4uzb - Revision history

OCA at 10:38, 10 January 2024

OCA — Wed, 10 Jan 2024 10:38:27 GMT

←Older revision		Revision as of 10:38, 10 January 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4uzb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_8 Human gammaherpesvirus 8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UZB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4uzb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_8 Human gammaherpesvirus 8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UZB FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uzb OCA], [https://pdbe.org/4uzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uzb RCSB], [https://www.ebi.ac.uk/pdbsum/4uzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uzb ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.865Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uzb OCA], [https://pdbe.org/4uzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uzb RCSB], [https://www.ebi.ac.uk/pdbsum/4uzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uzb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 07:53, 29 March 2023

OCA — Wed, 29 Mar 2023 07:53:32 GMT

←Older revision		Revision as of 07:53, 29 March 2023
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	<StructureSection load='4uzb' size='340' side='right'caption='[[4uzb]], [[Resolution\|resolution]] 2.87Å' scene=''>		<StructureSection load='4uzb' size='340' side='right'caption='[[4uzb]], [[Resolution\|resolution]] 2.87Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4uzb]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Hhv-8 Hhv-~~8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UZB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4UZB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4uzb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_8 Human gammaherpesvirus 8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UZB FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uzc\|4uzc]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uzb OCA], [https://pdbe.org/4uzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uzb RCSB], [https://www.ebi.ac.uk/pdbsum/4uzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uzb ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4uzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uzb OCA], [~~http~~://pdbe.org/4uzb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4uzb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4uzb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4uzb ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/LANA1_HHV8P LANA1_HHV8P] Multifunctional protein that plays a role in the replication and long-term persistence of the viral episomal genome in dividing cells. Binds to mitotic chromosomes via its N-terminal region and to a 16-bp imperfect palindrome within the origin of replication (oriP) located in the viral terminal repeat (TR) through its C-terminal. Tethers viral episomes to chromosomes during mitosis. Plays a critical role in the shutdown of lytic gene expression during the early stage of infection by interacting with host TRIM28. Plays also a role in the repression of host NF-kappa-B activity upon TNF-alpha stimulation by promoting the proteasomal degradation of host RELA (PubMed:21697472). Promotes nuclear localization and cleavage of host STAT6 leading to constitutive activation of the IL13/STAT6 signaling pathway to promote viral latency (PubMed:28099521). Interacts with and modulates the histone methyltransferase MLL1 complex activity, leading to its recruitment on viral DNA terminal repeats changing the dynamic of histone H3 methylated 'Lys-4'(H3K4me) profile during the initial hours following infection (PubMed:34850113).<ref>PMID:10213686</ref> <ref>PMID:16227282</ref> <ref>PMID:16469929</ref> <ref>PMID:21697472</ref> <ref>PMID:24741090</ref> <ref>PMID:25995248</ref> <ref>PMID:26223641</ref> <ref>PMID:27599637</ref> <ref>PMID:28099521</ref> <ref>PMID:28696226</ref> <ref>PMID:34850113</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Hhv-~~8]]	+	[[Category: Human gammaherpesvirus 8]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hellert, J]]	+	[[Category: Hellert J]]
-	[[Category: Krausze, J]]	+	[[Category: Krausze J]]
-	[[Category: Luhrs, T]]	+	[[Category: Luhrs T]]
-	~~[[Category: Cancer]]~~	+
-	~~[[Category: Dna-binding domain]]~~	+
-	~~[[Category: Gammaherpesvirus]]~~	+
-	~~[[Category: Multicentric castleman's disease]]~~	+
-	~~[[Category: Oligomerization domain]]~~	+
-	~~[[Category: Origin-binding domain]]~~	+
-	~~[[Category: Primary effusion lymphoma]]~~	+
-	~~[[Category: Rhadinovirus]]~~	+
-	~~[[Category: Tumor virus]]~~	+
-	~~[[Category: Viral protein-dna complex~~]]	+

OCA at 12:54, 10 May 2019

OCA — Fri, 10 May 2019 12:54:47 GMT

←Older revision		Revision as of 12:54, 10 May 2019
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	==KSHV LANA (ORF73) C-terminal domain mutant bound to LBS1 DNA (R1039Q, R1040Q, K1055E, K1109A, D1110A, A1121E, K1138S, K1140D, K1141D)==		==KSHV LANA (ORF73) C-terminal domain mutant bound to LBS1 DNA (R1039Q, R1040Q, K1055E, K1109A, D1110A, A1121E, K1138S, K1140D, K1141D)==
-	<StructureSection load='4uzb' size='340' side='right' caption='[[4uzb]], [[Resolution\|resolution]] 2.87Å' scene=''>	+	<StructureSection load='4uzb' size='340' side='right'caption='[[4uzb]], [[Resolution\|resolution]] 2.87Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4uzb]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UZB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4uzb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Hhv-8 Hhv-8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UZB FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uzc\|4uzc]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uzc\|4uzc]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uzb OCA], [http://pdbe.org/4uzb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uzb RCSB], [http://www.ebi.ac.uk/pdbsum/4uzb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uzb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uzb OCA], [http://pdbe.org/4uzb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uzb RCSB], [http://www.ebi.ac.uk/pdbsum/4uzb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uzb ProSAT]</span></td></tr>
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Hhv-8]]
		+	[[Category: Large Structures]]
	[[Category: Hellert, J]]		[[Category: Hellert, J]]
	[[Category: Krausze, J]]		[[Category: Krausze, J]]
Line 26:		Line 28:
	[[Category: Dna-binding domain]]		[[Category: Dna-binding domain]]
	[[Category: Gammaherpesvirus]]		[[Category: Gammaherpesvirus]]
-	[[Category: Hhv-8]]
	[[Category: Multicentric castleman's disease]]		[[Category: Multicentric castleman's disease]]
	[[Category: Oligomerization domain]]		[[Category: Oligomerization domain]]

OCA at 02:06, 11 March 2017

OCA — Sat, 11 Mar 2017 02:06:05 GMT

←Older revision		Revision as of 02:06, 11 March 2017
Line 1:		Line 1:
		+
	==KSHV LANA (ORF73) C-terminal domain mutant bound to LBS1 DNA (R1039Q, R1040Q, K1055E, K1109A, D1110A, A1121E, K1138S, K1140D, K1141D)==		==KSHV LANA (ORF73) C-terminal domain mutant bound to LBS1 DNA (R1039Q, R1040Q, K1055E, K1109A, D1110A, A1121E, K1138S, K1140D, K1141D)==
	<StructureSection load='4uzb' size='340' side='right' caption='[[4uzb]], [[Resolution\|resolution]] 2.87Å' scene=''>		<StructureSection load='4uzb' size='340' side='right' caption='[[4uzb]], [[Resolution\|resolution]] 2.87Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4uzb]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UZB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4uzb]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UZB FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uzc\|4uzc]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uzc\|4uzc]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uzb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uzb RCSB], [http://www.ebi.ac.uk/pdbsum/4uzb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uzb OCA], [http://pdbe.org/4uzb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uzb RCSB], [http://www.ebi.ac.uk/pdbsum/4uzb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uzb ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4uzb" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:35, 20 May 2015

OCA — Wed, 20 May 2015 06:35:04 GMT

←Older revision		Revision as of 06:35, 20 May 2015
Line 8:		Line 8:
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
-	~~The~~ latency-associated nuclear antigen (LANA) is the ~~latent origin-binding protein and chromatin anchor~~ of the ~~Kaposi's sarcoma herpesvirus (~~KSHV~~/HHV~~-8) ~~genome~~. ~~Its C~~-~~terminal domain~~ (~~CTD~~) ~~binds sequence~~-~~specifically~~ to the ~~viral origin~~ of ~~replication~~, ~~whereas~~ the N-~~terminal domain links it to nucleosomes~~ of ~~cellular chromatin for long~~-~~term persistence in dividing host cells~~. ~~Here~~, the ~~crystallization and X~~-~~ray data acquisition~~ of a ~~mutant LANA CTD~~ in ~~complex with its wild-type target~~ DNA ~~LBS1 is described~~. ~~This report describes~~ the ~~rational protein engineering for successful co-crystallization with DNA and X-ray diffraction~~ data ~~collection at room temperature on~~ the ~~high-brilliance third~~-~~generation synchrotron PETRA III at DESY~~, ~~Germany~~.	+	Kaposi sarcoma herpesvirus (KSHV) persists as a latent nuclear episome in dividing host cells. This episome is tethered to host chromatin to ensure proper segregation during mitosis. For duplication of the latent genome, the cellular replication machinery is recruited. Both of these functions rely on the constitutively expressed latency-associated nuclear antigen (LANA) of the virus. Here, we report the crystal structure of the KSHV LANA DNA-binding domain (DBD) in complex with its high-affinity viral target DNA, LANA binding site 1 (LBS1), at 2.9 A resolution. In contrast to homologous proteins such as Epstein-Barr virus nuclear antigen 1 (EBNA-1) of the related gamma-herpesvirus Epstein-Barr virus, specific DNA recognition by LANA is highly asymmetric. In addition to solving the crystal structure, we found that apart from the two known LANA binding sites, LBS1 and LBS2, LANA also binds to a novel site, denoted LBS3. All three sites are located in a region of the KSHV terminal repeat subunit previously recognized as a minimal replicator. Moreover, we show that the LANA DBD can coat DNA of arbitrary sequence by virtue of a characteristic lysine patch, which is absent in EBNA-1 of the Epstein-Barr virus. Likely, these higher-order assemblies involve the self-association of LANA into supermolecular spirals. One such spiral assembly was solved as a crystal structure of 3.7 A resolution in the absence of DNA. On the basis of our data, we propose a model for the controlled nucleation of higher-order LANA oligomers that might contribute to the characteristic subnuclear KSHV microdomains ("LANA speckles"), a hallmark of KSHV latency.

-	~~Crystallization, room-temperature X-ray diffraction and preliminary analysis~~ of Kaposi's sarcoma herpesvirus LANA bound to DNA.,Hellert J, Krausze J, Schulz TF, Luhrs T ~~Acta Crystallogr F Struct Biol Commun~~. ~~2014 Nov;70(Pt 11):1570-4~~. ~~doi~~:~~, 10.1107/S2053230X14019906. Epub 2014 Oct 25~~. PMID:~~25372834~~<ref>PMID:~~25372834~~</ref>	+	The 3D structure of Kaposi sarcoma herpesvirus LANA C-terminal domain bound to DNA.,Hellert J, Weidner-Glunde M, Krausze J, Lunsdorf H, Ritter C, Schulz TF, Luhrs T Proc Natl Acad Sci U S A. 2015 May 6. pii: 201421804. PMID:25947153<ref>PMID:25947153</ref>

	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

OCA at 12:16, 13 May 2015

OCA — Wed, 13 May 2015 12:16:58 GMT

←Older revision		Revision as of 12:16, 13 May 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==KSHV LANA (ORF73) C-terminal domain mutant bound to LBS1 DNA (R1039Q, R1040Q, K1055E, K1109A, D1110A, A1121E, K1138S, K1140D, K1141D)==
		+	<StructureSection load='4uzb' size='340' side='right' caption='[[4uzb]], [[Resolution\|resolution]] 2.87Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4uzb]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UZB FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uzc\|4uzc]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uzb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uzb RCSB], [http://www.ebi.ac.uk/pdbsum/4uzb PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The latency-associated nuclear antigen (LANA) is the latent origin-binding protein and chromatin anchor of the Kaposi's sarcoma herpesvirus (KSHV/HHV-8) genome. Its C-terminal domain (CTD) binds sequence-specifically to the viral origin of replication, whereas the N-terminal domain links it to nucleosomes of cellular chromatin for long-term persistence in dividing host cells. Here, the crystallization and X-ray data acquisition of a mutant LANA CTD in complex with its wild-type target DNA LBS1 is described. This report describes the rational protein engineering for successful co-crystallization with DNA and X-ray diffraction data collection at room temperature on the high-brilliance third-generation synchrotron PETRA III at DESY, Germany.

-	~~The entry 4uzb is ON HOLD until Paper Publication~~	+	Crystallization, room-temperature X-ray diffraction and preliminary analysis of Kaposi's sarcoma herpesvirus LANA bound to DNA.,Hellert J, Krausze J, Schulz TF, Luhrs T Acta Crystallogr F Struct Biol Commun. 2014 Nov;70(Pt 11):1570-4. doi:, 10.1107/S2053230X14019906. Epub 2014 Oct 25. PMID:25372834<ref>PMID:25372834</ref>

-	~~Authors: Hellert~~, J.~~, Krausze, J~~.~~, Luhrs, T~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: KSHV LANA (ORF73) C-terminal domain mutant bound to LBS1 DNA (R1039Q, R1040Q, K1055E, K1109A, D1110A, A1121E, K1138S, K1140D, K1141D)~~	+	== References ==
-	~~[[Category: Unreleased Structures]]~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Hellert, J]]		[[Category: Hellert, J]]
		+	[[Category: Krausze, J]]
	[[Category: Luhrs, T]]		[[Category: Luhrs, T]]
-	[[Category: ~~Krausze, J~~]]	+	[[Category: Cancer]]
		+	[[Category: Dna-binding domain]]
		+	[[Category: Gammaherpesvirus]]
		+	[[Category: Hhv-8]]
		+	[[Category: Multicentric castleman's disease]]
		+	[[Category: Oligomerization domain]]
		+	[[Category: Origin-binding domain]]
		+	[[Category: Primary effusion lymphoma]]
		+	[[Category: Rhadinovirus]]
		+	[[Category: Tumor virus]]
		+	[[Category: Viral protein-dna complex]]

OCA at 18:54, 24 December 2014

OCA — Wed, 24 Dec 2014 18:54:14 GMT

←Older revision		Revision as of 18:54, 24 December 2014
Line 6:		Line 6:

	Description: KSHV LANA (ORF73) C-terminal domain mutant bound to LBS1 DNA (R1039Q, R1040Q, K1055E, K1109A, D1110A, A1121E, K1138S, K1140D, K1141D)		Description: KSHV LANA (ORF73) C-terminal domain mutant bound to LBS1 DNA (R1039Q, R1040Q, K1055E, K1109A, D1110A, A1121E, K1138S, K1140D, K1141D)
		+	[[Category: Unreleased Structures]]
		+	[[Category: Hellert, J]]
		+	[[Category: Luhrs, T]]
		+	[[Category: Krausze, J]]

OCA: Protected "4uzb" [edit=sysop:move=sysop]

OCA — Wed, 24 Sep 2014 08:56:28 GMT

Protected "4uzb" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:56, 24 September 2014

OCA: New page: '''Unreleased structure''' The entry 4uzb is ON HOLD until Paper Publication Authors: Hellert, J., Krausze, J., Luhrs, T. Description: KSHV LANA (ORF73) C-terminal domain mutant bound ...

OCA — Wed, 24 Sep 2014 08:56:26 GMT

New page: '''Unreleased structure''' The entry 4uzb is ON HOLD until Paper Publication Authors: Hellert, J., Krausze, J., Luhrs, T. Description: KSHV LANA (ORF73) C-terminal domain mutant bound ...

New page

'''Unreleased structure'''

The entry 4uzb is ON HOLD until Paper Publication

Authors: Hellert, J., Krausze, J., Luhrs, T.

Description: KSHV LANA (ORF73) C-terminal domain mutant bound to LBS1 DNA (R1039Q, R1040Q, K1055E, K1109A, D1110A, A1121E, K1138S, K1140D, K1141D)