4xc8 - Revision history

OCA at 07:43, 27 September 2023

OCA — Wed, 27 Sep 2023 07:43:45 GMT

←Older revision		Revision as of 07:43, 27 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xc8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cupriavidus_metallidurans_CH34 Cupriavidus metallidurans CH34]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XC8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XC8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xc8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cupriavidus_metallidurans_CH34 Cupriavidus metallidurans CH34]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XC8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XC8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCO:BUTYRYL+COENZYME+A'>BCO</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.25Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCO:BUTYRYL+COENZYME+A'>BCO</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xc8 OCA], [https://pdbe.org/4xc8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xc8 RCSB], [https://www.ebi.ac.uk/pdbsum/4xc8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xc8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xc8 OCA], [https://pdbe.org/4xc8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xc8 RCSB], [https://www.ebi.ac.uk/pdbsum/4xc8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xc8 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 21:22, 12 April 2023

OCA — Wed, 12 Apr 2023 21:22:17 GMT

←Older revision		Revision as of 21:22, 12 April 2023
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	<StructureSection load='4xc8' size='340' side='right'caption='[[4xc8]], [[Resolution\|resolution]] 3.25Å' scene=''>		<StructureSection load='4xc8' size='340' side='right'caption='[[4xc8]], [[Resolution\|resolution]] 3.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xc8]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Cupmc Cupmc~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XC8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4XC8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xc8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cupriavidus_metallidurans_CH34 Cupriavidus metallidurans CH34]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XC8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XC8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCO:BUTYRYL+COENZYME+A'>BCO</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCO:BUTYRYL+COENZYME+A'>BCO</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xc6\|4xc6]], [[4xc7\|4xc7]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xc8 OCA], [https://pdbe.org/4xc8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xc8 RCSB], [https://www.ebi.ac.uk/pdbsum/4xc8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xc8 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IcmF, Rmet_0210 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=266264 CUPMC])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Isobutyryl-CoA_mutase Isobutyryl-CoA mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.13 5.4.99.13] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4xc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xc8 OCA], [~~http~~://pdbe.org/4xc8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4xc8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4xc8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4xc8 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ICMF_CUPMC ICMF_CUPMC] Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, and to a much lesser extent, of pivalyl-CoA and isovaleryl-CoA, using radical chemistry (PubMed:22167181). Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly (PubMed:22167181, PubMed:25675500). The G-domain of IcmF has also a role in its cofactor repair (PubMed:28130442). Does not display ATPase activity.<ref>PMID:22167181</ref> <ref>PMID:25675500</ref> <ref>PMID:28130442</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cupmc]]~~	+	[[Category: Cupriavidus metallidurans CH34]]
-	~~[[Category: Isobutyryl-CoA mutase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Drennan~~, C L~~]]	+	[[Category: Drennan CL]]
-	[[Category: Jost, M]]	+	[[Category: Jost M]]
-	~~[[Category: Complex]]~~	+
-	~~[[Category: G-protein chaperone]]~~	+
-	~~[[Category: Isomerase]]~~	+
-	~~[[Category: Radical enzyme~~]]	+

OCA at 16:04, 20 November 2019

OCA — Wed, 20 Nov 2019 16:04:32 GMT

←Older revision		Revision as of 16:04, 20 November 2019
Line 3:		Line 3:
	<StructureSection load='4xc8' size='340' side='right'caption='[[4xc8]], [[Resolution\|resolution]] 3.25Å' scene=''>		<StructureSection load='4xc8' size='340' side='right'caption='[[4xc8]], [[Resolution\|resolution]] 3.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xc8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XC8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XC8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xc8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cupmc Cupmc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XC8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XC8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCO:BUTYRYL+COENZYME+A'>BCO</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCO:BUTYRYL+COENZYME+A'>BCO</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xc6\|4xc6]], [[4xc7\|4xc7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xc6\|4xc6]], [[4xc7\|4xc7]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IcmF, Rmet_0210 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=266264 CUPMC])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Isobutyryl-CoA_mutase Isobutyryl-CoA mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.13 5.4.99.13] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Isobutyryl-CoA_mutase Isobutyryl-CoA mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.13 5.4.99.13] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xc8 OCA], [http://pdbe.org/4xc8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xc8 RCSB], [http://www.ebi.ac.uk/pdbsum/4xc8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xc8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xc8 OCA], [http://pdbe.org/4xc8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xc8 RCSB], [http://www.ebi.ac.uk/pdbsum/4xc8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xc8 ProSAT]</span></td></tr>
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Cupmc]]
	[[Category: Isobutyryl-CoA mutase]]		[[Category: Isobutyryl-CoA mutase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 07:29, 10 July 2019

