4xpi - Revision history

OCA at 07:48, 27 September 2023

OCA — Wed, 27 Sep 2023 07:48:00 GMT

←Older revision		Revision as of 07:48, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xpi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Azotobacter_vinelandii Azotobacter vinelandii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XPI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XPI FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xpi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Azotobacter_vinelandii Azotobacter vinelandii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XPI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XPI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1CL:FE(8)-S(7)+CLUSTER,+OXIDIZED'>1CL</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HCA:3-HYDROXY-3-CARBOXY-ADIPIC+ACID'>HCA</scene>, <scene name='pdbligand=ICS:IRON-SULFUR-MOLYBDENUM+CLUSTER+WITH+INTERSTITIAL+CARBON'>ICS</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.97Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1CL:FE(8)-S(7)+CLUSTER,+OXIDIZED'>1CL</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HCA:3-HYDROXY-3-CARBOXY-ADIPIC+ACID'>HCA</scene>, <scene name='pdbligand=ICS:IRON-SULFUR-MOLYBDENUM+CLUSTER+WITH+INTERSTITIAL+CARBON'>ICS</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xpi OCA], [https://pdbe.org/4xpi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xpi RCSB], [https://www.ebi.ac.uk/pdbsum/4xpi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xpi ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xpi OCA], [https://pdbe.org/4xpi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xpi RCSB], [https://www.ebi.ac.uk/pdbsum/4xpi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xpi ProSAT]</span></td></tr>
	</table>		</table>

OCA at 17:46, 26 April 2023

OCA — Wed, 26 Apr 2023 17:46:31 GMT

←Older revision		Revision as of 17:46, 26 April 2023
Line 3:		Line 3:
	<StructureSection load='4xpi' size='340' side='right'caption='[[4xpi]], [[Resolution\|resolution]] 1.97Å' scene=''>		<StructureSection load='4xpi' size='340' side='right'caption='[[4xpi]], [[Resolution\|resolution]] 1.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xpi]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_478 Atcc 478~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XPI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4XPI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xpi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Azotobacter_vinelandii Azotobacter vinelandii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XPI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XPI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1CL:FE(8)-S(7)+CLUSTER,+OXIDIZED'>1CL</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HCA:3-HYDROXY-3-CARBOXY-ADIPIC+ACID'>HCA</scene>, <scene name='pdbligand=ICS:IRON-SULFUR-MOLYBDENUM+CLUSTER+WITH+INTERSTITIAL+CARBON'>ICS</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1CL:FE(8)-S(7)+CLUSTER,+OXIDIZED'>1CL</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HCA:3-HYDROXY-3-CARBOXY-ADIPIC+ACID'>HCA</scene>, <scene name='pdbligand=ICS:IRON-SULFUR-MOLYBDENUM+CLUSTER+WITH+INTERSTITIAL+CARBON'>ICS</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nifD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=354 ATCC 478]), nifK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=354 ATCC 478])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xpi OCA], [https://pdbe.org/4xpi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xpi RCSB], [https://www.ebi.ac.uk/pdbsum/4xpi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xpi ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitrogenase Nitrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.18.6.1 1.18.6.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4xpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xpi OCA], [~~http~~://pdbe.org/4xpi PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4xpi RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4xpi PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4xpi ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/NIFD_AZOVI NIFD_AZOVI~~]] This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation. [[http://www.uniprot.org/uniprot/NIFK_AZOVI NIFK_AZOVI]~~] This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.	+	[https://www.uniprot.org/uniprot/NIFD_AZOVI NIFD_AZOVI] This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 478~~]]	+	[[Category: Azotobacter vinelandii]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Nitrogenase]]~~	+	[[Category: Danyal K]]
-	[[Category: Danyal, K]]	+	[[Category: Dean DR]]
-	[[Category: Dean~~, D R~~]]	+	[[Category: Duval S]]
-	[[Category: Duval, S]]	+	[[Category: Keable SM]]
-	[[Category: Keable~~, S M~~]]	+	[[Category: Peters JW]]
-	[[Category: Peters~~, J W~~]]	+	[[Category: Rasmusen AJ]]
-	[[Category: Rasmusen~~, A J~~]]	+	[[Category: Raugei S]]
-	[[Category: Raugei, S]]	+	[[Category: Seefeldt LC]]
-	[[Category: Seefeldt~~, L C~~]]	+	[[Category: Shaw S]]
-	[[Category: Shaw, S]]	+	[[Category: Zadvornyy O]]
-	[[Category: Zadvornyy, O]]	+
-	~~[[Category: Acetylene]]~~	+
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Hydride reduction]]~~	+
-	~~[[Category: Iron]]~~	+
-	~~[[Category: Iron-sulfur]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Mofe protein]]~~	+
-	~~[[Category: Molybdenum]]~~	+
-	~~[[Category: Nitrogen]]~~	+
-	~~[[Category: Nitrogen fixation]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Proton reduction~~]]	+

OCA at 07:22, 27 November 2019

OCA — Wed, 27 Nov 2019 07:22:52 GMT

←Older revision		Revision as of 07:22, 27 November 2019
Line 3:		Line 3:
	<StructureSection load='4xpi' size='340' side='right'caption='[[4xpi]], [[Resolution\|resolution]] 1.97Å' scene=''>		<StructureSection load='4xpi' size='340' side='right'caption='[[4xpi]], [[Resolution\|resolution]] 1.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xpi]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XPI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xpi]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_478 Atcc 478]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XPI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1CL:FE(8)-S(7)+CLUSTER,+OXIDIZED'>1CL</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HCA:3-HYDROXY-3-CARBOXY-ADIPIC+ACID'>HCA</scene>, <scene name='pdbligand=ICS:IRON-SULFUR-MOLYBDENUM+CLUSTER+WITH+INTERSTITIAL+CARBON'>ICS</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1CL:FE(8)-S(7)+CLUSTER,+OXIDIZED'>1CL</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HCA:3-HYDROXY-3-CARBOXY-ADIPIC+ACID'>HCA</scene>, <scene name='pdbligand=ICS:IRON-SULFUR-MOLYBDENUM+CLUSTER+WITH+INTERSTITIAL+CARBON'>ICS</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nifD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=354 ATCC 478]), nifK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=354 ATCC 478])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitrogenase Nitrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.18.6.1 1.18.6.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitrogenase Nitrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.18.6.1 1.18.6.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xpi OCA], [http://pdbe.org/4xpi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xpi RCSB], [http://www.ebi.ac.uk/pdbsum/4xpi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xpi ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xpi OCA], [http://pdbe.org/4xpi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xpi RCSB], [http://www.ebi.ac.uk/pdbsum/4xpi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xpi ProSAT]</span></td></tr>
Line 21:		Line 22:

	==See Also==		==See Also==
-	*[[Nitrogenase\|Nitrogenase]]	+	*[[Nitrogenase 3D structures\|Nitrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 478]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Nitrogenase]]		[[Category: Nitrogenase]]

OCA at 07:13, 10 July 2019

OCA — Wed, 10 Jul 2019 07:13:17 GMT

←Older revision		Revision as of 07:13, 10 July 2019
Line 1:		Line 1:

	==Fe protein independent substrate reduction by nitrogenase variants altered in intramolecular electron transfer==		==Fe protein independent substrate reduction by nitrogenase variants altered in intramolecular electron transfer==
-	<StructureSection load='4xpi' size='340' side='right' caption='[[4xpi]], [[Resolution\|resolution]] 1.97Å' scene=''>	+	<StructureSection load='4xpi' size='340' side='right'caption='[[4xpi]], [[Resolution\|resolution]] 1.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xpi]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XPI FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xpi]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XPI FirstGlance]. <br>
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Nitrogenase]]		[[Category: Nitrogenase]]
	[[Category: Danyal, K]]		[[Category: Danyal, K]]

OCA at 06:09, 6 October 2017

OCA — Fri, 06 Oct 2017 06:09:55 GMT

←Older revision		Revision as of 06:09, 6 October 2017
Line 1:		Line 1:
		+
	==Fe protein independent substrate reduction by nitrogenase variants altered in intramolecular electron transfer==		==Fe protein independent substrate reduction by nitrogenase variants altered in intramolecular electron transfer==
	<StructureSection load='4xpi' size='340' side='right' caption='[[4xpi]], [[Resolution\|resolution]] 1.97Å' scene=''>		<StructureSection load='4xpi' size='340' side='right' caption='[[4xpi]], [[Resolution\|resolution]] 1.97Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1CL:FE(8)-S(7)+CLUSTER,+OXIDIZED'>1CL</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HCA:3-HYDROXY-3-CARBOXY-ADIPIC+ACID'>HCA</scene>, <scene name='pdbligand=ICS:IRON-SULFUR-MOLYBDENUM+CLUSTER+WITH+INTERSTITIAL+CARBON'>ICS</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1CL:FE(8)-S(7)+CLUSTER,+OXIDIZED'>1CL</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HCA:3-HYDROXY-3-CARBOXY-ADIPIC+ACID'>HCA</scene>, <scene name='pdbligand=ICS:IRON-SULFUR-MOLYBDENUM+CLUSTER+WITH+INTERSTITIAL+CARBON'>ICS</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitrogenase Nitrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.18.6.1 1.18.6.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitrogenase Nitrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.18.6.1 1.18.6.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xpi OCA], [http://pdbe.org/4xpi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xpi RCSB], [http://www.ebi.ac.uk/pdbsum/4xpi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xpi OCA], [http://pdbe.org/4xpi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xpi RCSB], [http://www.ebi.ac.uk/pdbsum/4xpi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xpi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4xpi" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4xpi" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Nitrogenase\|Nitrogenase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 03:54, 16 October 2015

OCA — Fri, 16 Oct 2015 03:54:04 GMT

←Older revision		Revision as of 03:54, 16 October 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Fe protein independent substrate reduction by nitrogenase variants altered in intramolecular electron transfer==
		+	<StructureSection load='4xpi' size='340' side='right' caption='[[4xpi]], [[Resolution\|resolution]] 1.97Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4xpi]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XPI FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1CL:FE(8)-S(7)+CLUSTER,+OXIDIZED'>1CL</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HCA:3-HYDROXY-3-CARBOXY-ADIPIC+ACID'>HCA</scene>, <scene name='pdbligand=ICS:IRON-SULFUR-MOLYBDENUM+CLUSTER+WITH+INTERSTITIAL+CARBON'>ICS</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitrogenase Nitrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.18.6.1 1.18.6.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xpi OCA], [http://pdbe.org/4xpi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xpi RCSB], [http://www.ebi.ac.uk/pdbsum/4xpi PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NIFD_AZOVI NIFD_AZOVI]] This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation. [[http://www.uniprot.org/uniprot/NIFK_AZOVI NIFK_AZOVI]] This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The reduction of substrates catalyzed by nitrogenase normally requires nucleotide-dependent Fe protein delivery of electrons to the MoFe protein, which contains the active site FeMo cofactor. Here, it is reported that independent substitution of three amino acids (beta-98(Tyr-->His), alpha-64(Tyr-->His), and beta-99(Phe-->His)) located between the P cluster and FeMo cofactor within the MoFe protein endows it with the ability to reduce protons to H2, azide to ammonia, and hydrazine to ammonia without the need for Fe protein or ATP. Instead, electrons can be provided by the low-potential reductant polyaminocarboxylate-ligated Eu(II) (Em values of -1.1 to -0.84 V vs the normal hydrogen electrode). The crystal structure of the beta-98(Tyr-->His) variant MoFe protein was determined, revealing only small changes near the amino acid substitution that affect the solvent structure and the immediate vicinity between the P cluster and the FeMo cofactor, with no global conformational changes observed. Computational normal-mode analysis of the nitrogenase complex reveals coupling in the motions of the Fe protein and the region of the MoFe protein with these three amino acids, which suggests a possible mechanism for how Fe protein might communicate subtle changes deep within the MoFe protein that profoundly affect intramolecular electron transfer and substrate reduction.

-	~~The entry 4xpi is ON HOLD~~	+	Fe protein-independent substrate reduction by nitrogenase MoFe protein variants.,Danyal K, Rasmussen AJ, Keable SM, Inglet BS, Shaw S, Zadvornyy OA, Duval S, Dean DR, Raugei S, Peters JW, Seefeldt LC Biochemistry. 2015 Apr 21;54(15):2456-62. doi: 10.1021/acs.biochem.5b00140. Epub , 2015 Apr 7. PMID:25831270<ref>PMID:25831270</ref>

-	~~Authors: Danyal~~, K.~~, Rasmusen, A.J., Keable,~~ S.~~M., Shaw, S., Zadvornyy, O., Duval, S., Dean, D.R., Raugei, S., Peters, J.W., Seefeldt, L.C~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Fe protein independent substrate reduction by nitrogenase variants altered in intramolecular electron transfer~~	+	<div class="pdbe-citations 4xpi" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Unreleased Structures~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Nitrogenase]]
	[[Category: Danyal, K]]		[[Category: Danyal, K]]
		+	[[Category: Dean, D R]]
	[[Category: Duval, S]]		[[Category: Duval, S]]
		+	[[Category: Keable, S M]]
		+	[[Category: Peters, J W]]
		+	[[Category: Rasmusen, A J]]
	[[Category: Raugei, S]]		[[Category: Raugei, S]]
-	[[Category: ~~Peters~~, ~~J.W~~]]	+	[[Category: Seefeldt, L C]]
	[[Category: Shaw, S]]		[[Category: Shaw, S]]
-	[[Category: Rasmusen, A.J]]
	[[Category: Zadvornyy, O]]		[[Category: Zadvornyy, O]]
-	[[Category: ~~Keable, S.M~~]]	+	[[Category: Acetylene]]
-	[[Category: ~~Seefeldt, L.C~~]]	+	[[Category: Atp-binding]]
-	[[Category: ~~Dean, D.R~~]]	+	[[Category: Hydride reduction]]
		+	[[Category: Iron]]
		+	[[Category: Iron-sulfur]]
		+	[[Category: Metal-binding]]
		+	[[Category: Mofe protein]]
		+	[[Category: Molybdenum]]
		+	[[Category: Nitrogen]]
		+	[[Category: Nitrogen fixation]]
		+	[[Category: Nucleotide-binding]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Proton reduction]]

OCA at 09:15, 26 August 2015

OCA — Wed, 26 Aug 2015 09:15:51 GMT

←Older revision		Revision as of 09:15, 26 August 2015
Line 3:		Line 3:
	The entry 4xpi is ON HOLD		The entry 4xpi is ON HOLD

-	Authors: Danyal, K, Rasmusen, A.J., Keable, S.M., Shaw, S., Zadvornyy, O., Duval, S., Dean, D.R., Raugei, S., Peters, J.W., Seefeldt, L.C.	+	Authors: Danyal, K., Rasmusen, A.J., Keable, S.M., Shaw, S., Zadvornyy, O., Duval, S., Dean, D.R., Raugei, S., Peters, J.W., Seefeldt, L.C.

	Description: Fe protein independent substrate reduction by nitrogenase variants altered in intramolecular electron transfer		Description: Fe protein independent substrate reduction by nitrogenase variants altered in intramolecular electron transfer
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Danyal, K~~, Rasmusen, A.J~~]]	+	[[Category: Danyal, K]]
	[[Category: Duval, S]]		[[Category: Duval, S]]
	[[Category: Raugei, S]]		[[Category: Raugei, S]]
	[[Category: Peters, J.W]]		[[Category: Peters, J.W]]
	[[Category: Shaw, S]]		[[Category: Shaw, S]]
		+	[[Category: Rasmusen, A.J]]
	[[Category: Zadvornyy, O]]		[[Category: Zadvornyy, O]]
	[[Category: Keable, S.M]]		[[Category: Keable, S.M]]
	[[Category: Seefeldt, L.C]]		[[Category: Seefeldt, L.C]]
	[[Category: Dean, D.R]]		[[Category: Dean, D.R]]

OCA at 11:33, 18 February 2015

OCA — Wed, 18 Feb 2015 11:33:30 GMT

←Older revision		Revision as of 11:33, 18 February 2015
Line 3:		Line 3:
	The entry 4xpi is ON HOLD		The entry 4xpi is ON HOLD

-	Authors: Danyal, K, Rasmusen, A. J., Keable, S. M., Shaw, S., Zadvornyy, O., Duval, S., Dean, D. R., Raugei, S., Peters, J. W., Seefeldt, L. C.	+	Authors: Danyal, K, Rasmusen, A.J., Keable, S.M., Shaw, S., Zadvornyy, O., Duval, S., Dean, D.R., Raugei, S., Peters, J.W., Seefeldt, L.C.

	Description: Fe protein independent substrate reduction by nitrogenase variants altered in intramolecular electron transfer		Description: Fe protein independent substrate reduction by nitrogenase variants altered in intramolecular electron transfer
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Seefeldt~~, ~~L. C]]~~	+	[[Category: Danyal, K, Rasmusen, A.J]]
-	~~[[Category: Dean~~, D. R]]	+
	[[Category: Duval, S]]		[[Category: Duval, S]]
-	[[Category: Keable, S. M]]
	[[Category: Raugei, S]]		[[Category: Raugei, S]]
-	[[Category: Peters, J. W]]	+	[[Category: Peters, J.W]]
-	~~[[Category: Danyal, K, Rasmusen, A. J~~]]	+
	[[Category: Shaw, S]]		[[Category: Shaw, S]]
	[[Category: Zadvornyy, O]]		[[Category: Zadvornyy, O]]
		+	[[Category: Keable, S.M]]
		+	[[Category: Seefeldt, L.C]]
		+	[[Category: Dean, D.R]]

OCA at 10:35, 12 February 2015

OCA — Thu, 12 Feb 2015 10:35:43 GMT

←Older revision		Revision as of 10:35, 12 February 2015
Line 3:		Line 3:
	The entry 4xpi is ON HOLD		The entry 4xpi is ON HOLD

-	Authors: Danyal, K, Rasmusen, A.J., Keable, S.M., Shaw, S., Zadvornyy, O., Duval, S., Dean, D.R., Raugei, S., Peters, J.W., Seefeldt, L.C.	+	Authors: Danyal, K, Rasmusen, A. J., Keable, S. M., Shaw, S., Zadvornyy, O., Duval, S., Dean, D. R., Raugei, S., Peters, J. W., Seefeldt, L. C.

	Description: Fe protein independent substrate reduction by nitrogenase variants altered in intramolecular electron transfer		Description: Fe protein independent substrate reduction by nitrogenase variants altered in intramolecular electron transfer
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Danyal~~, ~~K, Rasmusen~~, A.J]]	+	[[Category: Seefeldt, L. C]]
		+	[[Category: Dean, D. R]]
	[[Category: Duval, S]]		[[Category: Duval, S]]
		+	[[Category: Keable, S. M]]
	[[Category: Raugei, S]]		[[Category: Raugei, S]]
-	[[Category: Peters, J.W]]	+	[[Category: Peters, J. W]]
		+	[[Category: Danyal, K, Rasmusen, A. J]]
	[[Category: Shaw, S]]		[[Category: Shaw, S]]
	[[Category: Zadvornyy, O]]		[[Category: Zadvornyy, O]]
-	[[Category: Keable, S.M]]
-	[[Category: Seefeldt, L.C]]
-	[[Category: Dean, D.R]]

OCA: Protected "4xpi" [edit=sysop:move=sysop]

OCA — Wed, 28 Jan 2015 15:39:05 GMT

Protected "4xpi" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:39, 28 January 2015