4uyi - Revision history

OCA at 11:24, 9 May 2024

OCA — Thu, 09 May 2024 11:24:53 GMT

←Older revision		Revision as of 11:24, 9 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4uyi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UYI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UYI FirstGlance]. <br>		<table><tr><td colspan='2'>[[4uyi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UYI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UYI FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uyi OCA], [https://pdbe.org/4uyi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uyi RCSB], [https://www.ebi.ac.uk/pdbsum/4uyi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uyi ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.86Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uyi OCA], [https://pdbe.org/4uyi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uyi RCSB], [https://www.ebi.ac.uk/pdbsum/4uyi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uyi ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 07:51, 29 March 2023

OCA — Wed, 29 Mar 2023 07:51:38 GMT

←Older revision		Revision as of 07:51, 29 March 2023
Line 3:		Line 3:
	<StructureSection load='4uyi' size='340' side='right'caption='[[4uyi]], [[Resolution\|resolution]] 1.86Å' scene=''>		<StructureSection load='4uyi' size='340' side='right'caption='[[4uyi]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4uyi]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UYI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4UYI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4uyi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UYI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UYI FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4uyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uyi OCA], [~~http~~://pdbe.org/4uyi PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4uyi RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4uyi PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4uyi ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uyi OCA], [https://pdbe.org/4uyi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uyi RCSB], [https://www.ebi.ac.uk/pdbsum/4uyi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uyi ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/SLX4_HUMAN SLX4_HUMAN]] Fanconi anemia. The disease is caused by mutations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/SLX4_HUMAN SLX4_HUMAN] Fanconi anemia. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SLX4_HUMAN SLX4_HUMAN]] Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks.<ref>PMID:19596235</ref> <ref>PMID:19596236</ref> <ref>PMID:19595721</ref> <ref>PMID:19595722</ref>	+	[https://www.uniprot.org/uniprot/SLX4_HUMAN SLX4_HUMAN] Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks.<ref>PMID:19596235</ref> <ref>PMID:19596236</ref> <ref>PMID:19595721</ref> <ref>PMID:19595722</ref>

	==See Also==		==See Also==
Line 17:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Bountra, C]]	+	[[Category: Bountra C]]
-	[[Category: Bradley, A]]	+	[[Category: Bradley A]]
-	[[Category: Bullock, A]]	+	[[Category: Bullock A]]
-	[[Category: Burgess-Brown~~, N A~~]]	+	[[Category: Burgess-Brown NA]]
-	[[Category: Chaikuad, A]]	+	[[Category: Chaikuad A]]
-	[[Category: Cooper~~, C D.O]]~~	+	[[Category: Cooper CDO]]
-	~~[[Category: Delft, F von~~]]	+	[[Category: Edwards AM]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Fairhead M]]
-	[[Category: Fairhead, M]]	+	[[Category: Filippakopoulos P]]
-	[[Category: Filippakopoulos, P]]	+	[[Category: Fitzpatrick F]]
-	[[Category: Fitzpatrick, F]]	+	[[Category: Hozjan V]]
-	[[Category: Hozjan, V]]	+	[[Category: Kopec J]]
-	[[Category: Kopec, J]]	+	[[Category: Krojer T]]
-	[[Category: Krojer, T]]	+	[[Category: Marsden BD]]
-	[[Category: Marsden~~, B D~~]]	+	[[Category: Nowak R]]
-	[[Category: Nowak, R]]	+	[[Category: Pike ACW]]
-	[[Category: Pike~~, A C.W~~]]	+	[[Category: Pinkas DM]]
-	[[Category: Pinkas~~, D M~~]]	+	[[Category: Roos AK]]
-	[[Category: Roos~~, A K~~]]	+	[[Category: Sanvitale CE]]
-	[[Category: Sanvitale~~, C E~~]]	+	[[Category: Savitsky P]]
-	[[Category: Savitsky, P]]	+	[[Category: Sorrell FJ]]
-	[[Category: Sorrell~~, F J~~]]	+	[[Category: Strain-Damerell C]]
-	[[Category: Strain-Damerell, C]]	+	[[Category: Tallant C]]
-	[[Category: Tallant, C]]	+	[[Category: Wang D]]
-	[[Category: Wang, D]]	+	[[Category: Ying Z]]
-	[[Category: Ying, Z]]	+	[[Category: Von Delft F]]
-	[[Category: ~~Hydrolase~~]]	+

OCA at 10:57, 26 February 2020

OCA — Wed, 26 Feb 2020 10:57:54 GMT

←Older revision		Revision as of 10:57, 26 February 2020
Line 1:		Line 1:

	==Crystal structure of the BTB domain of human SLX4 (BTBD12)==		==Crystal structure of the BTB domain of human SLX4 (BTBD12)==
-	<StructureSection load='4uyi' size='340' side='right' caption='[[4uyi]], [[Resolution\|resolution]] 1.86Å' scene=''>	+	<StructureSection load='4uyi' size='340' side='right'caption='[[4uyi]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4uyi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UYI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UYI FirstGlance]. <br>		<table><tr><td colspan='2'>[[4uyi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UYI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UYI FirstGlance]. <br>
Line 10:		Line 10:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/SLX4_HUMAN SLX4_HUMAN]] Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks.<ref>PMID:19596235</ref> <ref>PMID:19596236</ref> <ref>PMID:19595721</ref> <ref>PMID:19595722</ref>		[[http://www.uniprot.org/uniprot/SLX4_HUMAN SLX4_HUMAN]] Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks.<ref>PMID:19596235</ref> <ref>PMID:19596236</ref> <ref>PMID:19595721</ref> <ref>PMID:19595722</ref>
		+
		+	==See Also==
		+	*[[Endonuclease 3D structures\|Endonuclease 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 15:		Line 18:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA at 20:22, 24 January 2018

OCA — Wed, 24 Jan 2018 20:22:43 GMT

←Older revision		Revision as of 20:22, 24 January 2018
Line 3:		Line 3:
	<StructureSection load='4uyi' size='340' side='right' caption='[[4uyi]], [[Resolution\|resolution]] 1.86Å' scene=''>		<StructureSection load='4uyi' size='340' side='right' caption='[[4uyi]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4uyi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UYI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UYI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4uyi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UYI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UYI FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uyi OCA], [http://pdbe.org/4uyi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uyi RCSB], [http://www.ebi.ac.uk/pdbsum/4uyi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uyi ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uyi OCA], [http://pdbe.org/4uyi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uyi RCSB], [http://www.ebi.ac.uk/pdbsum/4uyi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uyi ProSAT]</span></td></tr>
	</table>		</table>
Line 14:		Line 14:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]
Line 21:		Line 22:
	[[Category: Chaikuad, A]]		[[Category: Chaikuad, A]]
	[[Category: Cooper, C D.O]]		[[Category: Cooper, C D.O]]
-	[[Category: Delft, F ~~Von~~]]	+	[[Category: Delft, F von]]
	[[Category: Edwards, A M]]		[[Category: Edwards, A M]]
	[[Category: Fairhead, M]]		[[Category: Fairhead, M]]

OCA at 18:02, 11 August 2016

OCA — Thu, 11 Aug 2016 18:02:57 GMT

←Older revision		Revision as of 18:02, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the BTB domain of human SLX4 (BTBD12)==		==Crystal structure of the BTB domain of human SLX4 (BTBD12)==
	<StructureSection load='4uyi' size='340' side='right' caption='[[4uyi]], [[Resolution\|resolution]] 1.86Å' scene=''>		<StructureSection load='4uyi' size='340' side='right' caption='[[4uyi]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4uyi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UYI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UYI FirstGlance]. <br>		<table><tr><td colspan='2'>[[4uyi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UYI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UYI FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uyi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uyi RCSB], [http://www.ebi.ac.uk/pdbsum/4uyi PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uyi OCA], [http://pdbe.org/4uyi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uyi RCSB], [http://www.ebi.ac.uk/pdbsum/4uyi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uyi ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 06:48, 22 January 2015

OCA — Thu, 22 Jan 2015 06:48:53 GMT

←Older revision		Revision as of 06:48, 22 January 2015
Line 13:		Line 13:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Bountra, C.]]	+	[[Category: Bountra, C]]
-	[[Category: Bradley, A.]]	+	[[Category: Bradley, A]]
-	[[Category: Bullock, A.]]	+	[[Category: Bullock, A]]
-	[[Category: Burgess-Brown, N A.]]	+	[[Category: Burgess-Brown, N A]]
-	[[Category: Chaikuad, A.]]	+	[[Category: Chaikuad, A]]
-	[[Category: Cooper, C D.O.]]	+	[[Category: Cooper, C D.O]]
-	[[Category: Delft, F Von.]]	+	[[Category: Delft, F Von]]
-	[[Category: Edwards, A M.]]	+	[[Category: Edwards, A M]]
-	[[Category: Fairhead, M.]]	+	[[Category: Fairhead, M]]
-	[[Category: Filippakopoulos, P.]]	+	[[Category: Filippakopoulos, P]]
-	[[Category: Fitzpatrick, F.]]	+	[[Category: Fitzpatrick, F]]
-	[[Category: Hozjan, V.]]	+	[[Category: Hozjan, V]]
-	[[Category: Kopec, J.]]	+	[[Category: Kopec, J]]
-	[[Category: Krojer, T.]]	+	[[Category: Krojer, T]]
-	[[Category: Marsden, B D.]]	+	[[Category: Marsden, B D]]
-	[[Category: Nowak, R.]]	+	[[Category: Nowak, R]]
-	[[Category: Pike, A C.W.]]	+	[[Category: Pike, A C.W]]
-	[[Category: Pinkas, D M.]]	+	[[Category: Pinkas, D M]]
-	[[Category: Roos, A K.]]	+	[[Category: Roos, A K]]
-	[[Category: Sanvitale, C E.]]	+	[[Category: Sanvitale, C E]]
-	[[Category: Savitsky, P.]]	+	[[Category: Savitsky, P]]
-	[[Category: Sorrell, F J.]]	+	[[Category: Sorrell, F J]]
-	[[Category: Strain-Damerell, C.]]	+	[[Category: Strain-Damerell, C]]
-	[[Category: Tallant, C.]]	+	[[Category: Tallant, C]]
-	[[Category: Wang, D.]]	+	[[Category: Wang, D]]
-	[[Category: Ying, Z.]]	+	[[Category: Ying, Z]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 08:51, 20 October 2014

OCA — Mon, 20 Oct 2014 08:51:08 GMT

←Older revision		Revision as of 08:51, 20 October 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4uyi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UYI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UYI FirstGlance]. <br>		<table><tr><td colspan='2'>[[4uyi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UYI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UYI FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uyi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uyi RCSB], [http://www.ebi.ac.uk/pdbsum/4uyi PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uyi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uyi RCSB], [http://www.ebi.ac.uk/pdbsum/4uyi PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/SLX4_HUMAN SLX4_HUMAN]] Fanconi anemia. The disease is caused by mutations affecting the gene represented in this entry.		[[http://www.uniprot.org/uniprot/SLX4_HUMAN SLX4_HUMAN]] Fanconi anemia. The disease is caused by mutations affecting the gene represented in this entry.

OCA at 00:30, 2 October 2014

OCA — Thu, 02 Oct 2014 00:30:49 GMT

←Older revision		Revision as of 00:30, 2 October 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of the BTB domain of human SLX4 (BTBD12)==
-		+	<StructureSection load='4uyi' size='340' side='right' caption='[[4uyi]], [[Resolution\|resolution]] 1.86Å' scene=''>
-	~~The entry~~ 4uyi is ~~ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4uyi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UYI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UYI FirstGlance]. <br>
-	~~Authors~~: ~~Pinkas, D~~.M.~~, Sanvitale, C~~.E., ~~Strain~~-~~Damerell~~, C.~~, Fairhead, M~~.~~, Wang, D~~., ~~Tallant, C~~.~~, Cooper, C~~.D.O.~~, Sorrell, F~~.J.~~, Kopec, J~~., ~~Chaikuad, A~~., ~~Fitzpatrick, F~~., ~~Pike, A~~.C.W., ~~Hozjan~~, V., ~~Ying~~, Z., ~~Roos~~, A.K., ~~Savitsky, P~~.~~, Bradley~~, A., ~~Nowak, R~~., Filippakopoulos, P., ~~Krojer~~, T., ~~Burgess-Brown, N.A~~., Marsden, B.D., ~~Von Delft, F~~., ~~Arrowsmith,~~ C.H., ~~Edwards~~, A.M., ~~Bountra~~, C., ~~Bullock~~, A.	+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uyi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uyi RCSB], [http://www.ebi.ac.uk/pdbsum/4uyi PDBsum]</span></td></tr>
-		+	<table>
-	~~Description~~: ~~Crystal structure of the BTB domain of human SLX4 (BTBD12)~~	+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/SLX4_HUMAN SLX4_HUMAN]] Fanconi anemia. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SLX4_HUMAN SLX4_HUMAN]] Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks.<ref>PMID:19596235</ref> <ref>PMID:19596236</ref> <ref>PMID:19595721</ref> <ref>PMID:19595722</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Arrowsmith, C H.]]
		+	[[Category: Bountra, C.]]
		+	[[Category: Bradley, A.]]
		+	[[Category: Bullock, A.]]
		+	[[Category: Burgess-Brown, N A.]]
		+	[[Category: Chaikuad, A.]]
		+	[[Category: Cooper, C D.O.]]
		+	[[Category: Delft, F Von.]]
		+	[[Category: Edwards, A M.]]
		+	[[Category: Fairhead, M.]]
		+	[[Category: Filippakopoulos, P.]]
		+	[[Category: Fitzpatrick, F.]]
		+	[[Category: Hozjan, V.]]
		+	[[Category: Kopec, J.]]
		+	[[Category: Krojer, T.]]
		+	[[Category: Marsden, B D.]]
		+	[[Category: Nowak, R.]]
		+	[[Category: Pike, A C.W.]]
		+	[[Category: Pinkas, D M.]]
		+	[[Category: Roos, A K.]]
		+	[[Category: Sanvitale, C E.]]
		+	[[Category: Savitsky, P.]]
		+	[[Category: Sorrell, F J.]]
		+	[[Category: Strain-Damerell, C.]]
		+	[[Category: Tallant, C.]]
		+	[[Category: Wang, D.]]
		+	[[Category: Ying, Z.]]
		+	[[Category: Hydrolase]]

OCA: Protected "4uyi" [edit=sysop:move=sysop]

OCA — Wed, 10 Sep 2014 08:46:45 GMT

Protected "4uyi" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:46, 10 September 2014

OCA: New page: '''Unreleased structure''' The entry 4uyi is ON HOLD Authors: Pinkas, D.M., Sanvitale, C.E., Strain-Damerell, C., Fairhead, M., Wang, D., Tallant, C., Cooper, C.D.O., Sorrell, F.J., Kop...

OCA — Wed, 10 Sep 2014 08:46:43 GMT

New page: '''Unreleased structure''' The entry 4uyi is ON HOLD Authors: Pinkas, D.M., Sanvitale, C.E., Strain-Damerell, C., Fairhead, M., Wang, D., Tallant, C., Cooper, C.D.O., Sorrell, F.J., Kop...

New page

'''Unreleased structure'''

The entry 4uyi is ON HOLD

Authors: Pinkas, D.M., Sanvitale, C.E., Strain-Damerell, C., Fairhead, M., Wang, D., Tallant, C., Cooper, C.D.O., Sorrell, F.J., Kopec, J., Chaikuad, A., Fitzpatrick, F., Pike, A.C.W., Hozjan, V., Ying, Z., Roos, A.K., Savitsky, P., Bradley, A., Nowak, R., Filippakopoulos, P., Krojer, T., Burgess-Brown, N.A., Marsden, B.D., Von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.

Description: Crystal structure of the BTB domain of human SLX4 (BTBD12)