4xgk - Revision history

OCA at 07:45, 27 September 2023

OCA — Wed, 27 Sep 2023 07:45:35 GMT

←Older revision		Revision as of 07:45, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xgk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Corynebacterium_diphtheriae_NCTC_13129 Corynebacterium diphtheriae NCTC 13129]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XGK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XGK FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xgk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Corynebacterium_diphtheriae_NCTC_13129 Corynebacterium diphtheriae NCTC 13129]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XGK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XGK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=40K:[(7S)-6-(4-CHLOROPHENYL)-3-(THIOPHEN-2-YL)-7H-[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZIN-7-YL]ACETIC+ACID'>40K</scene>, <scene name='pdbligand=FDA:DIHYDROFLAVINE-ADENINE+DINUCLEOTIDE'>FDA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.652Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=40K:[(7S)-6-(4-CHLOROPHENYL)-3-(THIOPHEN-2-YL)-7H-[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZIN-7-YL]ACETIC+ACID'>40K</scene>, <scene name='pdbligand=FDA:DIHYDROFLAVINE-ADENINE+DINUCLEOTIDE'>FDA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xgk OCA], [https://pdbe.org/4xgk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xgk RCSB], [https://www.ebi.ac.uk/pdbsum/4xgk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xgk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xgk OCA], [https://pdbe.org/4xgk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xgk RCSB], [https://www.ebi.ac.uk/pdbsum/4xgk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xgk ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:58, 19 April 2023

OCA — Wed, 19 Apr 2023 09:58:13 GMT

←Older revision		Revision as of 09:58, 19 April 2023
Line 3:		Line 3:
	<StructureSection load='4xgk' size='340' side='right'caption='[[4xgk]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='4xgk' size='340' side='right'caption='[[4xgk]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xgk]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Cordi Cordi~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XGK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=4XGK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xgk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Corynebacterium_diphtheriae_NCTC_13129 Corynebacterium diphtheriae NCTC 13129]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XGK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XGK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=40K:[(7S)-6-(4-CHLOROPHENYL)-3-(THIOPHEN-2-YL)-7H-[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZIN-7-YL]ACETIC+ACID'>40K</scene>, <scene name='pdbligand=FDA:DIHYDROFLAVINE-ADENINE+DINUCLEOTIDE'>FDA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=40K:[(7S)-6-(4-CHLOROPHENYL)-3-(THIOPHEN-2-YL)-7H-[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZIN-7-YL]ACETIC+ACID'>40K</scene>, <scene name='pdbligand=FDA:DIHYDROFLAVINE-ADENINE+DINUCLEOTIDE'>FDA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">glf, DIP2203 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=257309 CORDI])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xgk OCA], [https://pdbe.org/4xgk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xgk RCSB], [https://www.ebi.ac.uk/pdbsum/4xgk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xgk ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-galactopyranose_mutase UDP-galactopyranose mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.9 5.4.99.9] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=4xgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xgk OCA], [~~http~~://pdbe.org/4xgk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4xgk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4xgk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4xgk ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q6NER4_CORDI Q6NER4_CORDI]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cordi~~]]	+	[[Category: Corynebacterium diphtheriae NCTC 13129]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: UDP-galactopyranose mutase]]~~	+	[[Category: Forest KT]]
-	[[Category: Forest~~, K T~~]]	+	[[Category: Heroux A]]
-	[[Category: Heroux, A]]	+	[[Category: Kiessling LL]]
-	[[Category: Kiessling~~, L L~~]]	+	[[Category: Wangkanont K]]
-	[[Category: Wangkanont, K]]	+
-	~~[[Category: Corynebacterium diphtheriae]]~~	+
-	~~[[Category: Galactofuranose]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Isomerase-isomerase inhibitor complex]]~~	+
-	~~[[Category: Udp-galactopyranose mutase~~]]	+

OCA at 09:44, 9 September 2020

OCA — Wed, 09 Sep 2020 09:44:19 GMT

←Older revision		Revision as of 09:44, 9 September 2020
Line 1:		Line 1:

-	==Crystal ~~strucutre~~ of UDP-galactopyranose mutase from Corynebacterium diphtheriae in complex with 2-[4-(4-chlorophenyl)-7-(2-thienyl)-2-thia-5,6,8,9-tetrazabicyclo[4.3.0]nona-4,7,9-trien-3-yl]acetic==	+	==Crystal structure of UDP-galactopyranose mutase from Corynebacterium diphtheriae in complex with 2-[4-(4-chlorophenyl)-7-(2-thienyl)-2-thia-5,6,8,9-tetrazabicyclo[4.3.0]nona-4,7,9-trien-3-yl]acetic==
	<StructureSection load='4xgk' size='340' side='right'caption='[[4xgk]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='4xgk' size='340' side='right'caption='[[4xgk]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xgk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cordi Cordi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XGK OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4XGK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xgk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cordi Cordi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XGK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=4XGK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=40K:[(7S)-6-(4-CHLOROPHENYL)-3-(THIOPHEN-2-YL)-7H-[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZIN-7-YL]ACETIC+ACID'>40K</scene>, <scene name='pdbligand=FDA:DIHYDROFLAVINE-ADENINE+DINUCLEOTIDE'>FDA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=40K:[(7S)-6-(4-CHLOROPHENYL)-3-(THIOPHEN-2-YL)-7H-[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZIN-7-YL]ACETIC+ACID'>40K</scene>, <scene name='pdbligand=FDA:DIHYDROFLAVINE-ADENINE+DINUCLEOTIDE'>FDA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">glf, DIP2203 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=257309 CORDI])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">glf, DIP2203 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=257309 CORDI])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-galactopyranose_mutase UDP-galactopyranose mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.9 5.4.99.9] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-galactopyranose_mutase UDP-galactopyranose mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.9 5.4.99.9] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4xgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xgk OCA], [http://pdbe.org/4xgk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xgk RCSB], [http://www.ebi.ac.uk/pdbsum/4xgk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xgk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=4xgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xgk OCA], [http://pdbe.org/4xgk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xgk RCSB], [http://www.ebi.ac.uk/pdbsum/4xgk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xgk ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[UDP-galactopyranose mutase\|UDP-galactopyranose mutase]]	+	*[[UDP-galactopyranose mutase 3D structures\|UDP-galactopyranose mutase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:48, 11 December 2019

OCA — Wed, 11 Dec 2019 15:48:51 GMT

←Older revision		Revision as of 15:48, 11 December 2019
Line 1:		Line 1:

	==Crystal strucutre of UDP-galactopyranose mutase from Corynebacterium diphtheriae in complex with 2-[4-(4-chlorophenyl)-7-(2-thienyl)-2-thia-5,6,8,9-tetrazabicyclo[4.3.0]nona-4,7,9-trien-3-yl]acetic==		==Crystal strucutre of UDP-galactopyranose mutase from Corynebacterium diphtheriae in complex with 2-[4-(4-chlorophenyl)-7-(2-thienyl)-2-thia-5,6,8,9-tetrazabicyclo[4.3.0]nona-4,7,9-trien-3-yl]acetic==
-	<StructureSection load='4xgk' size='340' side='right' caption='[[4xgk]], [[Resolution\|resolution]] 2.65Å' scene=''>	+	<StructureSection load='4xgk' size='340' side='right'caption='[[4xgk]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xgk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cordi Cordi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XGK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XGK FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xgk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cordi Cordi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XGK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XGK FirstGlance]. <br>
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4xgk" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4xgk" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[UDP-galactopyranose mutase\|UDP-galactopyranose mutase]]
	== References ==		== References ==
	<references/>		<references/>
Line 23:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Cordi]]		[[Category: Cordi]]
		+	[[Category: Large Structures]]
	[[Category: UDP-galactopyranose mutase]]		[[Category: UDP-galactopyranose mutase]]
	[[Category: Forest, K T]]		[[Category: Forest, K T]]

OCA at 12:16, 6 November 2017

OCA — Mon, 06 Nov 2017 12:16:12 GMT

←Older revision		Revision as of 12:16, 6 November 2017
Line 1:		Line 1:
		+
	==Crystal strucutre of UDP-galactopyranose mutase from Corynebacterium diphtheriae in complex with 2-[4-(4-chlorophenyl)-7-(2-thienyl)-2-thia-5,6,8,9-tetrazabicyclo[4.3.0]nona-4,7,9-trien-3-yl]acetic==		==Crystal strucutre of UDP-galactopyranose mutase from Corynebacterium diphtheriae in complex with 2-[4-(4-chlorophenyl)-7-(2-thienyl)-2-thia-5,6,8,9-tetrazabicyclo[4.3.0]nona-4,7,9-trien-3-yl]acetic==
	<StructureSection load='4xgk' size='340' side='right' caption='[[4xgk]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='4xgk' size='340' side='right' caption='[[4xgk]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xgk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XGK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XGK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xgk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cordi Cordi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XGK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XGK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=40K:[(7S)-6-(4-CHLOROPHENYL)-3-(THIOPHEN-2-YL)-7H-[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZIN-7-YL]ACETIC+ACID'>40K</scene>, <scene name='pdbligand=FDA:DIHYDROFLAVINE-ADENINE+DINUCLEOTIDE'>FDA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=40K:[(7S)-6-(4-CHLOROPHENYL)-3-(THIOPHEN-2-YL)-7H-[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZIN-7-YL]ACETIC+ACID'>40K</scene>, <scene name='pdbligand=FDA:DIHYDROFLAVINE-ADENINE+DINUCLEOTIDE'>FDA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">glf, DIP2203 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=257309 CORDI])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-galactopyranose_mutase UDP-galactopyranose mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.9 5.4.99.9] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-galactopyranose_mutase UDP-galactopyranose mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.9 5.4.99.9] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xgk OCA], [http://pdbe.org/4xgk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xgk RCSB], [http://www.ebi.ac.uk/pdbsum/4xgk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xgk OCA], [http://pdbe.org/4xgk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xgk RCSB], [http://www.ebi.ac.uk/pdbsum/4xgk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xgk ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4xgk" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4xgk" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[S100 protein\|S100 protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Cordi]]
	[[Category: UDP-galactopyranose mutase]]		[[Category: UDP-galactopyranose mutase]]
	[[Category: Forest, K T]]		[[Category: Forest, K T]]

OCA at 19:55, 30 November 2015

OCA — Mon, 30 Nov 2015 19:55:28 GMT

←Older revision		Revision as of 19:55, 30 November 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=40K:[(7S)-6-(4-CHLOROPHENYL)-3-(THIOPHEN-2-YL)-7H-[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZIN-7-YL]ACETIC+ACID'>40K</scene>, <scene name='pdbligand=FDA:DIHYDROFLAVINE-ADENINE+DINUCLEOTIDE'>FDA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=40K:[(7S)-6-(4-CHLOROPHENYL)-3-(THIOPHEN-2-YL)-7H-[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZIN-7-YL]ACETIC+ACID'>40K</scene>, <scene name='pdbligand=FDA:DIHYDROFLAVINE-ADENINE+DINUCLEOTIDE'>FDA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-galactopyranose_mutase UDP-galactopyranose mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.9 5.4.99.9] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-galactopyranose_mutase UDP-galactopyranose mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.9 5.4.99.9] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xgk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xgk RCSB], [http://www.ebi.ac.uk/pdbsum/4xgk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xgk OCA], [http://pdbe.org/4xgk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xgk RCSB], [http://www.ebi.ac.uk/pdbsum/4xgk PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4xgk" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[S100 protein\|S100 protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:38, 12 August 2015

OCA — Wed, 12 Aug 2015 14:38:26 GMT

←Older revision		Revision as of 14:38, 12 August 2015
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-	'''~~Unreleased~~ structure'''	+	==Crystal strucutre of UDP-galactopyranose mutase from Corynebacterium diphtheriae in complex with 2-[4-(4-chlorophenyl)-7-(2-thienyl)-2-thia-5,6,8,9-tetrazabicyclo[4.3.0]nona-4,7,9-trien-3-yl]acetic==
		+	<StructureSection load='4xgk' size='340' side='right' caption='[[4xgk]], [[Resolution\|resolution]] 2.65Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4xgk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XGK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XGK FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=40K:[(7S)-6-(4-CHLOROPHENYL)-3-(THIOPHEN-2-YL)-7H-[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZIN-7-YL]ACETIC+ACID'>40K</scene>, <scene name='pdbligand=FDA:DIHYDROFLAVINE-ADENINE+DINUCLEOTIDE'>FDA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-galactopyranose_mutase UDP-galactopyranose mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.9 5.4.99.9] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xgk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xgk RCSB], [http://www.ebi.ac.uk/pdbsum/4xgk PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Galactofuranose (Galf) is present in glycans critical for virulence and viability of several pathogenic microbes, including Mycobacterium tuberculosis, yet the monosaccharide is absent from mammalian glycans. Uridine 5'-diphosphate-galactopyranose mutase (UGM) catalyzes the formation of UDP-Galf, which is required to produce Galf-containing glycoconjugates. Inhibitors of UGM have therefore been sought as antimicrobial leads and to delineate the roles of Galf in cells. Obtaining cell permeable UGM probes by either design or high throughput screens has been difficult, as has elucidating how UGM binds small molecule, non-carbohydrate inhibitors. To address these issues, we employed structure-based virtual screening to uncover new inhibitor chemotypes, including a triazolothiadiazine series. These compounds are among the most potent antimycobacterial UGM inhibitors described. They also facilitated determination of a UGM-small molecule inhibitor structure, which can guide optimization. A comparison of results from the computational screen and a high-throughput fluorescence polarization screen indicated that the scaffold hits from the former had been evaluated in the FP screen but missed. By focusing on promising compounds, the virtual screen rescued false negatives, providing a blueprint for generating new UGM probes and therapeutic leads.

-	~~The entry 4xgk is ON HOLD until Paper Publication~~	+	Virtual screening for UDP-galactopyranose mutase ligands identifies a new class of antimycobacterial agents.,Kincaid VA, London N, Wangkanont K, Wesener DA, Marcus SA, Heroux A, Nedyalkova L, Talaat AM, Forest KT, Shoichet BK, Kiessling LL ACS Chem Biol. 2015 Jul 27. PMID:26214585<ref>PMID:26214585</ref>

-	~~Authors: Wangkanont~~, K.~~, Heroux, A~~.~~, Forest, K.T., Kiessling, L.L~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal strucutre of~~ UDP-galactopyranose mutase ~~from Corynebacterium diphtheriae in complex with 2-~~[~~4-(4-chlorophenyl)-7-(2-thienyl)-2-thia-5~~,~~6,8,9-tetrazabicyclo~~[~~4.3.0~~]~~nona-4,7,9-trien-3-yl~~]~~acetic~~	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: UDP-galactopyranose mutase]]
		+	[[Category: Forest, K T]]
		+	[[Category: Heroux, A]]
		+	[[Category: Kiessling, L L]]
	[[Category: Wangkanont, K]]		[[Category: Wangkanont, K]]
-	[[Category: ~~Kiessling, L.L~~]]	+	[[Category: Corynebacterium diphtheriae]]
-	[[Category: ~~Forest, K.T~~]]	+	[[Category: Galactofuranose]]
-	[[Category: ~~Heroux, A~~]]	+	[[Category: Inhibitor]]
		+	[[Category: Isomerase-isomerase inhibitor complex]]
		+	[[Category: Udp-galactopyranose mutase]]

OCA at 15:23, 28 January 2015

OCA — Wed, 28 Jan 2015 15:23:54 GMT

←Older revision		Revision as of 15:23, 28 January 2015
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4xgk is ON HOLD	+	The entry 4xgk is ON HOLD until Paper Publication

	Authors: Wangkanont, K., Heroux, A., Forest, K.T., Kiessling, L.L.		Authors: Wangkanont, K., Heroux, A., Forest, K.T., Kiessling, L.L.

OCA: Protected "4xgk" [edit=sysop:move=sysop]

OCA — Wed, 07 Jan 2015 15:38:27 GMT

Protected "4xgk" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:38, 7 January 2015

OCA: New page: '''Unreleased structure''' The entry 4xgk is ON HOLD Authors: Wangkanont, K., Heroux, A., Forest, K.T., Kiessling, L.L. Description: Crystal strucutre of UDP-galactopyranose mutase fro...

OCA — Wed, 07 Jan 2015 15:38:26 GMT

New page: '''Unreleased structure''' The entry 4xgk is ON HOLD Authors: Wangkanont, K., Heroux, A., Forest, K.T., Kiessling, L.L. Description: Crystal strucutre of UDP-galactopyranose mutase fro...

New page

'''Unreleased structure'''

The entry 4xgk is ON HOLD

Authors: Wangkanont, K., Heroux, A., Forest, K.T., Kiessling, L.L.

Description: Crystal strucutre of UDP-galactopyranose mutase from Corynebacterium diphtheriae in complex with 2-[4-(4-chlorophenyl)-7-(2-thienyl)-2-thia-5,6,8,9-tetrazabicyclo[4.3.0]nona-4,7,9-trien-3-yl]acetic
[[Category: Unreleased Structures]]
[[Category: Wangkanont, K]]
[[Category: Kiessling, L.L]]
[[Category: Forest, K.T]]
[[Category: Heroux, A]]