4xdg - Revision history

OCA at 11:29, 9 May 2024

OCA — Thu, 09 May 2024 11:29:27 GMT

←Older revision		Revision as of 11:29, 9 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xdg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XDG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XDG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xdg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XDG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XDG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3ZU:(2S)-2-(4-AMINOPHENYL)-1-HYDROXY-5-METHOXY-1,2-DIHYDRO-3H-INDOL-3-ONE'>3ZU</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3ZU:(2S)-2-(4-AMINOPHENYL)-1-HYDROXY-5-METHOXY-1,2-DIHYDRO-3H-INDOL-3-ONE'>3ZU</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xdg OCA], [https://pdbe.org/4xdg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xdg RCSB], [https://www.ebi.ac.uk/pdbsum/4xdg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xdg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xdg OCA], [https://pdbe.org/4xdg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xdg RCSB], [https://www.ebi.ac.uk/pdbsum/4xdg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xdg ProSAT]</span></td></tr>
	</table>		</table>
Line 20:		Line 21:

	==See Also==		==See Also==
-	*[[Quinone reductase\|Quinone reductase]]	+	*[[Quinone reductase 3D structures\|Quinone reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 21:23, 12 April 2023

OCA — Wed, 12 Apr 2023 21:23:51 GMT

←Older revision		Revision as of 21:23, 12 April 2023
Line 3:		Line 3:
	<StructureSection load='4xdg' size='340' side='right'caption='[[4xdg]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='4xdg' size='340' side='right'caption='[[4xdg]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xdg]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XDG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4XDG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xdg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XDG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XDG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3ZU:(2S)-2-(4-AMINOPHENYL)-1-HYDROXY-5-METHOXY-1,2-DIHYDRO-3H-INDOL-3-ONE'>3ZU</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3ZU:(2S)-2-(4-AMINOPHENYL)-1-HYDROXY-5-METHOXY-1,2-DIHYDRO-3H-INDOL-3-ONE'>3ZU</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NQO2, NMOR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xdg OCA], [https://pdbe.org/4xdg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xdg RCSB], [https://www.ebi.ac.uk/pdbsum/4xdg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xdg ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribosyldihydronicotinamide_dehydrogenase_(quinone) Ribosyldihydronicotinamide dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.99.2 1.10.99.2] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4xdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xdg OCA], [~~http~~://pdbe.org/4xdg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4xdg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4xdg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4xdg ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN]] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>	+	[https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4xdg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4xdg" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Quinone reductase\|Quinone reductase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Boutin~~, J A~~]]	+	[[Category: Boutin JA]]
-	[[Category: Ferry, G]]	+	[[Category: Ferry G]]
-	[[Category: Isabet, T]]	+	[[Category: Isabet T]]
-	[[Category: Nepveu, F]]	+	[[Category: Nepveu F]]
-	[[Category: Sirigu, S]]	+	[[Category: Sirigu S]]
-	[[Category: Thompson, A]]	+	[[Category: Thompson A]]
-	[[Category: Vuillard, L]]	+	[[Category: Vuillard L]]
-	~~[[Category: Fad]]~~	+
-	~~[[Category: Flavoprotein]]~~	+
-	~~[[Category: Indolone oxide]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Qr2~~]]	+

OCA at 07:02, 29 May 2019

OCA — Wed, 29 May 2019 07:02:13 GMT

←Older revision		Revision as of 07:02, 29 May 2019
Line 1:		Line 1:

	==Crystal Structure of Quinone Reductase II in complex with 2-(4-aminophenyl)-5-methoxy-1-oxy-indol-3-one molecule==		==Crystal Structure of Quinone Reductase II in complex with 2-(4-aminophenyl)-5-methoxy-1-oxy-indol-3-one molecule==
-	<StructureSection load='4xdg' size='340' side='right' caption='[[4xdg]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='4xdg' size='340' side='right'caption='[[4xdg]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xdg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XDG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XDG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xdg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XDG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XDG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3ZU:(2S)-2-(4-AMINOPHENYL)-1-HYDROXY-5-METHOXY-1,2-DIHYDRO-3H-INDOL-3-ONE'>3ZU</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3ZU:(2S)-2-(4-AMINOPHENYL)-1-HYDROXY-5-METHOXY-1,2-DIHYDRO-3H-INDOL-3-ONE'>3ZU</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NQO2, NMOR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribosyldihydronicotinamide_dehydrogenase_(quinone) Ribosyldihydronicotinamide dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.99.2 1.10.99.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribosyldihydronicotinamide_dehydrogenase_(quinone) Ribosyldihydronicotinamide dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.99.2 1.10.99.2] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xdg OCA], [http://pdbe.org/4xdg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xdg RCSB], [http://www.ebi.ac.uk/pdbsum/4xdg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xdg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xdg OCA], [http://pdbe.org/4xdg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xdg RCSB], [http://www.ebi.ac.uk/pdbsum/4xdg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xdg ProSAT]</span></td></tr>
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Boutin, J A]]		[[Category: Boutin, J A]]
	[[Category: Ferry, G]]		[[Category: Ferry, G]]

OCA at 06:59, 9 March 2017

OCA — Thu, 09 Mar 2017 06:59:46 GMT

←Older revision		Revision as of 06:59, 9 March 2017
Line 1:		Line 1:
		+
	==Crystal Structure of Quinone Reductase II in complex with 2-(4-aminophenyl)-5-methoxy-1-oxy-indol-3-one molecule==		==Crystal Structure of Quinone Reductase II in complex with 2-(4-aminophenyl)-5-methoxy-1-oxy-indol-3-one molecule==
	<StructureSection load='4xdg' size='340' side='right' caption='[[4xdg]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='4xdg' size='340' side='right' caption='[[4xdg]], [[Resolution\|resolution]] 1.50Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3ZU:(2S)-2-(4-AMINOPHENYL)-1-HYDROXY-5-METHOXY-1,2-DIHYDRO-3H-INDOL-3-ONE'>3ZU</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3ZU:(2S)-2-(4-AMINOPHENYL)-1-HYDROXY-5-METHOXY-1,2-DIHYDRO-3H-INDOL-3-ONE'>3ZU</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribosyldihydronicotinamide_dehydrogenase_(quinone) Ribosyldihydronicotinamide dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.99.2 1.10.99.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribosyldihydronicotinamide_dehydrogenase_(quinone) Ribosyldihydronicotinamide dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.99.2 1.10.99.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xdg OCA], [http://pdbe.org/4xdg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xdg RCSB], [http://www.ebi.ac.uk/pdbsum/4xdg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xdg OCA], [http://pdbe.org/4xdg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xdg RCSB], [http://www.ebi.ac.uk/pdbsum/4xdg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xdg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN]] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>		[[http://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN]] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Indolone-N-oxides have antiplasmodial properties against Plasmodium falciparum at the erythrocytic stage, with IC50 values in the nanomolar range. The mechanism of action of indolone derivatives involves the production of free radicals, which follows their bioreduction by an unknown mechanism. In this study, we hypothesized that human quinone reductase 2 (hQR2), known to act as a flavin redox switch upon binding to the broadly used antimalarial chloroquine, could be involved in the activity of the redox-active indolone derivatives. Therefore, we investigated the role of hQR2 in the reduction of indolone derivatives. We analyzed the interaction between hQR2 and several indolone-type derivatives by examining enzymatic kinetics, the substrate/protein complex structure with X-ray diffraction analysis, and the production of free radicals with electron paramagnetic resonance. The reduction of each compound in cells overexpressing hQR2 was compared to its reduction in naive cells. This process could be inhibited by the specific hQR2 inhibitor, S29434. These results confirmed that the anti-malarial activity of indolone-type derivatives was linked to their ability to serve as hQR2 substrates and not as hQR2 inhibitors as reported for chloroquine, leading to the possibility that substrate of hQR2 could be considered as a new avenue for the design of new antimalarial compounds.
		+
		+	Role of Quinone Reductase 2 in the Antimalarial Properties of Indolone-Type Derivatives.,Cassagnes LE, Rakotoarivelo N, Sirigu S, Perio P, Najahi E, Chavas LM, Thompson A, Gayon R, Ferry G, Boutin JA, Valentin A, Reybier K, Nepveu F Molecules. 2017 Jan 30;22(2). pii: E210. doi: 10.3390/molecules22020210. PMID:28146103<ref>PMID:28146103</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4xdg" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:22, 13 January 2016

OCA — Wed, 13 Jan 2016 20:22:15 GMT

←Older revision		Revision as of 20:22, 13 January 2016
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal Structure of Quinone Reductase II in complex with 2-(4-aminophenyl)-5-methoxy-1-oxy-indol-3-one molecule==
-		+	<StructureSection load='4xdg' size='340' side='right' caption='[[4xdg]], [[Resolution\|resolution]] 1.50Å' scene=''>
-	~~The entry~~ 4xdg is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4xdg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XDG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XDG FirstGlance]. <br>
-	~~Authors~~: ~~Sirigu, S~~.~~, Nepveu, F~~.~~, Vuillard, L~~.~~, Ferry, G~~.~~, Isabet, T~~.~~, Thompson, A~~.~~, Boutin, J~~.A.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3ZU:(2S)-2-(4-AMINOPHENYL)-1-HYDROXY-5-METHOXY-1,2-DIHYDRO-3H-INDOL-3-ONE'>3ZU</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribosyldihydronicotinamide_dehydrogenase_(quinone) Ribosyldihydronicotinamide dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.99.2 1.10.99.2] </span></td></tr>
-	~~Description~~: ~~Crystal Structure of Quinone Reductase II in complex with~~ 2-(4-~~aminophenyl~~)-5-~~methoxy~~-1-~~oxy~~-~~indol~~-3-~~one molecule~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xdg OCA], [http://pdbe.org/4xdg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xdg RCSB], [http://www.ebi.ac.uk/pdbsum/4xdg PDBsum]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN]] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Boutin, J A]]
	[[Category: Ferry, G]]		[[Category: Ferry, G]]
-	[[Category: ~~Thompson~~, A]]	+	[[Category: Isabet, T]]
	[[Category: Nepveu, F]]		[[Category: Nepveu, F]]
	[[Category: Sirigu, S]]		[[Category: Sirigu, S]]
-	[[Category: ~~Isabet~~, T]]	+	[[Category: Thompson, A]]
	[[Category: Vuillard, L]]		[[Category: Vuillard, L]]
-	[[Category: ~~Boutin, J.A~~]]	+	[[Category: Fad]]
		+	[[Category: Flavoprotein]]
		+	[[Category: Indolone oxide]]
		+	[[Category: Metal-binding]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Qr2]]

OCA at 23:08, 30 November 2015

OCA — Mon, 30 Nov 2015 23:08:33 GMT

←Older revision		Revision as of 23:08, 30 November 2015
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	Description: Crystal Structure of Quinone Reductase II in complex with 2-(4-aminophenyl)-5-methoxy-1-oxy-indol-3-one molecule		Description: Crystal Structure of Quinone Reductase II in complex with 2-(4-aminophenyl)-5-methoxy-1-oxy-indol-3-one molecule
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Ferry, G]]
		+	[[Category: Thompson, A]]
	[[Category: Nepveu, F]]		[[Category: Nepveu, F]]
	[[Category: Sirigu, S]]		[[Category: Sirigu, S]]
	[[Category: Isabet, T]]		[[Category: Isabet, T]]
-	[[Category: Ferry, G]]
-	[[Category: Thompson, A]]
	[[Category: Vuillard, L]]		[[Category: Vuillard, L]]
	[[Category: Boutin, J.A]]		[[Category: Boutin, J.A]]

OCA at 12:35, 14 January 2015

OCA — Wed, 14 Jan 2015 12:35:55 GMT

←Older revision		Revision as of 12:35, 14 January 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4xdg is ON HOLD	+	The entry 4xdg is ON HOLD until Paper Publication

	Authors: Sirigu, S., Nepveu, F., Vuillard, L., Ferry, G., Isabet, T., Thompson, A., Boutin, J.A.		Authors: Sirigu, S., Nepveu, F., Vuillard, L., Ferry, G., Isabet, T., Thompson, A., Boutin, J.A.

OCA: Protected "4xdg" [edit=sysop:move=sysop]

OCA — Wed, 31 Dec 2014 14:00:53 GMT

Protected "4xdg" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:00, 31 December 2014

OCA: New page: '''Unreleased structure''' The entry 4xdg is ON HOLD Authors: Sirigu, S., Nepveu, F., Vuillard, L., Ferry, G., Isabet, T., Thompson, A., Boutin, J.A. Description: Crystal Structure of ...

OCA — Wed, 31 Dec 2014 14:00:52 GMT

New page: '''Unreleased structure''' The entry 4xdg is ON HOLD Authors: Sirigu, S., Nepveu, F., Vuillard, L., Ferry, G., Isabet, T., Thompson, A., Boutin, J.A. Description: Crystal Structure of ...

New page

'''Unreleased structure'''

The entry 4xdg is ON HOLD

Authors: Sirigu, S., Nepveu, F., Vuillard, L., Ferry, G., Isabet, T., Thompson, A., Boutin, J.A.

Description: Crystal Structure of Quinone Reductase II in complex with 2-(4-aminophenyl)-5-methoxy-1-oxy-indol-3-one molecule
[[Category: Unreleased Structures]]
[[Category: Nepveu, F]]
[[Category: Sirigu, S]]
[[Category: Isabet, T]]
[[Category: Ferry, G]]
[[Category: Thompson, A]]
[[Category: Vuillard, L]]
[[Category: Boutin, J.A]]