OCA — Wed, 10 Jul 2019 07:29:43 GMT

←Older revision		Revision as of 07:29, 10 July 2019
Line 1:		Line 1:

	==Isobutyryl-CoA mutase fused with bound butyryl-CoA, GDP, and Mg and without cobalamin (apo-IcmF/GDP)==		==Isobutyryl-CoA mutase fused with bound butyryl-CoA, GDP, and Mg and without cobalamin (apo-IcmF/GDP)==
-	<StructureSection load='4xc8' size='340' side='right' caption='[[4xc8]], [[Resolution\|resolution]] 3.25Å' scene=''>	+	<StructureSection load='4xc8' size='340' side='right'caption='[[4xc8]], [[Resolution\|resolution]] 3.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xc8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XC8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XC8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xc8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XC8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XC8 FirstGlance]. <br>
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Isobutyryl-CoA mutase]]		[[Category: Isobutyryl-CoA mutase]]
		+	[[Category: Large Structures]]
	[[Category: Drennan, C L]]		[[Category: Drennan, C L]]
	[[Category: Jost, M]]		[[Category: Jost, M]]

OCA at 06:08, 6 October 2017

OCA — Fri, 06 Oct 2017 06:08:37 GMT

←Older revision		Revision as of 06:08, 6 October 2017
Line 1:		Line 1:
		+
	==Isobutyryl-CoA mutase fused with bound butyryl-CoA, GDP, and Mg and without cobalamin (apo-IcmF/GDP)==		==Isobutyryl-CoA mutase fused with bound butyryl-CoA, GDP, and Mg and without cobalamin (apo-IcmF/GDP)==
	<StructureSection load='4xc8' size='340' side='right' caption='[[4xc8]], [[Resolution\|resolution]] 3.25Å' scene=''>		<StructureSection load='4xc8' size='340' side='right' caption='[[4xc8]], [[Resolution\|resolution]] 3.25Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xc6\|4xc6]], [[4xc7\|4xc7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xc6\|4xc6]], [[4xc7\|4xc7]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Isobutyryl-CoA_mutase Isobutyryl-CoA mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.13 5.4.99.13] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Isobutyryl-CoA_mutase Isobutyryl-CoA mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.13 5.4.99.13] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xc8 OCA], [http://pdbe.org/4xc8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xc8 RCSB], [http://www.ebi.ac.uk/pdbsum/4xc8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xc8 OCA], [http://pdbe.org/4xc8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xc8 RCSB], [http://www.ebi.ac.uk/pdbsum/4xc8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xc8 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 18:47, 27 January 2016

OCA — Wed, 27 Jan 2016 18:47:35 GMT

←Older revision		Revision as of 18:47, 27 January 2016
Line 6:		Line 6:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xc6\|4xc6]], [[4xc7\|4xc7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xc6\|4xc6]], [[4xc7\|4xc7]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Isobutyryl-CoA_mutase Isobutyryl-CoA mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.13 5.4.99.13] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Isobutyryl-CoA_mutase Isobutyryl-CoA mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.13 5.4.99.13] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xc8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xc8 RCSB], [http://www.ebi.ac.uk/pdbsum/4xc8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xc8 OCA], [http://pdbe.org/4xc8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xc8 RCSB], [http://www.ebi.ac.uk/pdbsum/4xc8 PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4xc8" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:29, 4 March 2015

OCA — Wed, 04 Mar 2015 11:29:21 GMT

←Older revision		Revision as of 11:29, 4 March 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCO:BUTYRYL+COENZYME+A'>BCO</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCO:BUTYRYL+COENZYME+A'>BCO</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xc6\|4xc6]], [[4xc7\|4xc7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xc6\|4xc6]], [[4xc7\|4xc7]]</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~Methylmalonyl~~-CoA_mutase ~~Methylmalonyl~~-CoA mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.2 5.4.99.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Isobutyryl-CoA_mutase Isobutyryl-CoA mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.13 5.4.99.13] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xc8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xc8 RCSB], [http://www.ebi.ac.uk/pdbsum/4xc8 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xc8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xc8 RCSB], [http://www.ebi.ac.uk/pdbsum/4xc8 PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	G-protein metallochaperones ensure fidelity during cofactor assembly for a variety of metalloproteins, including adenosylcobalamin (AdoCbl)-dependent methylmalonyl-CoA mutase and hydrogenase, and thus have both medical and biofuel development applications. Here, we present crystal structures of IcmF, a natural fusion protein of AdoCbl-dependent isobutyryl-CoA mutase and its corresponding G-protein chaperone, which reveal the molecular architecture of a G-protein metallochaperone in complex with its target protein. These structures show that conserved G-protein elements become ordered upon target protein association, creating the molecular pathways that both sense and report on the cofactor loading state. Structures determined of both apo- and holo-forms of IcmF depict both open and closed enzyme states, in which the cofactor-binding domain is alternatively positioned for cofactor loading and for catalysis. Notably, the G protein moves as a unit with the cofactor-binding domain, providing a visualization of how a chaperone assists in the sequestering of a precious cofactor inside an enzyme active site.
		+
		+	Visualization of a radical B12 enzyme with its G-protein chaperone.,Jost M, Cracan V, Hubbard PA, Banerjee R, Drennan CL Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2419-24. doi:, 10.1073/pnas.1419582112. Epub 2015 Feb 9. PMID:25675500<ref>PMID:25675500</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Methylmalonyl~~-CoA mutase]]	+	[[Category: Isobutyryl-CoA mutase]]
	[[Category: Drennan, C L]]		[[Category: Drennan, C L]]
	[[Category: Jost, M]]		[[Category: Jost, M]]

OCA at 12:06, 12 February 2015

OCA — Thu, 12 Feb 2015 12:06:12 GMT

←Older revision		Revision as of 12:06, 12 February 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Isobutyryl-CoA mutase fused with bound butyryl-CoA, GDP, and Mg and without cobalamin (apo-IcmF/GDP)==
-		+	<StructureSection load='4xc8' size='340' side='right' caption='[[4xc8]], [[Resolution\|resolution]] 3.25Å' scene=''>
-	~~The entry~~ 4xc8 is ~~ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4xc8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XC8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XC8 FirstGlance]. <br>
-	~~Authors~~: ~~Jost~~, M., ~~Drennan~~, C.L.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCO:BUTYRYL+COENZYME+A'>BCO</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xc6\|4xc6]], [[4xc7\|4xc7]]</td></tr>
-	~~Description:~~	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylmalonyl-CoA_mutase Methylmalonyl-CoA mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.2 5.4.99.2] </span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xc8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xc8 RCSB], [http://www.ebi.ac.uk/pdbsum/4xc8 PDBsum]</span></td></tr>
-	[[Category: Drennan, C.L]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Methylmalonyl-CoA mutase]]
		+	[[Category: Drennan, C L]]
	[[Category: Jost, M]]		[[Category: Jost, M]]
		+	[[Category: Complex]]
		+	[[Category: G-protein chaperone]]
		+	[[Category: Isomerase]]
		+	[[Category: Radical enzyme]]

OCA at 20:52, 24 December 2014

OCA — Wed, 24 Dec 2014 20:52:01 GMT

←Older revision		Revision as of 20:52, 24 December 2014
Line 5:		Line 5:
	Authors: Jost, M., Drennan, C.L.		Authors: Jost, M., Drennan, C.L.

-	Description:	+	Description:
		+	[[Category: Unreleased Structures]]
		+	[[Category: Drennan, C.L]]
		+	[[Category: Jost, M]]

OCA: Protected "4xc8" [edit=sysop:move=sysop]

OCA — Wed, 24 Dec 2014 10:06:22 GMT

Protected "4xc8" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:06, 24 December 2014