4v4b - Revision history

OCA at 12:58, 1 March 2024

OCA — Fri, 01 Mar 2024 12:58:23 GMT

←Older revision		Revision as of 12:58, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4v4b]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1s1h 1s1h] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1s1i 1s1i]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V4B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V4B FirstGlance]. <br>		<table><tr><td colspan='2'>[[4v4b]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1s1h 1s1h] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1s1i 1s1i]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V4B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V4B FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v4b OCA], [https://pdbe.org/4v4b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v4b RCSB], [https://www.ebi.ac.uk/pdbsum/4v4b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v4b ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 11.7Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v4b OCA], [https://pdbe.org/4v4b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v4b RCSB], [https://www.ebi.ac.uk/pdbsum/4v4b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v4b ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/EF2_YEAST EF2_YEAST]		[https://www.uniprot.org/uniprot/EF2_YEAST EF2_YEAST]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	An 11.7-A-resolution cryo-EM map of the yeast 80S.eEF2 complex in the presence of the antibiotic sordarin was interpreted in molecular terms, revealing large conformational changes within eEF2 and the 80S ribosome, including a rearrangement of the functionally important ribosomal intersubunit bridges. Sordarin positions domain III of eEF2 so that it can interact with the sarcin-ricin loop of 25S rRNA and protein rpS23 (S12p). This particular conformation explains the inhibitory action of sordarin and suggests that eEF2 is stalled on the 80S ribosome in a conformation that has similarities with the GTPase activation state. A ratchet-like subunit rearrangement (RSR) occurs in the 80S.eEF2.sordarin complex that, in contrast to Escherichia coli 70S ribosomes, is also present in vacant 80S ribosomes. A model is suggested, according to which the RSR is part of a mechanism for moving the tRNAs during the translocation reaction.
-
-	Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation.,Spahn CM, Gomez-Lorenzo MG, Grassucci RA, Jorgensen R, Andersen GR, Beckmann R, Penczek PA, Ballesta JP, Frank J EMBO J. 2004 Mar 10;23(5):1008-19. Epub 2004 Feb 19. PMID:14976550<ref>PMID:14976550</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4v4b" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 22:		Line 14:
	*[[Ribosomal protein S22\|Ribosomal protein S22]]		*[[Ribosomal protein S22\|Ribosomal protein S22]]
	*[[Ribosome 3D structures\|Ribosome 3D structures]]		*[[Ribosome 3D structures\|Ribosome 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</SX>		</SX>

