4xbu - Revision history

OCA at 15:26, 8 November 2023

OCA — Wed, 08 Nov 2023 15:26:38 GMT

←Older revision		Revision as of 15:26, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xbu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XBU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XBU FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xbu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XBU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XBU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.06Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xbu OCA], [https://pdbe.org/4xbu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xbu RCSB], [https://www.ebi.ac.uk/pdbsum/4xbu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xbu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xbu OCA], [https://pdbe.org/4xbu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xbu RCSB], [https://www.ebi.ac.uk/pdbsum/4xbu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xbu ProSAT]</span></td></tr>
	</table>		</table>

OCA at 21:21, 12 April 2023

OCA — Wed, 12 Apr 2023 21:21:41 GMT

←Older revision		Revision as of 21:21, 12 April 2023
Line 3:		Line 3:
	<StructureSection load='4xbu' size='340' side='right'caption='[[4xbu]], [[Resolution\|resolution]] 2.06Å' scene=''>		<StructureSection load='4xbu' size='340' side='right'caption='[[4xbu]], [[Resolution\|resolution]] 2.06Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xbu]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XBU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4XBU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xbu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XBU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XBU FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xbr\|4xbr]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xbu OCA], [https://pdbe.org/4xbu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xbu RCSB], [https://www.ebi.ac.uk/pdbsum/4xbu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xbu ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PAK4, KIAA1142 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4xbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xbu OCA], [~~http~~://pdbe.org/4xbu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4xbu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4xbu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4xbu ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PAK4_HUMAN PAK4_HUMAN]] Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.<ref>PMID:11278822</ref> <ref>PMID:11313478</ref> <ref>PMID:14560027</ref> <ref>PMID:15660133</ref> <ref>PMID:20507994</ref> <ref>PMID:20805321</ref> <ref>PMID:20631255</ref>	+	[https://www.uniprot.org/uniprot/PAK4_HUMAN PAK4_HUMAN] Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.<ref>PMID:11278822</ref> <ref>PMID:11313478</ref> <ref>PMID:14560027</ref> <ref>PMID:15660133</ref> <ref>PMID:20507994</ref> <ref>PMID:20805321</ref> <ref>PMID:20631255</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 20:

	==See Also==		==See Also==
-	*[[Serine/threonine protein kinase\|Serine/threonine protein kinase]]	+	*[[Serine/threonine protein kinase 3D structures\|Serine/threonine protein kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Non-specific serine/threonine protein kinase]]~~	+	[[Category: Anekal PV]]
-	[[Category: Anekal~~, P V~~]]	+	[[Category: Ang KC]]
-	[[Category: Ang~~, K C~~]]	+	[[Category: Baskaran Y]]
-	[[Category: Baskaran, Y]]	+	[[Category: Chan WL]]
-	[[Category: Chan~~, W L~~]]	+	[[Category: Grimes JM]]
-	[[Category: Grimes~~, J M~~]]	+	[[Category: Manser E]]
-	[[Category: Manser, E]]	+	[[Category: Robinson RC]]
-	[[Category: Robinson~~, R C]]~~	+
-	~~[[Category: Inka]]~~	+
-	~~[[Category: Pak4]]~~	+
-	~~[[Category: Transferase-peptide complex~~]]	+

OCA at 07:14, 29 May 2019

OCA — Wed, 29 May 2019 07:14:52 GMT

←Older revision		Revision as of 07:14, 29 May 2019
Line 1:		Line 1:
		+
	==In vitro Crystal Structure of PAK4 in complex with Inka peptide==		==In vitro Crystal Structure of PAK4 in complex with Inka peptide==
-	<StructureSection load='4xbu' size='340' side='right' caption='[[4xbu]], [[Resolution\|resolution]] 2.06Å' scene=''>	+	<StructureSection load='4xbu' size='340' side='right'caption='[[4xbu]], [[Resolution\|resolution]] 2.06Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xbu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XBU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XBU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xbu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XBU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XBU FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xbr\|4xbr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xbr\|4xbr]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PAK4, KIAA1142 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xbu OCA], [http://pdbe.org/4xbu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xbu RCSB], [http://www.ebi.ac.uk/pdbsum/4xbu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xbu OCA], [http://pdbe.org/4xbu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xbu RCSB], [http://www.ebi.ac.uk/pdbsum/4xbu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xbu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4xbu" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4xbu" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Serine/threonine protein kinase\|Serine/threonine protein kinase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Anekal, P V]]		[[Category: Anekal, P V]]

OCA at 07:29, 9 December 2015

OCA — Wed, 09 Dec 2015 07:29:09 GMT

←Older revision		Revision as of 07:29, 9 December 2015
Line 10:		Line 10:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PAK4_HUMAN PAK4_HUMAN]] Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.<ref>PMID:11278822</ref> <ref>PMID:11313478</ref> <ref>PMID:14560027</ref> <ref>PMID:15660133</ref> <ref>PMID:20507994</ref> <ref>PMID:20805321</ref> <ref>PMID:20631255</ref>		[[http://www.uniprot.org/uniprot/PAK4_HUMAN PAK4_HUMAN]] Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.<ref>PMID:11278822</ref> <ref>PMID:11313478</ref> <ref>PMID:14560027</ref> <ref>PMID:15660133</ref> <ref>PMID:20507994</ref> <ref>PMID:20805321</ref> <ref>PMID:20631255</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	PAK4 is a metazoan-specific kinase acting downstream of Cdc42. Here we describe the structure of human PAK4 in complex with Inka1, a potent endogenous kinase inhibitor. Using single mammalian cells containing crystals 50 mum in length, we have determined the in cellulo crystal structure at 2.95 A resolution, which reveals the details of how the PAK4 catalytic domain binds cellular ATP and the Inka1 inhibitor. The crystal lattice consists only of PAK4-PAK4 contacts, which form a hexagonal array with channels of 80 A in diameter that run the length of the crystal. The crystal accommodates a variety of other proteins when fused to the kinase inhibitor. Inka1-GFP was used to monitor the process crystal formation in living cells. Similar derivatives of Inka1 will allow us to study the effects of PAK4 inhibition in cells and model organisms, to allow better validation of therapeutic agents targeting PAK4.
		+
		+	An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1.,Baskaran Y, Ang KC, Anekal PV, Chan WL, Grimes JM, Manser E, Robinson RC Nat Commun. 2015 Nov 26;6:8681. doi: 10.1038/ncomms9681. PMID:26607847<ref>PMID:26607847</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4xbu" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:15, 2 December 2015

OCA — Wed, 02 Dec 2015 16:15:46 GMT

←Older revision		Revision as of 16:15, 2 December 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==In vitro Crystal Structure of PAK4 in complex with Inka peptide==
-		+	<StructureSection load='4xbu' size='340' side='right' caption='[[4xbu]], [[Resolution\|resolution]] 2.06Å' scene=''>
-	~~The entry~~ 4xbu is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4xbu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XBU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XBU FirstGlance]. <br>
-	~~Authors~~: ~~Baskaran, Y~~., ~~Ang, K~~.C.~~, Anekal, P~~.V.~~, Chan, W~~.L., ~~Grimes, J~~.M., ~~Manser~~, E., ~~Robinson, R~~.C.	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xbr\|4xbr]]</td></tr>
-	~~Description:~~	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xbu OCA], [http://pdbe.org/4xbu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xbu RCSB], [http://www.ebi.ac.uk/pdbsum/4xbu PDBsum]</span></td></tr>
-	~~[[Category: Manser~~, ~~E]]~~	+	</table>
-	[[Category: ~~Grimes, J.M~~]]	+	== Function ==
-	[[Category: ~~Chan~~, ~~W.L~~]]	+	[[http://www.uniprot.org/uniprot/PAK4_HUMAN PAK4_HUMAN]] Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.<ref>PMID:11278822</ref> <ref>PMID:11313478</ref> <ref>PMID:14560027</ref> <ref>PMID:15660133</ref> <ref>PMID:20507994</ref> <ref>PMID:20805321</ref> <ref>PMID:20631255</ref>
-	[[Category: ~~Anekal~~, ~~P.V~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Non-specific serine/threonine protein kinase]]
		+	[[Category: Anekal, P V]]
		+	[[Category: Ang, K C]]
	[[Category: Baskaran, Y]]		[[Category: Baskaran, Y]]
-	[[Category: Robinson, R.C]]	+	[[Category: Chan, W L]]
-	[[Category: ~~Ang, K.C~~]]	+	[[Category: Grimes, J M]]
		+	[[Category: Manser, E]]
		+	[[Category: Robinson, R C]]
		+	[[Category: Inka]]
		+	[[Category: Pak4]]
		+	[[Category: Transferase-peptide complex]]

OCA at 23:07, 30 November 2015

OCA — Mon, 30 Nov 2015 23:07:31 GMT

←Older revision		Revision as of 23:07, 30 November 2015
Line 7:		Line 7:
	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Chan, W.L]]
-	[[Category: Anekal, P.V]]
	[[Category: Manser, E]]		[[Category: Manser, E]]
	[[Category: Grimes, J.M]]		[[Category: Grimes, J.M]]
		+	[[Category: Chan, W.L]]
		+	[[Category: Anekal, P.V]]
	[[Category: Baskaran, Y]]		[[Category: Baskaran, Y]]
	[[Category: Robinson, R.C]]		[[Category: Robinson, R.C]]
	[[Category: Ang, K.C]]		[[Category: Ang, K.C]]

OCA at 13:57, 31 December 2014

OCA — Wed, 31 Dec 2014 13:57:36 GMT

←Older revision		Revision as of 13:57, 31 December 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4xbu is ON HOLD	+	The entry 4xbu is ON HOLD until Paper Publication

	Authors: Baskaran, Y., Ang, K.C., Anekal, P.V., Chan, W.L., Grimes, J.M., Manser, E., Robinson, R.C.		Authors: Baskaran, Y., Ang, K.C., Anekal, P.V., Chan, W.L., Grimes, J.M., Manser, E., Robinson, R.C.

OCA at 20:50, 24 December 2014

OCA — Wed, 24 Dec 2014 20:50:44 GMT

←Older revision		Revision as of 20:50, 24 December 2014
Line 5:		Line 5:
	Authors: Baskaran, Y., Ang, K.C., Anekal, P.V., Chan, W.L., Grimes, J.M., Manser, E., Robinson, R.C.		Authors: Baskaran, Y., Ang, K.C., Anekal, P.V., Chan, W.L., Grimes, J.M., Manser, E., Robinson, R.C.

-	Description:	+	Description:
		+	[[Category: Unreleased Structures]]
		+	[[Category: Chan, W.L]]
		+	[[Category: Anekal, P.V]]
		+	[[Category: Manser, E]]
		+	[[Category: Grimes, J.M]]
		+	[[Category: Baskaran, Y]]
		+	[[Category: Robinson, R.C]]
		+	[[Category: Ang, K.C]]

OCA: Protected "4xbu" [edit=sysop:move=sysop]

OCA — Wed, 24 Dec 2014 10:05:46 GMT

Protected "4xbu" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:05, 24 December 2014

OCA: New page: '''Unreleased structure''' The entry 4xbu is ON HOLD Authors: Baskaran, Y., Ang, K.C., Anekal, P.V., Chan, W.L., Grimes, J.M., Manser, E., Robinson, R.C. Description:

OCA — Wed, 24 Dec 2014 10:05:45 GMT

New page: '''Unreleased structure''' The entry 4xbu is ON HOLD Authors: Baskaran, Y., Ang, K.C., Anekal, P.V., Chan, W.L., Grimes, J.M., Manser, E., Robinson, R.C. Description:

New page

'''Unreleased structure'''

The entry 4xbu is ON HOLD

Authors: Baskaran, Y., Ang, K.C., Anekal, P.V., Chan, W.L., Grimes, J.M., Manser, E., Robinson, R.C.

Description: