4wsu - Revision history

OCA at 00:55, 28 December 2023

OCA — Thu, 28 Dec 2023 00:55:17 GMT

←Older revision		Revision as of 00:55, 28 December 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4wsu]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WSU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WSU FirstGlance]. <br>		<table><tr><td colspan='2'>[[4wsu]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WSU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WSU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wsu OCA], [https://pdbe.org/4wsu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wsu RCSB], [https://www.ebi.ac.uk/pdbsum/4wsu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wsu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wsu OCA], [https://pdbe.org/4wsu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wsu RCSB], [https://www.ebi.ac.uk/pdbsum/4wsu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wsu ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:24, 7 April 2023

OCA — Fri, 07 Apr 2023 07:24:37 GMT

←Older revision		Revision as of 07:24, 7 April 2023
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	<StructureSection load='4wsu' size='340' side='right'caption='[[4wsu]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='4wsu' size='340' side='right'caption='[[4wsu]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4wsu]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~9infa 9infa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WSU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4WSU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4wsu]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WSU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WSU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4wsr\|4wsr]], [[4wss\|4wss]], [[4wst\|4wst]], [[4wsv\|4wsv]], [[4wsw\|4wsw]], [[4wsx\|4wsx]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wsu OCA], [https://pdbe.org/4wsu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wsu RCSB], [https://www.ebi.ac.uk/pdbsum/4wsu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wsu ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4wsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wsu OCA], [~~http~~://pdbe.org/4wsu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4wsu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4wsu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4wsu ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0J9X246_9INFA A0A0J9X246_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
-	*[[Hemagglutinin\|Hemagglutinin]]	+	*[[Hemagglutinin 3D structures\|Hemagglutinin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Influenza A virus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Carney~~, P J~~]]	+	[[Category: Carney PJ]]
-	[[Category: Chang~~, J C~~]]	+	[[Category: Chang JC]]
-	[[Category: Stevens, J]]	+	[[Category: Stevens J]]
-	[[Category: Villanueva~~, J M~~]]	+	[[Category: Villanueva JM]]
-	[[Category: Yang, H]]	+	[[Category: Yang H]]
-	~~[[Category: H6]]~~	+
-	~~[[Category: Hemagglutinin]]~~	+
-	~~[[Category: Influenza virus]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 08:32, 23 May 2019

OCA — Thu, 23 May 2019 08:32:02 GMT

←Older revision		Revision as of 08:32, 23 May 2019
Line 1:		Line 1:

	==The crystal structure of hemagglutinin from A/Taiwan/1/2013 in complex with 3'SLN==		==The crystal structure of hemagglutinin from A/Taiwan/1/2013 in complex with 3'SLN==
-	<StructureSection load='4wsu' size='340' side='right' caption='[[4wsu]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='4wsu' size='340' side='right'caption='[[4wsu]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4wsu]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WSU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WSU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4wsu]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/9infa 9infa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WSU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WSU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4wsr\|4wsr]], [[4wss\|4wss]], [[4wst\|4wst]], [[4wsv\|4wsv]], [[4wsw\|4wsw]], [[4wsx\|4wsx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4wsr\|4wsr]], [[4wss\|4wss]], [[4wst\|4wst]], [[4wsv\|4wsv]], [[4wsw\|4wsw]], [[4wsx\|4wsx]]</td></tr>
Line 24:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Carney, P J]]		[[Category: Carney, P J]]
	[[Category: Chang, J C]]		[[Category: Chang, J C]]

OCA at 00:25, 26 January 2017

OCA — Thu, 26 Jan 2017 00:25:55 GMT

←Older revision		Revision as of 00:25, 26 January 2017
Line 1:		Line 1:
		+
	==The crystal structure of hemagglutinin from A/Taiwan/1/2013 in complex with 3'SLN==		==The crystal structure of hemagglutinin from A/Taiwan/1/2013 in complex with 3'SLN==
	<StructureSection load='4wsu' size='340' side='right' caption='[[4wsu]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='4wsu' size='340' side='right' caption='[[4wsu]], [[Resolution\|resolution]] 2.70Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4wsr\|4wsr]], [[4wss\|4wss]], [[4wst\|4wst]], [[4wsv\|4wsv]], [[4wsw\|4wsw]], [[4wsx\|4wsx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4wsr\|4wsr]], [[4wss\|4wss]], [[4wst\|4wst]], [[4wsv\|4wsv]], [[4wsw\|4wsw]], [[4wsx\|4wsx]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wsu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wsu RCSB], [http://www.ebi.ac.uk/pdbsum/4wsu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wsu OCA], [http://pdbe.org/4wsu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wsu RCSB], [http://www.ebi.ac.uk/pdbsum/4wsu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wsu ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4wsu" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Hemagglutinin\|Hemagglutinin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:58, 25 February 2015

OCA — Wed, 25 Feb 2015 13:58:54 GMT

←Older revision		Revision as of 13:58, 25 February 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==The crystal structure of hemagglutinin from A/Taiwan/1/2013 in complex with 3'SLN==
		+	<StructureSection load='4wsu' size='340' side='right' caption='[[4wsu]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4wsu]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WSU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WSU FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4wsr\|4wsr]], [[4wss\|4wss]], [[4wst\|4wst]], [[4wsv\|4wsv]], [[4wsw\|4wsw]], [[4wsx\|4wsx]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wsu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wsu RCSB], [http://www.ebi.ac.uk/pdbsum/4wsu PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	During 2013, three new avian influenza A virus subtypes, A(H7N9), A(H6N1) and A(H10N8), resulted in human infections. While the A(H7N9) virus resulted in a significant epidemic in China across 19 provinces and municipalities, both A(H6N1) and A(H10N8) viruses resulted in only a few human infections. This study focuses on the major surface glycoprotein hemagglutinin from both of these novel human viruses. The detailed structural and glycan microarray analyses presented here highlight that both A(H6N1) and A(H10N8) virus hemagglutinins retain a strong avian receptor binding preference, and thus currently pose a low risk for sustained human infections. IMPORTANCE: Human infections with zoonotic influenza virus subtypes continue to be a great public health concern. We report detailed structural analysis and glycan microarray data for recombinant hemagglutinins from A(H6N1) and A(H10N8) viruses, isolated from human infections in 2013, and compare them with hemagglutinins of avian origin. This is the first structural report of an H6 HA, and our results should further the understanding of these viruses, and provide useful information to aid continuous surveillance of these zoonotic influenza viruses.

-	~~The entry 4wsu is ON HOLD~~	+	Structure and receptor binding preferences of recombinant hemagglutinins from avian and human H6 and H10 influenza A virus subtypes.,Yang H, Carney PJ, Chang JC, Villanueva JM, Stevens J J Virol. 2015 Feb 11. pii: JVI.03456-14. PMID:25673707<ref>PMID:25673707</ref>

-	~~Authors: Yang~~, H., Carney, P.J., Chang, J.C~~., Villanueva, J.M., Stevens, J.~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: The crystal structure of hemagglutinin from A/Taiwan/1/2013 in complex with 3'SLN~~	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
-	[[Category: Villanueva, J.M]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Carney, P J]]
		+	[[Category: Chang, J C]]
		+	[[Category: Stevens, J]]
		+	[[Category: Villanueva, J M]]
	[[Category: Yang, H]]		[[Category: Yang, H]]
-	[[Category: ~~Carney, P.J~~]]	+	[[Category: H6]]
-	[[Category: ~~Stevens, J~~]]	+	[[Category: Hemagglutinin]]
-	[[Category: ~~Chang, J.C~~]]	+	[[Category: Influenza virus]]
		+	[[Category: Viral protein]]

OCA at 10:50, 18 February 2015

OCA — Wed, 18 Feb 2015 10:50:13 GMT

←Older revision		Revision as of 10:50, 18 February 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4wsu is ON HOLD ~~until sometime in the future~~	+	The entry 4wsu is ON HOLD

	Authors: Yang, H., Carney, P.J., Chang, J.C., Villanueva, J.M., Stevens, J.		Authors: Yang, H., Carney, P.J., Chang, J.C., Villanueva, J.M., Stevens, J.

OCA at 19:56, 24 December 2014

OCA — Wed, 24 Dec 2014 19:56:35 GMT

←Older revision		Revision as of 19:56, 24 December 2014
Line 6:		Line 6:

	Description: The crystal structure of hemagglutinin from A/Taiwan/1/2013 in complex with 3'SLN		Description: The crystal structure of hemagglutinin from A/Taiwan/1/2013 in complex with 3'SLN
		+	[[Category: Unreleased Structures]]
		+	[[Category: Villanueva, J.M]]
		+	[[Category: Yang, H]]
		+	[[Category: Carney, P.J]]
		+	[[Category: Stevens, J]]
		+	[[Category: Chang, J.C]]

OCA at 07:08, 26 November 2014

OCA — Wed, 26 Nov 2014 07:08:15 GMT

←Older revision		Revision as of 07:08, 26 November 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4wsu is ON HOLD	+	The entry 4wsu is ON HOLD until sometime in the future

	Authors: Yang, H., Carney, P.J., Chang, J.C., Villanueva, J.M., Stevens, J.		Authors: Yang, H., Carney, P.J., Chang, J.C., Villanueva, J.M., Stevens, J.

	Description: The crystal structure of hemagglutinin from A/Taiwan/1/2013 in complex with 3'SLN		Description: The crystal structure of hemagglutinin from A/Taiwan/1/2013 in complex with 3'SLN

OCA: Protected "4wsu" [edit=sysop:move=sysop]

OCA — Wed, 05 Nov 2014 08:07:55 GMT

Protected "4wsu" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:07, 5 November 2014

OCA: New page: '''Unreleased structure''' The entry 4wsu is ON HOLD Authors: Yang, H., Carney, P.J., Chang, J.C., Villanueva, J.M., Stevens, J. Description: The crystal structure of hemagglutinin fro...

OCA — Wed, 05 Nov 2014 08:07:53 GMT

New page: '''Unreleased structure''' The entry 4wsu is ON HOLD Authors: Yang, H., Carney, P.J., Chang, J.C., Villanueva, J.M., Stevens, J. Description: The crystal structure of hemagglutinin fro...

New page

'''Unreleased structure'''

The entry 4wsu is ON HOLD

Authors: Yang, H., Carney, P.J., Chang, J.C., Villanueva, J.M., Stevens, J.

Description: The crystal structure of hemagglutinin from A/Taiwan/1/2013 in complex with 3'SLN