OCA at 08:03, 29 March 2023

OCA — Wed, 29 Mar 2023 08:03:04 GMT

←Older revision		Revision as of 08:03, 29 March 2023
Line 3:		Line 3:
	<SX load='4v4b' size='340' side='right' viewer='molstar' caption='[[4v4b]], [[Resolution\|resolution]] 11.70Å' scene=''>		<SX load='4v4b' size='340' side='right' viewer='molstar' caption='[[4v4b]], [[Resolution\|resolution]] 11.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4v4b]] is a 47 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1s1h 1s1h] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1s1i 1s1i]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V4B OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=4V4B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4v4b]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1s1h 1s1h] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1s1i 1s1i]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V4B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V4B FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k5x\|1k5x]], [[1k5y\|1k5y]], [[1mms\|1mms]], [[1mzp\|1mzp]], [[1ffk\|1ffk]], [[1fjf\|1fjf]], [[1fka\|1fka]], [[1gix\|1gix]], [[1giy\|1giy]], [[1nou\|1nou]]</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v4b OCA], [https://pdbe.org/4v4b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v4b RCSB], [https://www.ebi.ac.uk/pdbsum/4v4b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v4b ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=4v4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v4b OCA], [~~http~~://pdbe.org/4v4b PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4v4b RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4v4b PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4v4b ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~RL4A_YEAST RL4A_YEAST~~]] Participates in the regulation of the accumulation of its own mRNA.<ref>PMID:2065661</ref> [[http://www.uniprot.org/uniprot/RS15_YEAST RS15_YEAST]] Involved in the nuclear export of the small ribosomal subunit. Has a role in the late stage of the assembly of pre-40S particles within the nucleus and controls their export to the cytoplasm.<ref>PMID:15167894</ref> [[http://www.uniprot.org/uniprot/RS9B_YEAST RS9B_YEAST]] Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.<ref>PMID:15590835</ref> [[http://www.uniprot.org/uniprot/RL5_YEAST RL5_YEAST]] Binds 5S RNA and is required for 60S subunit assembly. [[http://www.uniprot.org/uniprot/RS14A_YEAST RS14A_YEAST]] Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.<ref>PMID:15590835</ref> [[http://www.uniprot.org/uniprot/RL4B_YEAST RL4B_YEAST]] Participates in the regulation of the accumulation of its own mRNA. [[http://www.uniprot.org/uniprot/RS2_YEAST RS2_YEAST]] Important in the assembly and function of the 40S ribosomal subunit. Mutations in this protein affects the control of translational fidelity. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.<ref>PMID:15590835</ref> [[http://www.uniprot.org/uniprot/RL25_YEAST RL25_YEAST]] This protein binds to a specific region on the 26S rRNA. [[http://www.uniprot.org/uniprot/RSSA1_YEAST RSSA1_YEAST]] Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.<ref>PMID:9973221</ref> <ref>PMID:14627813</ref> [[http://www.uniprot.org/uniprot/RS19A_YEAST RS19A_YEAST]] Required for proper maturation of the small (40S) ribosomal subunit. Binds to 40s pre-ribosomal particles, probably required after association of NOC4 but before association of ENP1, TSR1 and RIO2 with 20/21S pre-rRNA.<ref>PMID:16159874</ref> <ref>PMID:17726054</ref> [[http://www.uniprot.org/uniprot/RS9A_YEAST RS9A_YEAST]] Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.<ref>PMID:15590835</ref>	+	[https://www.uniprot.org/uniprot/EF2_YEAST EF2_YEAST]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 29:		Line 28:
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Andersen~~, G R~~]]	+	[[Category: Andersen GR]]
-	[[Category: Ballesta~~, J P.G~~]]	+	[[Category: Ballesta JPG]]
-	[[Category: Beckmann, R]]	+	[[Category: Beckmann R]]
-	[[Category: Frank, J]]	+	[[Category: Frank J]]
-	[[Category: Gomez-Lorenzo~~, M G~~]]	+	[[Category: Gomez-Lorenzo MG]]
-	[[Category: Grassucci~~, R A~~]]	+	[[Category: Grassucci RA]]
-	[[Category: Jorgensen, R]]	+	[[Category: Jorgensen R]]
-	[[Category: Penczek~~, P A~~]]	+	[[Category: Penczek PA]]
-	[[Category: Spahn~~, C M]]~~	+	[[Category: Spahn CM]]
-	~~[[Category: 40s ribosomal subunit]]~~	+
-	~~[[Category: 80s ribosome]]~~	+
-	~~[[Category: Cryo-em]]~~	+
-	~~[[Category: Eef2]]~~	+
-	~~[[Category: Ribosome]]~~	+
-	~~[[Category: Sordarin]]~~	+
-	~~[[Category: Trna translocation~~]]	+

OCA at 19:20, 10 April 2020

OCA — Fri, 10 Apr 2020 19:20:28 GMT

←Older revision		Revision as of 19:20, 10 April 2020
Line 3:		Line 3:
	<SX load='4v4b' size='340' side='right' viewer='molstar' caption='[[4v4b]], [[Resolution\|resolution]] 11.70Å' scene=''>		<SX load='4v4b' size='340' side='right' viewer='molstar' caption='[[4v4b]], [[Resolution\|resolution]] 11.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4v4b]] is a 47 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1s1h 1s1h] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1s1i 1s1i]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V4B OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4V4B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4v4b]] is a 47 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1s1h 1s1h] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1s1i 1s1i]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V4B OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=4V4B FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k5x\|1k5x]], [[1k5y\|1k5y]], [[1mms\|1mms]], [[1mzp\|1mzp]], [[1ffk\|1ffk]], [[1fjf\|1fjf]], [[1fka\|1fka]], [[1gix\|1gix]], [[1giy\|1giy]], [[1nou\|1nou]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k5x\|1k5x]], [[1k5y\|1k5y]], [[1mms\|1mms]], [[1mzp\|1mzp]], [[1ffk\|1ffk]], [[1fjf\|1fjf]], [[1fka\|1fka]], [[1gix\|1gix]], [[1giy\|1giy]], [[1nou\|1nou]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4v4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v4b OCA], [http://pdbe.org/4v4b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4v4b RCSB], [http://www.ebi.ac.uk/pdbsum/4v4b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4v4b ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=4v4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v4b OCA], [http://pdbe.org/4v4b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4v4b RCSB], [http://www.ebi.ac.uk/pdbsum/4v4b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4v4b ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 18:01, 6 March 2020

OCA — Fri, 06 Mar 2020 18:01:16 GMT

←Older revision		Revision as of 18:01, 6 March 2020
Line 1:		Line 1:

	==Structure of the ribosomal 80S-eEF2-sordarin complex from yeast obtained by docking atomic models for RNA and protein components into a 11.7 A cryo-EM map.==		==Structure of the ribosomal 80S-eEF2-sordarin complex from yeast obtained by docking atomic models for RNA and protein components into a 11.7 A cryo-EM map.==
-	<~~StructureSection~~ load='4v4b' size='340' side='right'caption='[[4v4b]], [[Resolution\|resolution]] 11.70Å' scene=''>	+	<SX load='4v4b' size='340' side='right' viewer='molstar' caption='[[4v4b]], [[Resolution\|resolution]] 11.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4v4b]] is a 47 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1s1h 1s1h] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1s1i 1s1i]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V4B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V4B FirstGlance]. <br>		<table><tr><td colspan='2'>[[4v4b]] is a 47 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1s1h 1s1h] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1s1i 1s1i]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V4B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V4B FirstGlance]. <br>
Line 26:		Line 26:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]

OCA at 08:35, 18 December 2019

OCA — Wed, 18 Dec 2019 08:35:32 GMT

←Older revision		Revision as of 08:35, 18 December 2019
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Elongation factor\|Elongation factor]]	+	*[[Elongation factor 3D structures\|Elongation factor 3D structures]]
	*[[Ribosomal protein S22\|Ribosomal protein S22]]		*[[Ribosomal protein S22\|Ribosomal protein S22]]
	*[[Ribosome 3D structures\|Ribosome 3D structures]]		*[[Ribosome 3D structures\|Ribosome 3D structures]]

OCA at 08:27, 23 May 2019

OCA — Thu, 23 May 2019 08:27:21 GMT

←Older revision		Revision as of 08:27, 23 May 2019
Line 1:		Line 1:
		+
	==Structure of the ribosomal 80S-eEF2-sordarin complex from yeast obtained by docking atomic models for RNA and protein components into a 11.7 A cryo-EM map.==		==Structure of the ribosomal 80S-eEF2-sordarin complex from yeast obtained by docking atomic models for RNA and protein components into a 11.7 A cryo-EM map.==
-	<StructureSection load='4v4b' size='340' side='right' caption='[[4v4b]], [[Resolution\|resolution]] 11.70Å' scene=''>	+	<StructureSection load='4v4b' size='340' side='right'caption='[[4v4b]], [[Resolution\|resolution]] 11.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4v4b]] is a 47 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. This structure supersedes ~~and combines~~ the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=~~1s1i 1s1i~~] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=~~1s1h 1s1h~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V4B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V4B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4v4b]] is a 47 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1s1h 1s1h] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1s1i 1s1i]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V4B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V4B FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k5x\|1k5x]], [[1k5y\|1k5y]], [[1mms\|1mms]], [[1mzp\|1mzp]], [[1ffk\|1ffk]], [[1fjf\|1fjf]], [[1fka\|1fka]], [[1gix\|1gix]], [[1giy\|1giy]], [[1nou\|1nou]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k5x\|1k5x]], [[1k5y\|1k5y]], [[1mms\|1mms]], [[1mzp\|1mzp]], [[1ffk\|1ffk]], [[1fjf\|1fjf]], [[1fka\|1fka]], [[1gix\|1gix]], [[1giy\|1giy]], [[1nou\|1nou]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v4b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4v4b RCSB], [http://www.ebi.ac.uk/pdbsum/4v4b PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v4b OCA], [http://pdbe.org/4v4b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4v4b RCSB], [http://www.ebi.ac.uk/pdbsum/4v4b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4v4b ProSAT]</span></td></tr>
	</table>		</table>
-	{{Large structure}}
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/RL4A_YEAST RL4A_YEAST]] Participates in the regulation of the accumulation of its own mRNA.<ref>PMID:2065661</ref> [[http://www.uniprot.org/uniprot/RS15_YEAST RS15_YEAST]] Involved in the nuclear export of the small ribosomal subunit. Has a role in the late stage of the assembly of pre-40S particles within the nucleus and controls their export to the cytoplasm.<ref>PMID:15167894</ref> [[http://www.uniprot.org/uniprot/RS9B_YEAST RS9B_YEAST]] Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.<ref>PMID:15590835</ref> [[http://www.uniprot.org/uniprot/RL5_YEAST RL5_YEAST]] Binds 5S RNA and is required for 60S subunit assembly. [[http://www.uniprot.org/uniprot/RS14A_YEAST RS14A_YEAST]] Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.<ref>PMID:15590835</ref> [[http://www.uniprot.org/uniprot/RL4B_YEAST RL4B_YEAST]] Participates in the regulation of the accumulation of its own mRNA. [[http://www.uniprot.org/uniprot/RS2_YEAST RS2_YEAST]] Important in the assembly and function of the 40S ribosomal subunit. Mutations in this protein affects the control of translational fidelity. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.<ref>PMID:15590835</ref> [[http://www.uniprot.org/uniprot/RL25_YEAST RL25_YEAST]] This protein binds to a specific region on the 26S rRNA. [[http://www.uniprot.org/uniprot/RSSA1_YEAST RSSA1_YEAST]] Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.<ref>PMID:9973221</ref> <ref>PMID:14627813</ref> [[http://www.uniprot.org/uniprot/RS19A_YEAST RS19A_YEAST]] Required for proper maturation of the small (40S) ribosomal subunit. Binds to 40s pre-ribosomal particles, probably required after association of NOC4 but before association of ENP1, TSR1 and RIO2 with 20/21S pre-rRNA.<ref>PMID:16159874</ref> <ref>PMID:17726054</ref> [[http://www.uniprot.org/uniprot/RS9A_YEAST RS9A_YEAST]] Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.<ref>PMID:15590835</ref>		[[http://www.uniprot.org/uniprot/RL4A_YEAST RL4A_YEAST]] Participates in the regulation of the accumulation of its own mRNA.<ref>PMID:2065661</ref> [[http://www.uniprot.org/uniprot/RS15_YEAST RS15_YEAST]] Involved in the nuclear export of the small ribosomal subunit. Has a role in the late stage of the assembly of pre-40S particles within the nucleus and controls their export to the cytoplasm.<ref>PMID:15167894</ref> [[http://www.uniprot.org/uniprot/RS9B_YEAST RS9B_YEAST]] Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.<ref>PMID:15590835</ref> [[http://www.uniprot.org/uniprot/RL5_YEAST RL5_YEAST]] Binds 5S RNA and is required for 60S subunit assembly. [[http://www.uniprot.org/uniprot/RS14A_YEAST RS14A_YEAST]] Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.<ref>PMID:15590835</ref> [[http://www.uniprot.org/uniprot/RL4B_YEAST RL4B_YEAST]] Participates in the regulation of the accumulation of its own mRNA. [[http://www.uniprot.org/uniprot/RS2_YEAST RS2_YEAST]] Important in the assembly and function of the 40S ribosomal subunit. Mutations in this protein affects the control of translational fidelity. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.<ref>PMID:15590835</ref> [[http://www.uniprot.org/uniprot/RL25_YEAST RL25_YEAST]] This protein binds to a specific region on the 26S rRNA. [[http://www.uniprot.org/uniprot/RSSA1_YEAST RSSA1_YEAST]] Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.<ref>PMID:9973221</ref> <ref>PMID:14627813</ref> [[http://www.uniprot.org/uniprot/RS19A_YEAST RS19A_YEAST]] Required for proper maturation of the small (40S) ribosomal subunit. Binds to 40s pre-ribosomal particles, probably required after association of NOC4 but before association of ENP1, TSR1 and RIO2 with 20/21S pre-rRNA.<ref>PMID:16159874</ref> <ref>PMID:17726054</ref> [[http://www.uniprot.org/uniprot/RS9A_YEAST RS9A_YEAST]] Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.<ref>PMID:15590835</ref>
Line 17:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4v4b" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Elongation factor\|Elongation factor]]
		+	*[[Ribosomal protein S22\|Ribosomal protein S22]]
		+	*[[Ribosome 3D structures\|Ribosome 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Andersen, G R]]		[[Category: Andersen, G R]]
Line 35:		Line 42:
	[[Category: Cryo-em]]		[[Category: Cryo-em]]
	[[Category: Eef2]]		[[Category: Eef2]]
		+	[[Category: Ribosome]]
	[[Category: Sordarin]]		[[Category: Sordarin]]
	[[Category: Trna translocation]]		[[Category: Trna translocation]]

