4xqa - Revision history

OCA at 10:50, 10 January 2024

OCA — Wed, 10 Jan 2024 10:50:24 GMT

←Older revision		Revision as of 10:50, 10 January 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xqa]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_adenovirus_D37 Human adenovirus D37]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XQA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XQA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xqa]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_adenovirus_D37 Human adenovirus D37]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XQA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XQA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=423:(1-{2-[BIS(2-{4-[({(6R)-5-(ACETYLAMINO)-3,5-DIDEOXY-6-[(1R,2R)-1,2,3-TRIHYDROXYPROPYL]-BETA-L-THREO-HEX-2-ULOPYRANONOSYL}OXY)METHYL]-1H-1,2,3-TRIAZOL-1-YL}ETHYL)AMINO]ETHYL}-1H-1,2,3-TRIAZOL-4-YL)METHYL+(6R)-5-(ACETYLAMINO)-3,5-DIDEOXY-6-[(1R,2R)-1,2,3-TRIHYDROXYPROPYL]-BETA-L-THREO-HEX-2-ULOPYRANOSIDONIC+ACID'>423</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.4072Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=423:(1-{2-[BIS(2-{4-[({(6R)-5-(ACETYLAMINO)-3,5-DIDEOXY-6-[(1R,2R)-1,2,3-TRIHYDROXYPROPYL]-BETA-L-THREO-HEX-2-ULOPYRANONOSYL}OXY)METHYL]-1H-1,2,3-TRIAZOL-1-YL}ETHYL)AMINO]ETHYL}-1H-1,2,3-TRIAZOL-4-YL)METHYL+(6R)-5-(ACETYLAMINO)-3,5-DIDEOXY-6-[(1R,2R)-1,2,3-TRIHYDROXYPROPYL]-BETA-L-THREO-HEX-2-ULOPYRANOSIDONIC+ACID'>423</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xqa OCA], [https://pdbe.org/4xqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xqa RCSB], [https://www.ebi.ac.uk/pdbsum/4xqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xqa ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xqa OCA], [https://pdbe.org/4xqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xqa RCSB], [https://www.ebi.ac.uk/pdbsum/4xqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xqa ProSAT]</span></td></tr>
	</table>		</table>

OCA at 17:47, 26 April 2023

OCA — Wed, 26 Apr 2023 17:47:42 GMT

←Older revision		Revision as of 17:47, 26 April 2023
Line 3:		Line 3:
	<StructureSection load='4xqa' size='340' side='right'caption='[[4xqa]], [[Resolution\|resolution]] 1.41Å' scene=''>		<StructureSection load='4xqa' size='340' side='right'caption='[[4xqa]], [[Resolution\|resolution]] 1.41Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xqa]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Adenovirus_type_37 Adenovirus type 37~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XQA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4XQA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xqa]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_adenovirus_D37 Human adenovirus D37]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XQA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XQA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=423:(1-{2-[BIS(2-{4-[({(6R)-5-(ACETYLAMINO)-3,5-DIDEOXY-6-[(1R,2R)-1,2,3-TRIHYDROXYPROPYL]-BETA-L-THREO-HEX-2-ULOPYRANONOSYL}OXY)METHYL]-1H-1,2,3-TRIAZOL-1-YL}ETHYL)AMINO]ETHYL}-1H-1,2,3-TRIAZOL-4-YL)METHYL+(6R)-5-(ACETYLAMINO)-3,5-DIDEOXY-6-[(1R,2R)-1,2,3-TRIHYDROXYPROPYL]-BETA-L-THREO-HEX-2-ULOPYRANOSIDONIC+ACID'>423</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=423:(1-{2-[BIS(2-{4-[({(6R)-5-(ACETYLAMINO)-3,5-DIDEOXY-6-[(1R,2R)-1,2,3-TRIHYDROXYPROPYL]-BETA-L-THREO-HEX-2-ULOPYRANONOSYL}OXY)METHYL]-1H-1,2,3-TRIAZOL-1-YL}ETHYL)AMINO]ETHYL}-1H-1,2,3-TRIAZOL-4-YL)METHYL+(6R)-5-(ACETYLAMINO)-3,5-DIDEOXY-6-[(1R,2R)-1,2,3-TRIHYDROXYPROPYL]-BETA-L-THREO-HEX-2-ULOPYRANOSIDONIC+ACID'>423</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4k6t\|4k6t]], [[4k6u\|4k6u]], [[4k6v\|4k6v]], [[4k6w\|4k6w]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xqa OCA], [https://pdbe.org/4xqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xqa RCSB], [https://www.ebi.ac.uk/pdbsum/4xqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xqa ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">L5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=52275 Adenovirus type 37])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4xqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xqa OCA], [~~http~~://pdbe.org/4xqa PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4xqa RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4xqa PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4xqa ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q64823_9ADEN Q64823_9ADEN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Adenovirus type 37~~]]	+	[[Category: Human adenovirus D37]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Liaci~~, A M~~]]	+	[[Category: Liaci AM]]
-	[[Category: Stehle, T]]	+	[[Category: Stehle T]]
-	~~[[Category: Adenovirus]]~~	+
-	~~[[Category: Carbohydrate mimic]]~~	+
-	~~[[Category: Fiber knob]]~~	+
-	~~[[Category: Multivalent ligand]]~~	+
-	~~[[Category: Protein carbohydrate interaction]]~~	+
-	~~[[Category: Sialic acid]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 05:54, 12 June 2019

OCA — Wed, 12 Jun 2019 05:54:52 GMT

←Older revision		Revision as of 05:54, 12 June 2019
Line 24:		Line 24:
	[[Category: Adenovirus type 37]]		[[Category: Adenovirus type 37]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~LIACI~~, A M]]	+	[[Category: Liaci, A M]]
-	[[Category: ~~STEHLE~~, T]]	+	[[Category: Stehle, T]]
	[[Category: Adenovirus]]		[[Category: Adenovirus]]
	[[Category: Carbohydrate mimic]]		[[Category: Carbohydrate mimic]]

OCA at 23:23, 5 June 2019

OCA — Wed, 05 Jun 2019 23:23:46 GMT

←Older revision		Revision as of 23:23, 5 June 2019
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF AD37 FIBER KNOB IN COMPLEX WITH TRIVALENT SIALIC ACID INHIBITOR ME0462==		==CRYSTAL STRUCTURE OF AD37 FIBER KNOB IN COMPLEX WITH TRIVALENT SIALIC ACID INHIBITOR ME0462==
-	<StructureSection load='4xqa' size='340' side='right' caption='[[4xqa]], [[Resolution\|resolution]] 1.41Å' scene=''>	+	<StructureSection load='4xqa' size='340' side='right'caption='[[4xqa]], [[Resolution\|resolution]] 1.41Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xqa]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XQA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XQA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xqa]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Adenovirus_type_37 Adenovirus type 37]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XQA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XQA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=423:(1-{2-[BIS(2-{4-[({(6R)-5-(ACETYLAMINO)-3,5-DIDEOXY-6-[(1R,2R)-1,2,3-TRIHYDROXYPROPYL]-BETA-L-THREO-HEX-2-ULOPYRANONOSYL}OXY)METHYL]-1H-1,2,3-TRIAZOL-1-YL}ETHYL)AMINO]ETHYL}-1H-1,2,3-TRIAZOL-4-YL)METHYL+(6R)-5-(ACETYLAMINO)-3,5-DIDEOXY-6-[(1R,2R)-1,2,3-TRIHYDROXYPROPYL]-BETA-L-THREO-HEX-2-ULOPYRANOSIDONIC+ACID'>423</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=423:(1-{2-[BIS(2-{4-[({(6R)-5-(ACETYLAMINO)-3,5-DIDEOXY-6-[(1R,2R)-1,2,3-TRIHYDROXYPROPYL]-BETA-L-THREO-HEX-2-ULOPYRANONOSYL}OXY)METHYL]-1H-1,2,3-TRIAZOL-1-YL}ETHYL)AMINO]ETHYL}-1H-1,2,3-TRIAZOL-4-YL)METHYL+(6R)-5-(ACETYLAMINO)-3,5-DIDEOXY-6-[(1R,2R)-1,2,3-TRIHYDROXYPROPYL]-BETA-L-THREO-HEX-2-ULOPYRANOSIDONIC+ACID'>423</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4k6t\|4k6t]], [[4k6u\|4k6u]], [[4k6v\|4k6v]], [[4k6w\|4k6w]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4k6t\|4k6t]], [[4k6u\|4k6u]], [[4k6v\|4k6v]], [[4k6w\|4k6w]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">L5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=52275 Adenovirus type 37])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xqa OCA], [http://pdbe.org/4xqa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xqa RCSB], [http://www.ebi.ac.uk/pdbsum/4xqa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xqa ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xqa OCA], [http://pdbe.org/4xqa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xqa RCSB], [http://www.ebi.ac.uk/pdbsum/4xqa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xqa ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Adenovirus type 37]]
		+	[[Category: Large Structures]]
	[[Category: LIACI, A M]]		[[Category: LIACI, A M]]
	[[Category: STEHLE, T]]		[[Category: STEHLE, T]]

