4w4v - Revision history

OCA at 00:51, 28 December 2023

OCA — Thu, 28 Dec 2023 00:51:16 GMT

←Older revision		Revision as of 00:51, 28 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4w4v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4W4V FirstGlance]. <br>		<table><tr><td colspan='2'>[[4w4v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4W4V FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3H8:3-(4-{[(2-CHLOROPHENYL)CARBAMOYL]AMINO}-1H-PYRAZOL-1-YL)-N-(2-METHYLPYRIDIN-4-YL)BENZAMIDE'>3H8</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.01Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3H8:3-(4-{[(2-CHLOROPHENYL)CARBAMOYL]AMINO}-1H-PYRAZOL-1-YL)-N-(2-METHYLPYRIDIN-4-YL)BENZAMIDE'>3H8</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4w4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w4v OCA], [https://pdbe.org/4w4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4w4v RCSB], [https://www.ebi.ac.uk/pdbsum/4w4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4w4v ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4w4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w4v OCA], [https://pdbe.org/4w4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4w4v RCSB], [https://www.ebi.ac.uk/pdbsum/4w4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4w4v ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:16, 29 March 2023

OCA — Wed, 29 Mar 2023 08:16:56 GMT

←Older revision		Revision as of 08:16, 29 March 2023
Line 3:		Line 3:
	<StructureSection load='4w4v' size='340' side='right'caption='[[4w4v]], [[Resolution\|resolution]] 2.01Å' scene=''>		<StructureSection load='4w4v' size='340' side='right'caption='[[4w4v]], [[Resolution\|resolution]] 2.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4w4v]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W4V OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4W4V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4w4v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4W4V FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3H8:3-(4-{[(2-CHLOROPHENYL)CARBAMOYL]AMINO}-1H-PYRAZOL-1-YL)-N-(2-METHYLPYRIDIN-4-YL)BENZAMIDE'>3H8</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3H8:3-(4-{[(2-CHLOROPHENYL)CARBAMOYL]AMINO}-1H-PYRAZOL-1-YL)-N-(2-METHYLPYRIDIN-4-YL)BENZAMIDE'>3H8</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4w4w\|4w4w]], [[4w4x\|4w4x]], [[4w4y\|4w4y]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4w4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w4v OCA], [https://pdbe.org/4w4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4w4v RCSB], [https://www.ebi.ac.uk/pdbsum/4w4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4w4v ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAPK10, JNK3, JNK3A, PRKM10, SAPK1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4w4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w4v OCA], [~~http~~://pdbe.org/4w4v PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4w4v RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4w4v PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4w4v ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/MK10_HUMAN MK10_HUMAN]] Defects in MAPK10 are a cause of epileptic encephalopathy Lennox-Gastaut type (EELG) [MIM:[~~http~~://omim.org/entry/606369 606369]]. Epileptic encephalopathies of the Lennox-Gastaut group are childhood epileptic disorders characterized by severe psychomotor delay and seizures. Note=A chromosomal aberration involving MAPK10 has been found in a single patient. Translocation t(Y;4)(q11.2;q21) which causes MAPK10 truncation.	+	[https://www.uniprot.org/uniprot/MK10_HUMAN MK10_HUMAN] Defects in MAPK10 are a cause of epileptic encephalopathy Lennox-Gastaut type (EELG) [MIM:[https://omim.org/entry/606369 606369]. Epileptic encephalopathies of the Lennox-Gastaut group are childhood epileptic disorders characterized by severe psychomotor delay and seizures. Note=A chromosomal aberration involving MAPK10 has been found in a single patient. Translocation t(Y;4)(q11.2;q21) which causes MAPK10 truncation.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MK10_HUMAN MK10_HUMAN]] Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons.<ref>PMID:11718727</ref>	+	[https://www.uniprot.org/uniprot/MK10_HUMAN MK10_HUMAN] Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons.<ref>PMID:11718727</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Mitogen-activated protein kinase]]~~	+	[[Category: Feng Y]]
-	[[Category: Feng, Y]]	+	[[Category: Hernandez P]]
-	[[Category: Hernandez, P]]	+	[[Category: Iqbal S]]
-	[[Category: Iqbal, S]]	+	[[Category: LoGrasso P]]
-	[[Category: LoGrasso, P]]	+	[[Category: Mora R]]
-	[[Category: Mora, R]]	+	[[Category: Park H]]
-	[[Category: Park, H]]	+	[[Category: Zheng K]]
-	[[Category: Zheng, K]]	+
-	~~[[Category: Isoform selective]]~~	+
-	~~[[Category: Jnk]]~~	+
-	~~[[Category: Map kinase]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 07:37, 10 April 2019

OCA — Wed, 10 Apr 2019 07:37:03 GMT

←Older revision		Revision as of 07:37, 10 April 2019
Line 1:		Line 1:

	==JNK2/3 in complex with 3-(4-{[(2-chlorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide==		==JNK2/3 in complex with 3-(4-{[(2-chlorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide==
-	<StructureSection load='4w4v' size='340' side='right' caption='[[4w4v]], [[Resolution\|resolution]] 2.01Å' scene=''>	+	<StructureSection load='4w4v' size='340' side='right'caption='[[4w4v]], [[Resolution\|resolution]] 2.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4w4v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4W4V FirstGlance]. <br>		<table><tr><td colspan='2'>[[4w4v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4W4V FirstGlance]. <br>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Mitogen-activated protein kinase]]		[[Category: Mitogen-activated protein kinase]]
	[[Category: Feng, Y]]		[[Category: Feng, Y]]

OCA at 15:07, 15 November 2017

OCA — Wed, 15 Nov 2017 15:07:06 GMT

←Older revision		Revision as of 15:07, 15 November 2017
Line 3:		Line 3:
	<StructureSection load='4w4v' size='340' side='right' caption='[[4w4v]], [[Resolution\|resolution]] 2.01Å' scene=''>		<StructureSection load='4w4v' size='340' side='right' caption='[[4w4v]], [[Resolution\|resolution]] 2.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4w4v]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4W4V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4w4v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4W4V FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3H8:3-(4-{[(2-CHLOROPHENYL)CARBAMOYL]AMINO}-1H-PYRAZOL-1-YL)-N-(2-METHYLPYRIDIN-4-YL)BENZAMIDE'>3H8</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3H8:3-(4-{[(2-CHLOROPHENYL)CARBAMOYL]AMINO}-1H-PYRAZOL-1-YL)-N-(2-METHYLPYRIDIN-4-YL)BENZAMIDE'>3H8</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4w4w\|4w4w]], [[4w4x\|4w4x]], [[4w4y\|4w4y]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4w4w\|4w4w]], [[4w4x\|4w4x]], [[4w4y\|4w4y]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAPK10, JNK3, JNK3A, PRKM10, SAPK1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4w4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w4v OCA], [http://pdbe.org/4w4v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4w4v RCSB], [http://www.ebi.ac.uk/pdbsum/4w4v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4w4v ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4w4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w4v OCA], [http://pdbe.org/4w4v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4w4v RCSB], [http://www.ebi.ac.uk/pdbsum/4w4v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4w4v ProSAT]</span></td></tr>
Line 26:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Mitogen-activated protein kinase]]		[[Category: Mitogen-activated protein kinase]]
	[[Category: Feng, Y]]		[[Category: Feng, Y]]

OCA at 01:17, 19 January 2017

OCA — Thu, 19 Jan 2017 01:17:15 GMT

←Older revision		Revision as of 01:17, 19 January 2017
Line 1:		Line 1:
		+
	==JNK2/3 in complex with 3-(4-{[(2-chlorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide==		==JNK2/3 in complex with 3-(4-{[(2-chlorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide==
	<StructureSection load='4w4v' size='340' side='right' caption='[[4w4v]], [[Resolution\|resolution]] 2.01Å' scene=''>		<StructureSection load='4w4v' size='340' side='right' caption='[[4w4v]], [[Resolution\|resolution]] 2.01Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4w4w\|4w4w]], [[4w4x\|4w4x]], [[4w4y\|4w4y]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4w4w\|4w4w]], [[4w4x\|4w4x]], [[4w4y\|4w4y]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4w4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w4v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4w4v RCSB], [http://www.ebi.ac.uk/pdbsum/4w4v PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4w4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w4v OCA], [http://pdbe.org/4w4v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4w4v RCSB], [http://www.ebi.ac.uk/pdbsum/4w4v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4w4v ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4w4v" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:46, 12 February 2015

OCA — Thu, 12 Feb 2015 11:46:52 GMT

←Older revision		Revision as of 11:46, 12 February 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==JNK2/3 in complex with 3-(4-{[(2-chlorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide==
		+	<StructureSection load='4w4v' size='340' side='right' caption='[[4w4v]], [[Resolution\|resolution]] 2.01Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4w4v]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4W4V FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3H8:3-(4-{[(2-CHLOROPHENYL)CARBAMOYL]AMINO}-1H-PYRAZOL-1-YL)-N-(2-METHYLPYRIDIN-4-YL)BENZAMIDE'>3H8</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4w4w\|4w4w]], [[4w4x\|4w4x]], [[4w4y\|4w4y]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4w4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w4v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4w4v RCSB], [http://www.ebi.ac.uk/pdbsum/4w4v PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/MK10_HUMAN MK10_HUMAN]] Defects in MAPK10 are a cause of epileptic encephalopathy Lennox-Gastaut type (EELG) [MIM:[http://omim.org/entry/606369 606369]]. Epileptic encephalopathies of the Lennox-Gastaut group are childhood epileptic disorders characterized by severe psychomotor delay and seizures. Note=A chromosomal aberration involving MAPK10 has been found in a single patient. Translocation t(Y;4)(q11.2;q21) which causes MAPK10 truncation.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MK10_HUMAN MK10_HUMAN]] Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons.<ref>PMID:11718727</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Three JNK isoforms, JNK1, JNK2, and JNK3 have been reported and unique biological function has been ascribed to each. It is unknown if selective inhibition of these isoforms would confer therapeutic or safety benefit. To probe JNK isoform function we designed JNK2/3 inhibitors that have >30-fold selectivity over JNK1. Utilizing site-directed mutagenesis and x-ray crystallography we identified L144 in JNK3 as a key residue for selectivity. To test whether JNK2/3 selective inhibitors protect human dopaminergic neurons against neurotoxin-induced mitochondrial dysfunction, we monitored reactive oxygen species (ROS) generation and mitochondrial membrane potential (MMP). The results showed that JNK2/3 selective inhibitors protected against 6-hydroxydopamine-induced ROS generation and MMP depolarization. These results suggest that it was possible to develop JNK2/3 selective inhibitors and that residues in hydrophobic pocket I were responsible for selectivity. Moreover, the findings also suggest that inhibition of JNK2/3 likely contributed to protecting mitochondrial function and prevented ultimate cell death.

-	~~The entry 4w4v is ON HOLD until Paper Publication~~	+	Structural Basis and Biological Consequences for JNK2/3 Isoform Selective Aminopyrazoles.,Park H, Iqbal S, Hernandez P, Mora R, Zheng K, Feng Y, LoGrasso P Sci Rep. 2015 Jan 27;5:8047. doi: 10.1038/srep08047. PMID:25623238<ref>PMID:25623238</ref>

-	~~Authors: Park~~, H.~~, Iqbal,~~ S.~~, Hernandez, P., Mora, R., Zheng, K., Feng, Y., LoGrasso, P~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description:~~	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
-	[[Category: ~~Lograsso~~, P]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Mitogen-activated protein kinase]]
		+	[[Category: Feng, Y]]
	[[Category: Hernandez, P]]		[[Category: Hernandez, P]]
-	[[Category: Zheng, K]]
-	[[Category: Park, H]]
-	[[Category: Feng, Y]]
	[[Category: Iqbal, S]]		[[Category: Iqbal, S]]
		+	[[Category: LoGrasso, P]]
	[[Category: Mora, R]]		[[Category: Mora, R]]
		+	[[Category: Park, H]]
		+	[[Category: Zheng, K]]
		+	[[Category: Isoform selective]]
		+	[[Category: Jnk]]
		+	[[Category: Map kinase]]
		+	[[Category: Transferase]]
		+	[[Category: Transferase-transferase inhibitor complex]]

OCA at 19:06, 24 December 2014

OCA — Wed, 24 Dec 2014 19:06:09 GMT

←Older revision		Revision as of 19:06, 24 December 2014
Line 5:		Line 5:
	Authors: Park, H., Iqbal, S., Hernandez, P., Mora, R., Zheng, K., Feng, Y., LoGrasso, P.		Authors: Park, H., Iqbal, S., Hernandez, P., Mora, R., Zheng, K., Feng, Y., LoGrasso, P.

-	Description:	+	Description:
		+	[[Category: Unreleased Structures]]
		+	[[Category: Lograsso, P]]
		+	[[Category: Hernandez, P]]
		+	[[Category: Zheng, K]]
		+	[[Category: Park, H]]
		+	[[Category: Feng, Y]]
		+	[[Category: Iqbal, S]]
		+	[[Category: Mora, R]]

OCA at 13:53, 10 December 2014

OCA — Wed, 10 Dec 2014 13:53:06 GMT

←Older revision		Revision as of 13:53, 10 December 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4w4v is ON HOLD	+	The entry 4w4v is ON HOLD until Paper Publication

	Authors: Park, H., Iqbal, S., Hernandez, P., Mora, R., Zheng, K., Feng, Y., LoGrasso, P.		Authors: Park, H., Iqbal, S., Hernandez, P., Mora, R., Zheng, K., Feng, Y., LoGrasso, P.

	Description:		Description:

OCA: Protected "4w4v" [edit=sysop:move=sysop]

OCA — Wed, 27 Aug 2014 07:26:56 GMT

Protected "4w4v" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:26, 27 August 2014

OCA: New page: '''Unreleased structure''' The entry 4w4v is ON HOLD Authors: Park, H., Iqbal, S., Hernandez, P., Mora, R., Zheng, K., Feng, Y., LoGrasso, P. Description:

OCA — Wed, 27 Aug 2014 07:26:54 GMT

New page: '''Unreleased structure''' The entry 4w4v is ON HOLD Authors: Park, H., Iqbal, S., Hernandez, P., Mora, R., Zheng, K., Feng, Y., LoGrasso, P. Description:

New page

'''Unreleased structure'''

The entry 4w4v is ON HOLD

Authors: Park, H., Iqbal, S., Hernandez, P., Mora, R., Zheng, K., Feng, Y., LoGrasso, P.

Description: