4xfq - Revision history

OCA at 15:27, 8 November 2023

OCA — Wed, 08 Nov 2023 15:27:34 GMT

←Older revision		Revision as of 15:27, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xfq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Porcine_epidemic_diarrhea_virus Porcine epidemic diarrhea virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XFQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xfq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Porcine_epidemic_diarrhea_virus Porcine epidemic diarrhea virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XFQ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xfq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfq OCA], [https://pdbe.org/4xfq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xfq RCSB], [https://www.ebi.ac.uk/pdbsum/4xfq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xfq ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.65Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xfq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfq OCA], [https://pdbe.org/4xfq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xfq RCSB], [https://www.ebi.ac.uk/pdbsum/4xfq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xfq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 21:26, 12 April 2023

OCA — Wed, 12 Apr 2023 21:26:49 GMT

←Older revision		Revision as of 21:26, 12 April 2023
Line 3:		Line 3:
	<StructureSection load='4xfq' size='340' side='right'caption='[[4xfq]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='4xfq' size='340' side='right'caption='[[4xfq]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xfq]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Pedv Pedv~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4XFQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xfq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Porcine_epidemic_diarrhea_virus Porcine epidemic diarrhea virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XFQ FirstGlance]. <br>
-	</td></tr>~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pol1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28295 PEDV])</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xfq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfq OCA], [https://pdbe.org/4xfq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xfq RCSB], [https://www.ebi.ac.uk/pdbsum/4xfq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xfq ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4xfq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfq OCA], [~~http~~://pdbe.org/4xfq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4xfq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4xfq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4xfq ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/K4L9I6_9ALPC K4L9I6_9ALPC]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 4xfq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4xfq" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Virus protease 3D structures\|Virus protease 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 21:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Pedv]]
-	[[Category: Fu, Z F]]
-	[[Category: Peng, G Q]]
-	[[Category: Ye, G]]
-	[[Category: 3c-like protease]]
-	[[Category: Hydrolase]]
	[[Category: Porcine epidemic diarrhea virus]]		[[Category: Porcine epidemic diarrhea virus]]
		+	[[Category: Fu ZF]]
		+	[[Category: Peng GQ]]
		+	[[Category: Ye G]]

OCA at 07:30, 29 May 2019

OCA — Wed, 29 May 2019 07:30:34 GMT

←Older revision		Revision as of 07:30, 29 May 2019
Line 1:		Line 1:

	==Crystal Structure Basis for PEDV 3C Like Protease==		==Crystal Structure Basis for PEDV 3C Like Protease==
-	<StructureSection load='4xfq' size='340' side='right' caption='[[4xfq]], [[Resolution\|resolution]] 1.65Å' scene=''>	+	<StructureSection load='4xfq' size='340' side='right'caption='[[4xfq]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xfq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XFQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xfq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pedv Pedv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XFQ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xfq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfq OCA], [http://pdbe.org/4xfq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xfq RCSB], [http://www.ebi.ac.uk/pdbsum/4xfq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xfq ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pol1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28295 PEDV])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xfq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfq OCA], [http://pdbe.org/4xfq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xfq RCSB], [http://www.ebi.ac.uk/pdbsum/4xfq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xfq ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 19:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Pedv]]
	[[Category: Fu, Z F]]		[[Category: Fu, Z F]]
	[[Category: Peng, G Q]]		[[Category: Peng, G Q]]

OCA at 02:32, 13 July 2016

OCA — Wed, 13 Jul 2016 02:32:40 GMT

←Older revision		Revision as of 02:32, 13 July 2016
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xfq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XFQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xfq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XFQ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xfq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfq OCA], [http://pdbe.org/4xfq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xfq RCSB], [http://www.ebi.ac.uk/pdbsum/4xfq PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xfq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfq OCA], [http://pdbe.org/4xfq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xfq RCSB], [http://www.ebi.ac.uk/pdbsum/4xfq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xfq ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:56, 23 June 2016

OCA — Thu, 23 Jun 2016 15:56:20 GMT

←Older revision		Revision as of 15:56, 23 June 2016
Line 1:		Line 1:
		+
	==Crystal Structure Basis for PEDV 3C Like Protease==		==Crystal Structure Basis for PEDV 3C Like Protease==
	<StructureSection load='4xfq' size='340' side='right' caption='[[4xfq]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='4xfq' size='340' side='right' caption='[[4xfq]], [[Resolution\|resolution]] 1.65Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xfq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfq OCA], [http://pdbe.org/4xfq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xfq RCSB], [http://www.ebi.ac.uk/pdbsum/4xfq PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xfq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfq OCA], [http://pdbe.org/4xfq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xfq RCSB], [http://www.ebi.ac.uk/pdbsum/4xfq PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Porcine epidemic diarrhea virus (PEDV), a member of the genus Alphacoronavirus, has caused significant damage to the Asian and American pork industries. Coronavirus 3C-like protease (3CL(pro)), which is involved in the processing of viral polyproteins for viral replication, is an appealing antiviral drug target. Here, we present the crystal structures of PEDV 3CL(pro) and a molecular complex between an inactive PEDV 3CL(pro) variant C144A bound to a peptide substrate. Structural characterization, mutagenesis and biochemical analysis reveal the substrate-binding pockets and the residues that comprise the active site of PEDV 3CL(pro). The dimerization of PEDV 3CL(pro) is similar to that of other Alphacoronavirus 3CL(pro)s but has several differences from that of SARS-CoV 3CL(pro) from the genus Betacoronavirus. Furthermore, the non-conserved motifs in the pockets cause different cleavage of substrate between PEDV and SARS-CoV 3CL(pro)s, which may provide new insights into the recognition of substrates by 3CL(pro)s in various coronavirus genera.
		+
		+	Structural basis for the dimerization and substrate recognition specificity of porcine epidemic diarrhea virus 3C-like protease.,Ye G, Deng F, Shen Z, Luo R, Zhao L, Xiao S, Fu ZF, Peng G Virology. 2016 Jul;494:225-35. doi: 10.1016/j.virol.2016.04.018. Epub 2016 Apr, 26. PMID:27128350<ref>PMID:27128350</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4xfq" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 17:12, 20 January 2016

OCA — Wed, 20 Jan 2016 17:12:29 GMT

←Older revision		Revision as of 17:12, 20 January 2016
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal Structure Basis for PEDV 3C Like Protease==
-		+	<StructureSection load='4xfq' size='340' side='right' caption='[[4xfq]], [[Resolution\|resolution]] 1.65Å' scene=''>
-	~~The entry~~ 4xfq is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4xfq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XFQ FirstGlance]. <br>
-	~~Authors~~: Ye, G., Fu, Z.F., ~~Peng, G~~.Q.	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xfq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfq OCA], [http://pdbe.org/4xfq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xfq RCSB], [http://www.ebi.ac.uk/pdbsum/4xfq PDBsum]</span></td></tr>
-		+	</table>
-	~~Description: Crystal Structure Basis for PEDV 3C Like Protease~~	+	__TOC__
-	[[Category: ~~Unreleased Structures~~]]	+	</StructureSection>
-	[[Category: Peng, G.Q]]	+	[[Category: Fu, Z F]]
-	~~[[Category: Fu, Z.F~~]]	+	[[Category: Peng, G Q]]
	[[Category: Ye, G]]		[[Category: Ye, G]]
		+	[[Category: 3c-like protease]]
		+	[[Category: Hydrolase]]
		+	[[Category: Porcine epidemic diarrhea virus]]

OCA at 15:22, 28 January 2015

OCA — Wed, 28 Jan 2015 15:22:41 GMT

←Older revision		Revision as of 15:22, 28 January 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4xfq is ON HOLD	+	The entry 4xfq is ON HOLD until Paper Publication

	Authors: Ye, G., Fu, Z.F., Peng, G.Q.		Authors: Ye, G., Fu, Z.F., Peng, G.Q.

OCA: Protected "4xfq" [edit=sysop:move=sysop]

OCA — Wed, 07 Jan 2015 15:36:34 GMT

Protected "4xfq" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:36, 7 January 2015

OCA: New page: '''Unreleased structure''' The entry 4xfq is ON HOLD Authors: Ye, G., Fu, Z.F., Peng, G.Q. Description: Crystal Structure Basis for PEDV 3C Like Protease [[Category: Unreleased Structu...

OCA — Wed, 07 Jan 2015 15:36:33 GMT

New page: '''Unreleased structure''' The entry 4xfq is ON HOLD Authors: Ye, G., Fu, Z.F., Peng, G.Q. Description: Crystal Structure Basis for PEDV 3C Like Protease [[Category: Unreleased Structu...

New page

'''Unreleased structure'''

The entry 4xfq is ON HOLD

Authors: Ye, G., Fu, Z.F., Peng, G.Q.

Description: Crystal Structure Basis for PEDV 3C Like Protease
[[Category: Unreleased Structures]]
[[Category: Peng, G.Q]]
[[Category: Fu, Z.F]]
[[Category: Ye, G]]