4xe1 - Revision history

OCA at 10:48, 10 January 2024

OCA — Wed, 10 Jan 2024 10:48:16 GMT

←Older revision		Revision as of 10:48, 10 January 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xe1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XE1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XE1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xe1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XE1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XE1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HGB:4-(HYDROXYMERCURY)BENZOIC+ACID'>HGB</scene>, <scene name='pdbligand=IL5:3-OXO-2,3-DIHYDRO-1,2-BENZOTHIAZOLE-6-SULFONAMIDE+1,1-DIOXIDE'>IL5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HGB:4-(HYDROXYMERCURY)BENZOIC+ACID'>HGB</scene>, <scene name='pdbligand=IL5:3-OXO-2,3-DIHYDRO-1,2-BENZOTHIAZOLE-6-SULFONAMIDE+1,1-DIOXIDE'>IL5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xe1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xe1 OCA], [https://pdbe.org/4xe1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xe1 RCSB], [https://www.ebi.ac.uk/pdbsum/4xe1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xe1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xe1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xe1 OCA], [https://pdbe.org/4xe1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xe1 RCSB], [https://www.ebi.ac.uk/pdbsum/4xe1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xe1 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 21:24, 12 April 2023

OCA — Wed, 12 Apr 2023 21:24:52 GMT

←Older revision		Revision as of 21:24, 12 April 2023
Line 3:		Line 3:
	<StructureSection load='4xe1' size='340' side='right'caption='[[4xe1]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4xe1' size='340' side='right'caption='[[4xe1]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xe1]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XE1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4XE1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xe1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XE1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XE1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HGB:4-(HYDROXYMERCURY)BENZOIC+ACID'>HGB</scene>, <scene name='pdbligand=IL5:3-OXO-2,3-DIHYDRO-1,2-BENZOTHIAZOLE-6-SULFONAMIDE+1,1-DIOXIDE'>IL5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HGB:4-(HYDROXYMERCURY)BENZOIC+ACID'>HGB</scene>, <scene name='pdbligand=IL5:3-OXO-2,3-DIHYDRO-1,2-BENZOTHIAZOLE-6-SULFONAMIDE+1,1-DIOXIDE'>IL5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xe1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xe1 OCA], [https://pdbe.org/4xe1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xe1 RCSB], [https://www.ebi.ac.uk/pdbsum/4xe1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xe1 ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4xe1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xe1 OCA], [~~http~~://pdbe.org/4xe1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4xe1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4xe1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4xe1 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[~~http~~://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>	+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[https://omim.org/entry/259730 259730]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>	+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Carbonate dehydratase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Alterio, V]]	+	[[Category: Alterio V]]
-	[[Category: Simone, G ~~De]]~~	+	[[Category: De Simone G]]
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Lyase~~]]	+

OCA at 06:55, 29 May 2019

OCA — Wed, 29 May 2019 06:55:37 GMT

←Older revision		Revision as of 06:55, 29 May 2019
Line 1:		Line 1:

	==Human carbonic anhydrase II in complex with 6-SULFAMOYL-SACCHARIN==		==Human carbonic anhydrase II in complex with 6-SULFAMOYL-SACCHARIN==
-	<StructureSection load='4xe1' size='340' side='right' caption='[[4xe1]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='4xe1' size='340' side='right'caption='[[4xe1]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xe1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XE1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XE1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xe1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XE1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XE1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HGB:4-(HYDROXYMERCURY)BENZOIC+ACID'>HGB</scene>, <scene name='pdbligand=IL5:3-OXO-2,3-DIHYDRO-1,2-BENZOTHIAZOLE-6-SULFONAMIDE+1,1-DIOXIDE'>IL5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HGB:4-(HYDROXYMERCURY)BENZOIC+ACID'>HGB</scene>, <scene name='pdbligand=IL5:3-OXO-2,3-DIHYDRO-1,2-BENZOTHIAZOLE-6-SULFONAMIDE+1,1-DIOXIDE'>IL5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xe1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xe1 OCA], [http://pdbe.org/4xe1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xe1 RCSB], [http://www.ebi.ac.uk/pdbsum/4xe1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xe1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xe1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xe1 OCA], [http://pdbe.org/4xe1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xe1 RCSB], [http://www.ebi.ac.uk/pdbsum/4xe1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xe1 ProSAT]</span></td></tr>
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	</div>		</div>
	<div class="pdbe-citations 4xe1" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4xe1" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Carbonic anhydrase 3D structures\|Carbonic anhydrase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Alterio, V]]		[[Category: Alterio, V]]
	[[Category: Simone, G De]]		[[Category: Simone, G De]]

OCA at 00:12, 26 January 2017

OCA — Thu, 26 Jan 2017 00:12:55 GMT

←Older revision		Revision as of 00:12, 26 January 2017
Line 1:		Line 1:
		+
	==Human carbonic anhydrase II in complex with 6-SULFAMOYL-SACCHARIN==		==Human carbonic anhydrase II in complex with 6-SULFAMOYL-SACCHARIN==
	<StructureSection load='4xe1' size='340' side='right' caption='[[4xe1]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4xe1' size='340' side='right' caption='[[4xe1]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HGB:4-(HYDROXYMERCURY)BENZOIC+ACID'>HGB</scene>, <scene name='pdbligand=IL5:3-OXO-2,3-DIHYDRO-1,2-BENZOTHIAZOLE-6-SULFONAMIDE+1,1-DIOXIDE'>IL5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HGB:4-(HYDROXYMERCURY)BENZOIC+ACID'>HGB</scene>, <scene name='pdbligand=IL5:3-OXO-2,3-DIHYDRO-1,2-BENZOTHIAZOLE-6-SULFONAMIDE+1,1-DIOXIDE'>IL5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xe1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xe1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xe1 RCSB], [http://www.ebi.ac.uk/pdbsum/4xe1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xe1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xe1 OCA], [http://pdbe.org/4xe1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xe1 RCSB], [http://www.ebi.ac.uk/pdbsum/4xe1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xe1 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4xe1" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:03, 18 March 2015

OCA — Wed, 18 Mar 2015 12:03:09 GMT

←Older revision		Revision as of 12:03, 18 March 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Human carbonic anhydrase II in complex with 6-SULFAMOYL-SACCHARIN==
		+	<StructureSection load='4xe1' size='340' side='right' caption='[[4xe1]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4xe1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XE1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XE1 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HGB:4-(HYDROXYMERCURY)BENZOIC+ACID'>HGB</scene>, <scene name='pdbligand=IL5:3-OXO-2,3-DIHYDRO-1,2-BENZOTHIAZOLE-6-SULFONAMIDE+1,1-DIOXIDE'>IL5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xe1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xe1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xe1 RCSB], [http://www.ebi.ac.uk/pdbsum/4xe1 PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[http://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	6-Sulfamoyl-saccharin was investigated as an inhibitor of 11 alpha-carbonic anhydrase (CA, EC 4.2.1.1) isoforms of human (h) origin, hCA I-XIV, and X-ray crystallographic data were obtained for its adduct with hCA II, the physiologically dominant isoform. This compound possesses two potential zinc-binding groups, the primary sulfamoyl one and the secondary, acylatedsulfonamide. Saccharin itself binds to the Zn(ii) ion from the CA active site coordinating with this last group, in deprotonated (SO2N-CO) form. Here we explain why 6-sulfamoyl-saccharin, unlike saccharin, binds to the metal ion from the hCA II active site by its primary sulfonamide moiety and not the secondary one as saccharin itself. Our study is useful for shedding new light to the structure-based drug design of isoform-selective CA inhibitors of the sulfonamide type.

-	~~The entry 4xe1 is ON HOLD~~	+	X-ray crystallographic and kinetic investigations of 6-sulfamoyl-saccharin as a carbonic anhydrase inhibitor.,Alterio V, Tanc M, Ivanova J, Zalubovskis R, Vozny I, Monti SM, Di Fiore A, De Simone G, Supuran CT Org Biomol Chem. 2015 Mar 3. PMID:25733161<ref>PMID:25733161</ref>

-	~~Authors: Alterio~~, V.~~, De Simone, G~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: Human carbonic anhydrase II in complex with 6-SULFAMOYL-SACCHARIN~~	+	== References ==
-	~~[[Category: Unreleased Structures]]~~	+	<references/>
-	[[Category: ~~De Simone, G~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Carbonate dehydratase]]
	[[Category: Alterio, V]]		[[Category: Alterio, V]]
		+	[[Category: Simone, G De]]
		+	[[Category: Cytoplasm]]
		+	[[Category: Inhibitor]]
		+	[[Category: Lyase]]

OCA: Protected "4xe1" [edit=sysop:move=sysop]

OCA — Wed, 31 Dec 2014 14:02:32 GMT

Protected "4xe1" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:02, 31 December 2014

OCA: New page: '''Unreleased structure''' The entry 4xe1 is ON HOLD Authors: Alterio, V., De Simone, G. Description: Human carbonic anhydrase II in complex with 6-SULFAMOYL-SACCHARIN [[Category: Unre...

OCA — Wed, 31 Dec 2014 14:02:31 GMT

New page: '''Unreleased structure''' The entry 4xe1 is ON HOLD Authors: Alterio, V., De Simone, G. Description: Human carbonic anhydrase II in complex with 6-SULFAMOYL-SACCHARIN [[Category: Unre...

New page

'''Unreleased structure'''

The entry 4xe1 is ON HOLD

Authors: Alterio, V., De Simone, G.

Description: Human carbonic anhydrase II in complex with 6-SULFAMOYL-SACCHARIN
[[Category: Unreleased Structures]]
[[Category: De Simone, G]]
[[Category: Alterio, V]]