4xfo - Revision history

OCA at 13:00, 1 March 2024

OCA — Fri, 01 Mar 2024 13:00:46 GMT

←Older revision		Revision as of 13:00, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xfo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XFO FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xfo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XFO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xfo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfo OCA], [https://pdbe.org/4xfo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xfo RCSB], [https://www.ebi.ac.uk/pdbsum/4xfo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xfo ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.35Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xfo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfo OCA], [https://pdbe.org/4xfo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xfo RCSB], [https://www.ebi.ac.uk/pdbsum/4xfo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xfo ProSAT]</span></td></tr>
	</table>		</table>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The tetrameric thyroxine transport protein transthyretin (TTR) forms amyloid fibrils upon dissociation and monomer unfolding. The aggregation of transthyretin has been reported as the cause of the life-threatening transthyretin amyloidosis. The standard treatment of familial cases of TTR amyloidosis has been liver transplantation. Although aggregation-preventing strategies involving ligands are known, understanding the mechanism of TTR aggregation can lead to additional inhibition approaches. Several models of TTR amyloid fibrils have been proposed, but the segments that drive aggregation of the protein have remained unknown. Here we identify beta-strands F and H as necessary for TTR aggregation. Based on the crystal structures of these segments, we designed two non-natural peptide inhibitors that block aggregation. This work provides the first characterization of peptide inhibitors for TTR aggregation, establishing a novel therapeutic strategy.
-
-	Uncovering the Mechanism of Aggregation of Human Transthyretin.,Saelices L, Johnson LM, Liang WY, Sawaya MR, Cascio D, Ruchala P, Whitelegge J, Jiang L, Riek R, Eisenberg DS J Biol Chem. 2015 Nov 27;290(48):28932-43. doi: 10.1074/jbc.M115.659912. Epub, 2015 Oct 12. PMID:26459562<ref>PMID:26459562</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4xfo" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Transthyretin 3D structures\|Transthyretin 3D structures]]		*[[Transthyretin 3D structures\|Transthyretin 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 21:26, 12 April 2023

OCA — Wed, 12 Apr 2023 21:26:44 GMT

←Older revision		Revision as of 21:26, 12 April 2023
Line 3:		Line 3:
	<StructureSection load='4xfo' size='340' side='right'caption='[[4xfo]], [[Resolution\|resolution]] 1.35Å' scene=''>		<StructureSection load='4xfo' size='340' side='right'caption='[[4xfo]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xfo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4XFO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xfo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XFO FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xfn\|4xfn]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xfo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfo OCA], [https://pdbe.org/4xfo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xfo RCSB], [https://www.ebi.ac.uk/pdbsum/4xfo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xfo ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4xfo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfo OCA], [~~http~~://pdbe.org/4xfo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4xfo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4xfo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4xfo ProSAT]</span></td></tr>	+
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 18:		Line 17:

	==See Also==		==See Also==
-	*[[Transthyretin\|Transthyretin]]	+	*[[Transthyretin 3D structures\|Transthyretin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Cascio, D~~]]	+	[[Category: Synthetic construct]]
-	[[Category: ~~Eisenberg,~~ D S]]	+	[[Category: Cascio D]]
-	[[Category: ~~Saelices, L~~]]	+	[[Category: Eisenberg DS]]
-	[[Category: ~~Sawaya, M~~]]	+	[[Category: Saelices L]]
-	[[Category: ~~Amyloid]]~~	+	[[Category: Sawaya M]]
-	~~[[Category: Fibril]]~~	+
-	~~[[Category: Protein fibril]]~~	+
-	~~[[Category: Transthyretin~~]]	+

OCA at 07:26, 29 May 2019

OCA — Wed, 29 May 2019 07:26:35 GMT

←Older revision		Revision as of 07:26, 29 May 2019
Line 1:		Line 1:
		+
	==Structure of an amyloid-forming segment TAVVTN from human Transthyretin==		==Structure of an amyloid-forming segment TAVVTN from human Transthyretin==
-	<StructureSection load='4xfo' size='340' side='right' caption='[[4xfo]], [[Resolution\|resolution]] 1.35Å' scene=''>	+	<StructureSection load='4xfo' size='340' side='right'caption='[[4xfo]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xfo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XFO FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xfo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XFO FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xfn\|4xfn]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xfn\|4xfn]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xfo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfo OCA], [http://pdbe.org/4xfo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xfo RCSB], [http://www.ebi.ac.uk/pdbsum/4xfo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xfo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfo OCA], [http://pdbe.org/4xfo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xfo RCSB], [http://www.ebi.ac.uk/pdbsum/4xfo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xfo ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	</div>		</div>
	<div class="pdbe-citations 4xfo" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4xfo" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Transthyretin\|Transthyretin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Cascio, D]]		[[Category: Cascio, D]]
	[[Category: Eisenberg, D S]]		[[Category: Eisenberg, D S]]

OCA at 20:54, 30 November 2015

OCA — Mon, 30 Nov 2015 20:54:46 GMT

←Older revision		Revision as of 20:54, 30 November 2015
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xfo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfo OCA], [http://pdbe.org/4xfo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xfo RCSB], [http://www.ebi.ac.uk/pdbsum/4xfo PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xfo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfo OCA], [http://pdbe.org/4xfo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xfo RCSB], [http://www.ebi.ac.uk/pdbsum/4xfo PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The tetrameric thyroxine transport protein transthyretin (TTR) forms amyloid fibrils upon dissociation and monomer unfolding. The aggregation of transthyretin has been reported as the cause of the life-threatening transthyretin amyloidosis. The standard treatment of familial cases of TTR amyloidosis has been liver transplantation. Although aggregation-preventing strategies involving ligands are known, understanding the mechanism of TTR aggregation can lead to additional inhibition approaches. Several models of TTR amyloid fibrils have been proposed, but the segments that drive aggregation of the protein have remained unknown. Here we identify beta-strands F and H as necessary for TTR aggregation. Based on the crystal structures of these segments, we designed two non-natural peptide inhibitors that block aggregation. This work provides the first characterization of peptide inhibitors for TTR aggregation, establishing a novel therapeutic strategy.
		+
		+	Uncovering the Mechanism of Aggregation of Human Transthyretin.,Saelices L, Johnson LM, Liang WY, Sawaya MR, Cascio D, Ruchala P, Whitelegge J, Jiang L, Riek R, Eisenberg DS J Biol Chem. 2015 Nov 27;290(48):28932-43. doi: 10.1074/jbc.M115.659912. Epub, 2015 Oct 12. PMID:26459562<ref>PMID:26459562</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4xfo" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 05:30, 22 October 2015

OCA — Thu, 22 Oct 2015 05:30:34 GMT

←Older revision		Revision as of 05:30, 22 October 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Structure of an amyloid-forming segment TAVVTN from human Transthyretin==
-		+	<StructureSection load='4xfo' size='340' side='right' caption='[[4xfo]], [[Resolution\|resolution]] 1.35Å' scene=''>
-	~~The entry~~ 4xfo is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4xfo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XFO FirstGlance]. <br>
-	~~Authors~~: ~~Saelices, L~~.~~, Sawaya, M~~.~~, Cascio, D~~.~~, Eisenberg, D.S~~.	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xfn\|4xfn]]</td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xfo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfo OCA], [http://pdbe.org/4xfo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xfo RCSB], [http://www.ebi.ac.uk/pdbsum/4xfo PDBsum]</span></td></tr>
-	~~Description~~: ~~Structure of an amyloid~~-~~forming segment TAVVTN from human Transthyretin~~	+	</table>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	__TOC__
-	[[~~Category: Sawaya, M~~]]	+	</StructureSection>
-	[[~~Category~~: ~~Eisenberg~~, D.S]]	+
-	[~~[Category~~: ~~Saelices~~, L]]	+
	[[Category: Cascio, D]]		[[Category: Cascio, D]]
		+	[[Category: Eisenberg, D S]]
		+	[[Category: Saelices, L]]
		+	[[Category: Sawaya, M]]
		+	[[Category: Amyloid]]
		+	[[Category: Fibril]]
		+	[[Category: Protein fibril]]
		+	[[Category: Transthyretin]]

OCA at 10:21, 12 February 2015

OCA — Thu, 12 Feb 2015 10:21:12 GMT

←Older revision		Revision as of 10:21, 12 February 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4xfo is ON HOLD	+	The entry 4xfo is ON HOLD until Paper Publication

	Authors: Saelices, L., Sawaya, M., Cascio, D., Eisenberg, D.S.		Authors: Saelices, L., Sawaya, M., Cascio, D., Eisenberg, D.S.

OCA: Protected "4xfo" [edit=sysop:move=sysop]

OCA — Wed, 07 Jan 2015 15:36:29 GMT

Protected "4xfo" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:36, 7 January 2015

OCA: New page: '''Unreleased structure''' The entry 4xfo is ON HOLD Authors: Saelices, L., Sawaya, M., Cascio, D., Eisenberg, D.S. Description: Structure of an amyloid-forming segment TAVVTN from hum...

OCA — Wed, 07 Jan 2015 15:36:27 GMT

New page: '''Unreleased structure''' The entry 4xfo is ON HOLD Authors: Saelices, L., Sawaya, M., Cascio, D., Eisenberg, D.S. Description: Structure of an amyloid-forming segment TAVVTN from hum...

New page

'''Unreleased structure'''

The entry 4xfo is ON HOLD

Authors: Saelices, L., Sawaya, M., Cascio, D., Eisenberg, D.S.

Description: Structure of an amyloid-forming segment TAVVTN from human Transthyretin
[[Category: Unreleased Structures]]
[[Category: Sawaya, M]]
[[Category: Eisenberg, D.S]]
[[Category: Saelices, L]]
[[Category: Cascio, D]]