4uyk - Revision history

OCA at 07:51, 29 March 2023

OCA — Wed, 29 Mar 2023 07:51:45 GMT

←Older revision		Revision as of 07:51, 29 March 2023
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	<StructureSection load='4uyk' size='340' side='right'caption='[[4uyk]], [[Resolution\|resolution]] 3.22Å' scene=''>		<StructureSection load='4uyk' size='340' side='right'caption='[[4uyk]], [[Resolution\|resolution]] 3.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4uyk]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UYK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4UYK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4uyk]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UYK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UYK FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=CCC:CYTIDINE-5-PHOSPHATE-2,3-CYCLIC+PHOSPHATE'>CCC</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CCC:CYTIDINE-5-PHOSPHATE-2,3-CYCLIC+PHOSPHATE'>CCC</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uyj\|4uyj]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uyk OCA], [https://pdbe.org/4uyk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uyk RCSB], [https://www.ebi.ac.uk/pdbsum/4uyk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uyk ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4uyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uyk OCA], [~~http~~://pdbe.org/4uyk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4uyk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4uyk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4uyk ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SRP09_HUMAN SRP09_HUMAN]] Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding. [[http://www.uniprot.org/uniprot/SRP14_HUMAN SRP14_HUMAN]] Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.	+	[https://www.uniprot.org/uniprot/SRP09_HUMAN SRP09_HUMAN] Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bousset, L]]	+	[[Category: Pyrococcus horikoshii OT3]]
-	[[Category: Brooks~~, M A~~]]	+	[[Category: Bousset L]]
-	[[Category: Cusack, S]]	+	[[Category: Brooks MA]]
-	[[Category: Mary, C]]	+	[[Category: Cusack S]]
-	[[Category: Scherrer, A]]	+	[[Category: Mary C]]
-	[[Category: Strub, K]]	+	[[Category: Scherrer A]]
-	~~[[Category: Rna]]~~	+	[[Category: Strub K]]
-	~~[[Category: Rna folding]]~~	+
-	~~[[Category: Signal recognition particle]]~~	+
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Translation~~]]	+

OCA at 08:15, 23 May 2019

OCA — Thu, 23 May 2019 08:15:22 GMT

←Older revision		Revision as of 08:15, 23 May 2019
Line 1:		Line 1:

	==Crystal structure of a Signal Recognition Particle Alu domain in the elongation arrest conformation==		==Crystal structure of a Signal Recognition Particle Alu domain in the elongation arrest conformation==
-	<StructureSection load='4uyk' size='340' side='right' caption='[[4uyk]], [[Resolution\|resolution]] 3.22Å' scene=''>	+	<StructureSection load='4uyk' size='340' side='right'caption='[[4uyk]], [[Resolution\|resolution]] 3.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4uyk]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UYK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UYK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4uyk]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UYK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UYK FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CCC:CYTIDINE-5-PHOSPHATE-2,3-CYCLIC+PHOSPHATE'>CCC</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CCC:CYTIDINE-5-PHOSPHATE-2,3-CYCLIC+PHOSPHATE'>CCC</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uyj\|4uyj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uyj\|4uyj]]</td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bousset, L]]		[[Category: Bousset, L]]
	[[Category: Brooks, M A]]		[[Category: Brooks, M A]]

OCA at 21:21, 5 August 2016

OCA — Fri, 05 Aug 2016 21:21:28 GMT

←Older revision		Revision as of 21:21, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of a Signal Recognition Particle Alu domain in the elongation arrest conformation==		==Crystal structure of a Signal Recognition Particle Alu domain in the elongation arrest conformation==
	<StructureSection load='4uyk' size='340' side='right' caption='[[4uyk]], [[Resolution\|resolution]] 3.22Å' scene=''>		<StructureSection load='4uyk' size='340' side='right' caption='[[4uyk]], [[Resolution\|resolution]] 3.22Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CCC:CYTIDINE-5-PHOSPHATE-2,3-CYCLIC+PHOSPHATE'>CCC</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CCC:CYTIDINE-5-PHOSPHATE-2,3-CYCLIC+PHOSPHATE'>CCC</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uyj\|4uyj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uyj\|4uyj]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uyk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uyk RCSB], [http://www.ebi.ac.uk/pdbsum/4uyk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uyk OCA], [http://pdbe.org/4uyk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uyk RCSB], [http://www.ebi.ac.uk/pdbsum/4uyk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uyk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4uyk" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Signal recognition particle protein\|Signal recognition particle protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 22:00, 25 December 2014

OCA — Thu, 25 Dec 2014 22:00:01 GMT

←Older revision		Revision as of 22:00, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uyk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uyk RCSB], [http://www.ebi.ac.uk/pdbsum/4uyk PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uyk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uyk RCSB], [http://www.ebi.ac.uk/pdbsum/4uyk PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SRP09_HUMAN SRP09_HUMAN]] Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding. [[http://www.uniprot.org/uniprot/SRP14_HUMAN SRP14_HUMAN]] Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:33, 3 December 2014

