4xc2 - Revision history

OCA at 10:47, 10 January 2024

OCA — Wed, 10 Jan 2024 10:47:58 GMT

←Older revision		Revision as of 10:47, 10 January 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xc2]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XC2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XC2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xc2]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XC2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XC2 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xc2 OCA], [https://pdbe.org/4xc2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xc2 RCSB], [https://www.ebi.ac.uk/pdbsum/4xc2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xc2 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xc2 OCA], [https://pdbe.org/4xc2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xc2 RCSB], [https://www.ebi.ac.uk/pdbsum/4xc2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xc2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 21:21, 12 April 2023

OCA — Wed, 12 Apr 2023 21:21:59 GMT

←Older revision		Revision as of 21:21, 12 April 2023
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	<StructureSection load='4xc2' size='340' side='right'caption='[[4xc2]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4xc2' size='340' side='right'caption='[[4xc2]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xc2]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XC2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4XC2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xc2]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XC2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XC2 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GABARAP, hCG_1987397 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xc2 OCA], [https://pdbe.org/4xc2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xc2 RCSB], [https://www.ebi.ac.uk/pdbsum/4xc2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xc2 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4xc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xc2 OCA], [~~http~~://pdbe.org/4xc2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4xc2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4xc2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4xc2 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GBRAP_HUMAN GBRAP_HUMAN] May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy (By similarity).<ref>PMID:15977068</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
		+	*[[GABA receptor-associated protein 3D structures\|GABA receptor-associated protein 3D structures]]
	*[[GABA(A) receptor-associated protein\|GABA(A) receptor-associated protein]]		*[[GABA(A) receptor-associated protein\|GABA(A) receptor-associated protein]]
	== References ==		== References ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Akutsu, M]]	+	[[Category: Akutsu M]]
-	[[Category: Baschieri, F]]	+	[[Category: Baschieri F]]
-	[[Category: Behrends, C]]	+	[[Category: Behrends C]]
-	[[Category: Doetsch, V]]	+	[[Category: Doetsch V]]
-	[[Category: Farhan, H]]	+	[[Category: Farhan H]]
-	[[Category: Genau~~, H M~~]]	+	[[Category: Genau HM]]
-	[[Category: Huber, J]]	+	[[Category: Huber J]]
-	[[Category: Rogov~~, V V]]~~	+	[[Category: Rogov VV]]
-	~~[[Category: Autophagy]]~~	+
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Immune system~~]]	+

OCA at 07:38, 29 May 2019

OCA — Wed, 29 May 2019 07:38:19 GMT

←Older revision		Revision as of 07:38, 29 May 2019
Line 1:		Line 1:

	==Crystal structure of GABARAP in complex with KBTBD6 LIR peptide==		==Crystal structure of GABARAP in complex with KBTBD6 LIR peptide==
-	<StructureSection load='4xc2' size='340' side='right' caption='[[4xc2]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='4xc2' size='340' side='right'caption='[[4xc2]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xc2]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XC2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XC2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xc2]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XC2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XC2 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xc2 OCA], [http://pdbe.org/4xc2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xc2 RCSB], [http://www.ebi.ac.uk/pdbsum/4xc2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xc2 ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GABARAP, hCG_1987397 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xc2 OCA], [http://pdbe.org/4xc2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xc2 RCSB], [http://www.ebi.ac.uk/pdbsum/4xc2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xc2 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 4xc2" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4xc2" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[GABA(A) receptor-associated protein\|GABA(A) receptor-associated protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Akutsu, M]]		[[Category: Akutsu, M]]
	[[Category: Baschieri, F]]		[[Category: Baschieri, F]]

OCA at 11:16, 26 October 2016

OCA — Wed, 26 Oct 2016 11:16:21 GMT

←Older revision		Revision as of 11:16, 26 October 2016
Line 1:		Line 1:
		+
	==Crystal structure of GABARAP in complex with KBTBD6 LIR peptide==		==Crystal structure of GABARAP in complex with KBTBD6 LIR peptide==
	<StructureSection load='4xc2' size='340' side='right' caption='[[4xc2]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4xc2' size='340' side='right' caption='[[4xc2]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xc2]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XC2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XC2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xc2]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XC2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XC2 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xc2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xc2 RCSB], [http://www.ebi.ac.uk/pdbsum/4xc2 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xc2 OCA], [http://pdbe.org/4xc2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xc2 RCSB], [http://www.ebi.ac.uk/pdbsum/4xc2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xc2 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 13:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4xc2" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 26:
	[[Category: Genau, H M]]		[[Category: Genau, H M]]
	[[Category: Huber, J]]		[[Category: Huber, J]]
-	[[Category: Rogov, V]]	+	[[Category: Rogov, V V]]
	[[Category: Autophagy]]		[[Category: Autophagy]]
	[[Category: Complex]]		[[Category: Complex]]
	[[Category: Immune system]]		[[Category: Immune system]]

OCA at 11:24, 4 March 2015

OCA — Wed, 04 Mar 2015 11:24:30 GMT

←Older revision		Revision as of 11:24, 4 March 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of GABARAP in complex with KBTBD6 LIR peptide==
		+	<StructureSection load='4xc2' size='340' side='right' caption='[[4xc2]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4xc2]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XC2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XC2 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xc2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xc2 RCSB], [http://www.ebi.ac.uk/pdbsum/4xc2 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The small Rho GTPase RAC1 is an essential regulator of cellular signaling that controls actin rearrangements and cell motility. Here, we identify a novel CUL3 RING ubiquitin ligase complex, containing the substrate adaptors KBTBD6 and KBTBD7, that mediates ubiquitylation and proteasomal degradation of TIAM1, a RAC1-specific GEF. Increasing the abundance of TIAM1 by depletion of KBTBD6 and/or KBTBD7 leads to elevated RAC1 activity, changes in actin morphology, loss of focal adhesions, reduced proliferation, and enhanced invasion. KBTBD6 and KBTBD7 employ ATG8 family-interacting motifs to bind preferentially to GABARAP proteins. Surprisingly, ubiquitylation and degradation of TIAM1 by CUL3KBTBD6/KBTBD7 depends on its binding to GABARAP proteins. Our study reveals that recruitment of CUL3KBTBD6/KBTBD7 to GABARAP-containing vesicles regulates the abundance of membrane-associated TIAM1 and subsequently spatially restricted RAC1 signaling. Besides their role in autophagy and trafficking, we uncovered a previously unknown function of GABARAP proteins as membrane-localized signaling scaffolds.

-	~~The entry 4xc2 is ON HOLD until Paper Publication~~	+	CUL3-KBTBD6/KBTBD7 Ubiquitin Ligase Cooperates with GABARAP Proteins to Spatially Restrict TIAM1-RAC1 Signaling.,Genau HM, Huber J, Baschieri F, Akutsu M, Dotsch V, Farhan H, Rogov V, Behrends C Mol Cell. 2015 Feb 11. pii: S1097-2765(14)01018-1. doi:, 10.1016/j.molcel.2014.12.040. PMID:25684205<ref>PMID:25684205</ref>

-	~~Authors: Huber~~, J.~~, Genau, H~~.~~M., Baschieri, F., Doetsch, V., Farhan, H., Rogov, V., Behrends, C., Akutsu, M~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: Crystal structure of GABARAP in complex with KBTBD6 LIR peptide~~	+	== References ==
-	~~[[Category: Unreleased Structures]]~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Akutsu, M]]		[[Category: Akutsu, M]]
		+	[[Category: Baschieri, F]]
		+	[[Category: Behrends, C]]
	[[Category: Doetsch, V]]		[[Category: Doetsch, V]]
		+	[[Category: Farhan, H]]
		+	[[Category: Genau, H M]]
	[[Category: Huber, J]]		[[Category: Huber, J]]
-	[[Category: Baschieri, F]]
-	[[Category: Farhan, H]]
	[[Category: Rogov, V]]		[[Category: Rogov, V]]
-	[[Category: ~~Behrends, C~~]]	+	[[Category: Autophagy]]
-	[[Category: ~~Genau, H.M~~]]	+	[[Category: Complex]]
		+	[[Category: Immune system]]

OCA at 20:51, 24 December 2014

OCA — Wed, 24 Dec 2014 20:51:08 GMT

←Older revision		Revision as of 20:51, 24 December 2014
Line 6:		Line 6:

	Description: Crystal structure of GABARAP in complex with KBTBD6 LIR peptide		Description: Crystal structure of GABARAP in complex with KBTBD6 LIR peptide
		+	[[Category: Unreleased Structures]]
		+	[[Category: Akutsu, M]]
		+	[[Category: Doetsch, V]]
		+	[[Category: Huber, J]]
		+	[[Category: Baschieri, F]]
		+	[[Category: Farhan, H]]
		+	[[Category: Rogov, V]]
		+	[[Category: Behrends, C]]
		+	[[Category: Genau, H.M]]

OCA: Protected "4xc2" [edit=sysop:move=sysop]

OCA — Wed, 24 Dec 2014 10:06:06 GMT

Protected "4xc2" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:06, 24 December 2014

OCA: New page: '''Unreleased structure''' The entry 4xc2 is ON HOLD until Paper Publication Authors: Huber, J., Genau, H.M., Baschieri, F., Doetsch, V., Farhan, H., Rogov, V., Behrends, C., Akutsu, M....

OCA — Wed, 24 Dec 2014 10:06:05 GMT

New page: '''Unreleased structure''' The entry 4xc2 is ON HOLD until Paper Publication Authors: Huber, J., Genau, H.M., Baschieri, F., Doetsch, V., Farhan, H., Rogov, V., Behrends, C., Akutsu, M....

New page

'''Unreleased structure'''

The entry 4xc2 is ON HOLD until Paper Publication

Authors: Huber, J., Genau, H.M., Baschieri, F., Doetsch, V., Farhan, H., Rogov, V., Behrends, C., Akutsu, M.

Description: Crystal structure of GABARAP in complex with KBTBD6 LIR peptide