4xi6 - Revision history

OCA at 00:55, 28 December 2023

OCA — Thu, 28 Dec 2023 00:55:55 GMT

←Older revision		Revision as of 00:55, 28 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xi6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XI6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XI6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xi6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XI6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XI6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.04Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xi6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xi6 OCA], [https://pdbe.org/4xi6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xi6 RCSB], [https://www.ebi.ac.uk/pdbsum/4xi6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xi6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xi6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xi6 OCA], [https://pdbe.org/4xi6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xi6 RCSB], [https://www.ebi.ac.uk/pdbsum/4xi6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xi6 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:59, 19 April 2023

OCA — Wed, 19 Apr 2023 09:59:58 GMT

←Older revision		Revision as of 09:59, 19 April 2023
Line 3:		Line 3:
	<StructureSection load='4xi6' size='340' side='right'caption='[[4xi6]], [[Resolution\|resolution]] 2.04Å' scene=''>		<StructureSection load='4xi6' size='340' side='right'caption='[[4xi6]], [[Resolution\|resolution]] 2.04Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xi6]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XI6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4XI6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xi6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XI6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XI6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xi7\|4xi7]], [[4xib\|4xib]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xi6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xi6 OCA], [https://pdbe.org/4xi6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xi6 RCSB], [https://www.ebi.ac.uk/pdbsum/4xi6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xi6 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MIB1, DIP1, KIAA1323, ZZANK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4xi6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xi6 OCA], [~~http~~://pdbe.org/4xi6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4xi6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4xi6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4xi6 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/MIB1_HUMAN MIB1_HUMAN]] Left ventricular noncompaction. The disease is caused by mutations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/MIB1_HUMAN MIB1_HUMAN] Left ventricular noncompaction. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MIB1_HUMAN MIB1_HUMAN]] E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.<ref>PMID:24121310</ref>	+	[https://www.uniprot.org/uniprot/MIB1_HUMAN MIB1_HUMAN] E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.<ref>PMID:24121310</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:

	==See Also==		==See Also==
-	*[[Ubiquitin protein ligase\|Ubiquitin protein ligase]]	+	*[[Ubiquitin protein ligase 3D structures\|Ubiquitin protein ligase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Blacklow~~, S C~~]]	+	[[Category: Blacklow SC]]
-	[[Category: McMillan~~, B J]]~~	+	[[Category: McMillan BJ]]
-	~~[[Category: E3 ligase]]~~	+
-	~~[[Category: Ligase]]~~	+
-	~~[[Category: Notch signaling~~]]	+

OCA at 08:44, 4 December 2019

OCA — Wed, 04 Dec 2019 08:44:50 GMT

←Older revision		Revision as of 08:44, 4 December 2019
Line 1:		Line 1:

	==Crystal structure of the MZM-REP domains of Mind bomb 1==		==Crystal structure of the MZM-REP domains of Mind bomb 1==
-	<StructureSection load='4xi6' size='340' side='right' caption='[[4xi6]], [[Resolution\|resolution]] 2.04Å' scene=''>	+	<StructureSection load='4xi6' size='340' side='right'caption='[[4xi6]], [[Resolution\|resolution]] 2.04Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xi6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XI6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XI6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xi6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XI6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XI6 FirstGlance]. <br>
Line 22:		Line 22:
	</div>		</div>
	<div class="pdbe-citations 4xi6" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4xi6" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ubiquitin protein ligase\|Ubiquitin protein ligase]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Blacklow, S C]]		[[Category: Blacklow, S C]]
	[[Category: McMillan, B J]]		[[Category: McMillan, B J]]

OCA at 12:16, 6 November 2017

OCA — Mon, 06 Nov 2017 12:16:29 GMT

←Older revision		Revision as of 12:16, 6 November 2017
Line 3:		Line 3:
	<StructureSection load='4xi6' size='340' side='right' caption='[[4xi6]], [[Resolution\|resolution]] 2.04Å' scene=''>		<StructureSection load='4xi6' size='340' side='right' caption='[[4xi6]], [[Resolution\|resolution]] 2.04Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xi6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XI6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XI6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xi6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XI6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XI6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xi7\|4xi7]], [[4xib\|4xib]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xi7\|4xi7]], [[4xib\|4xib]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MIB1, DIP1, KIAA1323, ZZANK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xi6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xi6 OCA], [http://pdbe.org/4xi6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xi6 RCSB], [http://www.ebi.ac.uk/pdbsum/4xi6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xi6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xi6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xi6 OCA], [http://pdbe.org/4xi6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xi6 RCSB], [http://www.ebi.ac.uk/pdbsum/4xi6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xi6 ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 22:
	</div>		</div>
	<div class="pdbe-citations 4xi6" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4xi6" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Ubiquitin protein ligase\|Ubiquitin protein ligase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Blacklow, S C]]		[[Category: Blacklow, S C]]
	[[Category: McMillan, B J]]		[[Category: McMillan, B J]]

OCA at 00:13, 26 January 2017

OCA — Thu, 26 Jan 2017 00:13:55 GMT

←Older revision		Revision as of 00:13, 26 January 2017
Line 1:		Line 1:
		+
	==Crystal structure of the MZM-REP domains of Mind bomb 1==		==Crystal structure of the MZM-REP domains of Mind bomb 1==
	<StructureSection load='4xi6' size='340' side='right' caption='[[4xi6]], [[Resolution\|resolution]] 2.04Å' scene=''>		<StructureSection load='4xi6' size='340' side='right' caption='[[4xi6]], [[Resolution\|resolution]] 2.04Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xi7\|4xi7]], [[4xib\|4xib]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xi7\|4xi7]], [[4xib\|4xib]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xi6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xi6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xi6 RCSB], [http://www.ebi.ac.uk/pdbsum/4xi6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xi6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xi6 OCA], [http://pdbe.org/4xi6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xi6 RCSB], [http://www.ebi.ac.uk/pdbsum/4xi6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xi6 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4xi6" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ubiquitin protein ligase\|Ubiquitin protein ligase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:31, 26 March 2015

OCA — Thu, 26 Mar 2015 07:31:46 GMT

←Older revision		Revision as of 07:31, 26 March 2015
Line 11:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/MIB1_HUMAN MIB1_HUMAN]] E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.<ref>PMID:24121310</ref>		[[http://www.uniprot.org/uniprot/MIB1_HUMAN MIB1_HUMAN]] E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.<ref>PMID:24121310</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mind bomb (Mib) proteins are large, multi-domain E3 ligases that promote ubiquitination of the cytoplasmic tails of Notch ligands. This ubiquitination step marks the ligand proteins for epsin-dependent endocytosis, which is critical for in vivo Notch receptor activation. We present here crystal structures of the substrate recognition domains of Mib1, both in isolation and in complex with peptides derived from Notch ligands. The structures, in combination with biochemical, cellular, and in vivo assays, show that Mib1 contains two independent substrate recognition domains that engage two distinct epitopes from the cytoplasmic tail of the ligand Jagged1, one in the intracellular membrane proximal region and the other near the C terminus. Together, these studies provide insights into the mechanism of ubiquitin transfer by Mind bomb E3 ligases, illuminate a key event in ligand-induced activation of Notch receptors, and identify a potential target for therapeutic modulation of Notch signal transduction in disease.
		+
		+	A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb e3 ligases.,McMillan BJ, Schnute B, Ohlenhard N, Zimmerman B, Miles L, Beglova N, Klein T, Blacklow SC Mol Cell. 2015 Mar 5;57(5):912-24. doi: 10.1016/j.molcel.2015.01.019. PMID:25747658<ref>PMID:25747658</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:17, 18 March 2015

OCA — Wed, 18 Mar 2015 12:17:22 GMT

←Older revision		Revision as of 12:17, 18 March 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of the MZM-REP domains of Mind bomb 1==
-		+	<StructureSection load='4xi6' size='340' side='right' caption='[[4xi6]], [[Resolution\|resolution]] 2.04Å' scene=''>
-	~~The entry~~ 4xi6 is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4xi6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XI6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XI6 FirstGlance]. <br>
-	~~Authors~~: ~~McMillan~~, B.J., ~~Blacklow~~, S.C.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xi7\|4xi7]], [[4xib\|4xib]]</td></tr>
-	~~Description~~:	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xi6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xi6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xi6 RCSB], [http://www.ebi.ac.uk/pdbsum/4xi6 PDBsum]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
-	[[Category: ~~Mcmillan~~, B.J]]	+	== Disease ==
-	[[Category: ~~Blacklow, S.C~~]]	+	[[http://www.uniprot.org/uniprot/MIB1_HUMAN MIB1_HUMAN]] Left ventricular noncompaction. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MIB1_HUMAN MIB1_HUMAN]] E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.<ref>PMID:24121310</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Blacklow, S C]]
		+	[[Category: McMillan, B J]]
		+	[[Category: E3 ligase]]
		+	[[Category: Ligase]]
		+	[[Category: Notch signaling]]

OCA at 11:22, 18 February 2015

OCA — Wed, 18 Feb 2015 11:22:33 GMT

←Older revision		Revision as of 11:22, 18 February 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4xi6 is ON HOLD	+	The entry 4xi6 is ON HOLD until Paper Publication

	Authors: McMillan, B.J., Blacklow, S.C.		Authors: McMillan, B.J., Blacklow, S.C.

OCA: Protected "4xi6" [edit=sysop:move=sysop]

OCA — Wed, 14 Jan 2015 12:45:35 GMT

Protected "4xi6" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:45, 14 January 2015

OCA: New page: '''Unreleased structure''' The entry 4xi6 is ON HOLD Authors: McMillan, B.J., Blacklow, S.C. Description: Category: Unreleased Structures Category: Mcmillan, B.J [[Category: B...

OCA — Wed, 14 Jan 2015 12:45:34 GMT

New page: '''Unreleased structure''' The entry 4xi6 is ON HOLD Authors: McMillan, B.J., Blacklow, S.C. Description: Category: Unreleased Structures Category: Mcmillan, B.J [[Category: B...

New page

'''Unreleased structure'''

The entry 4xi6 is ON HOLD

Authors: McMillan, B.J., Blacklow, S.C.

Description:
[[Category: Unreleased Structures]]
[[Category: Mcmillan, B.J]]
[[Category: Blacklow, S.C]]