OCA — Wed, 03 Dec 2014 07:33:24 GMT

←Older revision		Revision as of 07:33, 3 December 2014
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bousset, L.]]	+	[[Category: Bousset, L]]
-	[[Category: Brooks, M A.]]	+	[[Category: Brooks, M A]]
-	[[Category: Cusack, S.]]	+	[[Category: Cusack, S]]
-	[[Category: Mary, C.]]	+	[[Category: Mary, C]]
-	[[Category: Scherrer, A.]]	+	[[Category: Scherrer, A]]
-	[[Category: Strub, K.]]	+	[[Category: Strub, K]]
	[[Category: Rna]]		[[Category: Rna]]
	[[Category: Rna folding]]		[[Category: Rna folding]]

OCA at 08:44, 5 November 2014

OCA — Wed, 05 Nov 2014 08:44:43 GMT

←Older revision		Revision as of 08:44, 5 November 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of a Signal Recognition Particle Alu domain in the elongation arrest conformation==
		+	<StructureSection load='4uyk' size='340' side='right' caption='[[4uyk]], [[Resolution\|resolution]] 3.22Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4uyk]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UYK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UYK FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CCC:CYTIDINE-5-PHOSPHATE-2,3-CYCLIC+PHOSPHATE'>CCC</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uyj\|4uyj]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uyk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uyk RCSB], [http://www.ebi.ac.uk/pdbsum/4uyk PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The signal recognition particle (SRP) is a conserved ribonucleoprotein particle that targets membrane and secreted proteins to translocation channels in membranes. In eukaryotes, the Alu domain, which comprises the 5' and 3' extremities of the SRP RNA bound to the SRP9/14 heterodimer, is thought to interact with the ribosome to pause translation elongation during membrane docking. We present the 3.2 A resolution crystal structure of a chimeric Alu domain, comprising Alu RNA from the archaeon Pyrococcus horikoshii bound to the human Alu binding proteins SRP9/14. The structure reveals how intricate tertiary interactions stabilize the RNA 5' domain structure and how an extra, archaeal-specific, terminal stem helps constrain the Alu RNA into the active closed conformation. In this conformation, highly conserved noncanonical base pairs allow unusually tight side-by-side packing of 5' and 3' RNA stems within the SRP9/14 RNA binding surface. The biological relevance of this structure is confirmed by showing that a reconstituted full-length chimeric archaeal-human SRP is competent to elicit elongation arrest in vitro. The structure will be useful in refining our understanding of how the SRP Alu domain interacts with the ribosome.

-	~~The entry 4uyk is ON HOLD until Paper Publication~~	+	Crystal structure of a signal recognition particle Alu domain in the elongation arrest conformation.,Bousset L, Mary C, Brooks MA, Scherrer A, Strub K, Cusack S RNA. 2014 Oct 21. PMID:25336584<ref>PMID:25336584</ref>

-	~~Authors~~: Bousset, L.~~, Mary, C.,~~ Brooks, M.A., Scherrer, A., Strub, K.~~, Cusack, S.~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of a~~ Signal ~~Recognition Particle Alu domain in the elongation arrest conformation~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bousset, L.]]
		+	[[Category: Brooks, M A.]]
		+	[[Category: Cusack, S.]]
		+	[[Category: Mary, C.]]
		+	[[Category: Scherrer, A.]]
		+	[[Category: Strub, K.]]
		+	[[Category: Rna]]
		+	[[Category: Rna folding]]
		+	[[Category: Signal recognition particle]]
		+	[[Category: Signaling protein]]
		+	[[Category: Translation]]

OCA at 10:01, 22 October 2014

OCA — Wed, 22 Oct 2014 10:01:58 GMT

←Older revision		Revision as of 10:01, 22 October 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4uyk is ON HOLD	+	The entry 4uyk is ON HOLD until Paper Publication

	Authors: Bousset, L., Mary, C., Brooks, M.A., Scherrer, A., Strub, K., Cusack, S.		Authors: Bousset, L., Mary, C., Brooks, M.A., Scherrer, A., Strub, K., Cusack, S.

	Description: Crystal structure of a Signal Recognition Particle Alu domain in the elongation arrest conformation		Description: Crystal structure of a Signal Recognition Particle Alu domain in the elongation arrest conformation

OCA: Protected "4uyk" [edit=sysop:move=sysop]

OCA — Wed, 10 Sep 2014 08:46:53 GMT

Protected "4uyk" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:46, 10 September 2014

OCA: New page: '''Unreleased structure''' The entry 4uyk is ON HOLD Authors: Bousset, L., Mary, C., Brooks, M.A., Scherrer, A., Strub, K., Cusack, S. Description: Crystal structure of a Signal Recogn...

OCA — Wed, 10 Sep 2014 08:46:50 GMT

New page: '''Unreleased structure''' The entry 4uyk is ON HOLD Authors: Bousset, L., Mary, C., Brooks, M.A., Scherrer, A., Strub, K., Cusack, S. Description: Crystal structure of a Signal Recogn...

New page

'''Unreleased structure'''

The entry 4uyk is ON HOLD

Authors: Bousset, L., Mary, C., Brooks, M.A., Scherrer, A., Strub, K., Cusack, S.

Description: Crystal structure of a Signal Recognition Particle Alu domain in the elongation arrest conformation