OCA at 16:11, 1 September 2015

OCA — Tue, 01 Sep 2015 16:11:26 GMT

←Older revision		Revision as of 16:11, 1 September 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4v4b]] is a 47 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. This structure supersedes and combines the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1s1i 1s1i] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1s1h 1s1h]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V4B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V4B FirstGlance]. <br>		<table><tr><td colspan='2'>[[4v4b]] is a 47 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. This structure supersedes and combines the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1s1i 1s1i] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1s1h 1s1h]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V4B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V4B FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">~~[[1s1i\|1s1i]], [[1s1h\|1s1h]],~~ [[1k5x\|1k5x]], [[1k5y\|1k5y]], [[1mms\|1mms]], [[1mzp\|1mzp]], [[1ffk\|1ffk]], [[1fjf\|1fjf]], [[1fka\|1fka]], [[1gix\|1gix]], [[1giy\|1giy]], [[1nou\|1nou]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k5x\|1k5x]], [[1k5y\|1k5y]], [[1mms\|1mms]], [[1mzp\|1mzp]], [[1ffk\|1ffk]], [[1fjf\|1fjf]], [[1fka\|1fka]], [[1gix\|1gix]], [[1giy\|1giy]], [[1nou\|1nou]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v4b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4v4b RCSB], [http://www.ebi.ac.uk/pdbsum/4v4b PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v4b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4v4b RCSB], [http://www.ebi.ac.uk/pdbsum/4v4b PDBsum]</span></td></tr>
	</table>		</table>