OCA at 17:10, 12 July 2016

OCA — Tue, 12 Jul 2016 17:10:53 GMT

←Older revision		Revision as of 17:10, 12 July 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF AD37 FIBER KNOB IN COMPLEX WITH TRIVALENT SIALIC ACID INHIBITOR ME0462==		==CRYSTAL STRUCTURE OF AD37 FIBER KNOB IN COMPLEX WITH TRIVALENT SIALIC ACID INHIBITOR ME0462==
	<StructureSection load='4xqa' size='340' side='right' caption='[[4xqa]], [[Resolution\|resolution]] 1.41Å' scene=''>		<StructureSection load='4xqa' size='340' side='right' caption='[[4xqa]], [[Resolution\|resolution]] 1.41Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=423:(1-{2-[BIS(2-{4-[({(6R)-5-(ACETYLAMINO)-3,5-DIDEOXY-6-[(1R,2R)-1,2,3-TRIHYDROXYPROPYL]-BETA-L-THREO-HEX-2-ULOPYRANONOSYL}OXY)METHYL]-1H-1,2,3-TRIAZOL-1-YL}ETHYL)AMINO]ETHYL}-1H-1,2,3-TRIAZOL-4-YL)METHYL+(6R)-5-(ACETYLAMINO)-3,5-DIDEOXY-6-[(1R,2R)-1,2,3-TRIHYDROXYPROPYL]-BETA-L-THREO-HEX-2-ULOPYRANOSIDONIC+ACID'>423</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=423:(1-{2-[BIS(2-{4-[({(6R)-5-(ACETYLAMINO)-3,5-DIDEOXY-6-[(1R,2R)-1,2,3-TRIHYDROXYPROPYL]-BETA-L-THREO-HEX-2-ULOPYRANONOSYL}OXY)METHYL]-1H-1,2,3-TRIAZOL-1-YL}ETHYL)AMINO]ETHYL}-1H-1,2,3-TRIAZOL-4-YL)METHYL+(6R)-5-(ACETYLAMINO)-3,5-DIDEOXY-6-[(1R,2R)-1,2,3-TRIHYDROXYPROPYL]-BETA-L-THREO-HEX-2-ULOPYRANOSIDONIC+ACID'>423</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4k6t\|4k6t]], [[4k6u\|4k6u]], [[4k6v\|4k6v]], [[4k6w\|4k6w]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4k6t\|4k6t]], [[4k6u\|4k6u]], [[4k6v\|4k6v]], [[4k6w\|4k6w]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xqa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xqa RCSB], [http://www.ebi.ac.uk/pdbsum/4xqa PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xqa OCA], [http://pdbe.org/4xqa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xqa RCSB], [http://www.ebi.ac.uk/pdbsum/4xqa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xqa ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4xqa" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:35, 29 July 2015

OCA — Wed, 29 Jul 2015 14:35:55 GMT

←Older revision		Revision as of 14:35, 29 July 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==CRYSTAL STRUCTURE OF AD37 FIBER KNOB IN COMPLEX WITH TRIVALENT SIALIC ACID INHIBITOR ME0462==
		+	<StructureSection load='4xqa' size='340' side='right' caption='[[4xqa]], [[Resolution\|resolution]] 1.41Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4xqa]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XQA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XQA FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=423:(1-{2-[BIS(2-{4-[({(6R)-5-(ACETYLAMINO)-3,5-DIDEOXY-6-[(1R,2R)-1,2,3-TRIHYDROXYPROPYL]-BETA-L-THREO-HEX-2-ULOPYRANONOSYL}OXY)METHYL]-1H-1,2,3-TRIAZOL-1-YL}ETHYL)AMINO]ETHYL}-1H-1,2,3-TRIAZOL-4-YL)METHYL+(6R)-5-(ACETYLAMINO)-3,5-DIDEOXY-6-[(1R,2R)-1,2,3-TRIHYDROXYPROPYL]-BETA-L-THREO-HEX-2-ULOPYRANOSIDONIC+ACID'>423</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4k6t\|4k6t]], [[4k6u\|4k6u]], [[4k6v\|4k6v]], [[4k6w\|4k6w]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xqa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xqa RCSB], [http://www.ebi.ac.uk/pdbsum/4xqa PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Adenovirus type 37 (Ad37) is one of the principal agents responsible for epidemic keratoconjunctivitis (EKC), a severe ocular infection that remains without any available treatment. Recently, a trivalent sialic acid derivative (, Angew. Chem. Int. Ed., 2011, , 6519) was shown to function as a highly potent inhibitor of Ad37, efficiently preventing the attachment of the virion to the host cells and subsequent infection. Here, new trivalent sialic acid derivatives were designed, synthesized and their inhibitory properties against Ad37 infection of the human corneal epithelial cells were investigated. In comparison to , the best compound () was found to be over three orders of magnitude more potent in a cell-attachment assay (IC50 = 1.4 nM) and about 140 times more potent in a cell-infection assay (IC50 = 2.9 nM). X-ray crystallographic analysis demonstrated a trivalent binding mode of all compounds to the Ad37 fiber knob. For the most potent compound ophthalmic toxicity in rabbits was investigated and it was concluded that repeated eye administration did not cause any adverse effects.

-	~~The entry 4xqa is ON HOLD until Paper Publication~~	+	Triazole linker-based trivalent sialic acid inhibitors of adenovirus type 37 infection of human corneal epithelial cells.,Caraballo R, Saleeb M, Bauer J, Liaci AM, Chandra N, Storm RJ, Frangsmyr L, Qian W, Stehle T, Arnberg N, Elofsson M Org Biomol Chem. 2015 Jul 16. PMID:26177934<ref>PMID:26177934</ref>

-	~~Authors: STEHLE~~, T., LIACI, A.M.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~:	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
-	[[Category: ~~Stehle, T~~]]	+	__TOC__
-	[[Category: ~~Liaci, A.M~~]]	+	</StructureSection>
		+	[[Category: LIACI, A M]]
		+	[[Category: STEHLE, T]]
		+	[[Category: Adenovirus]]
		+	[[Category: Carbohydrate mimic]]
		+	[[Category: Fiber knob]]
		+	[[Category: Multivalent ligand]]
		+	[[Category: Protein carbohydrate interaction]]
		+	[[Category: Sialic acid]]
		+	[[Category: Viral protein]]

OCA at 14:42, 7 February 2015

OCA — Sat, 07 Feb 2015 14:42:57 GMT

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-	The entry 4xqa is ON HOLD	+	The entry 4xqa is ON HOLD until Paper Publication

	Authors: STEHLE, T., LIACI, A.M.		Authors: STEHLE, T., LIACI, A.M.

OCA: Protected "4xqa" [edit=sysop:move=sysop]

OCA — Wed, 28 Jan 2015 15:41:49 GMT

Protected "4xqa" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:41, 28 January 2015

OCA: New page: '''Unreleased structure''' The entry 4xqa is ON HOLD Authors: STEHLE, T., LIACI, A.M. Description: Category: Unreleased Structures Category: Stehle, T Category: Liaci, A.M

OCA — Wed, 28 Jan 2015 15:41:47 GMT

New page: '''Unreleased structure''' The entry 4xqa is ON HOLD Authors: STEHLE, T., LIACI, A.M. Description: Category: Unreleased Structures Category: Stehle, T Category: Liaci, A.M

New page

'''Unreleased structure'''

The entry 4xqa is ON HOLD

Authors: STEHLE, T., LIACI, A.M.

Description:
[[Category: Unreleased Structures]]
[[Category: Stehle, T]]
[[Category: Liaci, A.M]]