4xfz - Revision history

OCA at 07:45, 27 September 2023

OCA — Wed, 27 Sep 2023 07:45:29 GMT

←Older revision		Revision as of 07:45, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xfz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_(NEW_YORK-5_ISOLATE) Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XFZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xfz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_(NEW_YORK-5_ISOLATE) Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XFZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1B0:N-METHYL-NALPHA-[(2-METHYL-1H-INDOL-3-YL)ACETYL]-N-PHENYL-L-PHENYLALANINAMIDE'>1B0</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1B0:N-METHYL-NALPHA-[(2-METHYL-1H-INDOL-3-YL)ACETYL]-N-PHENYL-L-PHENYLALANINAMIDE'>1B0</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfz OCA], [https://pdbe.org/4xfz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xfz RCSB], [https://www.ebi.ac.uk/pdbsum/4xfz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xfz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfz OCA], [https://pdbe.org/4xfz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xfz RCSB], [https://www.ebi.ac.uk/pdbsum/4xfz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xfz ProSAT]</span></td></tr>
	</table>		</table>

OCA at 21:27, 12 April 2023

OCA — Wed, 12 Apr 2023 21:27:06 GMT

←Older revision		Revision as of 21:27, 12 April 2023
Line 3:		Line 3:
	<StructureSection load='4xfz' size='340' side='right'caption='[[4xfz]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='4xfz' size='340' side='right'caption='[[4xfz]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xfz]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Hiv~~-1 ~~Hiv~~-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4XFZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xfz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_(NEW_YORK-5_ISOLATE) Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XFZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1B0:N-METHYL-NALPHA-[(2-METHYL-1H-INDOL-3-YL)ACETYL]-N-PHENYL-L-PHENYLALANINAMIDE'>1B0</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1B0:N-METHYL-NALPHA-[(2-METHYL-1H-INDOL-3-YL)ACETYL]-N-PHENYL-L-PHENYLALANINAMIDE'>1B0</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xfx\|4xfx]], [[4xfy\|4xfy]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfz OCA], [https://pdbe.org/4xfz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xfz RCSB], [https://www.ebi.ac.uk/pdbsum/4xfz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xfz ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gag ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11698 HIV-1])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4xfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfz OCA], [~~http~~://pdbe.org/4xfz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4xfz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4xfz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4xfz ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GAG_HV1N5 GAG_HV1N5]] Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu. Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity).	+	[https://www.uniprot.org/uniprot/GAG_HV1N5 GAG_HV1N5] Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu. Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4xfz" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4xfz" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Virus coat proteins 3D structures\|Virus coat proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Hiv-1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gres~~, A T~~]]	+	[[Category: Gres AT]]
-	[[Category: Kirby~~, K A~~]]	+	[[Category: Kirby KA]]
-	[[Category: Sarafianos~~, S G]]~~	+	[[Category: Sarafianos SG]]
-	~~[[Category: Antiviral]]~~	+
-	~~[[Category: Capsid protein]]~~	+
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Pf-3450074]]~~	+
-	~~[[Category: Pf74]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 15:48, 11 December 2019

OCA — Wed, 11 Dec 2019 15:48:44 GMT

←Older revision		Revision as of 15:48, 11 December 2019
Line 1:		Line 1:

	==Structure of the native full-length HIV-1 capsid protein in complex with PF-3450074 (PF74)==		==Structure of the native full-length HIV-1 capsid protein in complex with PF-3450074 (PF74)==
-	<StructureSection load='4xfz' size='340' side='right' caption='[[4xfz]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='4xfz' size='340' side='right'caption='[[4xfz]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xfz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hiv-1 Hiv-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XFZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xfz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hiv-1 Hiv-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XFZ FirstGlance]. <br>
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Hiv-1]]		[[Category: Hiv-1]]
		+	[[Category: Large Structures]]
	[[Category: Gres, A T]]		[[Category: Gres, A T]]
	[[Category: Kirby, K A]]		[[Category: Kirby, K A]]

OCA at 15:29, 15 November 2017

OCA — Wed, 15 Nov 2017 15:29:38 GMT

←Older revision		Revision as of 15:29, 15 November 2017
Line 3:		Line 3:
	<StructureSection load='4xfz' size='340' side='right' caption='[[4xfz]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='4xfz' size='340' side='right' caption='[[4xfz]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xfz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XFZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xfz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hiv-1 Hiv-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XFZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1B0:N-METHYL-NALPHA-[(2-METHYL-1H-INDOL-3-YL)ACETYL]-N-PHENYL-L-PHENYLALANINAMIDE'>1B0</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1B0:N-METHYL-NALPHA-[(2-METHYL-1H-INDOL-3-YL)ACETYL]-N-PHENYL-L-PHENYLALANINAMIDE'>1B0</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xfx\|4xfx]], [[4xfy\|4xfy]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xfx\|4xfx]], [[4xfy\|4xfy]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gag ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11698 HIV-1])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfz OCA], [http://pdbe.org/4xfz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xfz RCSB], [http://www.ebi.ac.uk/pdbsum/4xfz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xfz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfz OCA], [http://pdbe.org/4xfz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xfz RCSB], [http://www.ebi.ac.uk/pdbsum/4xfz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xfz ProSAT]</span></td></tr>
	</table>		</table>
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Hiv-1]]
	[[Category: Gres, A T]]		[[Category: Gres, A T]]
	[[Category: Kirby, K A]]		[[Category: Kirby, K A]]

OCA at 13:27, 19 April 2017

OCA — Wed, 19 Apr 2017 13:27:51 GMT

←Older revision		Revision as of 13:27, 19 April 2017
Line 1:		Line 1:
		+
	==Structure of the native full-length HIV-1 capsid protein in complex with PF-3450074 (PF74)==		==Structure of the native full-length HIV-1 capsid protein in complex with PF-3450074 (PF74)==
	<StructureSection load='4xfz' size='340' side='right' caption='[[4xfz]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='4xfz' size='340' side='right' caption='[[4xfz]], [[Resolution\|resolution]] 2.70Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1B0:N-METHYL-NALPHA-[(2-METHYL-1H-INDOL-3-YL)ACETYL]-N-PHENYL-L-PHENYLALANINAMIDE'>1B0</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1B0:N-METHYL-NALPHA-[(2-METHYL-1H-INDOL-3-YL)ACETYL]-N-PHENYL-L-PHENYLALANINAMIDE'>1B0</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xfx\|4xfx]], [[4xfy\|4xfy]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xfx\|4xfx]], [[4xfy\|4xfy]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xfz RCSB], [http://www.ebi.ac.uk/pdbsum/4xfz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfz OCA], [http://pdbe.org/4xfz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xfz RCSB], [http://www.ebi.ac.uk/pdbsum/4xfz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xfz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4xfz" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:21, 17 June 2015

OCA — Wed, 17 Jun 2015 08:21:07 GMT

←Older revision		Revision as of 08:21, 17 June 2015
Line 9:		Line 9:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/GAG_HV1N5 GAG_HV1N5]] Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu. Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity).		[[http://www.uniprot.org/uniprot/GAG_HV1N5 GAG_HV1N5]] Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu. Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The detailed molecular interactions between native HIV-1 capsid protein (CA) hexamers that shield the viral genome and proteins have been elusive. We report crystal structures describing interactions between CA monomers related by 6-fold symmetry within hexamers (intra-hexamer), and 3-fold and 2-fold symmetry between neighboring hexamers (inter-hexamer). The structures describe how CA builds hexagonal lattices, the foundation of mature capsids. Lattice structure depends on an adaptable hydration layer modulating interactions among CA molecules. Disruption of this layer alters inter-hexamer interfaces, highlighting an inherent structural variability. A CA-targeting antiviral affects capsid stability by binding across CA molecules and altering inter-hexamer interfaces remote to the ligand-binding site. Inherent structural plasticity, hydration layer rearrangement, and effector-binding affect capsid stability and have functional implications for the retroviral life-cycle.
		+
		+	X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability.,Gres AT, Kirby KA, KewalRamani VN, Tanner JJ, Pornillos O, Sarafianos SG Science. 2015 Jun 4. pii: aaa5936. PMID:26044298<ref>PMID:26044298</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
Line 19:		Line 29:
	[[Category: Pf-3450074]]		[[Category: Pf-3450074]]
	[[Category: Pf74]]		[[Category: Pf74]]
		+	[[Category: Viral protein]]

OCA at 14:09, 10 June 2015

OCA — Wed, 10 Jun 2015 14:09:39 GMT

←Older revision		Revision as of 14:09, 10 June 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Structure of the native full-length HIV-1 capsid protein in complex with PF-3450074 (PF74)==
-		+	<StructureSection load='4xfz' size='340' side='right' caption='[[4xfz]], [[Resolution\|resolution]] 2.70Å' scene=''>
-	~~The entry~~ 4xfz is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4xfz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XFZ FirstGlance]. <br>
-	~~Authors~~: ~~Gres~~, A.T., ~~Kirby~~, K.A., ~~Sarafianos~~, S.G.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1B0:N-METHYL-NALPHA-[(2-METHYL-1H-INDOL-3-YL)ACETYL]-N-PHENYL-L-PHENYLALANINAMIDE'>1B0</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xfx\|4xfx]], [[4xfy\|4xfy]]</td></tr>
-	~~Description~~:	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xfz RCSB], [http://www.ebi.ac.uk/pdbsum/4xfz PDBsum]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
-	[[Category: Sarafianos, S.G]]	+	== Function ==
-	[[Category: ~~Kirby, K.A~~]]	+	[[http://www.uniprot.org/uniprot/GAG_HV1N5 GAG_HV1N5]] Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu. Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity).
-	[[Category: ~~Gres, A.T~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Gres, A T]]
		+	[[Category: Kirby, K A]]
		+	[[Category: Sarafianos, S G]]
		+	[[Category: Antiviral]]
		+	[[Category: Capsid protein]]
		+	[[Category: Complex]]
		+	[[Category: Pf-3450074]]
		+	[[Category: Pf74]]

OCA at 10:21, 12 February 2015

OCA — Thu, 12 Feb 2015 10:21:40 GMT

←Older revision		Revision as of 10:21, 12 February 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4xfz is ON HOLD	+	The entry 4xfz is ON HOLD until Paper Publication

	Authors: Gres, A.T., Kirby, K.A., Sarafianos, S.G.		Authors: Gres, A.T., Kirby, K.A., Sarafianos, S.G.

OCA: Protected "4xfz" [edit=sysop:move=sysop]

OCA — Wed, 07 Jan 2015 15:37:14 GMT

Protected "4xfz" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:37, 7 January 2015

OCA: New page: '''Unreleased structure''' The entry 4xfz is ON HOLD Authors: Gres, A.T., Kirby, K.A., Sarafianos, S.G. Description: Category: Unreleased Structures Category: Sarafianos, S.G ...

OCA — Wed, 07 Jan 2015 15:37:13 GMT

New page: '''Unreleased structure''' The entry 4xfz is ON HOLD Authors: Gres, A.T., Kirby, K.A., Sarafianos, S.G. Description: Category: Unreleased Structures Category: Sarafianos, S.G ...

New page

'''Unreleased structure'''

The entry 4xfz is ON HOLD

Authors: Gres, A.T., Kirby, K.A., Sarafianos, S.G.

Description:
[[Category: Unreleased Structures]]
[[Category: Sarafianos, S.G]]
[[Category: Kirby, K.A]]
[[Category: Gres, A.T]]