OCA at 13:19, 1 September 2015

OCA — Tue, 01 Sep 2015 13:19:37 GMT

←Older revision		Revision as of 13:19, 1 September 2015
Line 2:		Line 2:
	<StructureSection load='4v4b' size='340' side='right' caption='[[4v4b]], [[Resolution\|resolution]] 11.70Å' scene=''>		<StructureSection load='4v4b' size='340' side='right' caption='[[4v4b]], [[Resolution\|resolution]] 11.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4v4b]] is a 47 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. This structure supersedes the now removed PDB entries ~~and~~ [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1s1i 1s1i]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V4B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V4B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4v4b]] is a 47 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. This structure supersedes and combines the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1s1i 1s1i] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1s1h 1s1h]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V4B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V4B FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s1i\|1s1i]], [[1s1h\|1s1h]], [[1k5x\|1k5x]], [[1k5y\|1k5y]], [[1mms\|1mms]], [[1mzp\|1mzp]], [[1ffk\|1ffk]], [[1fjf\|1fjf]], [[1fka\|1fka]], [[1gix\|1gix]], [[1giy\|1giy]], [[1nou\|1nou]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s1i\|1s1i]], [[1s1h\|1s1h]], [[1k5x\|1k5x]], [[1k5y\|1k5y]], [[1mms\|1mms]], [[1mzp\|1mzp]], [[1ffk\|1ffk]], [[1fjf\|1fjf]], [[1fka\|1fka]], [[1gix\|1gix]], [[1giy\|1giy]], [[1nou\|1nou]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v4b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4v4b RCSB], [http://www.ebi.ac.uk/pdbsum/4v4b PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v4b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4v4b RCSB], [http://www.ebi.ac.uk/pdbsum/4v4b PDBsum]</span></td></tr>
	</table>		</table>
		+	{{Large structure}}
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/RL4A_YEAST RL4A_YEAST]] Participates in the regulation of the accumulation of its own mRNA.<ref>PMID:2065661</ref> [[http://www.uniprot.org/uniprot/RS15_YEAST RS15_YEAST]] Involved in the nuclear export of the small ribosomal subunit. Has a role in the late stage of the assembly of pre-40S particles within the nucleus and controls their export to the cytoplasm.<ref>PMID:15167894</ref> [[http://www.uniprot.org/uniprot/RS9B_YEAST RS9B_YEAST]] Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.<ref>PMID:15590835</ref> [[http://www.uniprot.org/uniprot/RL5_YEAST RL5_YEAST]] Binds 5S RNA and is required for 60S subunit assembly. [[http://www.uniprot.org/uniprot/RS14A_YEAST RS14A_YEAST]] Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.<ref>PMID:15590835</ref> [[http://www.uniprot.org/uniprot/RL4B_YEAST RL4B_YEAST]] Participates in the regulation of the accumulation of its own mRNA. [[http://www.uniprot.org/uniprot/RS2_YEAST RS2_YEAST]] Important in the assembly and function of the 40S ribosomal subunit. Mutations in this protein affects the control of translational fidelity. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.<ref>PMID:15590835</ref> [[http://www.uniprot.org/uniprot/RL25_YEAST RL25_YEAST]] This protein binds to a specific region on the 26S rRNA. [[http://www.uniprot.org/uniprot/RSSA1_YEAST RSSA1_YEAST]] Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.<ref>PMID:9973221</ref> <ref>PMID:14627813</ref> [[http://www.uniprot.org/uniprot/RS19A_YEAST RS19A_YEAST]] Required for proper maturation of the small (40S) ribosomal subunit. Binds to 40s pre-ribosomal particles, probably required after association of NOC4 but before association of ENP1, TSR1 and RIO2 with 20/21S pre-rRNA.<ref>PMID:16159874</ref> <ref>PMID:17726054</ref> [[http://www.uniprot.org/uniprot/RS9A_YEAST RS9A_YEAST]] Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.<ref>PMID:15590835</ref>		[[http://www.uniprot.org/uniprot/RL4A_YEAST RL4A_YEAST]] Participates in the regulation of the accumulation of its own mRNA.<ref>PMID:2065661</ref> [[http://www.uniprot.org/uniprot/RS15_YEAST RS15_YEAST]] Involved in the nuclear export of the small ribosomal subunit. Has a role in the late stage of the assembly of pre-40S particles within the nucleus and controls their export to the cytoplasm.<ref>PMID:15167894</ref> [[http://www.uniprot.org/uniprot/RS9B_YEAST RS9B_YEAST]] Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.<ref>PMID:15590835</ref> [[http://www.uniprot.org/uniprot/RL5_YEAST RL5_YEAST]] Binds 5S RNA and is required for 60S subunit assembly. [[http://www.uniprot.org/uniprot/RS14A_YEAST RS14A_YEAST]] Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.<ref>PMID:15590835</ref> [[http://www.uniprot.org/uniprot/RL4B_YEAST RL4B_YEAST]] Participates in the regulation of the accumulation of its own mRNA. [[http://www.uniprot.org/uniprot/RS2_YEAST RS2_YEAST]] Important in the assembly and function of the 40S ribosomal subunit. Mutations in this protein affects the control of translational fidelity. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.<ref>PMID:15590835</ref> [[http://www.uniprot.org/uniprot/RL25_YEAST RL25_YEAST]] This protein binds to a specific region on the 26S rRNA. [[http://www.uniprot.org/uniprot/RSSA1_YEAST RSSA1_YEAST]] Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.<ref>PMID:9973221</ref> <ref>PMID:14627813</ref> [[http://www.uniprot.org/uniprot/RS19A_YEAST RS19A_YEAST]] Required for proper maturation of the small (40S) ribosomal subunit. Binds to 40s pre-ribosomal particles, probably required after association of NOC4 but before association of ENP1, TSR1 and RIO2 with 20/21S pre-rRNA.<ref>PMID:16159874</ref> <ref>PMID:17726054</ref> [[http://www.uniprot.org/uniprot/RS9A_YEAST RS9A_YEAST]] Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.<ref>PMID:15590835</ref>

OCA: Protected "4v4b" [edit=sysop:move=sysop]

OCA — Thu, 25 Dec 2014 05:27:55 GMT

Protected "4v4b" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:27, 25 December 2014

OCA: New page: ==Structure of the ribosomal 80S-eEF2-sordarin complex from yeast obtained by docking atomic models for RNA and protein components into a 11.7 A cryo-EM map.==
New page
==Structure of the ribosomal 80S-eEF2-sordarin complex from yeast obtained by docking atomic models for RNA and protein components into a 11.7 A cryo-EM map.==
<StructureSection load='4v4b' size='340' side='right' caption='[[4v4b]], [[Resolution|resolution]] 11.70Å' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4v4b]] is a 47 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. This structure supersedes the now removed PDB entries and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1s1i 1s1i]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V4B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V4B FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1s1i|1s1i]], [[1s1h|1s1h]], [[1k5x|1k5x]], [[1k5y|1k5y]], [[1mms|1mms]], [[1mzp|1mzp]], [[1ffk|1ffk]], [[1fjf|1fjf]], [[1fka|1fka]], [[1gix|1gix]], [[1giy|1giy]], [[1nou|1nou]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v4b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4v4b RCSB], [http://www.ebi.ac.uk/pdbsum/4v4b PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/RL4A_YEAST RL4A_YEAST]] Participates in the regulation of the accumulation of its own mRNA.<ref>PMID:2065661</ref> [[http://www.uniprot.org/uniprot/RS15_YEAST RS15_YEAST]] Involved in the nuclear export of the small ribosomal subunit. Has a role in the late stage of the assembly of pre-40S particles within the nucleus and controls their export to the cytoplasm.<ref>PMID:15167894</ref> [[http://www.uniprot.org/uniprot/RS9B_YEAST RS9B_YEAST]] Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.<ref>PMID:15590835</ref> [[http://www.uniprot.org/uniprot/RL5_YEAST RL5_YEAST]] Binds 5S RNA and is required for 60S subunit assembly. [[http://www.uniprot.org/uniprot/RS14A_YEAST RS14A_YEAST]] Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.<ref>PMID:15590835</ref> [[http://www.uniprot.org/uniprot/RL4B_YEAST RL4B_YEAST]] Participates in the regulation of the accumulation of its own mRNA. [[http://www.uniprot.org/uniprot/RS2_YEAST RS2_YEAST]] Important in the assembly and function of the 40S ribosomal subunit. Mutations in this protein affects the control of translational fidelity. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.<ref>PMID:15590835</ref> [[http://www.uniprot.org/uniprot/RL25_YEAST RL25_YEAST]] This protein binds to a specific region on the 26S rRNA. [[http://www.uniprot.org/uniprot/RSSA1_YEAST RSSA1_YEAST]] Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.<ref>PMID:9973221</ref> <ref>PMID:14627813</ref> [[http://www.uniprot.org/uniprot/RS19A_YEAST RS19A_YEAST]] Required for proper maturation of the small (40S) ribosomal subunit. Binds to 40s pre-ribosomal particles, probably required after association of NOC4 but before association of ENP1, TSR1 and RIO2 with 20/21S pre-rRNA.<ref>PMID:16159874</ref> <ref>PMID:17726054</ref> [[http://www.uniprot.org/uniprot/RS9A_YEAST RS9A_YEAST]] Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.<ref>PMID:15590835</ref>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
An 11.7-A-resolution cryo-EM map of the yeast 80S.eEF2 complex in the presence of the antibiotic sordarin was interpreted in molecular terms, revealing large conformational changes within eEF2 and the 80S ribosome, including a rearrangement of the functionally important ribosomal intersubunit bridges. Sordarin positions domain III of eEF2 so that it can interact with the sarcin-ricin loop of 25S rRNA and protein rpS23 (S12p). This particular conformation explains the inhibitory action of sordarin and suggests that eEF2 is stalled on the 80S ribosome in a conformation that has similarities with the GTPase activation state. A ratchet-like subunit rearrangement (RSR) occurs in the 80S.eEF2.sordarin complex that, in contrast to Escherichia coli 70S ribosomes, is also present in vacant 80S ribosomes. A model is suggested, according to which the RSR is part of a mechanism for moving the tRNAs during the translocation reaction.

Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation.,Spahn CM, Gomez-Lorenzo MG, Grassucci RA, Jorgensen R, Andersen GR, Beckmann R, Penczek PA, Ballesta JP, Frank J EMBO J. 2004 Mar 10;23(5):1008-19. Epub 2004 Feb 19. PMID:14976550<ref>PMID:14976550</ref>

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
</div>
== References ==
<references/>
TOC
</StructureSection>
[[Category: Saccharomyces cerevisiae]]
[[Category: Andersen, G R]]
[[Category: Ballesta, J P.G]]
[[Category: Beckmann, R]]
[[Category: Frank, J]]
[[Category: Gomez-Lorenzo, M G]]
[[Category: Grassucci, R A]]
[[Category: Jorgensen, R]]
[[Category: Penczek, P A]]
[[Category: Spahn, C M]]
[[Category: 40s ribosomal subunit]]
[[Category: 80s ribosome]]
[[Category: Cryo-em]]
[[Category: Eef2]]
[[Category: Sordarin]]
[[Category: Trna translocation]]