4xhm - Revision history

OCA at 09:59, 19 April 2023

OCA — Wed, 19 Apr 2023 09:59:18 GMT

←Older revision		Revision as of 09:59, 19 April 2023
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	<StructureSection load='4xhm' size='340' side='right'caption='[[4xhm]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='4xhm' size='340' side='right'caption='[[4xhm]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xhm]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Arcfu Arcfu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XHM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4XHM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xhm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus_DSM_4304 Archaeoglobus fulgidus DSM 4304]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XHM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XHM FirstGlance]. <br>
-	</td></tr>~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AF_1284 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224325 ARCFU])</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xhm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xhm OCA], [https://pdbe.org/4xhm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xhm RCSB], [https://www.ebi.ac.uk/pdbsum/4xhm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xhm ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4xhm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xhm OCA], [~~http~~://pdbe.org/4xhm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4xhm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4xhm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4xhm ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/O28984_ARCFU O28984_ARCFU]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
-	*[[Thioredoxin\|Thioredoxin]]	+	*[[Thioredoxin 3D structures\|Thioredoxin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arcfu~~]]	+	[[Category: Archaeoglobus fulgidus DSM 4304]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bjork~~, R E~~]]	+	[[Category: Bjork RE]]
-	[[Category: Dey, M]]	+	[[Category: Dey M]]
-	[[Category: Drennan~~, C L]]~~	+	[[Category: Drennan CL]]
-	~~[[Category: Disulfide]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Thioredoxin~~]]	+

OCA at 16:04, 20 November 2019

OCA — Wed, 20 Nov 2019 16:04:37 GMT

←Older revision		Revision as of 16:04, 20 November 2019
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	<StructureSection load='4xhm' size='340' side='right'caption='[[4xhm]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='4xhm' size='340' side='right'caption='[[4xhm]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xhm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XHM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XHM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xhm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arcfu Arcfu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XHM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XHM FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xhm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xhm OCA], [http://pdbe.org/4xhm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xhm RCSB], [http://www.ebi.ac.uk/pdbsum/4xhm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xhm ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AF_1284 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224325 ARCFU])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xhm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xhm OCA], [http://pdbe.org/4xhm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xhm RCSB], [http://www.ebi.ac.uk/pdbsum/4xhm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xhm ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Arcfu]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Bjork, R E]]		[[Category: Bjork, R E]]

OCA at 06:39, 12 June 2019

OCA — Wed, 12 Jun 2019 06:39:16 GMT

←Older revision		Revision as of 06:39, 12 June 2019
Line 1:		Line 1:

	==Archaeoglobus fulgidus thioredoxin 3 M60H==		==Archaeoglobus fulgidus thioredoxin 3 M60H==
-	<StructureSection load='4xhm' size='340' side='right' caption='[[4xhm]], [[Resolution\|resolution]] 1.95Å' scene=''>	+	<StructureSection load='4xhm' size='340' side='right'caption='[[4xhm]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xhm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XHM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XHM FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xhm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XHM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XHM FirstGlance]. <br>
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Bjork, R E]]		[[Category: Bjork, R E]]
	[[Category: Dey, M]]		[[Category: Dey, M]]

OCA at 03:45, 6 September 2017

OCA — Wed, 06 Sep 2017 03:45:25 GMT

←Older revision		Revision as of 03:45, 6 September 2017
Line 15:		Line 15:
	</div>		</div>
	<div class="pdbe-citations 4xhm" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4xhm" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Thioredoxin\|Thioredoxin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:41, 1 February 2017

OCA — Wed, 01 Feb 2017 18:41:42 GMT

←Older revision		Revision as of 18:41, 1 February 2017
Line 1:		Line 1:
		+
	==Archaeoglobus fulgidus thioredoxin 3 M60H==		==Archaeoglobus fulgidus thioredoxin 3 M60H==
	<StructureSection load='4xhm' size='340' side='right' caption='[[4xhm]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='4xhm' size='340' side='right' caption='[[4xhm]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xhm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XHM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XHM FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xhm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XHM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XHM FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xhm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xhm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xhm RCSB], [http://www.ebi.ac.uk/pdbsum/4xhm PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xhm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xhm OCA], [http://pdbe.org/4xhm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xhm RCSB], [http://www.ebi.ac.uk/pdbsum/4xhm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xhm ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 13:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4xhm" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:36, 30 April 2015

OCA — Thu, 30 Apr 2015 11:36:36 GMT

←Older revision		Revision as of 11:36, 30 April 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Archaeoglobus fulgidus thioredoxin 3 M60H==
		+	<StructureSection load='4xhm' size='340' side='right' caption='[[4xhm]], [[Resolution\|resolution]] 1.95Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4xhm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XHM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XHM FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xhm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xhm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xhm RCSB], [http://www.ebi.ac.uk/pdbsum/4xhm PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Thioredoxins are small soluble proteins that contain a redox-active disulfide (CXXC). These disulfides are tuned to oxidizing or reducing potentials depending on the function of the thioredoxin within the cell. The mechanism by which the potential is tuned has been controversial, with two main hypotheses: first, that redox potential (Em) is specifically governed by a molecular 'rheostat'-the XX amino acids, which influence the Cys pKa values, and thereby, Em; and second, the overall thermodynamics of protein folding stability regulates the potential. Here, we use protein film voltammetry (PFV) to measure the pH dependence of the redox potentials of a series of wild-type and mutant archaeal Trxs, PFV and glutathionine-equilibrium to corroborate the measured potentials, the fluorescence probe BADAN to measure pKa values, guanidinium-based denaturation to measure protein unfolding, and X-ray crystallography to provide a structural basis for our functional analyses. We find that when these archaeal thioredoxins are probed directly using PFV, both the high and low potential thioredoxins display consistent 2H+:2e- coupling over a physiological pH range, in conflict with the conventional 'rheostat' model. Instead, folding measurements reveals an excellent correlation to reduction potentials, supporting the second hypothesis and revealing the molecular mechanism of reduction potential control in the ubiquitous Trx family.

-	~~The entry 4xhm is ON HOLD until Paper Publication~~	+	Rheostat re-wired: alternative hypotheses for the control of thioredoxin reduction potentials.,Bewley KD, Dey M, Bjork RE, Mitra S, Chobot SE, Drennan CL, Elliott SJ PLoS One. 2015 Apr 13;10(4):e0122466. doi: 10.1371/journal.pone.0122466., eCollection 2015. PMID:25874934<ref>PMID:25874934</ref>

-	~~Authors: Dey~~, M.~~, Bjork, R~~.~~E., Drennan, C.L~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: Archaeoglobus fulgidus thioredoxin 3 M60H~~	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bjork, R E]]
	[[Category: Dey, M]]		[[Category: Dey, M]]
-	[[Category: Drennan, C.L]]	+	[[Category: Drennan, C L]]
-	[[Category: ~~Bjork, R.E~~]]	+	[[Category: Disulfide]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Thioredoxin]]

OCA: Protected "4xhm" [edit=sysop:move=sysop]

OCA — Wed, 14 Jan 2015 12:43:06 GMT

Protected "4xhm" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:43, 14 January 2015

OCA: New page: '''Unreleased structure''' The entry 4xhm is ON HOLD until Paper Publication Authors: Dey, M., Bjork, R.E., Drennan, C.L. Description: Archaeoglobus fulgidus thioredoxin 3 M60H [[Categ...

OCA — Wed, 14 Jan 2015 12:43:05 GMT

New page: '''Unreleased structure''' The entry 4xhm is ON HOLD until Paper Publication Authors: Dey, M., Bjork, R.E., Drennan, C.L. Description: Archaeoglobus fulgidus thioredoxin 3 M60H [[Categ...

New page

'''Unreleased structure'''

The entry 4xhm is ON HOLD until Paper Publication

Authors: Dey, M., Bjork, R.E., Drennan, C.L.

Description: Archaeoglobus fulgidus thioredoxin 3 M60H
[[Category: Unreleased Structures]]
[[Category: Dey, M]]
[[Category: Drennan, C.L]]
[[Category: Bjork, R.E]]