4xke - Revision history

OCA at 07:46, 27 September 2023

OCA — Wed, 27 Sep 2023 07:46:49 GMT

←Older revision		Revision as of 07:46, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xke]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/H6N1_subtype H6N1 subtype]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XKE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XKE FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xke]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/H6N1_subtype H6N1 subtype]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XKE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XKE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900067:3-sialyl-N-acetyllactosamine'>PRD_900067</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.356Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900067:3-sialyl-N-acetyllactosamine'>PRD_900067</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xke OCA], [https://pdbe.org/4xke PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xke RCSB], [https://www.ebi.ac.uk/pdbsum/4xke PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xke ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xke OCA], [https://pdbe.org/4xke PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xke RCSB], [https://www.ebi.ac.uk/pdbsum/4xke PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xke ProSAT]</span></td></tr>
	</table>		</table>

OCA at 17:41, 26 April 2023

OCA — Wed, 26 Apr 2023 17:41:07 GMT

←Older revision		Revision as of 17:41, 26 April 2023
Line 1:		Line 1:

	==Crystal structure of hemagglutinin from Taiwan (2013) H6N1 influenza virus in complex with 3'-SLN==		==Crystal structure of hemagglutinin from Taiwan (2013) H6N1 influenza virus in complex with 3'-SLN==
-	<StructureSection load='4xke' size='340' side='right' caption='[[4xke]], [[Resolution\|resolution]] 2.36Å' scene=''>	+	<StructureSection load='4xke' size='340' side='right'caption='[[4xke]], [[Resolution\|resolution]] 2.36Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xke]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~H6n1_subtype H6n1~~ subtype]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XKE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4XKE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xke]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/H6N1_subtype H6N1 subtype]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XKE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XKE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=~~SIA~~:O-~~SIALIC+ACID~~'>~~SIA~~</scene><~~/td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900067:3-sialyl-N-acetyllactosamine'>PRD_900067</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat">[[4xkd\|4xkd]], [[4xkf\|4xkf]], [[4xkg\|4xkg]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xke OCA], [https://pdbe.org/4xke PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xke RCSB], [https://www.ebi.ac.uk/pdbsum/4xke PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xke ProSAT]</span></td></tr>
-	~~<tr id='gene~~'>~~<td class="sblockLbl"><b>[[Gene\|Gene:]]~~</b>~~</td><td class="sblockDat">HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=119212 H6N1 subtype])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4xke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xke OCA], [~~http~~://pdbe.org/4xke PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4xke RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4xke PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4xke ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0J9X268_9INFA A0A0J9X268_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[SAAS:SAAS00842036] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
-	*[[Hemagglutinin\|Hemagglutinin]]	+	*[[Hemagglutinin 3D structures\|Hemagglutinin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~H6n1~~ subtype]]	+	[[Category: H6N1 subtype]]
-	[[Category: ~~Tzarum, N~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Wilson, I A~~]]	+	[[Category: Tzarum N]]
-	[[Category: ~~Zhu, X~~]]	+	[[Category: Wilson IA]]
-	[[Category: ~~Viral protein~~]]	+	[[Category: Zhu X]]

OCA at 09:35, 22 November 2017

OCA — Wed, 22 Nov 2017 09:35:05 GMT

←Older revision		Revision as of 09:35, 22 November 2017
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	<StructureSection load='4xke' size='340' side='right' caption='[[4xke]], [[Resolution\|resolution]] 2.36Å' scene=''>		<StructureSection load='4xke' size='340' side='right' caption='[[4xke]], [[Resolution\|resolution]] 2.36Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xke]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XKE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XKE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xke]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/H6n1_subtype H6n1 subtype]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XKE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XKE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xkd\|4xkd]], [[4xkf\|4xkf]], [[4xkg\|4xkg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xkd\|4xkd]], [[4xkf\|4xkf]], [[4xkg\|4xkg]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=119212 H6N1 subtype])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xke OCA], [http://pdbe.org/4xke PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xke RCSB], [http://www.ebi.ac.uk/pdbsum/4xke PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xke ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xke OCA], [http://pdbe.org/4xke PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xke RCSB], [http://www.ebi.ac.uk/pdbsum/4xke PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xke ProSAT]</span></td></tr>
	</table>		</table>
Line 17:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4xke" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4xke" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Hemagglutinin\|Hemagglutinin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: H6n1 subtype]]
	[[Category: Tzarum, N]]		[[Category: Tzarum, N]]
	[[Category: Wilson, I A]]		[[Category: Wilson, I A]]
	[[Category: Zhu, X]]		[[Category: Zhu, X]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 18:35, 1 February 2017

OCA — Wed, 01 Feb 2017 18:35:09 GMT

←Older revision		Revision as of 18:35, 1 February 2017
Line 1:		Line 1:
		+
	==Crystal structure of hemagglutinin from Taiwan (2013) H6N1 influenza virus in complex with 3'-SLN==		==Crystal structure of hemagglutinin from Taiwan (2013) H6N1 influenza virus in complex with 3'-SLN==
	<StructureSection load='4xke' size='340' side='right' caption='[[4xke]], [[Resolution\|resolution]] 2.36Å' scene=''>		<StructureSection load='4xke' size='340' side='right' caption='[[4xke]], [[Resolution\|resolution]] 2.36Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xkd\|4xkd]], [[4xkf\|4xkf]], [[4xkg\|4xkg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xkd\|4xkd]], [[4xkf\|4xkf]], [[4xkg\|4xkg]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xke OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xke RCSB], [http://www.ebi.ac.uk/pdbsum/4xke PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xke OCA], [http://pdbe.org/4xke PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xke RCSB], [http://www.ebi.ac.uk/pdbsum/4xke PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xke ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4xke" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:09, 1 April 2015

OCA — Wed, 01 Apr 2015 13:09:21 GMT

←Older revision		Revision as of 13:09, 1 April 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of hemagglutinin from Taiwan (2013) H6N1 influenza virus in complex with 3'-SLN==
		+	<StructureSection load='4xke' size='340' side='right' caption='[[4xke]], [[Resolution\|resolution]] 2.36Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4xke]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XKE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XKE FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xkd\|4xkd]], [[4xkf\|4xkf]], [[4xkg\|4xkg]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xke OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xke RCSB], [http://www.ebi.ac.uk/pdbsum/4xke PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Avian influenza viruses that cause infection and are transmissible in humans involve changes in the receptor binding site (RBS) of the viral hemagglutinin (HA) that alter receptor preference from alpha2-3-linked (avian-like) to alpha2-6-linked (human-like) sialosides. A human case of avian-origin H6N1 influenza virus was recently reported, but the molecular mechanisms contributing to it crossing the species barrier are unknown. We find that, although the H6 HA RBS contains D190V and G228S substitutions that potentially promote human receptor binding, recombinant H6 HA preferentially binds alpha2-3-linked sialosides, indicating no adaptation to human receptors. Crystal structures of H6 HA with avian and human receptor analogs reveal that H6 HA preferentially interacts with avian receptor analogs. This binding mechanism differs from other HA subtypes due to a unique combination of RBS residues, highlighting additional variation in HA-receptor interactions and the challenges in predicting which influenza strains and subtypes can infect humans and cause pandemics.

-	~~The entry 4xke is ON HOLD~~	+	Structure and Receptor Binding of the Hemagglutinin from a Human H6N1 Influenza Virus.,Tzarum N, de Vries RP, Zhu X, Yu W, McBride R, Paulson JC, Wilson IA Cell Host Microbe. 2015 Mar 11;17(3):369-76. doi: 10.1016/j.chom.2015.02.005. PMID:25766295<ref>PMID:25766295</ref>

-	~~Authors: Tzarum~~, N.~~, Zhu, X~~.~~, Wilson, I.A~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description:~~	+	== References ==
-	~~[[Category: Unreleased Structures]]~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Tzarum, N]]		[[Category: Tzarum, N]]
-	[[Category: Wilson, I.A]]	+	[[Category: Wilson, I A]]
	[[Category: Zhu, X]]		[[Category: Zhu, X]]
		+	[[Category: Viral protein]]

OCA: Protected "4xke" [edit=sysop:move=sysop]

OCA — Wed, 21 Jan 2015 15:57:13 GMT

Protected "4xke" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:57, 21 January 2015

OCA: New page: '''Unreleased structure''' The entry 4xke is ON HOLD Authors: Tzarum, N., Zhu, X., Wilson, I.A. Description: Category: Unreleased Structures Category: Tzarum, N [[Category: Wi...

OCA — Wed, 21 Jan 2015 15:57:12 GMT

New page: '''Unreleased structure''' The entry 4xke is ON HOLD Authors: Tzarum, N., Zhu, X., Wilson, I.A. Description: Category: Unreleased Structures Category: Tzarum, N [[Category: Wi...

New page

'''Unreleased structure'''

The entry 4xke is ON HOLD

Authors: Tzarum, N., Zhu, X., Wilson, I.A.

Description:
[[Category: Unreleased Structures]]
[[Category: Tzarum, N]]
[[Category: Wilson, I.A]]
[[Category: Zhu, X]]