4x97 - Revision history

OCA at 07:42, 27 September 2023

OCA — Wed, 27 Sep 2023 07:42:02 GMT

←Older revision		Revision as of 07:42, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4x97]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X97 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X97 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4x97]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X97 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X97 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MAY:METHYL+ARACHIDONYL+FLUOROPHOSPHONATE'>MAY</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.65Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MAY:METHYL+ARACHIDONYL+FLUOROPHOSPHONATE'>MAY</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x97 OCA], [https://pdbe.org/4x97 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x97 RCSB], [https://www.ebi.ac.uk/pdbsum/4x97 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x97 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x97 OCA], [https://pdbe.org/4x97 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x97 RCSB], [https://www.ebi.ac.uk/pdbsum/4x97 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x97 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 21:18, 12 April 2023

OCA — Wed, 12 Apr 2023 21:18:40 GMT

←Older revision		Revision as of 21:18, 12 April 2023
Line 3:		Line 3:
	<StructureSection load='4x97' size='340' side='right'caption='[[4x97]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='4x97' size='340' side='right'caption='[[4x97]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4x97]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X97 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4X97 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4x97]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X97 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X97 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MAY:METHYL+ARACHIDONYL+FLUOROPHOSPHONATE'>MAY</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MAY:METHYL+ARACHIDONYL+FLUOROPHOSPHONATE'>MAY</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4x90\|4x90]], [[4x91\|4x91]], [[4x93\|4x93]], [[4x94\|4x94]], [[4x95\|4x95]], [[4x96\|4x96]], [[4x92\|4x92]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x97 OCA], [https://pdbe.org/4x97 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x97 RCSB], [https://www.ebi.ac.uk/pdbsum/4x97 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x97 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLA2G15, LYPLA3, UNQ341/PRO540 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4x97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x97 OCA], [~~http~~://pdbe.org/4x97 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4x97 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4x97 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4x97 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PAG15_HUMAN PAG15_HUMAN]] Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid (By similarity). May have weak lysophospholipase activity.	+	[https://www.uniprot.org/uniprot/PAG15_HUMAN PAG15_HUMAN] Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid (By similarity). May have weak lysophospholipase activity.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Glukhova, A]]	+	[[Category: Glukhova A]]
-	[[Category: Tesmer~~, J J.G]]~~	+	[[Category: Tesmer JJG]]
-	~~[[Category: Acyltransferase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Mafp]]~~	+
-	~~[[Category: Phospholipase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 08:42, 4 December 2019

OCA — Wed, 04 Dec 2019 08:42:52 GMT

←Older revision		Revision as of 08:42, 4 December 2019
Line 1:		Line 1:

	==Crystal structure of Lysosomal Phospholipase A2 in complex with methyl arachidonyl fluorophosphonate (MAFP)==		==Crystal structure of Lysosomal Phospholipase A2 in complex with methyl arachidonyl fluorophosphonate (MAFP)==
-	<StructureSection load='4x97' size='340' side='right' caption='[[4x97]], [[Resolution\|resolution]] 2.65Å' scene=''>	+	<StructureSection load='4x97' size='340' side='right'caption='[[4x97]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4x97]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X97 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X97 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4x97]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X97 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X97 FirstGlance]. <br>
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4x97" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4x97" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Phospholipase A2 3D structures\|Phospholipase A2 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Glukhova, A]]		[[Category: Glukhova, A]]
	[[Category: Tesmer, J J.G]]		[[Category: Tesmer, J J.G]]

OCA at 09:32, 22 November 2017

OCA — Wed, 22 Nov 2017 09:32:58 GMT

←Older revision		Revision as of 09:32, 22 November 2017
Line 3:		Line 3:
	<StructureSection load='4x97' size='340' side='right' caption='[[4x97]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='4x97' size='340' side='right' caption='[[4x97]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4x97]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X97 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X97 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4x97]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X97 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X97 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MAY:METHYL+ARACHIDONYL+FLUOROPHOSPHONATE'>MAY</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MAY:METHYL+ARACHIDONYL+FLUOROPHOSPHONATE'>MAY</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4x90\|4x90]], [[4x91\|4x91]], [[4x93\|4x93]], [[4x94\|4x94]], [[4x95\|4x95]], [[4x96\|4x96]], [[4x92\|4x92]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4x90\|4x90]], [[4x91\|4x91]], [[4x93\|4x93]], [[4x94\|4x94]], [[4x95\|4x95]], [[4x96\|4x96]], [[4x92\|4x92]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLA2G15, LYPLA3, UNQ341/PRO540 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x97 OCA], [http://pdbe.org/4x97 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x97 RCSB], [http://www.ebi.ac.uk/pdbsum/4x97 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4x97 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x97 OCA], [http://pdbe.org/4x97 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x97 RCSB], [http://www.ebi.ac.uk/pdbsum/4x97 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4x97 ProSAT]</span></td></tr>
	</table>		</table>
Line 19:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4x97" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4x97" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Phospholipase A2\|Phospholipase A2]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Glukhova, A]]		[[Category: Glukhova, A]]
	[[Category: Tesmer, J J.G]]		[[Category: Tesmer, J J.G]]

OCA at 00:14, 26 January 2017

OCA — Thu, 26 Jan 2017 00:14:05 GMT

←Older revision		Revision as of 00:14, 26 January 2017
Line 1:		Line 1:
		+
	==Crystal structure of Lysosomal Phospholipase A2 in complex with methyl arachidonyl fluorophosphonate (MAFP)==		==Crystal structure of Lysosomal Phospholipase A2 in complex with methyl arachidonyl fluorophosphonate (MAFP)==
	<StructureSection load='4x97' size='340' side='right' caption='[[4x97]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='4x97' size='340' side='right' caption='[[4x97]], [[Resolution\|resolution]] 2.65Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MAY:METHYL+ARACHIDONYL+FLUOROPHOSPHONATE'>MAY</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MAY:METHYL+ARACHIDONYL+FLUOROPHOSPHONATE'>MAY</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4x90\|4x90]], [[4x91\|4x91]], [[4x93\|4x93]], [[4x94\|4x94]], [[4x95\|4x95]], [[4x96\|4x96]], [[4x92\|4x92]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4x90\|4x90]], [[4x91\|4x91]], [[4x93\|4x93]], [[4x94\|4x94]], [[4x95\|4x95]], [[4x96\|4x96]], [[4x92\|4x92]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x97 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4x97 RCSB], [http://www.ebi.ac.uk/pdbsum/4x97 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x97 OCA], [http://pdbe.org/4x97 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x97 RCSB], [http://www.ebi.ac.uk/pdbsum/4x97 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4x97 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4x97" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Phospholipase A2\|Phospholipase A2]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:05, 18 March 2015

OCA — Wed, 18 Mar 2015 12:05:02 GMT

←Older revision		Revision as of 12:05, 18 March 2015
Line 9:		Line 9:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PAG15_HUMAN PAG15_HUMAN]] Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid (By similarity). May have weak lysophospholipase activity.		[[http://www.uniprot.org/uniprot/PAG15_HUMAN PAG15_HUMAN]] Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid (By similarity). May have weak lysophospholipase activity.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Lysosomal phospholipase A2 (LPLA2) and lecithin:cholesterol acyltransferase (LCAT) belong to a structurally uncharacterized family of key lipid-metabolizing enzymes responsible for lung surfactant catabolism and for reverse cholesterol transport, respectively. Whereas LPLA2 is predicted to underlie the development of drug-induced phospholipidosis, somatic mutations in LCAT cause fish eye disease and familial LCAT deficiency. Here we describe several high-resolution crystal structures of human LPLA2 and a low-resolution structure of LCAT that confirms its close structural relationship to LPLA2. Insertions in the alpha/beta hydrolase core of LPLA2 form domains that are responsible for membrane interaction and binding the acyl chains and head groups of phospholipid substrates. The LCAT structure suggests the molecular basis underlying human disease for most of the known LCAT missense mutations, and paves the way for rational development of new therapeutics to treat LCAT deficiency, atherosclerosis and acute coronary syndrome.
		+
		+	Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase.,Glukhova A, Hinkovska-Galcheva V, Kelly R, Abe A, Shayman JA, Tesmer JJ Nat Commun. 2015 Mar 2;6:6250. doi: 10.1038/ncomms7250. PMID:25727495<ref>PMID:25727495</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 12:00, 11 March 2015

OCA — Wed, 11 Mar 2015 12:00:25 GMT

←Older revision		Revision as of 12:00, 11 March 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of Lysosomal Phospholipase A2 in complex with methyl arachidonyl fluorophosphonate (MAFP)==
-		+	<StructureSection load='4x97' size='340' side='right' caption='[[4x97]], [[Resolution\|resolution]] 2.65Å' scene=''>
-	~~The entry~~ 4x97 is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4x97]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X97 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X97 FirstGlance]. <br>
-	~~Authors~~: ~~Glukhova~~, A., ~~Tesmer~~, J.J.G.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MAY:METHYL+ARACHIDONYL+FLUOROPHOSPHONATE'>MAY</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4x90\|4x90]], [[4x91\|4x91]], [[4x93\|4x93]], [[4x94\|4x94]], [[4x95\|4x95]], [[4x96\|4x96]], [[4x92\|4x92]]</td></tr>
-	~~Description: Crystal structure of Lysosomal Phospholipase A2 in complex with methyl arachidonyl fluorophosphonate (MAFP)~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x97 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4x97 RCSB], [http://www.ebi.ac.uk/pdbsum/4x97 PDBsum]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PAG15_HUMAN PAG15_HUMAN]] Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid (By similarity). May have weak lysophospholipase activity.
		+	__TOC__
		+	</StructureSection>
	[[Category: Glukhova, A]]		[[Category: Glukhova, A]]
-	[[Category: Tesmer, J.J.G]]	+	[[Category: Tesmer, J J.G]]
		+	[[Category: Acyltransferase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Mafp]]
		+	[[Category: Phospholipase]]
		+	[[Category: Transferase]]

OCA at 09:18, 4 March 2015

OCA — Wed, 04 Mar 2015 09:18:59 GMT

←Older revision		Revision as of 09:18, 4 March 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4x97 is ON HOLD	+	The entry 4x97 is ON HOLD until Paper Publication

	Authors: Glukhova, A., Tesmer, J.J.G.		Authors: Glukhova, A., Tesmer, J.J.G.

OCA at 20:41, 24 December 2014

OCA — Wed, 24 Dec 2014 20:41:06 GMT

←Older revision		Revision as of 20:41, 24 December 2014
Line 6:		Line 6:

	Description: Crystal structure of Lysosomal Phospholipase A2 in complex with methyl arachidonyl fluorophosphonate (MAFP)		Description: Crystal structure of Lysosomal Phospholipase A2 in complex with methyl arachidonyl fluorophosphonate (MAFP)
		+	[[Category: Unreleased Structures]]
		+	[[Category: Glukhova, A]]
		+	[[Category: Tesmer, J.J.G]]

OCA at 10:02, 24 December 2014

OCA — Wed, 24 Dec 2014 10:02:20 GMT

←Older revision		Revision as of 10:02, 24 December 2014
Line 3:		Line 3:
	The entry 4x97 is ON HOLD		The entry 4x97 is ON HOLD

-	Authors: Glukhova, A, Tesmer, J.J.G.	+	Authors: Glukhova, A., Tesmer, J.J.G.

	Description: Crystal structure of Lysosomal Phospholipase A2 in complex with methyl arachidonyl fluorophosphonate (MAFP)		Description: Crystal structure of Lysosomal Phospholipase A2 in complex with methyl arachidonyl fluorophosphonate (MAFP)