4xhz - Revision history

OCA at 07:45, 27 September 2023

OCA — Wed, 27 Sep 2023 07:45:53 GMT

←Older revision		Revision as of 07:45, 27 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xhz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XHZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XHZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xhz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XHZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XHZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.803Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xhz OCA], [https://pdbe.org/4xhz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xhz RCSB], [https://www.ebi.ac.uk/pdbsum/4xhz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xhz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xhz OCA], [https://pdbe.org/4xhz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xhz RCSB], [https://www.ebi.ac.uk/pdbsum/4xhz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xhz ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:59, 19 April 2023

OCA — Wed, 19 Apr 2023 09:59:37 GMT

←Older revision		Revision as of 09:59, 19 April 2023
Line 3:		Line 3:
	<StructureSection load='4xhz' size='340' side='right'caption='[[4xhz]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4xhz' size='340' side='right'caption='[[4xhz]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xhz]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XHZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4XHZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xhz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XHZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XHZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PCDH15, USH1F ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xhz OCA], [https://pdbe.org/4xhz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xhz RCSB], [https://www.ebi.ac.uk/pdbsum/4xhz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xhz ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4xhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xhz OCA], [~~http~~://pdbe.org/4xhz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4xhz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4xhz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4xhz ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/PCD15_HUMAN PCD15_HUMAN]] Usher syndrome type 1;Autosomal recessive non-syndromic sensorineural deafness type DFNB. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/PCD15_HUMAN PCD15_HUMAN] Usher syndrome type 1;Autosomal recessive non-syndromic sensorineural deafness type DFNB. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PCD15_HUMAN PCD15_HUMAN]] Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function.	+	[https://www.uniprot.org/uniprot/PCD15_HUMAN PCD15_HUMAN] Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Araya-Secchi, R]]	+	[[Category: Araya-Secchi R]]
-	[[Category: Sotomayor, M]]	+	[[Category: Sotomayor M]]
-	~~[[Category: Adhesion]]~~	+
-	~~[[Category: Calcium-binding protein]]~~	+
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Hearing]]~~	+
-	~~[[Category: Mechanotransduction~~]]	+

OCA at 06:57, 29 May 2019

OCA — Wed, 29 May 2019 06:57:48 GMT

←Older revision		Revision as of 06:57, 29 May 2019
Line 1:		Line 1:

	==Crystal Structure of Human Protocadherin-15 EC8-10==		==Crystal Structure of Human Protocadherin-15 EC8-10==
-	<StructureSection load='4xhz' size='340' side='right' caption='[[4xhz]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='4xhz' size='340' side='right'caption='[[4xhz]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xhz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XHZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xhz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XHZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PCDH15, USH1F ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xhz OCA], [http://pdbe.org/4xhz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xhz RCSB], [http://www.ebi.ac.uk/pdbsum/4xhz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xhz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xhz OCA], [http://pdbe.org/4xhz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xhz RCSB], [http://www.ebi.ac.uk/pdbsum/4xhz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xhz ProSAT]</span></td></tr>
	</table>		</table>
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Araya-Secchi, R]]		[[Category: Araya-Secchi, R]]
	[[Category: Sotomayor, M]]		[[Category: Sotomayor, M]]

OCA at 14:25, 22 December 2016

OCA — Thu, 22 Dec 2016 14:25:58 GMT

←Older revision		Revision as of 14:25, 22 December 2016
Line 11:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PCD15_HUMAN PCD15_HUMAN]] Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function.		[[http://www.uniprot.org/uniprot/PCD15_HUMAN PCD15_HUMAN]] Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Tip link filaments convey force and gate inner-ear hair-cell transduction channels to mediate perception of sound and head movements. Cadherin-23 and protocadherin-15 form tip links through a calcium-dependent interaction of their extracellular domains made of multiple extracellular cadherin (EC) repeats. These repeats are structurally similar, but not identical in sequence, often featuring linkers with conserved calcium-binding sites that confer mechanical strength to them. Here we present the X-ray crystal structures of human protocadherin-15 EC8-EC10 and mouse EC9-EC10, which show an EC8-9 canonical-like calcium-binding linker, and an EC9-10 calcium-free linker that alters the linear arrangement of EC repeats. Molecular dynamics simulations and small-angle X-ray scattering experiments support this non-linear conformation. Simulations also suggest that unbending of EC9-10 confers some elasticity to otherwise rigid tip links. The new structure provides a first view of protocadherin-15's non-canonical EC linkers and suggests how they may function in inner-ear mechanotransduction, with implications for other cadherins.
		+
		+	An elastic element in the protocadherin-15 tip link of the inner ear.,Araya-Secchi R, Neel BL, Sotomayor M Nat Commun. 2016 Nov 18;7:13458. doi: 10.1038/ncomms13458. PMID:27857071<ref>PMID:27857071</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4xhz" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 13:45, 21 September 2016

OCA — Wed, 21 Sep 2016 13:45:19 GMT

←Older revision		Revision as of 13:45, 21 September 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 4xhz is ~~ON HOLD until Sep 15 2017~~	+	==Crystal Structure of Human Protocadherin-15 EC8-10==
-		+	<StructureSection load='4xhz' size='340' side='right' caption='[[4xhz]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~Authors~~: ~~Araya~~-~~Secchi~~, R., ~~Sotomayor~~, M.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4xhz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XHZ FirstGlance]. <br>
-	~~Description~~: ~~Crystal Structure of Human Protocadherin~~-~~15 EC8~~-10	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xhz OCA], [http://pdbe.org/4xhz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xhz RCSB], [http://www.ebi.ac.uk/pdbsum/4xhz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xhz ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/PCD15_HUMAN PCD15_HUMAN]] Usher syndrome type 1;Autosomal recessive non-syndromic sensorineural deafness type DFNB. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PCD15_HUMAN PCD15_HUMAN]] Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Araya-Secchi, R]]
	[[Category: Sotomayor, M]]		[[Category: Sotomayor, M]]
-	[[Category: ~~Araya~~-~~Secchi, R~~]]	+	[[Category: Adhesion]]
		+	[[Category: Calcium-binding protein]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Hearing]]
		+	[[Category: Mechanotransduction]]

OCA at 08:45, 14 September 2016

OCA — Wed, 14 Sep 2016 08:45:03 GMT

←Older revision		Revision as of 08:45, 14 September 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4xhz is ON HOLD until Sep 08 2017	+	The entry 4xhz is ON HOLD until Sep 15 2017

	Authors: Araya-Secchi, R., Sotomayor, M.		Authors: Araya-Secchi, R., Sotomayor, M.

OCA at 10:12, 9 September 2016

OCA — Fri, 09 Sep 2016 10:12:47 GMT

←Older revision		Revision as of 10:12, 9 September 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4xhz is ON HOLD until ~~Aug 25~~ 2017	+	The entry 4xhz is ON HOLD until Sep 08 2017

	Authors: Araya-Secchi, R., Sotomayor, M.		Authors: Araya-Secchi, R., Sotomayor, M.

OCA at 09:05, 10 August 2016

OCA — Wed, 10 Aug 2016 09:05:13 GMT

←Older revision		Revision as of 09:05, 10 August 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4xhz is ON HOLD until Aug 09 2017	+	The entry 4xhz is ON HOLD until Aug 25 2017

	Authors: Araya-Secchi, R., Sotomayor, M.		Authors: Araya-Secchi, R., Sotomayor, M.

OCA at 21:05, 3 August 2016

OCA — Wed, 03 Aug 2016 21:05:14 GMT

←Older revision		Revision as of 21:05, 3 August 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4xhz is ON HOLD until Aug 02 2017	+	The entry 4xhz is ON HOLD until Aug 09 2017

	Authors: Araya-Secchi, R., Sotomayor, M.		Authors: Araya-Secchi, R., Sotomayor, M.

OCA at 04:14, 14 July 2016

OCA — Thu, 14 Jul 2016 04:14:43 GMT

←Older revision		Revision as of 04:14, 14 July 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4xhz is ON HOLD until ~~Jul 07~~ 2017	+	The entry 4xhz is ON HOLD until Aug 02 2017

	Authors: Araya-Secchi, R., Sotomayor, M.		Authors: Araya-Secchi, R., Sotomayor, M.