4wq6 - Revision history

OCA at 07:35, 27 September 2023

OCA — Wed, 27 Sep 2023 07:35:07 GMT

←Older revision		Revision as of 07:35, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4wq6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WQ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WQ6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4wq6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WQ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WQ6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3TQ:N-(4-{(S)-[1-(2-METHYLPROPYL)PIPERIDIN-4-YL]SULFINYL}BENZYL)FURO[2,3-C]PYRIDINE-2-CARBOXAMIDE'>3TQ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.72Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3TQ:N-(4-{(S)-[1-(2-METHYLPROPYL)PIPERIDIN-4-YL]SULFINYL}BENZYL)FURO[2,3-C]PYRIDINE-2-CARBOXAMIDE'>3TQ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wq6 OCA], [https://pdbe.org/4wq6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wq6 RCSB], [https://www.ebi.ac.uk/pdbsum/4wq6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wq6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wq6 OCA], [https://pdbe.org/4wq6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wq6 RCSB], [https://www.ebi.ac.uk/pdbsum/4wq6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wq6 ProSAT]</span></td></tr>
	</table>		</table>
Line 20:		Line 21:

	==See Also==		==See Also==
		+	*[[Glycosyltransferase 3D structures\|Glycosyltransferase 3D structures]]
	*[[Phosphoribosyltransferase 3D structures\|Phosphoribosyltransferase 3D structures]]		*[[Phosphoribosyltransferase 3D structures\|Phosphoribosyltransferase 3D structures]]
	== References ==		== References ==

OCA at 07:20, 7 April 2023

OCA — Fri, 07 Apr 2023 07:20:54 GMT

←Older revision		Revision as of 07:20, 7 April 2023
Line 3:		Line 3:
	<StructureSection load='4wq6' size='340' side='right'caption='[[4wq6]], [[Resolution\|resolution]] 1.72Å' scene=''>		<StructureSection load='4wq6' size='340' side='right'caption='[[4wq6]], [[Resolution\|resolution]] 1.72Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4wq6]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WQ6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4WQ6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4wq6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WQ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WQ6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3TQ:N-(4-{(S)-[1-(2-METHYLPROPYL)PIPERIDIN-4-YL]SULFINYL}BENZYL)FURO[2,3-C]PYRIDINE-2-CARBOXAMIDE'>3TQ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3TQ:N-(4-{(S)-[1-(2-METHYLPROPYL)PIPERIDIN-4-YL]SULFINYL}BENZYL)FURO[2,3-C]PYRIDINE-2-CARBOXAMIDE'>3TQ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NAMPT, PBEF, PBEF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wq6 OCA], [https://pdbe.org/4wq6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wq6 RCSB], [https://www.ebi.ac.uk/pdbsum/4wq6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wq6 ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4wq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wq6 OCA], [~~http~~://pdbe.org/4wq6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4wq6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4wq6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4wq6 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).	+	[https://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:

	==See Also==		==See Also==
-	*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]	+	*[[Phosphoribosyltransferase 3D structures\|Phosphoribosyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Nicotinamide phosphoribosyltransferase]]~~	+	[[Category: Li D]]
-	[[Category: Li, D]]	+	[[Category: Wang W]]
-	[[Category: Wang, W]]	+
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 08:10, 23 May 2019

OCA — Thu, 23 May 2019 08:10:15 GMT

←Older revision		Revision as of 08:10, 23 May 2019
Line 1:		Line 1:

	==The crystal structure of human Nicotinamide phosphoribosyltransferase (NAMPT) in complex with N-(4-{(S)-[1-(2-methylpropyl)piperidin-4-yl]sulfinyl}benzyl)furo[2,3-c]pyridine-2-carboxamide inhibitor (compound 21)==		==The crystal structure of human Nicotinamide phosphoribosyltransferase (NAMPT) in complex with N-(4-{(S)-[1-(2-methylpropyl)piperidin-4-yl]sulfinyl}benzyl)furo[2,3-c]pyridine-2-carboxamide inhibitor (compound 21)==
-	<StructureSection load='4wq6' size='340' side='right' caption='[[4wq6]], [[Resolution\|resolution]] 1.72Å' scene=''>	+	<StructureSection load='4wq6' size='340' side='right'caption='[[4wq6]], [[Resolution\|resolution]] 1.72Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4wq6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WQ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WQ6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4wq6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WQ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WQ6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3TQ:N-(4-{(S)-[1-(2-METHYLPROPYL)PIPERIDIN-4-YL]SULFINYL}BENZYL)FURO[2,3-C]PYRIDINE-2-CARBOXAMIDE'>3TQ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3TQ:N-(4-{(S)-[1-(2-METHYLPROPYL)PIPERIDIN-4-YL]SULFINYL}BENZYL)FURO[2,3-C]PYRIDINE-2-CARBOXAMIDE'>3TQ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NAMPT, PBEF, PBEF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wq6 OCA], [http://pdbe.org/4wq6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wq6 RCSB], [http://www.ebi.ac.uk/pdbsum/4wq6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wq6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wq6 OCA], [http://pdbe.org/4wq6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wq6 RCSB], [http://www.ebi.ac.uk/pdbsum/4wq6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wq6 ProSAT]</span></td></tr>
Line 26:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Nicotinamide phosphoribosyltransferase]]		[[Category: Nicotinamide phosphoribosyltransferase]]
	[[Category: Li, D]]		[[Category: Li, D]]
	[[Category: Wang, W]]		[[Category: Wang, W]]
	[[Category: Transferase-transferase inhibitor complex]]		[[Category: Transferase-transferase inhibitor complex]]

OCA at 00:18, 26 January 2017

OCA — Thu, 26 Jan 2017 00:18:36 GMT

←Older revision		Revision as of 00:18, 26 January 2017
Line 1:		Line 1:
		+
	==The crystal structure of human Nicotinamide phosphoribosyltransferase (NAMPT) in complex with N-(4-{(S)-[1-(2-methylpropyl)piperidin-4-yl]sulfinyl}benzyl)furo[2,3-c]pyridine-2-carboxamide inhibitor (compound 21)==		==The crystal structure of human Nicotinamide phosphoribosyltransferase (NAMPT) in complex with N-(4-{(S)-[1-(2-methylpropyl)piperidin-4-yl]sulfinyl}benzyl)furo[2,3-c]pyridine-2-carboxamide inhibitor (compound 21)==
	<StructureSection load='4wq6' size='340' side='right' caption='[[4wq6]], [[Resolution\|resolution]] 1.72Å' scene=''>		<StructureSection load='4wq6' size='340' side='right' caption='[[4wq6]], [[Resolution\|resolution]] 1.72Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3TQ:N-(4-{(S)-[1-(2-METHYLPROPYL)PIPERIDIN-4-YL]SULFINYL}BENZYL)FURO[2,3-C]PYRIDINE-2-CARBOXAMIDE'>3TQ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3TQ:N-(4-{(S)-[1-(2-METHYLPROPYL)PIPERIDIN-4-YL]SULFINYL}BENZYL)FURO[2,3-C]PYRIDINE-2-CARBOXAMIDE'>3TQ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wq6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wq6 RCSB], [http://www.ebi.ac.uk/pdbsum/4wq6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wq6 OCA], [http://pdbe.org/4wq6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wq6 RCSB], [http://www.ebi.ac.uk/pdbsum/4wq6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wq6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4wq6" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:45, 12 February 2015

OCA — Thu, 12 Feb 2015 11:45:28 GMT

←Older revision		Revision as of 11:45, 12 February 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==The crystal structure of human Nicotinamide phosphoribosyltransferase (NAMPT) in complex with N-(4-{(S)-[1-(2-methylpropyl)piperidin-4-yl]sulfinyl}benzyl)furo[2,3-c]pyridine-2-carboxamide inhibitor (compound 21)==
		+	<StructureSection load='4wq6' size='340' side='right' caption='[[4wq6]], [[Resolution\|resolution]] 1.72Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4wq6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WQ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WQ6 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3TQ:N-(4-{(S)-[1-(2-METHYLPROPYL)PIPERIDIN-4-YL]SULFINYL}BENZYL)FURO[2,3-C]PYRIDINE-2-CARBOXAMIDE'>3TQ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wq6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wq6 RCSB], [http://www.ebi.ac.uk/pdbsum/4wq6 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Herein we report the optimization efforts to ameliorate the potent CYP3A4 time-dependent inhibition (TDI) and low aqueous solubility exhibited by a previously identified lead compound from our NAMPT inhibitor program (1, GNE-617). Metabolite identification studies pinpointed the imidazopyridine moiety present in 1 as the likely source of the TDI signal, and replacement with other bicyclic systems was found to reduce or eliminate the TDI finding. A strategy of reducing the number of aromatic rings and/or lowering cLogD7.4 was then employed to significantly improve aqueous solubility. These efforts culminated in the discovery of 42, a compound with no evidence of TDI, improved aqueous solubility, and robust efficacy in tumor xenograft studies.

-	~~The entry 4wq6 is ON HOLD until Paper Publication~~	+	Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility.,Zak M, Liederer BM, Sampath D, Yuen PW, Bair KW, Baumeister T, Buckmelter AJ, Clodfelter KH, Cheng E, Crocker L, Fu B, Han B, Li G, Ho YC, Lin J, Liu X, Ly J, O'Brien T, Reynolds DJ, Skelton N, Smith CC, Tay S, Wang W, Wang Z, Xiao Y, Zhang L, Zhao G, Zheng X, Dragovich PS Bioorg Med Chem Lett. 2015 Feb 1;25(3):529-41. doi: 10.1016/j.bmcl.2014.12.026., Epub 2014 Dec 17. PMID:25556090<ref>PMID:25556090</ref>

-	~~Authors: Li~~, D.~~, Wang, W~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description:~~	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Nicotinamide phosphoribosyltransferase]]
	[[Category: Li, D]]		[[Category: Li, D]]
	[[Category: Wang, W]]		[[Category: Wang, W]]
		+	[[Category: Transferase-transferase inhibitor complex]]

OCA at 19:51, 24 December 2014

OCA — Wed, 24 Dec 2014 19:51:39 GMT

←Older revision		Revision as of 19:51, 24 December 2014
Line 5:		Line 5:
	Authors: Li, D., Wang, W.		Authors: Li, D., Wang, W.

-	Description:	+	Description:
		+	[[Category: Unreleased Structures]]
		+	[[Category: Li, D]]
		+	[[Category: Wang, W]]

OCA at 11:55, 19 November 2014

OCA — Wed, 19 Nov 2014 11:55:10 GMT

←Older revision		Revision as of 11:55, 19 November 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4wq6 is ON HOLD	+	The entry 4wq6 is ON HOLD until Paper Publication

-	Authors: Li, D., Li, S.	+	Authors: Li, D., Wang, W.

	Description:		Description:

OCA at 08:05, 5 November 2014

OCA — Wed, 05 Nov 2014 08:05:21 GMT

←Older revision		Revision as of 08:05, 5 November 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4wq6 is ON HOLD ~~until sometime in the future~~	+	The entry 4wq6 is ON HOLD

-	Authors: Li, D, Li, S	+	Authors: Li, D., Li, S.

-	Description: ~~The crystal structure of human Nicotinamide phosphoribosyltransferase (NAMPT) in complex with an inhibitor -compound 21~~	+	Description:

OCA: Protected "4wq6" [edit=sysop:move=sysop]

OCA — Wed, 29 Oct 2014 10:35:00 GMT

Protected "4wq6" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:35, 29 October 2014

OCA: New page: '''Unreleased structure''' The entry 4wq6 is ON HOLD until sometime in the future Authors: Li, D, Li, S Description: The crystal structure of human Nicotinamide phosphoribosyltransfera...

OCA — Wed, 29 Oct 2014 10:34:58 GMT

New page: '''Unreleased structure''' The entry 4wq6 is ON HOLD until sometime in the future Authors: Li, D, Li, S Description: The crystal structure of human Nicotinamide phosphoribosyltransfera...

New page

'''Unreleased structure'''

The entry 4wq6 is ON HOLD until sometime in the future

Authors: Li, D, Li, S

Description: The crystal structure of human Nicotinamide phosphoribosyltransferase (NAMPT) in complex with an inhibitor -compound 21