4x27 - Revision history

OCA at 07:40, 27 September 2023

OCA — Wed, 27 Sep 2023 07:40:21 GMT

←Older revision		Revision as of 07:40, 27 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4x27]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Entomopoxvirinae Entomopoxvirinae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X27 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4x27]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Entomopoxvirinae Entomopoxvirinae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X27 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x27 OCA], [https://pdbe.org/4x27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x27 RCSB], [https://www.ebi.ac.uk/pdbsum/4x27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x27 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x27 OCA], [https://pdbe.org/4x27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x27 RCSB], [https://www.ebi.ac.uk/pdbsum/4x27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x27 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 21:07, 12 April 2023

OCA — Wed, 12 Apr 2023 21:07:32 GMT

←Older revision		Revision as of 21:07, 12 April 2023
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	<StructureSection load='4x27' size='340' side='right'caption='[[4x27]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='4x27' size='340' side='right'caption='[[4x27]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4x27]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Entomopoxvirinae Entomopoxvirinae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X27 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4X27 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4x27]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Entomopoxvirinae Entomopoxvirinae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X27 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ow5\|4ow5]], [[4x29\|4x29]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x27 OCA], [https://pdbe.org/4x27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x27 RCSB], [https://www.ebi.ac.uk/pdbsum/4x27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x27 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4x27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x27 OCA], [~~http~~://pdbe.org/4x27 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4x27 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4x27 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4x27 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q83389_9POXV Q83389_9POXV]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	[[Category: Entomopoxvirinae]]		[[Category: Entomopoxvirinae]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Aizel, K]]	+	[[Category: Aizel K]]
-	[[Category: Boudes, M]]	+	[[Category: Boudes M]]
-	[[Category: Coulibaly, F]]	+	[[Category: Coulibaly F]]
-	~~[[Category: Chitin-binding]]~~	+
-	~~[[Category: Fibronectin type iii fold]]~~	+
-	~~[[Category: Lmpo]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 08:45, 1 January 2020

OCA — Wed, 01 Jan 2020 08:45:00 GMT

←Older revision		Revision as of 08:45, 1 January 2020
Line 1:		Line 1:

	==Structural basis for the enhancement of virulence by entomopoxvirus fusolin and its in vivo crystallization into viral spindles (complex with Copper)==		==Structural basis for the enhancement of virulence by entomopoxvirus fusolin and its in vivo crystallization into viral spindles (complex with Copper)==
-	<StructureSection load='4x27' size='340' side='right' caption='[[4x27]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='4x27' size='340' side='right'caption='[[4x27]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4x27]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Entomopoxvirinae Entomopoxvirinae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X27 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4x27]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Entomopoxvirinae Entomopoxvirinae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X27 FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Entomopoxvirinae]]		[[Category: Entomopoxvirinae]]
		+	[[Category: Large Structures]]
	[[Category: Aizel, K]]		[[Category: Aizel, K]]
	[[Category: Boudes, M]]		[[Category: Boudes, M]]

OCA at 12:14, 6 November 2017

OCA — Mon, 06 Nov 2017 12:14:46 GMT

←Older revision		Revision as of 12:14, 6 November 2017
Line 28:		Line 28:
	[[Category: Fibronectin type iii fold]]		[[Category: Fibronectin type iii fold]]
	[[Category: Lmpo]]		[[Category: Lmpo]]
		+	[[Category: Viral protein]]

OCA at 00:13, 26 January 2017

OCA — Thu, 26 Jan 2017 00:13:44 GMT

←Older revision		Revision as of 00:13, 26 January 2017
Line 1:		Line 1:
		+
	==Structural basis for the enhancement of virulence by entomopoxvirus fusolin and its in vivo crystallization into viral spindles (complex with Copper)==		==Structural basis for the enhancement of virulence by entomopoxvirus fusolin and its in vivo crystallization into viral spindles (complex with Copper)==
	<StructureSection load='4x27' size='340' side='right' caption='[[4x27]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='4x27' size='340' side='right' caption='[[4x27]], [[Resolution\|resolution]] 2.40Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ow5\|4ow5]], [[4x29\|4x29]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ow5\|4ow5]], [[4x29\|4x29]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x27 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4x27 RCSB], [http://www.ebi.ac.uk/pdbsum/4x27 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x27 OCA], [http://pdbe.org/4x27 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x27 RCSB], [http://www.ebi.ac.uk/pdbsum/4x27 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4x27 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4x27" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:14, 1 April 2015

OCA — Wed, 01 Apr 2015 07:14:15 GMT

←Older revision		Revision as of 07:14, 1 April 2015
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x27 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4x27 RCSB], [http://www.ebi.ac.uk/pdbsum/4x27 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x27 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4x27 RCSB], [http://www.ebi.ac.uk/pdbsum/4x27 PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The great benefits that chemical pesticides have brought to agriculture are partly offset by widespread environmental damage to nontarget species and threats to human health. Microbial bioinsecticides are considered safe and highly specific alternatives but generally lack potency. Spindles produced by insect poxviruses are crystals of the fusolin protein that considerably boost not only the virulence of these viruses but also, in cofeeding experiments, the insecticidal activity of unrelated pathogens. However, the mechanisms by which spindles assemble into ultra-stable crystals and enhance virulence are unknown. Here we describe the structure of viral spindles determined by X-ray microcrystallography from in vivo crystals purified from infected insects. We found that a C-terminal molecular arm of fusolin mediates the assembly of a globular domain, which has the hallmarks of lytic polysaccharide monooxygenases of chitinovorous bacteria. Explaining their unique stability, a 3D network of disulfide bonds between fusolin dimers covalently crosslinks the entire crystalline matrix of spindles. However, upon ingestion by a new host, removal of the molecular arm abolishes this stabilizing network leading to the dissolution of spindles. The released monooxygenase domain is then free to disrupt the chitin-rich peritrophic matrix that protects insects against oral infections. The mode of action revealed here may guide the design of potent spindles as synergetic additives to bioinsecticides.
		+
		+	Structural basis for the enhancement of virulence by viral spindles and their in vivo crystallization.,Chiu E, Hijnen M, Bunker RD, Boudes M, Rajendran C, Aizel K, Olieric V, Schulze-Briese C, Mitsuhashi W, Young V, Ward VK, Bergoin M, Metcalf P, Coulibaly F Proc Natl Acad Sci U S A. 2015 Mar 18. pii: 201418798. PMID:25787255<ref>PMID:25787255</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 12:16, 18 March 2015

OCA — Wed, 18 Mar 2015 12:16:44 GMT

←Older revision		Revision as of 12:16, 18 March 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Structural basis for the enhancement of virulence by entomopoxvirus fusolin and its in vivo crystallization into viral spindles (complex with Copper)==
-		+	<StructureSection load='4x27' size='340' side='right' caption='[[4x27]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~The entry~~ 4x27 is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4x27]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Entomopoxvirinae Entomopoxvirinae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X27 FirstGlance]. <br>
-	~~Authors~~: ~~Aizel, K~~.~~, Boudes, M~~.~~, Coulibaly, F~~.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ow5\|4ow5]], [[4x29\|4x29]]</td></tr>
-	~~Description~~: ~~Structure of~~ a ~~viral protein in complex with Copper~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x27 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4x27 RCSB], [http://www.ebi.ac.uk/pdbsum/4x27 PDBsum]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Coulibaly~~, F]]	+	__TOC__
-	[[~~Category~~: ~~Boudes~~, M]]	+	</StructureSection>
		+	[[Category: Entomopoxvirinae]]
	[[Category: Aizel, K]]		[[Category: Aizel, K]]
		+	[[Category: Boudes, M]]
		+	[[Category: Coulibaly, F]]
		+	[[Category: Chitin-binding]]
		+	[[Category: Fibronectin type iii fold]]
		+	[[Category: Lmpo]]

OCA at 20:21, 24 December 2014

OCA — Wed, 24 Dec 2014 20:21:43 GMT

←Older revision		Revision as of 20:21, 24 December 2014
Line 6:		Line 6:

	Description: Structure of a viral protein in complex with Copper		Description: Structure of a viral protein in complex with Copper
		+	[[Category: Unreleased Structures]]
		+	[[Category: Coulibaly, F]]
		+	[[Category: Boudes, M]]
		+	[[Category: Aizel, K]]

OCA at 14:17, 10 December 2014

OCA — Wed, 10 Dec 2014 14:17:25 GMT

←Older revision		Revision as of 14:17, 10 December 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4x27 is ON HOLD	+	The entry 4x27 is ON HOLD until Paper Publication

-	Authors: ~~Hijnen~~, M., Boudes, M~~., Aizel, K~~., Coulibaly, F.	+	Authors: Aizel, K., Boudes, M., Coulibaly, F.

	Description: Structure of a viral protein in complex with Copper		Description: Structure of a viral protein in complex with Copper

OCA: Protected "4x27" [edit=sysop:move=sysop]

OCA — Wed, 03 Dec 2014 08:46:31 GMT

Protected "4x27" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:46, 3 December 2014