4whj - Revision history

OCA at 07:31, 27 September 2023

OCA — Wed, 27 Sep 2023 07:31:34 GMT

←Older revision		Revision as of 07:31, 27 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4whj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WHJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WHJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4whj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WHJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WHJ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4whj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4whj OCA], [https://pdbe.org/4whj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4whj RCSB], [https://www.ebi.ac.uk/pdbsum/4whj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4whj ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.2Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4whj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4whj OCA], [https://pdbe.org/4whj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4whj RCSB], [https://www.ebi.ac.uk/pdbsum/4whj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4whj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 07:08, 7 April 2023

OCA — Fri, 07 Apr 2023 07:08:48 GMT

←Older revision		Revision as of 07:08, 7 April 2023
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	==Myxovirus Resistance Protein 2 (MxB)==		==Myxovirus Resistance Protein 2 (MxB)==
-	<StructureSection load='4whj' size='340' side='right' caption='[[4whj]], [[Resolution\|resolution]] 3.20Å' scene=''>	+	<StructureSection load='4whj' size='340' side='right'caption='[[4whj]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4whj]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WHJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4WHJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4whj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WHJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WHJ FirstGlance]. <br>
-	</td></tr>~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MX2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4whj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4whj OCA], [https://pdbe.org/4whj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4whj RCSB], [https://www.ebi.ac.uk/pdbsum/4whj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4whj ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4whj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4whj OCA], [~~http~~://pdbe.org/4whj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4whj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4whj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4whj ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MX2_HUMAN MX2_HUMAN]] Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression.<ref>PMID:15184662</ref> <ref>PMID:24048477</ref> <ref>PMID:24055605</ref> <ref>PMID:24121441</ref>	+	[https://www.uniprot.org/uniprot/MX2_HUMAN MX2_HUMAN] Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression.<ref>PMID:15184662</ref> <ref>PMID:24048477</ref> <ref>PMID:24055605</ref> <ref>PMID:24121441</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 4whj" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4whj" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[GTP-binding protein 3D structures\|GTP-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Fribourgh, J L~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Nguyen, H C~~]]	+	[[Category: Fribourgh JL]]
-	[[Category: ~~Xiong, Y~~]]	+	[[Category: Nguyen HC]]
-	[[Category: ~~4-helix bundle]]~~	+	[[Category: Xiong Y]]
-	~~[[Category: Antiviral protein]]~~	+
-	~~[[Category: Dimer]]~~	+
-	~~[[Category: Gtpase]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 09:25, 22 November 2017

OCA — Wed, 22 Nov 2017 09:25:52 GMT

←Older revision		Revision as of 09:25, 22 November 2017
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	<StructureSection load='4whj' size='340' side='right' caption='[[4whj]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='4whj' size='340' side='right' caption='[[4whj]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4whj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WHJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WHJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4whj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WHJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WHJ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4whj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4whj OCA], [http://pdbe.org/4whj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4whj RCSB], [http://www.ebi.ac.uk/pdbsum/4whj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4whj ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MX2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4whj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4whj OCA], [http://pdbe.org/4whj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4whj RCSB], [http://www.ebi.ac.uk/pdbsum/4whj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4whj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Fribourgh, J L]]		[[Category: Fribourgh, J L]]
	[[Category: Nguyen, H C]]		[[Category: Nguyen, H C]]

OCA at 15:12, 5 August 2016

OCA — Fri, 05 Aug 2016 15:12:15 GMT

←Older revision		Revision as of 15:12, 5 August 2016
Line 1:		Line 1:
		+
	==Myxovirus Resistance Protein 2 (MxB)==		==Myxovirus Resistance Protein 2 (MxB)==
	<StructureSection load='4whj' size='340' side='right' caption='[[4whj]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='4whj' size='340' side='right' caption='[[4whj]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4whj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WHJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WHJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4whj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WHJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WHJ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4whj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4whj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4whj RCSB], [http://www.ebi.ac.uk/pdbsum/4whj PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4whj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4whj OCA], [http://pdbe.org/4whj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4whj RCSB], [http://www.ebi.ac.uk/pdbsum/4whj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4whj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4whj" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:50, 25 December 2014

OCA — Thu, 25 Dec 2014 19:50:40 GMT

←Older revision		Revision as of 19:50, 25 December 2014
Line 5:		Line 5:
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4whj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4whj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4whj RCSB], [http://www.ebi.ac.uk/pdbsum/4whj PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4whj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4whj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4whj RCSB], [http://www.ebi.ac.uk/pdbsum/4whj PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MX2_HUMAN MX2_HUMAN]] Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression.<ref>PMID:15184662</ref> <ref>PMID:24048477</ref> <ref>PMID:24055605</ref> <ref>PMID:24121441</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:33, 10 December 2014

OCA — Wed, 10 Dec 2014 12:33:32 GMT

←Older revision		Revision as of 12:33, 10 December 2014
Line 17:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Fribourgh, J L.]]	+	[[Category: Fribourgh, J L]]
-	[[Category: Nguyen, H C.]]	+	[[Category: Nguyen, H C]]
-	[[Category: Xiong, Y.]]	+	[[Category: Xiong, Y]]
	[[Category: 4-helix bundle]]		[[Category: 4-helix bundle]]
	[[Category: Antiviral protein]]		[[Category: Antiviral protein]]

OCA at 11:21, 29 October 2014

OCA — Wed, 29 Oct 2014 11:21:04 GMT

←Older revision		Revision as of 11:21, 29 October 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Myxovirus Resistance Protein 2 (MxB)==
		+	<StructureSection load='4whj' size='340' side='right' caption='[[4whj]], [[Resolution\|resolution]] 3.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4whj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WHJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WHJ FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4whj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4whj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4whj RCSB], [http://www.ebi.ac.uk/pdbsum/4whj PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The myxovirus resistance (Mx) proteins are interferon-induced dynamin GTPases that can inhibit a variety of viruses. Recently, MxB, but not MxA, was shown to restrict HIV-1 by an unknown mechanism that likely occurs in close proximity to the host cell nucleus and involves the viral capsid. Here, we present the crystal structure of MxB and reveal determinants involved in HIV-1 restriction. MxB adopts an extended antiparallel dimer and dimerization, but not higher-ordered oligomerization, is critical for restriction. Although MxB is structurally similar to MxA, the orientation of individual domains differs between MxA and MxB, and their antiviral functions rely on separate determinants, indicating distinct mechanisms for virus inhibition. Additionally, MxB directly binds the HIV-1 capsid, and this interaction depends on dimerization and the N terminus of MxB as well as the assembled capsid lattice. These insights establish a framework for understanding the mechanism by which MxB restricts HIV-1.

-	~~The entry 4whj is ON HOLD until Paper Publication~~	+	Structural Insight into HIV-1 Restriction by MxB.,Fribourgh JL, Nguyen HC, Matreyek KA, Alvarez FJ, Summers BJ, Dewdney TG, Aiken C, Zhang P, Engelman A, Xiong Y Cell Host Microbe. 2014 Oct 8. pii: S1931-3128(14)00354-0. doi:, 10.1016/j.chom.2014.09.021. PMID:25312384<ref>PMID:25312384</ref>

-	~~Authors: Xiong~~, Y., Fribourgh, J.L., Nguyen, H.C.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~:	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Fribourgh, J L.]]
		+	[[Category: Nguyen, H C.]]
		+	[[Category: Xiong, Y.]]
		+	[[Category: 4-helix bundle]]
		+	[[Category: Antiviral protein]]
		+	[[Category: Dimer]]
		+	[[Category: Gtpase]]
		+	[[Category: Hydrolase]]

OCA at 09:53, 20 October 2014

OCA — Mon, 20 Oct 2014 09:53:18 GMT

←Older revision		Revision as of 09:53, 20 October 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4whj is ON HOLD	+	The entry 4whj is ON HOLD until Paper Publication

	Authors: Xiong, Y., Fribourgh, J.L., Nguyen, H.C.		Authors: Xiong, Y., Fribourgh, J.L., Nguyen, H.C.

	Description:		Description:

OCA: Protected "4whj" [edit=sysop:move=sysop]

OCA — Wed, 01 Oct 2014 23:33:23 GMT

Protected "4whj" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:33, 1 October 2014

OCA: New page: '''Unreleased structure''' The entry 4whj is ON HOLD Authors: Xiong, Y., Fribourgh, J.L., Nguyen, H.C. Description:

OCA — Wed, 01 Oct 2014 23:33:22 GMT

New page: '''Unreleased structure''' The entry 4whj is ON HOLD Authors: Xiong, Y., Fribourgh, J.L., Nguyen, H.C. Description:

New page

'''Unreleased structure'''

The entry 4whj is ON HOLD

Authors: Xiong, Y., Fribourgh, J.L., Nguyen, H.C.

Description: