4xmq - Revision history

OCA at 07:47, 27 September 2023

OCA — Wed, 27 Sep 2023 07:47:29 GMT

←Older revision		Revision as of 07:47, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xmq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Campylobacter_jejuni_subsp._jejuni_NCTC_11168_=_ATCC_700819 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XMQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XMQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xmq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Campylobacter_jejuni_subsp._jejuni_NCTC_11168_=_ATCC_700819 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XMQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XMQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xmq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xmq OCA], [https://pdbe.org/4xmq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xmq RCSB], [https://www.ebi.ac.uk/pdbsum/4xmq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xmq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xmq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xmq OCA], [https://pdbe.org/4xmq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xmq RCSB], [https://www.ebi.ac.uk/pdbsum/4xmq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xmq ProSAT]</span></td></tr>
	</table>		</table>

OCA at 17:43, 26 April 2023

OCA — Wed, 26 Apr 2023 17:43:14 GMT

←Older revision		Revision as of 17:43, 26 April 2023
Line 1:		Line 1:

	==Crystal structure of the sensory domain of the Campylobacter jejuni chemoreceptor Tlp3 (CcmL)==		==Crystal structure of the sensory domain of the Campylobacter jejuni chemoreceptor Tlp3 (CcmL)==
-	<StructureSection load='4xmq' size='340' side='right' caption='[[4xmq]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='4xmq' size='340' side='right'caption='[[4xmq]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xmq]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Camje Camje~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XMQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4XMQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xmq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Campylobacter_jejuni_subsp._jejuni_NCTC_11168_=_ATCC_700819 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XMQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XMQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xmr\|4xmr]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xmq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xmq OCA], [https://pdbe.org/4xmq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xmq RCSB], [https://www.ebi.ac.uk/pdbsum/4xmq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xmq ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cj1564 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=192222 CAMJE])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4xmq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xmq OCA], [~~http~~://pdbe.org/4xmq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4xmq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4xmq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4xmq ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q0P864_CAMJE Q0P864_CAMJE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Camje~~]]	+	[[Category: Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]]
-	[[Category: ~~Liu, Y C~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Machuca, M A~~]]	+	[[Category: Liu YC]]
-	[[Category: ~~Roujeinikova, A~~]]	+	[[Category: Machuca MA]]
-	[[Category: ~~Chemotactic receptor]]~~	+	[[Category: Roujeinikova A]]
-	~~[[Category: Sensory domain]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 09:35, 22 November 2017

OCA — Wed, 22 Nov 2017 09:35:30 GMT

←Older revision		Revision as of 09:35, 22 November 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 4xmq is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of the sensory domain of the Campylobacter jejuni chemoreceptor Tlp3 (CcmL)==
		+	<StructureSection load='4xmq' size='340' side='right' caption='[[4xmq]], [[Resolution\|resolution]] 1.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4xmq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Camje Camje]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XMQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XMQ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xmr\|4xmr]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cj1564 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=192222 CAMJE])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xmq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xmq OCA], [http://pdbe.org/4xmq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xmq RCSB], [http://www.ebi.ac.uk/pdbsum/4xmq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xmq ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Chemotaxis, mediated by methyl-accepting chemotaxis protein (MCP) receptors, plays an important role in the ecology of bacterial populations. This paper presents the first crystallographic analysis of the structure and ligand-induced conformational changes of the periplasmic tandem Per-Arnt-Sim (PAS) sensing domain (PTPSD) of a characterized MCP chemoreceptor. Analysis of the complex of the Campylobacter jejuni Tlp3 PTPSD with isoleucine (a chemoattractant) revealed that the PTPSD is a dimer in the crystal. The two ligand-binding sites are located in the membrane-distal PAS domains on the faces opposite to the dimer interface. Mutagenesis experiments show that the five strongly conserved residues that stabilize the main-chain moiety of isoleucine are essential for binding, suggesting that the mechanism by which this family of chemoreceptors recognizes amino acids is highly conserved. Although the fold and mode of ligand binding of the PTPSD are different from the aspartic acid receptor Tar, the structural analysis suggests that the PTPSDs of amino-acid chemoreceptors are also likely to signal by a piston displacement mechanism. The PTPSD fluctuates between piston (C-terminal helix) `up' and piston `down' states. Binding of an attractant to the distal PAS domain locks it in the closed form, weakening its association with the proximal domain and resulting in the transition of the latter into an open form, concomitant with a downward (towards the membrane) 4 A piston displacement of the C-terminal helix. In vivo, this movement would generate a transmembrane signal by driving a downward displacement of the transmembrane helix 2 towards the cytoplasm.

-	~~Authors: Roujeinikova, A~~., Liu, Y.C., ~~Machuca, M~~.A.	+	Structural basis for amino-acid recognition and transmembrane signalling by tandem Per-Arnt-Sim (tandem PAS) chemoreceptor sensory domains.,Liu YC, Machuca MA, Beckham SA, Gunzburg MJ, Roujeinikova A Acta Crystallogr D Biol Crystallogr. 2015 Oct;71(Pt 10):2127-36. doi:, 10.1107/S139900471501384X. Epub 2015 Sep 30. PMID:26457436<ref>PMID:26457436</ref>

-	~~Description: Crystal structure~~ of the ~~sensory domain~~ of ~~the Campylobacter jejuni chemoreceptor Tlp3 (CcmL)~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: Liu, Y.C]]	+	<div class="pdbe-citations 4xmq" style="background-color:#fffaf0;"></div>
-	[[Category: Machuca, M.A]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Camje]]
		+	[[Category: Liu, Y C]]
		+	[[Category: Machuca, M A]]
	[[Category: Roujeinikova, A]]		[[Category: Roujeinikova, A]]
		+	[[Category: Chemotactic receptor]]
		+	[[Category: Sensory domain]]
		+	[[Category: Signaling protein]]

OCA at 15:33, 28 January 2015

OCA — Wed, 28 Jan 2015 15:33:50 GMT

←Older revision		Revision as of 15:33, 28 January 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4xmq is ON HOLD	+	The entry 4xmq is ON HOLD until Paper Publication

-	Authors: Roujeinikova, A., Liu, YC., Machuca, M.A.	+	Authors: Roujeinikova, A., Liu, Y.C., Machuca, M.A.

-	Description: ~~Periplasmic portion~~ of the Campylobacter jejuni chemoreceptor ~~Ccml~~	+	Description: Crystal structure of the sensory domain of the Campylobacter jejuni chemoreceptor Tlp3 (CcmL)
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Liu, Yc]]	+	[[Category: Liu, Y.C]]
	[[Category: Machuca, M.A]]		[[Category: Machuca, M.A]]
	[[Category: Roujeinikova, A]]		[[Category: Roujeinikova, A]]

OCA: Protected "4xmq" [edit=sysop:move=sysop]

OCA — Wed, 21 Jan 2015 16:02:14 GMT

Protected "4xmq" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:02, 21 January 2015

OCA: New page: '''Unreleased structure''' The entry 4xmq is ON HOLD Authors: Roujeinikova, A., Liu, YC., Machuca, M.A. Description: Periplasmic portion of the Campylobacter jejuni chemoreceptor Ccml ...

OCA — Wed, 21 Jan 2015 16:02:13 GMT

New page: '''Unreleased structure''' The entry 4xmq is ON HOLD Authors: Roujeinikova, A., Liu, YC., Machuca, M.A. Description: Periplasmic portion of the Campylobacter jejuni chemoreceptor Ccml ...

New page

'''Unreleased structure'''

The entry 4xmq is ON HOLD

Authors: Roujeinikova, A., Liu, YC., Machuca, M.A.

Description: Periplasmic portion of the Campylobacter jejuni chemoreceptor Ccml
[[Category: Unreleased Structures]]
[[Category: Liu, Yc]]
[[Category: Machuca, M.A]]
[[Category: Roujeinikova, A]]