4x1h - Revision history

OCA at 07:39, 27 September 2023

OCA — Wed, 27 Sep 2023 07:39:55 GMT

←Older revision		Revision as of 07:39, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4x1h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X1H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X1H FirstGlance]. <br>		<table><tr><td colspan='2'>[[4x1h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X1H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X1H FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=BNG:B-NONYLGLUCOSIDE'>BNG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.29Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=BNG:B-NONYLGLUCOSIDE'>BNG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x1h OCA], [https://pdbe.org/4x1h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x1h RCSB], [https://www.ebi.ac.uk/pdbsum/4x1h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x1h ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x1h OCA], [https://pdbe.org/4x1h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x1h RCSB], [https://www.ebi.ac.uk/pdbsum/4x1h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x1h ProSAT]</span></td></tr>
	</table>		</table>

OCA at 21:06, 12 April 2023

OCA — Wed, 12 Apr 2023 21:06:45 GMT

←Older revision		Revision as of 21:06, 12 April 2023
Line 3:		Line 3:
	<StructureSection load='4x1h' size='340' side='right'caption='[[4x1h]], [[Resolution\|resolution]] 2.29Å' scene=''>		<StructureSection load='4x1h' size='340' side='right'caption='[[4x1h]], [[Resolution\|resolution]] 2.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4x1h]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X1H OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4X1H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4x1h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X1H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X1H FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=BNG:B-NONYLGLUCOSIDE'>BNG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=BNG:B-NONYLGLUCOSIDE'>BNG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4x1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x1h OCA], [~~http~~://pdbe.org/4x1h PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4x1h RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4x1h PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4x1h ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x1h OCA], [https://pdbe.org/4x1h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x1h RCSB], [https://www.ebi.ac.uk/pdbsum/4x1h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x1h ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/OPSD_BOVIN OPSD_BOVIN]] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).<ref>PMID:16908857</ref> <ref>PMID:17060607</ref>	+	[https://www.uniprot.org/uniprot/OPSD_BOVIN OPSD_BOVIN] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).<ref>PMID:16908857</ref> <ref>PMID:17060607</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Blankenship, E]]	+	[[Category: Blankenship E]]
-	[[Category: Lodowski~~, D T]]~~	+	[[Category: Lodowski DT]]
-	~~[[Category: Gpcr]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Rhodopsin]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 15:46, 11 December 2019

OCA — Wed, 11 Dec 2019 15:46:46 GMT

←Older revision		Revision as of 15:46, 11 December 2019
Line 1:		Line 1:

	==Opsin/G(alpha) peptide complex stabilized by nonyl-glucoside==		==Opsin/G(alpha) peptide complex stabilized by nonyl-glucoside==
-	<StructureSection load='4x1h' size='340' side='right' caption='[[4x1h]], [[Resolution\|resolution]] 2.29Å' scene=''>	+	<StructureSection load='4x1h' size='340' side='right'caption='[[4x1h]], [[Resolution\|resolution]] 2.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4x1h]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X1H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X1H FirstGlance]. <br>		<table><tr><td colspan='2'>[[4x1h]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X1H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X1H FirstGlance]. <br>
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
		+	[[Category: Large Structures]]
	[[Category: Blankenship, E]]		[[Category: Blankenship, E]]
	[[Category: Lodowski, D T]]		[[Category: Lodowski, D T]]

OCA at 09:30, 22 November 2017

OCA — Wed, 22 Nov 2017 09:30:54 GMT

←Older revision		Revision as of 09:30, 22 November 2017
Line 1:		Line 1:
		+
	==Opsin/G(alpha) peptide complex stabilized by nonyl-glucoside==		==Opsin/G(alpha) peptide complex stabilized by nonyl-glucoside==
	<StructureSection load='4x1h' size='340' side='right' caption='[[4x1h]], [[Resolution\|resolution]] 2.29Å' scene=''>		<StructureSection load='4x1h' size='340' side='right' caption='[[4x1h]], [[Resolution\|resolution]] 2.29Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4x1h]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X1H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X1H FirstGlance]. <br>		<table><tr><td colspan='2'>[[4x1h]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X1H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X1H FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=BNG:B-NONYLGLUCOSIDE'>BNG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=BNG:B-NONYLGLUCOSIDE'>BNG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x1h OCA], [http://pdbe.org/4x1h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x1h RCSB], [http://www.ebi.ac.uk/pdbsum/4x1h PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x1h OCA], [http://pdbe.org/4x1h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x1h RCSB], [http://www.ebi.ac.uk/pdbsum/4x1h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4x1h ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 20:13, 30 November 2015

OCA — Mon, 30 Nov 2015 20:13:22 GMT

←Older revision		Revision as of 20:13, 30 November 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Opsin/G(alpha) peptide complex stabilized by nonyl-glucoside==
		+	<StructureSection load='4x1h' size='340' side='right' caption='[[4x1h]], [[Resolution\|resolution]] 2.29Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4x1h]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X1H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X1H FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=BNG:B-NONYLGLUCOSIDE'>BNG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x1h OCA], [http://pdbe.org/4x1h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x1h RCSB], [http://www.ebi.ac.uk/pdbsum/4x1h PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/OPSD_BOVIN OPSD_BOVIN]] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).<ref>PMID:16908857</ref> <ref>PMID:17060607</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Rhodopsin, a light-activated G protein coupled receptor (GPCR), has been the subject of numerous biochemical and structural investigations, serving as a model receptor for GPCRs and their activation. We present the 2.3-A resolution structure of native source rhodopsin stabilized in a conformation competent for G protein binding. An extensive water-mediated hydrogen bond network linking the chromophore binding site to the site of G protein binding is observed, providing connections to conserved motifs essential for GPCR activation. Comparison of this extensive solvent-mediated hydrogen-bonding network with the positions of ordered solvent in earlier crystallographic structures of rhodopsin photointermediates reveals both static structural and dynamic functional water-protein interactions present during the activation process. When considered along with observations that solvent occupies similar positions in the structures of other GPCRs, these analyses strongly support an integral role for this dynamic ordered water network in both rhodopsin and GPCR activation.

-	The ~~entry 4x1h is ON HOLD until Paper Publication~~	+	The High-Resolution Structure of Activated Opsin Reveals a Conserved Solvent Network in the Transmembrane Region Essential for Activation.,Blankenship E, Vahedi-Faridi A, Lodowski DT Structure. 2015 Oct 27. pii: S0969-2126(15)00408-6. doi:, 10.1016/j.str.2015.09.015. PMID:26526852<ref>PMID:26526852</ref>

-	~~Authors: Blankenship~~, E.~~, Lodowski, D~~.T.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~:	+	<div class="pdbe-citations 4x1h" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Unreleased Structures~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bos taurus]]
	[[Category: Blankenship, E]]		[[Category: Blankenship, E]]
-	[[Category: Lodowski, D.T]]	+	[[Category: Lodowski, D T]]
		+	[[Category: Gpcr]]
		+	[[Category: Membrane protein]]
		+	[[Category: Rhodopsin]]
		+	[[Category: Signaling protein]]

OCA at 14:07, 7 February 2015

OCA — Sat, 07 Feb 2015 14:07:11 GMT

←Older revision		Revision as of 14:07, 7 February 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4x1h is ON HOLD	+	The entry 4x1h is ON HOLD until Paper Publication

	Authors: Blankenship, E., Lodowski, D.T.		Authors: Blankenship, E., Lodowski, D.T.

OCA at 20:19, 24 December 2014

OCA — Wed, 24 Dec 2014 20:19:51 GMT

←Older revision		Revision as of 20:19, 24 December 2014
Line 5:		Line 5:
	Authors: Blankenship, E., Lodowski, D.T.		Authors: Blankenship, E., Lodowski, D.T.

-	Description:	+	Description:
		+	[[Category: Unreleased Structures]]
		+	[[Category: Blankenship, E]]
		+	[[Category: Lodowski, D.T]]

OCA: Protected "4x1h" [edit=sysop:move=sysop]

OCA — Wed, 03 Dec 2014 08:45:26 GMT

Protected "4x1h" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:45, 3 December 2014

OCA: New page: '''Unreleased structure''' The entry 4x1h is ON HOLD Authors: Blankenship, E., Lodowski, D.T. Description:

OCA — Wed, 03 Dec 2014 08:45:25 GMT

New page: '''Unreleased structure''' The entry 4x1h is ON HOLD Authors: Blankenship, E., Lodowski, D.T. Description:

New page

'''Unreleased structure'''

The entry 4x1h is ON HOLD

Authors: Blankenship, E., Lodowski, D.T.

Description: