4w9y - Revision history

OCA at 11:50, 1 February 2024

OCA — Thu, 01 Feb 2024 11:50:00 GMT

←Older revision		Revision as of 11:50, 1 February 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4w9y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W9Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4W9Y FirstGlance]. <br>		<table><tr><td colspan='2'>[[4w9y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W9Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4W9Y FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3K0:N-SULFAMOYL-L-GLUTAMIC+ACID'>3K0</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.64Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3K0:N-SULFAMOYL-L-GLUTAMIC+ACID'>3K0</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4w9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w9y OCA], [https://pdbe.org/4w9y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4w9y RCSB], [https://www.ebi.ac.uk/pdbsum/4w9y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4w9y ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4w9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w9y OCA], [https://pdbe.org/4w9y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4w9y RCSB], [https://www.ebi.ac.uk/pdbsum/4w9y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4w9y ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:58, 7 April 2023

OCA — Fri, 07 Apr 2023 06:58:51 GMT

←Older revision		Revision as of 06:58, 7 April 2023
Line 1:		Line 1:

	==X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a glutamyl sulfamide inhibitor CJC47==		==X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a glutamyl sulfamide inhibitor CJC47==
-	<StructureSection load='4w9y' size='340' side='right' caption='[[4w9y]], [[Resolution\|resolution]] 1.64Å' scene=''>	+	<StructureSection load='4w9y' size='340' side='right'caption='[[4w9y]], [[Resolution\|resolution]] 1.64Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4w9y]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W9Y OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4W9Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4w9y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W9Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4W9Y FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3K0:N-SULFAMOYL-L-GLUTAMIC+ACID'>3K0</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3K0:N-SULFAMOYL-L-GLUTAMIC+ACID'>3K0</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FOLH1, FOLH, NAALAD1, PSM, PSMA, GIG27 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4w9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w9y OCA], [https://pdbe.org/4w9y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4w9y RCSB], [https://www.ebi.ac.uk/pdbsum/4w9y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4w9y ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate_carboxypeptidase_II Glutamate carboxypeptidase II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.21 3.4.17.21] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4w9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w9y OCA], [~~http~~://pdbe.org/4w9y PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4w9y RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4w9y PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4w9y ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/FOLH1_HUMAN FOLH1_HUMAN]] Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression. Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.	+	[https://www.uniprot.org/uniprot/FOLH1_HUMAN FOLH1_HUMAN] Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression. Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.
		+
		+	==See Also==
		+	*[[Carboxypeptidase 3D structures\|Carboxypeptidase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Glutamate carboxypeptidase II~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Human~~]]	+	[[Category: Large Structures]]
-	[[Category: Barinka, C]]	+	[[Category: Barinka C]]
-	[[Category: Pavlicek, J]]	+	[[Category: Pavlicek J]]
-	~~[[Category: Glutamyl sulfamide]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Naaladase]]~~	+
-	~~[[Category: Prostate-specific membrane antigen~~]]	+

OCA at 15:13, 16 November 2017

OCA — Thu, 16 Nov 2017 15:13:43 GMT

←Older revision		Revision as of 15:13, 16 November 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 4w9y is ON HOLD~~	+	==X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a glutamyl sulfamide inhibitor CJC47==
-		+	<StructureSection load='4w9y' size='340' side='right' caption='[[4w9y]], [[Resolution\|resolution]] 1.64Å' scene=''>
-	~~Authors: Pavlicek, J., Barinka, C.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4w9y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W9Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4W9Y FirstGlance]. <br>
-	~~Description:~~ X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a glutamyl sulfamide inhibitor CJC47	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3K0:N-SULFAMOYL-L-GLUTAMIC+ACID'>3K0</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FOLH1, FOLH, NAALAD1, PSM, PSMA, GIG27 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate_carboxypeptidase_II Glutamate carboxypeptidase II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.21 3.4.17.21] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4w9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w9y OCA], [http://pdbe.org/4w9y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4w9y RCSB], [http://www.ebi.ac.uk/pdbsum/4w9y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4w9y ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FOLH1_HUMAN FOLH1_HUMAN]] Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression. Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Glutamate carboxypeptidase II]]
		+	[[Category: Human]]
		+	[[Category: Barinka, C]]
	[[Category: Pavlicek, J]]		[[Category: Pavlicek, J]]
-	[[Category: ~~Barinka, C~~]]	+	[[Category: Glutamyl sulfamide]]
		+	[[Category: Hydrolase]]
		+	[[Category: Naaladase]]
		+	[[Category: Prostate-specific membrane antigen]]

OCA at 19:14, 24 December 2014

OCA — Wed, 24 Dec 2014 19:14:31 GMT

←Older revision		Revision as of 19:14, 24 December 2014
Line 6:		Line 6:

	Description: X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a glutamyl sulfamide inhibitor CJC47		Description: X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a glutamyl sulfamide inhibitor CJC47
		+	[[Category: Unreleased Structures]]
		+	[[Category: Pavlicek, J]]
		+	[[Category: Barinka, C]]

OCA: Protected "4w9y" [edit=sysop:move=sysop]

OCA — Thu, 04 Sep 2014 04:51:25 GMT

Protected "4w9y" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:51, 4 September 2014

OCA: New page: '''Unreleased structure''' The entry 4w9y is ON HOLD Authors: Pavlicek, J., Barinka, C. Description: X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a gl...

OCA — Thu, 04 Sep 2014 04:51:24 GMT

New page: '''Unreleased structure''' The entry 4w9y is ON HOLD Authors: Pavlicek, J., Barinka, C. Description: X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a gl...

New page

'''Unreleased structure'''

The entry 4w9y is ON HOLD

Authors: Pavlicek, J., Barinka, C.

Description: X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a glutamyl sulfamide inhibitor CJC47