 July 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==X-ray crystal structure of human TNKS in complex with a small molecule inhibitor==
-		+	<StructureSection load='4uw1' size='340' side='right' caption='[[4uw1]], [[Resolution\|resolution]] 3.37Å' scene=''>
-	~~The entry~~ 4uw1 is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4uw1]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UW1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UW1 FirstGlance]. <br>
-	~~Authors~~: ~~Oliver~~, A.W., ~~Rajasekaran~~, M.B., ~~Pearl, L~~.H.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=92R:3-{4-[(DIMETHYLAMINO)METHYL]PHENYL}-5-METHOXYISOQUINOLIN-1(2H)-ONE'>92R</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uuh\|4uuh]]</td></tr>
-	~~Description~~: X-~~ray crystal structure of human TNKS~~ in complex ~~with a small molecule inhibitor~~	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uw1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uw1 RCSB], [http://www.ebi.ac.uk/pdbsum/4uw1 PDBsum]</span></td></tr>
-	[[Category: Pearl, L.H]]	+	</table>
-	[[Category: Rajasekaran, M.B]]	+	== Function ==
-	[[Category: ~~Oliver, A.W~~]]	+	[[http://www.uniprot.org/uniprot/TNKS1_HUMAN TNKS1_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1.<ref>PMID:10988299</ref> <ref>PMID:11739745</ref> <ref>PMID:16076287</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref> <ref>PMID:22864114</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Oliver, A W]]
		+	[[Category: Pearl, L H]]
		+	[[Category: Rajasekaran, M B]]
		+	[[Category: Inhibitor]]
		+	[[Category: Tnk]]
		+	[[Category: Transferase]]
		+	[[Category: Wnt signalling]]

OCA at 18:47, 24 December 2014

OCA — Wed, 24 Dec 2014 18:47:16 GMT

←Older revision		Revision as of 18:47, 24 December 2014
Line 6:		Line 6:

	Description: X-ray crystal structure of human TNKS in complex with a small molecule inhibitor		Description: X-ray crystal structure of human TNKS in complex with a small molecule inhibitor
		+	[[Category: Unreleased Structures]]
		+	[[Category: Pearl, L.H]]
		+	[[Category: Rajasekaran, M.B]]
		+	[[Category: Oliver, A.W]]

OCA: Protected "4uw1" [edit=sysop:move=sysop]

OCA — Wed, 20 Aug 2014 15:13:32 GMT

Protected "4uw1" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:13, 20 August 2014

OCA: New page: '''Unreleased structure''' The entry 4uw1 is ON HOLD until Paper Publication Authors: Oliver, A.W., Rajasekaran, M.B., Pearl, L.H. Description: X-ray crystal structure of human TNKS in...

OCA — Wed, 20 Aug 2014 15:13:30 GMT

New page: '''Unreleased structure''' The entry 4uw1 is ON HOLD until Paper Publication Authors: Oliver, A.W., Rajasekaran, M.B., Pearl, L.H. Description: X-ray crystal structure of human TNKS in...

New page

'''Unreleased structure'''

The entry 4uw1 is ON HOLD until Paper Publication

Authors: Oliver, A.W., Rajasekaran, M.B., Pearl, L.H.

Description: X-ray crystal structure of human TNKS in complex with a small molecule inhibitor