4ux6 - Revision history

OCA at 07:48, 29 March 2023

OCA — Wed, 29 Mar 2023 07:48:43 GMT

←Older revision		Revision as of 07:48, 29 March 2023
Line 3:		Line 3:
	<StructureSection load='4ux6' size='340' side='right'caption='[[4ux6]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4ux6' size='340' side='right'caption='[[4ux6]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ux6]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UX6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4UX6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ux6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UX6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UX6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=YWO:O-(5-METHYL-2-NITROPHENYL)-D-TYROSINAMIDE'>YWO</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=YWO:O-(5-METHYL-2-NITROPHENYL)-D-TYROSINAMIDE'>YWO</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ux6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ux6 OCA], [https://pdbe.org/4ux6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ux6 RCSB], [https://www.ebi.ac.uk/pdbsum/4ux6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ux6 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ux6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ux6 OCA], [~~http~~://pdbe.org/4ux6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ux6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ux6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ux6 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE]] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>	+	[https://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Andrews, G]]	+	[[Category: Andrews G]]
-	[[Category: Beaton~~, H G~~]]	+	[[Category: Beaton HG]]
-	[[Category: Birkinshaw, T]]	+	[[Category: Birkinshaw T]]
-	[[Category: Boughton-Smith, N]]	+	[[Category: Boughton-Smith N]]
-	[[Category: Cheshire~~, D R~~]]	+	[[Category: Cheshire DR]]
-	[[Category: Connolly, S]]	+	[[Category: Connolly S]]
-	[[Category: Cook~~, T R~~]]	+	[[Category: Cook TR]]
-	[[Category: Cooper, A]]	+	[[Category: Cooper A]]
-	[[Category: Cooper~~, S L~~]]	+	[[Category: Cooper SL]]
-	[[Category: Cox, D]]	+	[[Category: Cox D]]
-	[[Category: Dixon, J]]	+	[[Category: Dixon J]]
-	[[Category: Gensmantel, N]]	+	[[Category: Gensmantel N]]
-	[[Category: Hamley~~, P J~~]]	+	[[Category: Hamley PJ]]
-	[[Category: Harrison, R]]	+	[[Category: Harrison R]]
-	[[Category: Hartopp, P]]	+	[[Category: Hartopp P]]
-	[[Category: Kack, H]]	+	[[Category: Kack H]]
-	[[Category: Luker, T]]	+	[[Category: Luker T]]
-	[[Category: Mete, A]]	+	[[Category: Mete A]]
-	[[Category: Millichip, I]]	+	[[Category: Millichip I]]
-	[[Category: Nicholls~~, D J~~]]	+	[[Category: Nicholls DJ]]
-	[[Category: Pimm~~, A D~~]]	+	[[Category: Pimm AD]]
-	[[Category: St-Gallay~~, S A~~]]	+	[[Category: St-Gallay SA]]
-	[[Category: Wallace~~, A V]]~~	+	[[Category: Wallace AV]]
-	~~[[Category: Drug design]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 11:09, 26 February 2020

OCA — Wed, 26 Feb 2020 11:09:57 GMT

←Older revision		Revision as of 11:09, 26 February 2020
Line 1:		Line 1:

	==The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)==		==The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)==
-	<StructureSection load='4ux6' size='340' side='right' caption='[[4ux6]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='4ux6' size='340' side='right'caption='[[4ux6]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ux6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UX6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UX6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ux6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UX6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UX6 FirstGlance]. <br>
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4ux6" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4ux6" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Nitric Oxide Synthase 3D structures\|Nitric Oxide Synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Andrews, G]]		[[Category: Andrews, G]]

OCA at 07:55, 17 January 2018

OCA — Wed, 17 Jan 2018 07:55:41 GMT

←Older revision		Revision as of 07:55, 17 January 2018
Line 3:		Line 3:
	<StructureSection load='4ux6' size='340' side='right' caption='[[4ux6]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4ux6' size='340' side='right' caption='[[4ux6]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ux6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UX6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UX6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ux6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UX6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UX6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=YWO:O-(5-METHYL-2-NITROPHENYL)-D-TYROSINAMIDE'>YWO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=YWO:O-(5-METHYL-2-NITROPHENYL)-D-TYROSINAMIDE'>YWO</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Andrews, G]]		[[Category: Andrews, G]]
	[[Category: Beaton, H G]]		[[Category: Beaton, H G]]

OCA at 14:18, 4 August 2016

OCA — Thu, 04 Aug 2016 14:18:48 GMT

←Older revision		Revision as of 14:18, 4 August 2016
Line 1:		Line 1:
		+
	==The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)==		==The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)==
	<StructureSection load='4ux6' size='340' side='right' caption='[[4ux6]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4ux6' size='340' side='right' caption='[[4ux6]], [[Resolution\|resolution]] 3.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=YWO:O-(5-METHYL-2-NITROPHENYL)-D-TYROSINAMIDE'>YWO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=YWO:O-(5-METHYL-2-NITROPHENYL)-D-TYROSINAMIDE'>YWO</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ux6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ux6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ux6 RCSB], [http://www.ebi.ac.uk/pdbsum/4ux6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ux6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ux6 OCA], [http://pdbe.org/4ux6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ux6 RCSB], [http://www.ebi.ac.uk/pdbsum/4ux6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ux6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ux6" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:33, 24 December 2014

OCA — Wed, 24 Dec 2014 15:33:38 GMT

←Older revision		Revision as of 15:33, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ux6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ux6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ux6 RCSB], [http://www.ebi.ac.uk/pdbsum/4ux6 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ux6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ux6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ux6 RCSB], [http://www.ebi.ac.uk/pdbsum/4ux6 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE]] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Andrews, G.]]	+	[[Category: Andrews, G]]
-	[[Category: Beaton, H G.]]	+	[[Category: Beaton, H G]]
-	[[Category: Birkinshaw, T.]]	+	[[Category: Birkinshaw, T]]
-	[[Category: Boughton-Smith, N.]]	+	[[Category: Boughton-Smith, N]]
-	[[Category: Cheshire, D R.]]	+	[[Category: Cheshire, D R]]
-	[[Category: Connolly, S.]]	+	[[Category: Connolly, S]]
-	[[Category: Cook, T R.]]	+	[[Category: Cook, T R]]
-	[[Category: Cooper, A.]]	+	[[Category: Cooper, A]]
-	[[Category: Cooper, S L.]]	+	[[Category: Cooper, S L]]
-	[[Category: Cox, D.]]	+	[[Category: Cox, D]]
-	[[Category: Dixon, J.]]	+	[[Category: Dixon, J]]
-	[[Category: Gensmantel, N.]]	+	[[Category: Gensmantel, N]]
-	[[Category: Hamley, P J.]]	+	[[Category: Hamley, P J]]
-	[[Category: Harrison, R.]]	+	[[Category: Harrison, R]]
-	[[Category: Hartopp, P.]]	+	[[Category: Hartopp, P]]
-	[[Category: Kack, H.]]	+	[[Category: Kack, H]]
-	[[Category: Luker, T.]]	+	[[Category: Luker, T]]
-	[[Category: Mete, A.]]	+	[[Category: Mete, A]]
-	[[Category: Millichip, I.]]	+	[[Category: Millichip, I]]
-	[[Category: Nicholls, D J.]]	+	[[Category: Nicholls, D J]]
-	[[Category: Pimm, A D.]]	+	[[Category: Pimm, A D]]
-	[[Category: St-Gallay, S A.]]	+	[[Category: St-Gallay, S A]]
-	[[Category: Wallace, A V.]]	+	[[Category: Wallace, A V]]
	[[Category: Drug design]]		[[Category: Drug design]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 08:37, 20 October 2014

OCA — Mon, 20 Oct 2014 08:37:05 GMT

←Older revision		Revision as of 08:37, 20 October 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ux6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ux6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ux6 RCSB], [http://www.ebi.ac.uk/pdbsum/4ux6 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ux6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ux6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ux6 RCSB], [http://www.ebi.ac.uk/pdbsum/4ux6 PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	By careful analysis of experimental X-ray ligand crystallographic protein data across several inhibitor series we have discovered a novel, potent and selective series of iNOS inhibitors exemplified by compound 8.
		+
		+	The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS).,Cheshire DR, Berg A, Andersson GM, Andrews G, Beaton HG, Birkinshaw TN, Boughton-Smith N, Connolly S, Cook TR, Cooper A, Cooper SL, Cox D, Dixon J, Gensmantel N, Hamley PJ, Harrison R, Hartopp P, Kack H, Leeson PD, Luker T, Mete A, Millichip I, Nicholls DJ, Pimm AD, St-Gallay SA, Wallace AV Bioorg Med Chem Lett. 2011 Apr 15;21(8):2468-71. Epub 2011 Feb 18. PMID:21398123<ref>PMID:21398123</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:58, 8 October 2014

