4v1g - Revision history

OCA at 10:39, 10 January 2024

OCA — Wed, 10 Jan 2024 10:39:07 GMT

←Older revision		Revision as of 10:39, 10 January 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4v1g]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_phlei Mycolicibacterium phlei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V1G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V1G FirstGlance]. <br>		<table><tr><td colspan='2'>[[4v1g]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_phlei Mycolicibacterium phlei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V1G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V1G FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.55Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v1g OCA], [https://pdbe.org/4v1g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v1g RCSB], [https://www.ebi.ac.uk/pdbsum/4v1g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v1g ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v1g OCA], [https://pdbe.org/4v1g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v1g RCSB], [https://www.ebi.ac.uk/pdbsum/4v1g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v1g ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:57, 29 March 2023

OCA — Wed, 29 Mar 2023 07:57:24 GMT

←Older revision		Revision as of 07:57, 29 March 2023
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	<StructureSection load='4v1g' size='340' side='right'caption='[[4v1g]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='4v1g' size='340' side='right'caption='[[4v1g]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4v1g]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Mycobacterium_phlei Mycobacterium~~ phlei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V1G OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4V1G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4v1g]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_phlei Mycolicibacterium phlei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V1G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V1G FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4v1f\|4v1f]], [[4v1h\|4v1h]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v1g OCA], [https://pdbe.org/4v1g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v1g RCSB], [https://www.ebi.ac.uk/pdbsum/4v1g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v1g ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/H(+)-transporting_two-sector_ATPase H(+)-transporting two-sector ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.14 3.6.3.14] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4v1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v1g OCA], [~~http~~://pdbe.org/4v1g PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4v1g RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4v1g PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4v1g ProSAT]</span></td></tr>	+
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 18:		Line 16:
	</div>		</div>
	<div class="pdbe-citations 4v1g" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4v1g" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[ATPase 3D structures\|ATPase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Mycobacterium~~ phlei]]	+	[[Category: Mycolicibacterium phlei]]
-	[[Category: Meier, T]]	+	[[Category: Meier T]]
-	[[Category: Preiss, L]]	+	[[Category: Preiss L]]
-	[[Category: Yildiz, O]]	+	[[Category: Yildiz O]]
-	~~[[Category: F1fo-atp synthase rotor membrane protein structure]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 08:55, 23 May 2019

OCA — Thu, 23 May 2019 08:55:09 GMT

←Older revision		Revision as of 08:55, 23 May 2019
Line 1:		Line 1:
		+
	==Crystal structure of a mycobacterial ATP synthase rotor ring==		==Crystal structure of a mycobacterial ATP synthase rotor ring==
-	<StructureSection load='4v1g' size='340' side='right' caption='[[4v1g]], [[Resolution\|resolution]] 1.55Å' scene=''>	+	<StructureSection load='4v1g' size='340' side='right'caption='[[4v1g]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4v1g]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_phlei Mycobacterium phlei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V1G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V1G FirstGlance]. <br>		<table><tr><td colspan='2'>[[4v1g]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_phlei Mycobacterium phlei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V1G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V1G FirstGlance]. <br>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4v1f\|4v1f]], [[4v1h\|4v1h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4v1f\|4v1f]], [[4v1h\|4v1h]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/H(+)-transporting_two-sector_ATPase H(+)-transporting two-sector ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.14 3.6.3.14] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/H(+)-transporting_two-sector_ATPase H(+)-transporting two-sector ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.14 3.6.3.14] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v1g OCA], [http://pdbe.org/4v1g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4v1g RCSB], [http://www.ebi.ac.uk/pdbsum/4v1g PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v1g OCA], [http://pdbe.org/4v1g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4v1g RCSB], [http://www.ebi.ac.uk/pdbsum/4v1g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4v1g ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mycobacterium phlei]]		[[Category: Mycobacterium phlei]]
	[[Category: Meier, T]]		[[Category: Meier, T]]

OCA at 07:10, 9 December 2015

OCA — Wed, 09 Dec 2015 07:10:44 GMT

←Older revision		Revision as of 07:10, 9 December 2015
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4v1f\|4v1f]], [[4v1h\|4v1h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4v1f\|4v1f]], [[4v1h\|4v1h]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/H(+)-transporting_two-sector_ATPase H(+)-transporting two-sector ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.14 3.6.3.14] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/H(+)-transporting_two-sector_ATPase H(+)-transporting two-sector ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.14 3.6.3.14] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v1g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4v1g RCSB], [http://www.ebi.ac.uk/pdbsum/4v1g PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v1g OCA], [http://pdbe.org/4v1g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4v1g RCSB], [http://www.ebi.ac.uk/pdbsum/4v1g PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Multidrug-resistant tuberculosis (MDR-TB) is more prevalent today than at any other time in human history. Bedaquiline (BDQ), a novel Mycobacterium-specific adenosine triphosphate (ATP) synthase inhibitor, is the first drug in the last 40 years to be approved for the treatment of MDR-TB. This bactericidal compound targets the membrane-embedded rotor (c-ring) of the mycobacterial ATP synthase, a key metabolic enzyme required for ATP generation. We report the x-ray crystal structures of a mycobacterial c9 ring without and with BDQ bound at 1.55- and 1.7-A resolution, respectively. The structures and supporting functional assays reveal how BDQ specifically interacts with the rotor ring via numerous interactions and thereby completely covers the c-ring's ion-binding sites. This prevents the rotor ring from acting as an ion shuttle and stalls ATP synthase operation. The structures explain how diarylquinoline chemicals specifically inhibit the mycobacterial ATP synthase and thus enable structure-based drug design of next-generation ATP synthase inhibitors against Mycobacterium tuberculosis and other bacterial pathogens.
		+
		+	Structure of the mycobacterial ATP synthase F rotor ring in complex with the anti-TB drug bedaquiline.,Preiss L, Langer JD, Yildiz O, Eckhardt-Strelau L, Guillemont JE, Koul A, Meier T Sci Adv. 2015 May 8;1(4):e1500106. eCollection 2015 May. PMID:26601184<ref>PMID:26601184</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4v1g" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 12:18, 20 May 2015

OCA — Wed, 20 May 2015 12:18:39 GMT

←Older revision		Revision as of 12:18, 20 May 2015
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-	'''~~Unreleased structure~~'''	+	==Crystal structure of a mycobacterial ATP synthase rotor ring==
-		+	<StructureSection load='4v1g' size='340' side='right' caption='[[4v1g]], [[Resolution\|resolution]] 1.55Å' scene=''>
-	~~The entry~~ 4v1g is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4v1g]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_phlei Mycobacterium phlei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V1G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V1G FirstGlance]. <br>
-	~~Authors~~: ~~Preiss~~, L.~~, Yildiz, O~~., ~~Meier, T~~.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4v1f\|4v1f]], [[4v1h\|4v1h]]</td></tr>
-	~~Description~~: ~~Crystal structure of a mycobacterial ATP synthase rotor ring~~	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/H(+)-transporting_two-sector_ATPase H(+)-transporting two-sector ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.14 3.6.3.14] </span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v1g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4v1g RCSB], [http://www.ebi.ac.uk/pdbsum/4v1g PDBsum]</span></td></tr>
-	[[Category: ~~Preiss, L~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Mycobacterium phlei]]
	[[Category: Meier, T]]		[[Category: Meier, T]]
		+	[[Category: Preiss, L]]
	[[Category: Yildiz, O]]		[[Category: Yildiz, O]]
		+	[[Category: F1fo-atp synthase rotor membrane protein structure]]
		+	[[Category: Hydrolase]]

OCA at 09:23, 15 April 2015

OCA — Wed, 15 Apr 2015 09:23:29 GMT

←Older revision		Revision as of 09:23, 15 April 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4v1g is ON HOLD	+	The entry 4v1g is ON HOLD until Paper Publication

	Authors: Preiss, L., Yildiz, O., Meier, T.		Authors: Preiss, L., Yildiz, O., Meier, T.

OCA at 18:59, 24 December 2014

OCA — Wed, 24 Dec 2014 18:59:40 GMT

←Older revision		Revision as of 18:59, 24 December 2014
Line 6:		Line 6:

	Description: Crystal structure of a mycobacterial ATP synthase rotor ring		Description: Crystal structure of a mycobacterial ATP synthase rotor ring
		+	[[Category: Unreleased Structures]]
		+	[[Category: Preiss, L]]
		+	[[Category: Meier, T]]
		+	[[Category: Yildiz, O]]

OCA: Protected "4v1g" [edit=sysop:move=sysop]

OCA — Wed, 08 Oct 2014 06:47:41 GMT

Protected "4v1g" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:47, 8 October 2014

OCA: New page: '''Unreleased structure''' The entry 4v1g is ON HOLD Authors: Preiss, L., Yildiz, O., Meier, T. Description: Crystal structure of a mycobacterial ATP synthase rotor ring

OCA — Wed, 08 Oct 2014 06:47:39 GMT

New page: '''Unreleased structure''' The entry 4v1g is ON HOLD Authors: Preiss, L., Yildiz, O., Meier, T. Description: Crystal structure of a mycobacterial ATP synthase rotor ring

New page

'''Unreleased structure'''

The entry 4v1g is ON HOLD

Authors: Preiss, L., Yildiz, O., Meier, T.

Description: Crystal structure of a mycobacterial ATP synthase rotor ring