4wn1 - Revision history

OCA at 00:54, 28 December 2023

OCA — Thu, 28 Dec 2023 00:54:22 GMT

←Older revision		Revision as of 00:54, 28 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4wn1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WN1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WN1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4wn1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WN1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WN1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3SJ:1-METHYL-5-(1-METHYL-3-{[4-(QUINOLIN-2-YL)PHENOXY]METHYL}-1H-PYRAZOL-4-YL)PYRIDIN-2(1H)-ONE'>3SJ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.13Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3SJ:1-METHYL-5-(1-METHYL-3-{[4-(QUINOLIN-2-YL)PHENOXY]METHYL}-1H-PYRAZOL-4-YL)PYRIDIN-2(1H)-ONE'>3SJ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wn1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wn1 OCA], [https://pdbe.org/4wn1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wn1 RCSB], [https://www.ebi.ac.uk/pdbsum/4wn1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wn1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wn1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wn1 OCA], [https://pdbe.org/4wn1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wn1 RCSB], [https://www.ebi.ac.uk/pdbsum/4wn1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wn1 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:16, 7 April 2023

OCA — Fri, 07 Apr 2023 07:16:41 GMT

←Older revision		Revision as of 07:16, 7 April 2023
Line 3:		Line 3:
	<StructureSection load='4wn1' size='340' side='right'caption='[[4wn1]], [[Resolution\|resolution]] 3.13Å' scene=''>		<StructureSection load='4wn1' size='340' side='right'caption='[[4wn1]], [[Resolution\|resolution]] 3.13Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4wn1]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WN1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4WN1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4wn1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WN1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WN1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3SJ:1-METHYL-5-(1-METHYL-3-{[4-(QUINOLIN-2-YL)PHENOXY]METHYL}-1H-PYRAZOL-4-YL)PYRIDIN-2(1H)-ONE'>3SJ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3SJ:1-METHYL-5-(1-METHYL-3-{[4-(QUINOLIN-2-YL)PHENOXY]METHYL}-1H-PYRAZOL-4-YL)PYRIDIN-2(1H)-ONE'>3SJ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE10A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wn1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wn1 OCA], [https://pdbe.org/4wn1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wn1 RCSB], [https://www.ebi.ac.uk/pdbsum/4wn1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wn1 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4wn1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wn1 OCA], [~~http~~://pdbe.org/4wn1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4wn1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4wn1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4wn1 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>	+	[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 20:

	==See Also==		==See Also==
-	*[[Phosphodiesterase\|Phosphodiesterase]]	+	*[[Phosphodiesterase 3D structures\|Phosphodiesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Amano, Y]]	+	[[Category: Amano Y]]
-	[[Category: Honbou, K]]	+	[[Category: Honbou K]]
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Phosphodiesterase~~]]	+

OCA at 09:04, 23 May 2019

OCA — Thu, 23 May 2019 09:04:42 GMT

←Older revision		Revision as of 09:04, 23 May 2019
Line 1:		Line 1:

	==Crystal structure of PDE10A in complex with 1-methyl-5-(1-methyl-3-{[4-(quinolin-2-yl)phenoxy]methyl}-1H-pyrazol-4-yl)pyridin-2(1H)-one==		==Crystal structure of PDE10A in complex with 1-methyl-5-(1-methyl-3-{[4-(quinolin-2-yl)phenoxy]methyl}-1H-pyrazol-4-yl)pyridin-2(1H)-one==
-	<StructureSection load='4wn1' size='340' side='right' caption='[[4wn1]], [[Resolution\|resolution]] 3.13Å' scene=''>	+	<StructureSection load='4wn1' size='340' side='right'caption='[[4wn1]], [[Resolution\|resolution]] 3.13Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4wn1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WN1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WN1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4wn1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WN1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WN1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3SJ:1-METHYL-5-(1-METHYL-3-{[4-(QUINOLIN-2-YL)PHENOXY]METHYL}-1H-PYRAZOL-4-YL)PYRIDIN-2(1H)-ONE'>3SJ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3SJ:1-METHYL-5-(1-METHYL-3-{[4-(QUINOLIN-2-YL)PHENOXY]METHYL}-1H-PYRAZOL-4-YL)PYRIDIN-2(1H)-ONE'>3SJ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE10A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wn1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wn1 OCA], [http://pdbe.org/4wn1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wn1 RCSB], [http://www.ebi.ac.uk/pdbsum/4wn1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wn1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wn1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wn1 OCA], [http://pdbe.org/4wn1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wn1 RCSB], [http://www.ebi.ac.uk/pdbsum/4wn1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wn1 ProSAT]</span></td></tr>
	</table>		</table>
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4wn1" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4wn1" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Phosphodiesterase\|Phosphodiesterase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Amano, Y]]		[[Category: Amano, Y]]
	[[Category: Honbou, K]]		[[Category: Honbou, K]]
	[[Category: Complex]]		[[Category: Complex]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Inhibitor]]		[[Category: Inhibitor]]
	[[Category: Phosphodiesterase]]		[[Category: Phosphodiesterase]]

OCA at 14:01, 11 August 2016

OCA — Thu, 11 Aug 2016 14:01:13 GMT

←Older revision		Revision as of 14:01, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of PDE10A in complex with 1-methyl-5-(1-methyl-3-{[4-(quinolin-2-yl)phenoxy]methyl}-1H-pyrazol-4-yl)pyridin-2(1H)-one==		==Crystal structure of PDE10A in complex with 1-methyl-5-(1-methyl-3-{[4-(quinolin-2-yl)phenoxy]methyl}-1H-pyrazol-4-yl)pyridin-2(1H)-one==
	<StructureSection load='4wn1' size='340' side='right' caption='[[4wn1]], [[Resolution\|resolution]] 3.13Å' scene=''>		<StructureSection load='4wn1' size='340' side='right' caption='[[4wn1]], [[Resolution\|resolution]] 3.13Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4wn1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WN1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WN1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4wn1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WN1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WN1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3SJ:1-METHYL-5-(1-METHYL-3-{[4-(QUINOLIN-2-YL)PHENOXY]METHYL}-1H-PYRAZOL-4-YL)PYRIDIN-2(1H)-ONE'>3SJ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3SJ:1-METHYL-5-(1-METHYL-3-{[4-(QUINOLIN-2-YL)PHENOXY]METHYL}-1H-PYRAZOL-4-YL)PYRIDIN-2(1H)-ONE'>3SJ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wn1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wn1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wn1 RCSB], [http://www.ebi.ac.uk/pdbsum/4wn1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wn1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wn1 OCA], [http://pdbe.org/4wn1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wn1 RCSB], [http://www.ebi.ac.uk/pdbsum/4wn1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wn1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4wn1" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:43, 31 December 2014

OCA — Wed, 31 Dec 2014 14:43:08 GMT

←Older revision		Revision as of 14:43, 31 December 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of PDE10A in complex with 1-methyl-5-(1-methyl-3-{[4-(quinolin-2-yl)phenoxy]methyl}-1H-pyrazol-4-yl)pyridin-2(1H)-one==
		+	<StructureSection load='4wn1' size='340' side='right' caption='[[4wn1]], [[Resolution\|resolution]] 3.13Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4wn1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WN1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WN1 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3SJ:1-METHYL-5-(1-METHYL-3-{[4-(QUINOLIN-2-YL)PHENOXY]METHYL}-1H-PYRAZOL-4-YL)PYRIDIN-2(1H)-ONE'>3SJ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wn1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wn1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wn1 RCSB], [http://www.ebi.ac.uk/pdbsum/4wn1 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A novel class of phosphodiesterase 10A inhibitors with potent PDE10A inhibitory activity and reduced CYP3A4 inhibition was designed and synthesized starting from 2-[4-({[1-methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl]oxy}methyl)phenyl]quinoline (1). Replacement of pyridine ring of 1 with N-methyl pyridone ring drastically improved CYP3A4 inhibition, and further optimization of these quinoline analogues identified 1-methyl-5-(1-methyl-3-{[4-(quinolin-2-yl)phenoxy]methyl}-1H-pyrazol-4-yl)pyridin -2(1H)-one (42b), which showed potent PDE10A inhibitory activity and a good CYP3A4 inhibition profile. A PET study with 11C-labeled 42b indicated that 42b exhibited good brain penetration and specifically accumulated in the rodent striatum. Further, oral administration of 42b dose-dependently attenuated phencyclidine-induced hyperlocomotion in mice with an ED50 value of 2.0mg/kg and improved visual-recognition memory impairment at 0.1 and 0.3mg/kg in mice novel object recognition test.

-	~~The entry 4wn1 is ON HOLD until Paper Publication~~	+	Synthesis, SAR study, and biological evaluation of novel quinoline derivatives as phosphodiesterase 10A inhibitors with reduced CYP3A4 inhibition.,Hamaguchi W, Masuda N, Miyamoto S, Shiina Y, Kikuchi S, Mihara T, Moriguchi H, Fushiki H, Murakami Y, Amano Y, Honbou K, Hattori K Bioorg Med Chem. 2014 Dec 3. pii: S0968-0896(14)00834-7. doi:, 10.1016/j.bmc.2014.11.039. PMID:25515954<ref>PMID:25515954</ref>

-	~~Authors: Amano~~, Y.~~, Honbou, K~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: Crystal structure of PDE10A in complex with 1-methyl-5-(1-methyl-3-{[4-(quinolin-2-yl)phenoxy]methyl}-1H-pyrazol-4-yl)pyridin-2(1H)-one~~	+	== References ==
-	~~[[Category: Unreleased Structures]]~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Amano, Y]]		[[Category: Amano, Y]]
	[[Category: Honbou, K]]		[[Category: Honbou, K]]
		+	[[Category: Complex]]
		+	[[Category: Inhibitor]]
		+	[[Category: Phosphodiesterase]]

OCA at 19:43, 24 December 2014

OCA — Wed, 24 Dec 2014 19:43:00 GMT

←Older revision		Revision as of 19:43, 24 December 2014
Line 6:		Line 6:

	Description: Crystal structure of PDE10A in complex with 1-methyl-5-(1-methyl-3-{[4-(quinolin-2-yl)phenoxy]methyl}-1H-pyrazol-4-yl)pyridin-2(1H)-one		Description: Crystal structure of PDE10A in complex with 1-methyl-5-(1-methyl-3-{[4-(quinolin-2-yl)phenoxy]methyl}-1H-pyrazol-4-yl)pyridin-2(1H)-one
		+	[[Category: Unreleased Structures]]
		+	[[Category: Amano, Y]]
		+	[[Category: Honbou, K]]

OCA at 10:31, 29 October 2014

OCA — Wed, 29 Oct 2014 10:31:51 GMT

←Older revision		Revision as of 10:31, 29 October 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4wn1 is ON HOLD	+	The entry 4wn1 is ON HOLD until Paper Publication

	Authors: Amano, Y., Honbou, K.		Authors: Amano, Y., Honbou, K.

	Description: Crystal structure of PDE10A in complex with 1-methyl-5-(1-methyl-3-{[4-(quinolin-2-yl)phenoxy]methyl}-1H-pyrazol-4-yl)pyridin-2(1H)-one		Description: Crystal structure of PDE10A in complex with 1-methyl-5-(1-methyl-3-{[4-(quinolin-2-yl)phenoxy]methyl}-1H-pyrazol-4-yl)pyridin-2(1H)-one

OCA: Protected "4wn1" [edit=sysop:move=sysop]

OCA — Mon, 20 Oct 2014 09:59:40 GMT

Protected "4wn1" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:59, 20 October 2014

OCA: New page: '''Unreleased structure''' The entry 4wn1 is ON HOLD Authors: Amano, Y., Honbou, K. Description: Crystal structure of PDE10A in complex with 1-methyl-5-(1-methyl-3-{[4-(quinolin-2-yl)p...

OCA — Mon, 20 Oct 2014 09:59:38 GMT

New page: '''Unreleased structure''' The entry 4wn1 is ON HOLD Authors: Amano, Y., Honbou, K. Description: Crystal structure of PDE10A in complex with 1-methyl-5-(1-methyl-3-{[4-(quinolin-2-yl)p...

New page

'''Unreleased structure'''

The entry 4wn1 is ON HOLD

Authors: Amano, Y., Honbou, K.

Description: Crystal structure of PDE10A in complex with 1-methyl-5-(1-methyl-3-{[4-(quinolin-2-yl)phenoxy]methyl}-1H-pyrazol-4-yl)pyridin-2(1H)-one