4wv3 - Revision history

OCA at 07:37, 27 September 2023

OCA — Wed, 27 Sep 2023 07:37:34 GMT

←Older revision		Revision as of 07:37, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4wv3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Stigmatella_aurantiaca Stigmatella aurantiaca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WV3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WV3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4wv3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Stigmatella_aurantiaca Stigmatella aurantiaca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WV3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WV3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3UK:5-O-[(S)-[(2-AMINOBENZOYL)OXY](HYDROXY)PHOSPHORYL]ADENOSINE'>3UK</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.599Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3UK:5-O-[(S)-[(2-AMINOBENZOYL)OXY](HYDROXY)PHOSPHORYL]ADENOSINE'>3UK</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wv3 OCA], [https://pdbe.org/4wv3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wv3 RCSB], [https://www.ebi.ac.uk/pdbsum/4wv3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wv3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wv3 OCA], [https://pdbe.org/4wv3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wv3 RCSB], [https://www.ebi.ac.uk/pdbsum/4wv3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wv3 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 20:58, 12 April 2023

OCA — Wed, 12 Apr 2023 20:58:42 GMT

←Older revision		Revision as of 20:58, 12 April 2023
Line 3:		Line 3:
	<StructureSection load='4wv3' size='340' side='right'caption='[[4wv3]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='4wv3' size='340' side='right'caption='[[4wv3]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4wv3]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"chondromyces_aurantiacus"_(berkeley_and_curtis)_thaxter_1892 "chondromyces aurantiacus" (berkeley and curtis) thaxter 1892~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WV3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4WV3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4wv3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Stigmatella_aurantiaca Stigmatella aurantiaca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WV3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WV3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3UK:5-O-[(S)-[(2-AMINOBENZOYL)OXY](HYDROXY)PHOSPHORYL]ADENOSINE'>3UK</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3UK:5-O-[(S)-[(2-AMINOBENZOYL)OXY](HYDROXY)PHOSPHORYL]ADENOSINE'>3UK</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">auaEII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=41 "Chondromyces aurantiacus" (Berkeley and Curtis) Thaxter 1892])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wv3 OCA], [https://pdbe.org/4wv3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wv3 RCSB], [https://www.ebi.ac.uk/pdbsum/4wv3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wv3 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4wv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wv3 OCA], [~~http~~://pdbe.org/4wv3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4wv3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4wv3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4wv3 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/F3Y661_STIAU F3Y661_STIAU]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Barajas~~, J F~~]]	+	[[Category: Stigmatella aurantiaca]]
-	[[Category: Jackson~~, D R~~]]	+	[[Category: Barajas JF]]
-	[[Category: Krug, D]]	+	[[Category: Jackson DR]]
-	[[Category: Muller, R]]	+	[[Category: Krug D]]
-	[[Category: Nguyen, M]]	+	[[Category: Muller R]]
-	[[Category: Pistorious, D]]	+	[[Category: Nguyen M]]
-	[[Category: Tsai~~, S C~~]]	+	[[Category: Pistorious D]]
-	[[Category: Tu~~, S S]]~~	+	[[Category: Tsai SC]]
-	~~[[Category: Anthranilate]]~~	+	[[Category: Tu SS]]
-	~~[[Category: Aurachin]]~~	+
-	~~[[Category: Coa ligase]]~~	+
-	~~[[Category: Ligase-ligase inhibitor complex]]~~	+
-	~~[[Category: Natural product biosynthesis~~]]	+

OCA at 10:31, 25 December 2019

OCA — Wed, 25 Dec 2019 10:31:35 GMT

←Older revision		Revision as of 10:31, 25 December 2019
Line 1:		Line 1:

	==Crystal structure of the anthranilate CoA ligase AuaEII in complex with anthranoyl-AMP==		==Crystal structure of the anthranilate CoA ligase AuaEII in complex with anthranoyl-AMP==
-	<StructureSection load='4wv3' size='340' side='right' caption='[[4wv3]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='4wv3' size='340' side='right'caption='[[4wv3]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4wv3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"chondromyces_aurantiacus"_(berkeley_and_curtis)_thaxter_1892 "chondromyces aurantiacus" (berkeley and curtis) thaxter 1892]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WV3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4wv3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"chondromyces_aurantiacus"_(berkeley_and_curtis)_thaxter_1892 "chondromyces aurantiacus" (berkeley and curtis) thaxter 1892]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WV3 FirstGlance]. <br>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Barajas, J F]]		[[Category: Barajas, J F]]
	[[Category: Jackson, D R]]		[[Category: Jackson, D R]]

OCA at 15:18, 15 November 2017

OCA — Wed, 15 Nov 2017 15:18:17 GMT

←Older revision		Revision as of 15:18, 15 November 2017
Line 1:		Line 1:
		+
	==Crystal structure of the anthranilate CoA ligase AuaEII in complex with anthranoyl-AMP==		==Crystal structure of the anthranilate CoA ligase AuaEII in complex with anthranoyl-AMP==
	<StructureSection load='4wv3' size='340' side='right' caption='[[4wv3]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='4wv3' size='340' side='right' caption='[[4wv3]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4wv3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WV3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4wv3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"chondromyces_aurantiacus"_(berkeley_and_curtis)_thaxter_1892 "chondromyces aurantiacus" (berkeley and curtis) thaxter 1892]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WV3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3UK:5-O-[(S)-[(2-AMINOBENZOYL)OXY](HYDROXY)PHOSPHORYL]ADENOSINE'>3UK</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3UK:5-O-[(S)-[(2-AMINOBENZOYL)OXY](HYDROXY)PHOSPHORYL]ADENOSINE'>3UK</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wv3 OCA], [http://pdbe.org/4wv3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wv3 RCSB], [http://www.ebi.ac.uk/pdbsum/4wv3 PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">auaEII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=41 "Chondromyces aurantiacus" (Berkeley and Curtis) Thaxter 1892])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wv3 OCA], [http://pdbe.org/4wv3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wv3 RCSB], [http://www.ebi.ac.uk/pdbsum/4wv3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wv3 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:01, 2 December 2015

