4wid - Revision history

OCA at 07:20, 1 May 2024

OCA — Wed, 01 May 2024 07:20:18 GMT

←Older revision		Revision as of 07:20, 1 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4wid]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Macacine_betaherpesvirus_3 Macacine betaherpesvirus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WID OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WID FirstGlance]. <br>		<table><tr><td colspan='2'>[[4wid]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Macacine_betaherpesvirus_3 Macacine betaherpesvirus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WID OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WID FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.31Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wid OCA], [https://pdbe.org/4wid PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wid RCSB], [https://www.ebi.ac.uk/pdbsum/4wid PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wid ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wid OCA], [https://pdbe.org/4wid PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wid RCSB], [https://www.ebi.ac.uk/pdbsum/4wid PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wid ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/Q2FAE9_9BETA Q2FAE9_9BETA]		[https://www.uniprot.org/uniprot/Q2FAE9_9BETA Q2FAE9_9BETA]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	PML nuclear bodies (PML-NBs) are enigmatic structures of the cell nucleus that act as key mediators of intrinsic immunity against viral pathogens. PML itself is a member of the E3-ligase TRIM family of proteins that regulates a variety of innate immune signaling pathways. Consequently, viruses have evolved effector proteins to modify PML-NBs; however, little is known concerning structure-function relationships of viral antagonists. The herpesvirus human cytomegalovirus (HCMV) expresses the abundant immediate-early protein IE1 that colocalizes with PML-NBs and induces their dispersal, which correlates with the antagonization of NB-mediated intrinsic immunity. Here, we delineate the molecular basis for this antagonization by presenting the first crystal structure for the evolutionary conserved primate cytomegalovirus IE1 proteins. We show that IE1 consists of a globular core (IE1CORE) flanked by intrinsically disordered regions. The 2.3 A crystal structure of IE1CORE displays an all alpha-helical, femur-shaped fold, which lacks overall fold similarity with known protein structures, but shares secondary structure features recently observed in the coiled-coil domain of TRIM proteins. Yeast two-hybrid and coimmunoprecipitation experiments demonstrate that IE1CORE binds efficiently to the TRIM family member PML, and is able to induce PML deSUMOylation. Intriguingly, this results in the release of NB-associated proteins into the nucleoplasm, but not of PML itself. Importantly, we show that PML deSUMOylation by IE1CORE is sufficient to antagonize PML-NB-instituted intrinsic immunity. Moreover, co-immunoprecipitation experiments demonstrate that IE1CORE binds via the coiled-coil domain to PML and also interacts with TRIM5alpha We propose that IE1CORE sequesters PML and possibly other TRIM family members via structural mimicry using an extended binding surface formed by the coiled-coil region. This mode of interaction might render the antagonizing activity less susceptible to mutational escape.
-
-	Crystal Structure of Cytomegalovirus IE1 Protein Reveals Targeting of TRIM Family Member PML via Coiled-Coil Interactions.,Scherer M, Klingl S, Sevvana M, Otto V, Schilling EM, Stump JD, Muller R, Reuter N, Sticht H, Muller YA, Stamminger T PLoS Pathog. 2014 Nov 20;10(11):e1004512. doi: 10.1371/journal.ppat.1004512., eCollection 2014 Nov. PMID:25412268<ref>PMID:25412268</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4wid" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:09, 7 April 2023

OCA — Fri, 07 Apr 2023 07:09:55 GMT

←Older revision		Revision as of 07:09, 7 April 2023
Line 3:		Line 3:
	<StructureSection load='4wid' size='340' side='right'caption='[[4wid]], [[Resolution\|resolution]] 2.31Å' scene=''>		<StructureSection load='4wid' size='340' side='right'caption='[[4wid]], [[Resolution\|resolution]] 2.31Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4wid]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Cehv-8 Cehv-8~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WID OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4WID FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4wid]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Macacine_betaherpesvirus_3 Macacine betaherpesvirus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WID OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WID FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, ~~<scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene><~~/td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wid OCA], [https://pdbe.org/4wid PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wid RCSB], [https://www.ebi.ac.uk/pdbsum/4wid PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wid ProSAT]</span></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td>~~<td class="sblockDat">[[4w1c\|4w1c]]~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4wid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wid OCA], [~~http~~://pdbe.org/4wid PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4wid RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4wid PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4wid ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q2FAE9_9BETA Q2FAE9_9BETA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Cehv-8]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Klingl, S]]	+	[[Category: Macacine betaherpesvirus 3]]
-	[[Category: Muller~~, Y A~~]]	+	[[Category: Klingl S]]
-	[[Category: Scherer, M]]	+	[[Category: Muller YA]]
-	[[Category: Sevvana, M]]	+	[[Category: Scherer M]]
-	[[Category: Stamminger, T]]	+	[[Category: Sevvana M]]
-	~~[[Category: Antagonist]]~~	+	[[Category: Stamminger T]]
-	~~[[Category: Cytomegalovirus]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 09:06, 23 May 2019

OCA — Thu, 23 May 2019 09:06:21 GMT

←Older revision		Revision as of 09:06, 23 May 2019
Line 1:		Line 1:

	==Crystal structure of the immediate-early 1 protein (IE1) at 2.31 angstrom (tetragonal form after crystal dehydration)==		==Crystal structure of the immediate-early 1 protein (IE1) at 2.31 angstrom (tetragonal form after crystal dehydration)==
-	<StructureSection load='4wid' size='340' side='right' caption='[[4wid]], [[Resolution\|resolution]] 2.31Å' scene=''>	+	<StructureSection load='4wid' size='340' side='right'caption='[[4wid]], [[Resolution\|resolution]] 2.31Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4wid]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WID OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WID FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4wid]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cehv-8 Cehv-8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WID OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WID FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene></td></tr>
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Cehv-8]]
		+	[[Category: Large Structures]]
	[[Category: Klingl, S]]		[[Category: Klingl, S]]
	[[Category: Muller, Y A]]		[[Category: Muller, Y A]]

OCA at 00:24, 26 January 2017

OCA — Thu, 26 Jan 2017 00:24:16 GMT

←Older revision		Revision as of 00:24, 26 January 2017
Line 1:		Line 1:
		+
	==Crystal structure of the immediate-early 1 protein (IE1) at 2.31 angstrom (tetragonal form after crystal dehydration)==		==Crystal structure of the immediate-early 1 protein (IE1) at 2.31 angstrom (tetragonal form after crystal dehydration)==
	<StructureSection load='4wid' size='340' side='right' caption='[[4wid]], [[Resolution\|resolution]] 2.31Å' scene=''>		<StructureSection load='4wid' size='340' side='right' caption='[[4wid]], [[Resolution\|resolution]] 2.31Å' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4w1c\|4w1c]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4w1c\|4w1c]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wid OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wid RCSB], [http://www.ebi.ac.uk/pdbsum/4wid PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wid OCA], [http://pdbe.org/4wid PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wid RCSB], [http://www.ebi.ac.uk/pdbsum/4wid PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wid ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4wid" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:11, 10 December 2014

OCA — Wed, 10 Dec 2014 12:11:57 GMT

←Older revision		Revision as of 12:11, 10 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wid OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wid RCSB], [http://www.ebi.ac.uk/pdbsum/4wid PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wid OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wid RCSB], [http://www.ebi.ac.uk/pdbsum/4wid PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	PML nuclear bodies (PML-NBs) are enigmatic structures of the cell nucleus that act as key mediators of intrinsic immunity against viral pathogens. PML itself is a member of the E3-ligase TRIM family of proteins that regulates a variety of innate immune signaling pathways. Consequently, viruses have evolved effector proteins to modify PML-NBs; however, little is known concerning structure-function relationships of viral antagonists. The herpesvirus human cytomegalovirus (HCMV) expresses the abundant immediate-early protein IE1 that colocalizes with PML-NBs and induces their dispersal, which correlates with the antagonization of NB-mediated intrinsic immunity. Here, we delineate the molecular basis for this antagonization by presenting the first crystal structure for the evolutionary conserved primate cytomegalovirus IE1 proteins. We show that IE1 consists of a globular core (IE1CORE) flanked by intrinsically disordered regions. The 2.3 A crystal structure of IE1CORE displays an all alpha-helical, femur-shaped fold, which lacks overall fold similarity with known protein structures, but shares secondary structure features recently observed in the coiled-coil domain of TRIM proteins. Yeast two-hybrid and coimmunoprecipitation experiments demonstrate that IE1CORE binds efficiently to the TRIM family member PML, and is able to induce PML deSUMOylation. Intriguingly, this results in the release of NB-associated proteins into the nucleoplasm, but not of PML itself. Importantly, we show that PML deSUMOylation by IE1CORE is sufficient to antagonize PML-NB-instituted intrinsic immunity. Moreover, co-immunoprecipitation experiments demonstrate that IE1CORE binds via the coiled-coil domain to PML and also interacts with TRIM5alpha We propose that IE1CORE sequesters PML and possibly other TRIM family members via structural mimicry using an extended binding surface formed by the coiled-coil region. This mode of interaction might render the antagonizing activity less susceptible to mutational escape.
		+
		+	Crystal Structure of Cytomegalovirus IE1 Protein Reveals Targeting of TRIM Family Member PML via Coiled-Coil Interactions.,Scherer M, Klingl S, Sevvana M, Otto V, Schilling EM, Stump JD, Muller R, Reuter N, Sticht H, Muller YA, Stamminger T PLoS Pathog. 2014 Nov 20;10(11):e1004512. doi: 10.1371/journal.ppat.1004512., eCollection 2014 Nov. PMID:25412268<ref>PMID:25412268</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Klingl, S.]]	+	[[Category: Klingl, S]]
-	[[Category: Muller, Y A.]]	+	[[Category: Muller, Y A]]
-	[[Category: Scherer, M.]]	+	[[Category: Scherer, M]]
-	[[Category: Sevvana, M.]]	+	[[Category: Sevvana, M]]
-	[[Category: Stamminger, T.]]	+	[[Category: Stamminger, T]]
	[[Category: Antagonist]]		[[Category: Antagonist]]
	[[Category: Cytomegalovirus]]		[[Category: Cytomegalovirus]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 11:34, 29 October 2014

OCA — Wed, 29 Oct 2014 11:34:26 GMT

←Older revision		Revision as of 11:34, 29 October 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of the immediate-early 1 protein (IE1) at 2.31 angstrom (tetragonal form after crystal dehydration)==
-		+	<StructureSection load='4wid' size='340' side='right' caption='[[4wid]], [[Resolution\|resolution]] 2.31Å' scene=''>
-	~~The entry~~ 4wid is ~~ON HOLD until Sep 25 2016~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4wid]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WID OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WID FirstGlance]. <br>
-	~~Authors~~: ~~Klingl~~, S., ~~Scherer, M~~., ~~Sevvana~~, M., Muller, Y.A., Stamminger, T.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene></td></tr>
-	~~Description~~: ~~Crystal structure of the immediate-early 1~~ protein ~~(IE1) at 2.31 angstrom (tetragonal form after crystal dehydration)~~	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4w1c\|4w1c]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wid OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wid RCSB], [http://www.ebi.ac.uk/pdbsum/4wid PDBsum]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Klingl, S.]]
		+	[[Category: Muller, Y A.]]
		+	[[Category: Scherer, M.]]
		+	[[Category: Sevvana, M.]]
		+	[[Category: Stamminger, T.]]
		+	[[Category: Antagonist]]
		+	[[Category: Cytomegalovirus]]
		+	[[Category: Viral protein]]

OCA at 06:56, 8 October 2014

OCA — Wed, 08 Oct 2014 06:56:33 GMT

←Older revision		Revision as of 06:56, 8 October 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4wid is ON HOLD	+	The entry 4wid is ON HOLD until Sep 25 2016

	Authors: Klingl, S., Scherer, M., Sevvana, M., Muller, Y.A., Stamminger, T.		Authors: Klingl, S., Scherer, M., Sevvana, M., Muller, Y.A., Stamminger, T.

	Description: Crystal structure of the immediate-early 1 protein (IE1) at 2.31 angstrom (tetragonal form after crystal dehydration)		Description: Crystal structure of the immediate-early 1 protein (IE1) at 2.31 angstrom (tetragonal form after crystal dehydration)

OCA: Protected "4wid" [edit=sysop:move=sysop]

OCA — Wed, 01 Oct 2014 23:34:41 GMT

Protected "4wid" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:34, 1 October 2014

OCA: New page: '''Unreleased structure''' The entry 4wid is ON HOLD Authors: Klingl, S., Scherer, M., Sevvana, M., Muller, Y.A., Stamminger, T. Description: Crystal structure of the immediate-early 1...

OCA — Wed, 01 Oct 2014 23:34:39 GMT

New page: '''Unreleased structure''' The entry 4wid is ON HOLD Authors: Klingl, S., Scherer, M., Sevvana, M., Muller, Y.A., Stamminger, T. Description: Crystal structure of the immediate-early 1...

New page

'''Unreleased structure'''

The entry 4wid is ON HOLD

Authors: Klingl, S., Scherer, M., Sevvana, M., Muller, Y.A., Stamminger, T.

Description: Crystal structure of the immediate-early 1 protein (IE1) at 2.31 angstrom (tetragonal form after crystal dehydration)