4wvo - Revision history

OCA at 14:14, 18 October 2023

OCA — Wed, 18 Oct 2023 14:14:02 GMT

←Older revision		Revision as of 14:14, 18 October 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4wvo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WVO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WVO FirstGlance]. <br>		<table><tr><td colspan='2'>[[4wvo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WVO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WVO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3UZ:(2S)-2-(4-CHLOROPHENYL)-N-{2-[3-METHOXY-4-(PROP-2-YN-1-YLOXY)PHENYL]ETHYL}-2-(PROP-2-YN-1-YLOXY)ETHANAMIDE'>3UZ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.251Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3UZ:(2S)-2-(4-CHLOROPHENYL)-N-{2-[3-METHOXY-4-(PROP-2-YN-1-YLOXY)PHENYL]ETHYL}-2-(PROP-2-YN-1-YLOXY)ETHANAMIDE'>3UZ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wvo OCA], [https://pdbe.org/4wvo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wvo RCSB], [https://www.ebi.ac.uk/pdbsum/4wvo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wvo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wvo OCA], [https://pdbe.org/4wvo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wvo RCSB], [https://www.ebi.ac.uk/pdbsum/4wvo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wvo ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:28, 3 November 2022

OCA — Thu, 03 Nov 2022 07:28:11 GMT

←Older revision		Revision as of 07:28, 3 November 2022
Line 3:		Line 3:
	<StructureSection load='4wvo' size='340' side='right'caption='[[4wvo]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='4wvo' size='340' side='right'caption='[[4wvo]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4wvo]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Arath Arath~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WVO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4WVO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4wvo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WVO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WVO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3UZ:(2S)-2-(4-CHLOROPHENYL)-N-{2-[3-METHOXY-4-(PROP-2-YN-1-YLOXY)PHENYL]ETHYL}-2-(PROP-2-YN-1-YLOXY)ETHANAMIDE'>3UZ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3UZ:(2S)-2-(4-CHLOROPHENYL)-N-{2-[3-METHOXY-4-(PROP-2-YN-1-YLOXY)PHENYL]ETHYL}-2-(PROP-2-YN-1-YLOXY)ETHANAMIDE'>3UZ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PYR1, ABIP6, RCAR11, At4g17870, T6K21.50 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH]), HAB1, P2C-HA, At1g72770, F28P22.4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wvo OCA], [https://pdbe.org/4wvo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wvo RCSB], [https://www.ebi.ac.uk/pdbsum/4wvo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wvo ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4wvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wvo OCA], [~~http~~://pdbe.org/4wvo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4wvo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4wvo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4wvo ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PYR1_ARATH PYR1_ARATH]] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.<ref>PMID:19624469</ref> <ref>PMID:19407142</ref> <ref>PMID:19769575</ref> [[http://www.uniprot.org/uniprot/P2C16_ARATH P2C16_ARATH]] Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth. Confers enhanced sensitivity to drought.<ref>PMID:14731256</ref> <ref>PMID:16876791</ref> <ref>PMID:16798945</ref> <ref>PMID:19033529</ref>	+	[https://www.uniprot.org/uniprot/PYR1_ARATH PYR1_ARATH] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.<ref>PMID:19624469</ref> <ref>PMID:19407142</ref> <ref>PMID:19769575</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 21:
	==See Also==		==See Also==
	*[[Abscisic acid receptor 3D structures\|Abscisic acid receptor 3D structures]]		*[[Abscisic acid receptor 3D structures\|Abscisic acid receptor 3D structures]]
-	*[[Protein phosphatase\|Protein phosphatase]]	+	*[[Protein phosphatase 3D structures\|Protein phosphatase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arath~~]]	+	[[Category: Arabidopsis thaliana]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Phosphoprotein phosphatase]]~~	+	[[Category: Cutler SR]]
-	[[Category: Cutler~~, S R~~]]	+	[[Category: Peterson FC]]
-	[[Category: Peterson~~, F C~~]]	+	[[Category: Volkman BF]]
-	[[Category: Volkman~~, B F]]~~	+
-	~~[[Category: Hab1]]~~	+
-	~~[[Category: Hydrolase-hydrolase inthibitor complex]]~~	+
-	~~[[Category: Mandipropamid]]~~	+
-	~~[[Category: Pp2c inhibitor]]~~	+
-	~~[[Category: Pyr/pyl/rcar]]~~	+
-	~~[[Category: Pyr1~~]]	+

OCA at 08:06, 23 May 2019

OCA — Thu, 23 May 2019 08:06:36 GMT

←Older revision		Revision as of 08:06, 23 May 2019
Line 1:		Line 1:

	==An engineered PYR1 mandipropamid receptor in complex with mandipropamid and HAB1==		==An engineered PYR1 mandipropamid receptor in complex with mandipropamid and HAB1==
-	<StructureSection load='4wvo' size='340' side='right' caption='[[4wvo]], [[Resolution\|resolution]] 2.25Å' scene=''>	+	<StructureSection load='4wvo' size='340' side='right'caption='[[4wvo]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4wvo]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WVO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4wvo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WVO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3UZ:(2S)-2-(4-CHLOROPHENYL)-N-{2-[3-METHOXY-4-(PROP-2-YN-1-YLOXY)PHENYL]ETHYL}-2-(PROP-2-YN-1-YLOXY)ETHANAMIDE'>3UZ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3UZ:(2S)-2-(4-CHLOROPHENYL)-N-{2-[3-METHOXY-4-(PROP-2-YN-1-YLOXY)PHENYL]ETHYL}-2-(PROP-2-YN-1-YLOXY)ETHANAMIDE'>3UZ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PYR1, ABIP6, RCAR11, At4g17870, T6K21.50 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH]), HAB1, P2C-HA, At1g72770, F28P22.4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wvo OCA], [http://pdbe.org/4wvo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wvo RCSB], [http://www.ebi.ac.uk/pdbsum/4wvo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wvo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wvo OCA], [http://pdbe.org/4wvo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wvo RCSB], [http://www.ebi.ac.uk/pdbsum/4wvo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wvo ProSAT]</span></td></tr>
Line 19:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4wvo" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4wvo" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Abscisic acid receptor 3D structures\|Abscisic acid receptor 3D structures]]
		+	*[[Protein phosphatase\|Protein phosphatase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Arath]]
		+	[[Category: Large Structures]]
	[[Category: Phosphoprotein phosphatase]]		[[Category: Phosphoprotein phosphatase]]
	[[Category: Cutler, S R]]		[[Category: Cutler, S R]]

OCA at 18:42, 1 February 2017

OCA — Wed, 01 Feb 2017 18:42:23 GMT

←Older revision		Revision as of 18:42, 1 February 2017
Line 1:		Line 1:
		+
	==An engineered PYR1 mandipropamid receptor in complex with mandipropamid and HAB1==		==An engineered PYR1 mandipropamid receptor in complex with mandipropamid and HAB1==
	<StructureSection load='4wvo' size='340' side='right' caption='[[4wvo]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='4wvo' size='340' side='right' caption='[[4wvo]], [[Resolution\|resolution]] 2.25Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3UZ:(2S)-2-(4-CHLOROPHENYL)-N-{2-[3-METHOXY-4-(PROP-2-YN-1-YLOXY)PHENYL]ETHYL}-2-(PROP-2-YN-1-YLOXY)ETHANAMIDE'>3UZ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3UZ:(2S)-2-(4-CHLOROPHENYL)-N-{2-[3-METHOXY-4-(PROP-2-YN-1-YLOXY)PHENYL]ETHYL}-2-(PROP-2-YN-1-YLOXY)ETHANAMIDE'>3UZ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wvo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wvo RCSB], [http://www.ebi.ac.uk/pdbsum/4wvo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wvo OCA], [http://pdbe.org/4wvo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wvo RCSB], [http://www.ebi.ac.uk/pdbsum/4wvo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wvo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4wvo" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:34, 18 February 2015

OCA — Wed, 18 Feb 2015 07:34:37 GMT

←Older revision		Revision as of 07:34, 18 February 2015
Line 9:		Line 9:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PYR1_ARATH PYR1_ARATH]] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.<ref>PMID:19624469</ref> <ref>PMID:19407142</ref> <ref>PMID:19769575</ref> [[http://www.uniprot.org/uniprot/P2C16_ARATH P2C16_ARATH]] Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth. Confers enhanced sensitivity to drought.<ref>PMID:14731256</ref> <ref>PMID:16876791</ref> <ref>PMID:16798945</ref> <ref>PMID:19033529</ref>		[[http://www.uniprot.org/uniprot/PYR1_ARATH PYR1_ARATH]] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.<ref>PMID:19624469</ref> <ref>PMID:19407142</ref> <ref>PMID:19769575</ref> [[http://www.uniprot.org/uniprot/P2C16_ARATH P2C16_ARATH]] Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth. Confers enhanced sensitivity to drought.<ref>PMID:14731256</ref> <ref>PMID:16876791</ref> <ref>PMID:16798945</ref> <ref>PMID:19033529</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Rising temperatures and lessening fresh water supplies are threatening agricultural productivity and have motivated efforts to improve plant water use and drought tolerance. During water deficit, plants produce elevated levels of abscisic acid (ABA), which improves water consumption and stress tolerance by controlling guard cell aperture and other protective responses. One attractive strategy for controlling water use is to develop compounds that activate ABA receptors, but agonists approved for use have yet to be developed. In principle, an engineered ABA receptor that can be activated by an existing agrochemical could achieve this goal. Here we describe a variant of the ABA receptor PYRABACTIN RESISTANCE 1 (PYR1) that possesses nanomolar sensitivity to the agrochemical mandipropamid and demonstrate its efficacy for controlling ABA responses and drought tolerance in transgenic plants. Furthermore, crystallographic studies provide a mechanistic basis for its activity and demonstrate the relative ease with which the PYR1 ligand-binding pocket can be altered to accommodate new ligands. Thus, we have successfully repurposed an agrochemical for a new application using receptor engineering. We anticipate that this strategy will be applied to other plant receptors and represents a new avenue for crop improvement.
		+
		+	Agrochemical control of plant water use using engineered abscisic acid receptors.,Park SY, Peterson FC, Mosquna A, Yao J, Volkman BF, Cutler SR Nature. 2015 Feb 4. doi: 10.1038/nature14123. PMID:25652827<ref>PMID:25652827</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:05, 12 February 2015

OCA — Thu, 12 Feb 2015 12:05:02 GMT

←Older revision		Revision as of 12:05, 12 February 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==An engineered PYR1 mandipropamid receptor in complex with mandipropamid and HAB1==
-		+	<StructureSection load='4wvo' size='340' side='right' caption='[[4wvo]], [[Resolution\|resolution]] 2.25Å' scene=''>
-	~~The entry~~ 4wvo is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4wvo]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WVO FirstGlance]. <br>
-	~~Authors~~: ~~Peterson~~, F.C., ~~Volkman~~, B.F., ~~Cutler, S~~.R.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3UZ:(2S)-2-(4-CHLOROPHENYL)-N-{2-[3-METHOXY-4-(PROP-2-YN-1-YLOXY)PHENYL]ETHYL}-2-(PROP-2-YN-1-YLOXY)ETHANAMIDE'>3UZ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
-	~~Description~~: ~~An engineered PYR1 mandipropamid receptor in complex with mandipropamid~~ and ~~HAB1~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wvo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wvo RCSB], [http://www.ebi.ac.uk/pdbsum/4wvo PDBsum]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
-	[[Category: Cutler, S.R]]	+	== Function ==
-	[[Category: Peterson, F.C]]	+	[[http://www.uniprot.org/uniprot/PYR1_ARATH PYR1_ARATH]] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.<ref>PMID:19624469</ref> <ref>PMID:19407142</ref> <ref>PMID:19769575</ref> [[http://www.uniprot.org/uniprot/P2C16_ARATH P2C16_ARATH]] Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth. Confers enhanced sensitivity to drought.<ref>PMID:14731256</ref> <ref>PMID:16876791</ref> <ref>PMID:16798945</ref> <ref>PMID:19033529</ref>
-	[[Category: Volkman, B.F]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Phosphoprotein phosphatase]]
		+	[[Category: Cutler, S R]]
		+	[[Category: Peterson, F C]]
		+	[[Category: Volkman, B F]]
		+	[[Category: Hab1]]
		+	[[Category: Hydrolase-hydrolase inthibitor complex]]
		+	[[Category: Mandipropamid]]
		+	[[Category: Pp2c inhibitor]]
		+	[[Category: Pyr/pyl/rcar]]
		+	[[Category: Pyr1]]

OCA at 20:03, 24 December 2014

OCA — Wed, 24 Dec 2014 20:03:54 GMT

←Older revision		Revision as of 20:03, 24 December 2014
Line 6:		Line 6:

	Description: An engineered PYR1 mandipropamid receptor in complex with mandipropamid and HAB1		Description: An engineered PYR1 mandipropamid receptor in complex with mandipropamid and HAB1
		+	[[Category: Unreleased Structures]]
		+	[[Category: Cutler, S.R]]
		+	[[Category: Peterson, F.C]]
		+	[[Category: Volkman, B.F]]

OCA at 09:54, 24 December 2014

OCA — Wed, 24 Dec 2014 09:54:15 GMT

←Older revision		Revision as of 09:54, 24 December 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4wvo is ON HOLD	+	The entry 4wvo is ON HOLD until Paper Publication

	Authors: Peterson, F.C., Volkman, B.F., Cutler, S.R.		Authors: Peterson, F.C., Volkman, B.F., Cutler, S.R.

	Description: An engineered PYR1 mandipropamid receptor in complex with mandipropamid and HAB1		Description: An engineered PYR1 mandipropamid receptor in complex with mandipropamid and HAB1

OCA: Protected "4wvo" [edit=sysop:move=sysop]

OCA — Wed, 19 Nov 2014 11:59:57 GMT

Protected "4wvo" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:59, 19 November 2014

OCA: New page: '''Unreleased structure''' The entry 4wvo is ON HOLD Authors: Peterson, F.C., Volkman, B.F., Cutler, S.R. Description: An engineered PYR1 mandipropamid receptor in complex with mandipr...

OCA — Wed, 19 Nov 2014 11:59:56 GMT

New page: '''Unreleased structure''' The entry 4wvo is ON HOLD Authors: Peterson, F.C., Volkman, B.F., Cutler, S.R. Description: An engineered PYR1 mandipropamid receptor in complex with mandipr...

New page

'''Unreleased structure'''

The entry 4wvo is ON HOLD

Authors: Peterson, F.C., Volkman, B.F., Cutler, S.R.

Description: An engineered PYR1 mandipropamid receptor in complex with mandipropamid and HAB1