OCA — Wed, 02 Dec 2015 10:01:43 GMT

←Older revision		Revision as of 10:01, 2 December 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of the anthranilate CoA ligase AuaEII in complex with anthranoyl-AMP==
		+	<StructureSection load='4wv3' size='340' side='right' caption='[[4wv3]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4wv3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WV3 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3UK:5-O-[(S)-[(2-AMINOBENZOYL)OXY](HYDROXY)PHOSPHORYL]ADENOSINE'>3UK</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wv3 OCA], [http://pdbe.org/4wv3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wv3 RCSB], [http://www.ebi.ac.uk/pdbsum/4wv3 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The incorporation of nonacetate starter units during type II polyketide biosynthesis helps diversify natural products. Currently, there are few enzymatic strategies for the incorporation of nonacetate starter units in type II polyketide synthase (PKS) pathways. Here we report the crystal structure of AuaEII, the anthranilate:CoA ligase responsible for the generation of anthraniloyl-CoA, which is used as a starter unit by a type II PKS in aurachin biosynthesis. We present structural and protein sequence comparisons to other aryl:CoA ligases. We also compare the AuaEII crystal structure to a model of a CoA ligase homologue, AuaE, which is present in the same gene cluster. AuaE is predicted to have the same fold as AuaEII, but instead of CoA ligation, AuaE catalyzes acyl transfer of anthranilate from anthraniloyl-CoA to the acyl carrier protein (ACP). Together, this work provides insight into the molecular basis for starter unit selection of anthranilate in type II PKS biosynthesis.

-	~~The entry 4wv3 is ON HOLD until Paper Publication~~	+	Structural Insights into Anthranilate Priming during Type II Polyketide Biosynthesis.,Jackson DR, Tu SS, Nguyen M, Barajas JF, Schaub AJ, Krug D, Pistorius D, Luo R, Muller R, Tsai SC ACS Chem Biol. 2015 Nov 3. PMID:26473393<ref>PMID:26473393</ref>

-	~~Authors: Tsai~~, S.~~C., Muller, R., Jackson, D.R., Tu,~~ S.S.~~, Nguyen, M.,~~ Barajas, J.F~~., Pistorious~~, D~~., Krug, D.~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description:~~	+	<div class="pdbe-citations 4wv3" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Unreleased Structures~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Barajas, J F]]
		+	[[Category: Jackson, D R]]
		+	[[Category: Krug, D]]
	[[Category: Muller, R]]		[[Category: Muller, R]]
	[[Category: Nguyen, M]]		[[Category: Nguyen, M]]
-	[[Category: Barajas, J.F]]
-	[[Category: Krug, D]]
	[[Category: Pistorious, D]]		[[Category: Pistorious, D]]
-	[[Category: Tu, S.S]]	+	[[Category: Tsai, S C]]
-	[[Category: ~~Jackson, D.R~~]]	+	[[Category: Tu, S S]]
-	[[Category: ~~Tsai, S.C~~]]	+	[[Category: Anthranilate]]
		+	[[Category: Aurachin]]
		+	[[Category: Coa ligase]]
		+	[[Category: Ligase-ligase inhibitor complex]]
		+	[[Category: Natural product biosynthesis]]

OCA at 20:02, 24 December 2014

OCA — Wed, 24 Dec 2014 20:02:19 GMT

←Older revision		Revision as of 20:02, 24 December 2014
Line 5:		Line 5:
	Authors: Tsai, S.C., Muller, R., Jackson, D.R., Tu, S.S., Nguyen, M., Barajas, J.F., Pistorious, D., Krug, D.		Authors: Tsai, S.C., Muller, R., Jackson, D.R., Tu, S.S., Nguyen, M., Barajas, J.F., Pistorious, D., Krug, D.

-	Description:	+	Description:
		+	[[Category: Unreleased Structures]]
		+	[[Category: Muller, R]]
		+	[[Category: Nguyen, M]]
		+	[[Category: Barajas, J.F]]
		+	[[Category: Krug, D]]
		+	[[Category: Pistorious, D]]
		+	[[Category: Tu, S.S]]
		+	[[Category: Jackson, D.R]]
		+	[[Category: Tsai, S.C]]

OCA: Protected "4wv3" [edit=sysop:move=sysop]

OCA — Wed, 19 Nov 2014 11:59:05 GMT

Protected "4wv3" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:59, 19 November 2014

OCA: New page: '''Unreleased structure''' The entry 4wv3 is ON HOLD until Paper Publication Authors: Tsai, S.C., Muller, R., Jackson, D.R., Tu, S.S., Nguyen, M., Barajas, J.F., Pistorious, D., Krug, D...

OCA — Wed, 19 Nov 2014 11:59:03 GMT

New page: '''Unreleased structure''' The entry 4wv3 is ON HOLD until Paper Publication Authors: Tsai, S.C., Muller, R., Jackson, D.R., Tu, S.S., Nguyen, M., Barajas, J.F., Pistorious, D., Krug, D...

New page

'''Unreleased structure'''

The entry 4wv3 is ON HOLD until Paper Publication

Authors: Tsai, S.C., Muller, R., Jackson, D.R., Tu, S.S., Nguyen, M., Barajas, J.F., Pistorious, D., Krug, D.

Description: