4x7o - Revision history

OCA at 07:41, 27 September 2023

OCA — Wed, 27 Sep 2023 07:41:44 GMT

←Older revision		Revision as of 07:41, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4x7o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X7O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X7O FirstGlance]. <br>		<table><tr><td colspan='2'>[[4x7o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X7O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X7O FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3Z6:1-[5-(4-AMINO-2,7-DIMETHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-2,3-DIHYDRO-1H-INDOL-1-YL]-2-[3-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]ETHANONE'>3Z6</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.65Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3Z6:1-[5-(4-AMINO-2,7-DIMETHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-2,3-DIHYDRO-1H-INDOL-1-YL]-2-[3-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]ETHANONE'>3Z6</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x7o OCA], [https://pdbe.org/4x7o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x7o RCSB], [https://www.ebi.ac.uk/pdbsum/4x7o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x7o ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x7o OCA], [https://pdbe.org/4x7o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x7o RCSB], [https://www.ebi.ac.uk/pdbsum/4x7o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x7o ProSAT]</span></td></tr>
	</table>		</table>

OCA at 21:16, 12 April 2023

OCA — Wed, 12 Apr 2023 21:16:22 GMT

←Older revision		Revision as of 21:16, 12 April 2023
Line 3:		Line 3:
	<StructureSection load='4x7o' size='340' side='right'caption='[[4x7o]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='4x7o' size='340' side='right'caption='[[4x7o]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4x7o]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X7O OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4X7O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4x7o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X7O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X7O FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3Z6:1-[5-(4-AMINO-2,7-DIMETHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-2,3-DIHYDRO-1H-INDOL-1-YL]-2-[3-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]ETHANONE'>3Z6</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3Z6:1-[5-(4-AMINO-2,7-DIMETHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-2,3-DIHYDRO-1H-INDOL-1-YL]-2-[3-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]ETHANONE'>3Z6</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4x7j\|4x7j]], [[4x7h\|4x7h]], [[4x7k\|4x7k]], [[4x7l\|4x7l]], [[4x7n\|4x7n]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x7o OCA], [https://pdbe.org/4x7o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x7o RCSB], [https://www.ebi.ac.uk/pdbsum/4x7o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x7o ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EIF2AK3, PEK, PERK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4x7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x7o OCA], [~~http~~://pdbe.org/4x7o PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4x7o RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4x7o PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4x7o ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/E2AK3_HUMAN E2AK3_HUMAN]] Wolcott-Rallison syndrome. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:10932183</ref>	+	[https://www.uniprot.org/uniprot/E2AK3_HUMAN E2AK3_HUMAN] Wolcott-Rallison syndrome. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:10932183</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/E2AK3_HUMAN E2AK3_HUMAN]] Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) (By similarity).	+	[https://www.uniprot.org/uniprot/E2AK3_HUMAN E2AK3_HUMAN] Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Non-specific serine/threonine protein kinase]]~~	+	[[Category: Chen H]]
-	[[Category: Chen, H]]	+	[[Category: Long AM]]
-	[[Category: Long~~, A M~~]]	+	[[Category: Shaffer PL]]
-	[[Category: Shaffer~~, P L]]~~	+
-	~~[[Category: Catalytic domain]]~~	+
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Transferase-transferase inhibitor]]~~	+
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 06:51, 29 May 2019

OCA — Wed, 29 May 2019 06:51:03 GMT

←Older revision		Revision as of 06:51, 29 May 2019
Line 1:		Line 1:

	==Co-crystal Structure of PERK bound to 1-[5-(4-amino-2,7-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-fluoro-5-(trifluoromethyl)phenyl]ethanone inhibitor==		==Co-crystal Structure of PERK bound to 1-[5-(4-amino-2,7-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-fluoro-5-(trifluoromethyl)phenyl]ethanone inhibitor==
-	<StructureSection load='4x7o' size='340' side='right' caption='[[4x7o]], [[Resolution\|resolution]] 2.65Å' scene=''>	+	<StructureSection load='4x7o' size='340' side='right'caption='[[4x7o]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4x7o]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X7O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X7O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4x7o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X7O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X7O FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3Z6:1-[5-(4-AMINO-2,7-DIMETHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-2,3-DIHYDRO-1H-INDOL-1-YL]-2-[3-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]ETHANONE'>3Z6</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3Z6:1-[5-(4-AMINO-2,7-DIMETHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-2,3-DIHYDRO-1H-INDOL-1-YL]-2-[3-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]ETHANONE'>3Z6</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4x7j\|4x7j]], [[4x7h\|4x7h]], [[4x7k\|4x7k]], [[4x7l\|4x7l]], [[4x7n\|4x7n]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4x7j\|4x7j]], [[4x7h\|4x7h]], [[4x7k\|4x7k]], [[4x7l\|4x7l]], [[4x7n\|4x7n]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EIF2AK3, PEK, PERK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x7o OCA], [http://pdbe.org/4x7o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x7o RCSB], [http://www.ebi.ac.uk/pdbsum/4x7o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4x7o ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x7o OCA], [http://pdbe.org/4x7o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x7o RCSB], [http://www.ebi.ac.uk/pdbsum/4x7o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4x7o ProSAT]</span></td></tr>
Line 26:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Chen, H]]		[[Category: Chen, H]]

OCA at 00:08, 26 January 2017

OCA — Thu, 26 Jan 2017 00:08:52 GMT

←Older revision		Revision as of 00:08, 26 January 2017
Line 1:		Line 1:
		+
	==Co-crystal Structure of PERK bound to 1-[5-(4-amino-2,7-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-fluoro-5-(trifluoromethyl)phenyl]ethanone inhibitor==		==Co-crystal Structure of PERK bound to 1-[5-(4-amino-2,7-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-fluoro-5-(trifluoromethyl)phenyl]ethanone inhibitor==
	<StructureSection load='4x7o' size='340' side='right' caption='[[4x7o]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='4x7o' size='340' side='right' caption='[[4x7o]], [[Resolution\|resolution]] 2.65Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4x7j\|4x7j]], [[4x7h\|4x7h]], [[4x7k\|4x7k]], [[4x7l\|4x7l]], [[4x7n\|4x7n]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4x7j\|4x7j]], [[4x7h\|4x7h]], [[4x7k\|4x7k]], [[4x7l\|4x7l]], [[4x7n\|4x7n]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x7o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4x7o RCSB], [http://www.ebi.ac.uk/pdbsum/4x7o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x7o OCA], [http://pdbe.org/4x7o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x7o RCSB], [http://www.ebi.ac.uk/pdbsum/4x7o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4x7o ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4x7o" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:33, 28 January 2015

OCA — Wed, 28 Jan 2015 16:33:20 GMT

←Older revision		Revision as of 16:33, 28 January 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Co-crystal Structure of PERK bound to 1-[5-(4-amino-2,7-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-fluoro-5-(trifluoromethyl)phenyl]ethanone inhibitor==
		+	<StructureSection load='4x7o' size='340' side='right' caption='[[4x7o]], [[Resolution\|resolution]] 2.65Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4x7o]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X7O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X7O FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3Z6:1-[5-(4-AMINO-2,7-DIMETHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-2,3-DIHYDRO-1H-INDOL-1-YL]-2-[3-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]ETHANONE'>3Z6</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4x7j\|4x7j]], [[4x7h\|4x7h]], [[4x7k\|4x7k]], [[4x7l\|4x7l]], [[4x7n\|4x7n]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x7o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4x7o RCSB], [http://www.ebi.ac.uk/pdbsum/4x7o PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/E2AK3_HUMAN E2AK3_HUMAN]] Wolcott-Rallison syndrome. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:10932183</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/E2AK3_HUMAN E2AK3_HUMAN]] Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The structure-based design and optimization of a novel series of selective PERK inhibitors are described resulting in the identification of 44 as a potent, highly selective, and orally active tool compound suitable for PERK pathway biology exploration both in vitro and in vivo.

-	~~The entry 4x7o is ON HOLD until Paper Publication~~	+	Discovery of 1H-Pyrazol-3(2H)-ones as Potent and Selective Inhibitors of Protein Kinase R-like Endoplasmic Reticulum Kinase (PERK).,Smith AL, Andrews KL, Beckmann H, Bellon SF, Beltran PJ, Booker S, Chen H, Chung YA, D'Angelo ND, Dao J, Dellamaggiore KR, Jaeckel P, Kendall R, Labitzke K, Long AM, Materna-Reichelt S, Mitchell P, Norman MH, Powers D, Rose M, Shaffer PL, Wu MM, Lipford JR J Med Chem. 2015 Jan 14. PMID:25587754<ref>PMID:25587754</ref>

-	~~Authors: Shaffer~~, P.L.~~, Long, A.M., Chen, H~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description:~~	+	== References ==
-	~~[[Category: Unreleased Structures]]~~	+	<references/>
-	[[Category: ~~Long, A.M~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Chen, H]]		[[Category: Chen, H]]
-	[[Category: Shaffer, P.L]]	+	[[Category: Long, A M]]
		+	[[Category: Shaffer, P L]]
		+	[[Category: Catalytic domain]]
		+	[[Category: Complex]]
		+	[[Category: Transferase-transferase inhibitor]]
		+	[[Category: Transferase-transferase inhibitor complex]]

OCA at 12:27, 14 January 2015

OCA — Wed, 14 Jan 2015 12:27:08 GMT

←Older revision		Revision as of 12:27, 14 January 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4x7o is ON HOLD	+	The entry 4x7o is ON HOLD until Paper Publication

	Authors: Shaffer, P.L., Long, A.M., Chen, H.		Authors: Shaffer, P.L., Long, A.M., Chen, H.

OCA at 20:36, 24 December 2014

OCA — Wed, 24 Dec 2014 20:36:25 GMT

←Older revision		Revision as of 20:36, 24 December 2014
Line 5:		Line 5:
	Authors: Shaffer, P.L., Long, A.M., Chen, H.		Authors: Shaffer, P.L., Long, A.M., Chen, H.

-	Description:	+	Description:
		+	[[Category: Unreleased Structures]]
		+	[[Category: Long, A.M]]
		+	[[Category: Chen, H]]
		+	[[Category: Shaffer, P.L]]

OCA: Protected "4x7o" [edit=sysop:move=sysop]

OCA — Wed, 17 Dec 2014 11:45:49 GMT

Protected "4x7o" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:45, 17 December 2014

OCA: New page: '''Unreleased structure''' The entry 4x7o is ON HOLD Authors: Shaffer, P.L., Long, A.M., Chen, H. Description:

OCA — Wed, 17 Dec 2014 11:45:47 GMT

New page: '''Unreleased structure''' The entry 4x7o is ON HOLD Authors: Shaffer, P.L., Long, A.M., Chen, H. Description:

New page

'''Unreleased structure'''

The entry 4x7o is ON HOLD

Authors: Shaffer, P.L., Long, A.M., Chen, H.

Description: