4xfs - Revision history

OCA at 07:45, 27 September 2023

OCA — Wed, 27 Sep 2023 07:45:23 GMT

←Older revision		Revision as of 07:45, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xfs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XFS FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xfs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XFS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.91Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfs OCA], [https://pdbe.org/4xfs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xfs RCSB], [https://www.ebi.ac.uk/pdbsum/4xfs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xfs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfs OCA], [https://pdbe.org/4xfs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xfs RCSB], [https://www.ebi.ac.uk/pdbsum/4xfs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xfs ProSAT]</span></td></tr>
	</table>		</table>

OCA at 21:26, 12 April 2023

OCA — Wed, 12 Apr 2023 21:26:54 GMT

←Older revision		Revision as of 21:26, 12 April 2023
Line 3:		Line 3:
	<StructureSection load='4xfs' size='340' side='right'caption='[[4xfs]], [[Resolution\|resolution]] 1.91Å' scene=''>		<StructureSection load='4xfs' size='340' side='right'caption='[[4xfs]], [[Resolution\|resolution]] 1.91Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xfs]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4XFS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xfs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XFS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IL18, IGIF, IL1F4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfs OCA], [https://pdbe.org/4xfs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xfs RCSB], [https://www.ebi.ac.uk/pdbsum/4xfs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xfs ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4xfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfs OCA], [~~http~~://pdbe.org/4xfs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4xfs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4xfs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4xfs ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/IL18_HUMAN IL18_HUMAN]] Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.	+	[https://www.uniprot.org/uniprot/IL18_HUMAN IL18_HUMAN] Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Deng, J]]	+	[[Category: Deng J]]
-	[[Category: Krumm~~, B E~~]]	+	[[Category: Krumm BE]]
-	[[Category: Meng, X]]	+	[[Category: Meng X]]
-	[[Category: Xiang, Y]]	+	[[Category: Xiang Y]]
-	~~[[Category: Cytokine]]~~	+
-	~~[[Category: Il-18]]~~	+
-	~~[[Category: Immune defense]]~~	+
-	~~[[Category: Interleukin-18]]~~	+
-	~~[[Category: Surface entropy reduction~~]]	+

OCA at 15:48, 11 December 2019

OCA — Wed, 11 Dec 2019 15:48:27 GMT

←Older revision		Revision as of 15:48, 11 December 2019
Line 1:		Line 1:

	==Structure of IL-18 SER Mutant I==		==Structure of IL-18 SER Mutant I==
-	<StructureSection load='4xfs' size='340' side='right' caption='[[4xfs]], [[Resolution\|resolution]] 1.91Å' scene=''>	+	<StructureSection load='4xfs' size='340' side='right'caption='[[4xfs]], [[Resolution\|resolution]] 1.91Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xfs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XFS FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xfs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XFS FirstGlance]. <br>
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4xfs" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4xfs" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Interleukin 3D structures\|Interleukin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Deng, J]]		[[Category: Deng, J]]
	[[Category: Krumm, B E]]		[[Category: Krumm, B E]]

OCA at 15:28, 15 November 2017

OCA — Wed, 15 Nov 2017 15:28:48 GMT

←Older revision		Revision as of 15:28, 15 November 2017
Line 3:		Line 3:
	<StructureSection load='4xfs' size='340' side='right' caption='[[4xfs]], [[Resolution\|resolution]] 1.91Å' scene=''>		<StructureSection load='4xfs' size='340' side='right' caption='[[4xfs]], [[Resolution\|resolution]] 1.91Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xfs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XFS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xfs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XFS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IL18, IGIF, IL1F4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfs OCA], [http://pdbe.org/4xfs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xfs RCSB], [http://www.ebi.ac.uk/pdbsum/4xfs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xfs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfs OCA], [http://pdbe.org/4xfs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xfs RCSB], [http://www.ebi.ac.uk/pdbsum/4xfs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xfs ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Deng, J]]		[[Category: Deng, J]]
	[[Category: Krumm, B E]]		[[Category: Krumm, B E]]

OCA at 12:11, 12 April 2017

OCA — Wed, 12 Apr 2017 12:11:41 GMT

←Older revision		Revision as of 12:11, 12 April 2017
Line 1:		Line 1:
		+
	==Structure of IL-18 SER Mutant I==		==Structure of IL-18 SER Mutant I==
	<StructureSection load='4xfs' size='340' side='right' caption='[[4xfs]], [[Resolution\|resolution]] 1.91Å' scene=''>		<StructureSection load='4xfs' size='340' side='right' caption='[[4xfs]], [[Resolution\|resolution]] 1.91Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4xfs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XFS FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xfs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XFS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xfs RCSB], [http://www.ebi.ac.uk/pdbsum/4xfs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfs OCA], [http://pdbe.org/4xfs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xfs RCSB], [http://www.ebi.ac.uk/pdbsum/4xfs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xfs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4xfs" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:12, 1 July 2015

OCA — Wed, 01 Jul 2015 12:12:32 GMT

←Older revision		Revision as of 12:12, 1 July 2015
Line 8:		Line 8:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/IL18_HUMAN IL18_HUMAN]] Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.		[[http://www.uniprot.org/uniprot/IL18_HUMAN IL18_HUMAN]] Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Interleukin-18 (IL-18) is a pleiotropic pro-inflammatory cytokine belonging to the IL-1 superfamily. IL-18 plays an important role in host innate and acquired immune defense, with its activity being modulated in vivo by its naturally occurring antagonist IL-18 binding protein (IL-18BP). Recent crystal structures of human IL-18 (hIL-18) in complex with its antagonist or cognate receptor(s) have revealed a conserved binding interface on hIL-18 representing a promising drug target. An important step in this process is obtaining crystals of apo hIL-18 or hIL-18 in complex with small-molecule inhibitors, preferably under low ionic strength conditions. In this study, surface-entropy reduction (SER) and rational protein design were employed to facilitate the crystallization of hIL-18. The results provide an excellent platform for structure-based drug design.
		+
		+	Crystallization of interleukin-18 for structure-based inhibitor design.,Krumm B, Meng X, Xiang Y, Deng J Acta Crystallogr F Struct Biol Commun. 2015 Jun 1;71(Pt 6):710-7. doi:, 10.1107/S2053230X15006871. Epub 2015 May 20. PMID:26057800<ref>PMID:26057800</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 14:09, 10 June 2015

OCA — Wed, 10 Jun 2015 14:09:27 GMT

←Older revision		Revision as of 14:09, 10 June 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Structure of IL-18 SER Mutant I==
-		+	<StructureSection load='4xfs' size='340' side='right' caption='[[4xfs]], [[Resolution\|resolution]] 1.91Å' scene=''>
-	~~The entry~~ 4xfs is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4xfs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XFS FirstGlance]. <br>
-	~~Authors~~: ~~Krumm~~, B.E.~~, Meng, X~~., ~~Xiang~~, Y., ~~Deng, J~~.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xfs RCSB], [http://www.ebi.ac.uk/pdbsum/4xfs PDBsum]</span></td></tr>
-	~~Description: Structure of IL-18 SER Mutant I~~	+	</table>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/IL18_HUMAN IL18_HUMAN]] Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.
		+	__TOC__
		+	</StructureSection>
	[[Category: Deng, J]]		[[Category: Deng, J]]
-	[[Category: Krumm, B.E]]	+	[[Category: Krumm, B E]]
	[[Category: Meng, X]]		[[Category: Meng, X]]
	[[Category: Xiang, Y]]		[[Category: Xiang, Y]]
		+	[[Category: Cytokine]]
		+	[[Category: Il-18]]
		+	[[Category: Immune defense]]
		+	[[Category: Interleukin-18]]
		+	[[Category: Surface entropy reduction]]

OCA at 15:22, 28 January 2015

OCA — Wed, 28 Jan 2015 15:22:44 GMT

←Older revision		Revision as of 15:22, 28 January 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4xfs is ON HOLD	+	The entry 4xfs is ON HOLD until Paper Publication

	Authors: Krumm, B.E., Meng, X., Xiang, Y., Deng, J.		Authors: Krumm, B.E., Meng, X., Xiang, Y., Deng, J.

OCA: Protected "4xfs" [edit=sysop:move=sysop]

OCA — Wed, 07 Jan 2015 15:36:42 GMT

Protected "4xfs" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:36, 7 January 2015

OCA: New page: '''Unreleased structure''' The entry 4xfs is ON HOLD Authors: Krumm, B.E., Meng, X., Xiang, Y., Deng, J. Description: Structure of IL-18 SER Mutant I [[Category: Unreleased Structures]...

OCA — Wed, 07 Jan 2015 15:36:41 GMT

New page: '''Unreleased structure''' The entry 4xfs is ON HOLD Authors: Krumm, B.E., Meng, X., Xiang, Y., Deng, J. Description: Structure of IL-18 SER Mutant I [[Category: Unreleased Structures]...

New page

'''Unreleased structure'''

The entry 4xfs is ON HOLD

Authors: Krumm, B.E., Meng, X., Xiang, Y., Deng, J.

Description: Structure of IL-18 SER Mutant I
[[Category: Unreleased Structures]]
[[Category: Deng, J]]
[[Category: Krumm, B.E]]
[[Category: Meng, X]]
[[Category: Xiang, Y]]