OCA — Wed, 08 Oct 2014 07:58:39 GMT

←Older revision		Revision as of 07:58, 8 October 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)==
-		+	<StructureSection load='4ux6' size='340' side='right' caption='[[4ux6]], [[Resolution\|resolution]] 3.00Å' scene=''>
-	~~The entry~~ 4ux6 is ~~ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4ux6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UX6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UX6 FirstGlance]. <br>
-	~~Authors~~: ~~Cheshire~~, D.R., Andrews, G., Beaton, H.G., Birkinshaw, T., Boughton-Smith, N., Connolly, S., Cook, T.R., Cooper, A., Cooper, S.L., Cox, D., Dixon, J., Gensmantel, N., Hamley, P.J., Harrison, R., Hartopp, P., Kack, H., Luker, T., Mete, A., Millichip, I., Nicholls, D.J., Pimm, A.D., St-Gallay, S.A., Wallace, A.V.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=YWO:O-(5-METHYL-2-NITROPHENYL)-D-TYROSINAMIDE'>YWO</scene></td></tr>
-		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>
-	~~Description~~: ~~The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ux6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ux6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ux6 RCSB], [http://www.ebi.ac.uk/pdbsum/4ux6 PDBsum]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Andrews, G.]]
		+	[[Category: Beaton, H G.]]
		+	[[Category: Birkinshaw, T.]]
		+	[[Category: Boughton-Smith, N.]]
		+	[[Category: Cheshire, D R.]]
		+	[[Category: Connolly, S.]]
		+	[[Category: Cook, T R.]]
		+	[[Category: Cooper, A.]]
		+	[[Category: Cooper, S L.]]
		+	[[Category: Cox, D.]]
		+	[[Category: Dixon, J.]]
		+	[[Category: Gensmantel, N.]]
		+	[[Category: Hamley, P J.]]
		+	[[Category: Harrison, R.]]
		+	[[Category: Hartopp, P.]]
		+	[[Category: Kack, H.]]
		+	[[Category: Luker, T.]]
		+	[[Category: Mete, A.]]
		+	[[Category: Millichip, I.]]
		+	[[Category: Nicholls, D J.]]
		+	[[Category: Pimm, A D.]]
		+	[[Category: St-Gallay, S A.]]
		+	[[Category: Wallace, A V.]]
		+	[[Category: Drug design]]
		+	[[Category: Oxidoreductase]]

OCA at 04:40, 4 September 2014

OCA — Thu, 04 Sep 2014 04:40:43 GMT

←Older revision		Revision as of 04:40, 4 September 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4ux6 is ON HOLD ~~until sometime in the future~~	+	The entry 4ux6 is ON HOLD

	Authors: Cheshire, D.R., Andrews, G., Beaton, H.G., Birkinshaw, T., Boughton-Smith, N., Connolly, S., Cook, T.R., Cooper, A., Cooper, S.L., Cox, D., Dixon, J., Gensmantel, N., Hamley, P.J., Harrison, R., Hartopp, P., Kack, H., Luker, T., Mete, A., Millichip, I., Nicholls, D.J., Pimm, A.D., St-Gallay, S.A., Wallace, A.V.		Authors: Cheshire, D.R., Andrews, G., Beaton, H.G., Birkinshaw, T., Boughton-Smith, N., Connolly, S., Cook, T.R., Cooper, A., Cooper, S.L., Cox, D., Dixon, J., Gensmantel, N., Hamley, P.J., Harrison, R., Hartopp, P., Kack, H., Luker, T., Mete, A., Millichip, I., Nicholls, D.J., Pimm, A.D., St-Gallay, S.A., Wallace, A.V.

	Description: The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)		Description: The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)

OCA: Protected "4ux6" [edit=sysop:move=sysop]

OCA — Wed, 27 Aug 2014 07:25:35 GMT

Protected "4ux6" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:25, 27 August 2014

OCA: New page: '''Unreleased structure''' The entry 4ux6 is ON HOLD until sometime in the future Authors: Cheshire, D.R., Andrews, G., Beaton, H.G., Birkinshaw, T., Boughton-Smith, N., Connolly, S., C...

OCA — Wed, 27 Aug 2014 07:25:33 GMT

New page: '''Unreleased structure''' The entry 4ux6 is ON HOLD until sometime in the future Authors: Cheshire, D.R., Andrews, G., Beaton, H.G., Birkinshaw, T., Boughton-Smith, N., Connolly, S., C...

New page

'''Unreleased structure'''

The entry 4ux6 is ON HOLD until sometime in the future

Authors: Cheshire, D.R., Andrews, G., Beaton, H.G., Birkinshaw, T., Boughton-Smith, N., Connolly, S., Cook, T.R., Cooper, A., Cooper, S.L., Cox, D., Dixon, J., Gensmantel, N., Hamley, P.J., Harrison, R., Hartopp, P., Kack, H., Luker, T., Mete, A., Millichip, I., Nicholls, D.J., Pimm, A.D., St-Gallay, S.A., Wallace, A.V.

Description: The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)